Nature, prevalence and clinical significance. Barcelona, Spain
|
|
- Delphia Hamilton
- 5 years ago
- Views:
Transcription
1 Nature, prevalence and clinical significance Jaime Kulisevsky Barcelona, Spain 1
2 Non motor (neuropsychiatric) symptoms are an integral part of Parkinson s s disease (PD) Affective disorders And are associated with Anxiety Depression Cognitive impairment Frontal executive Excess disability Worse quality of life Poorer outcomes Caregiver distress 23 impairment Main contributors to quality of life 4 Dementia Predictors of deterioration in health-related quality of life in Parkinson's disease: results Psychosis from the DATATOP t i l 5 Are particularly common 1 Neuropsychiatry Psychiatry Mood Affect Thought Behaviour Attention Alertness Perception Memory Language/speech Intelligence Cognition Motivation/apathy Neurology Motor Sensory (tactile, pain, temperature, two-point discrimination) 1 Aarsland et al. Arch Neurol 1999;56: ; 2 Goetz & Stebbins. Neurology 1993;43:2227 9; 3 Marsh et al. Neurology 2004;63: ; 4 Schrag et al. J Meurol Neurosurg Psychiatr 2000;69:308 12; ; 5 Marras et al. Mov Disord 2008;23:
3 Wide range of behavioural and personality changes in patients with PD according to the Neuropsychiatric Inventory (NPI) n=1,351 PD patients without dementia At least one psychiatric symptom reported in 68% of the sample Psychiatric symptoms, executive impairment i and excessive daytime somnolence (EDS) were significantly more common in patients with PD >7 years duration and Hoehn & Yahr stage IV-V disease Executive impairment (phonemic verbal fluency (PF)< 10, semantic verbal fluency (SF) < 15 and alternating verbal fluency (AF) < 8 words per minute) seen in 41% of patients EDS seen in 26% of patients t Anxiety seen in 21% (Hospital Anxiety and Depression Scale) Kulisevsky et al. Mov Disord 2008;23: To view abstract, click Abstracts link above 3
4 Incidence of neuropsychiatric symptoms in PD Patients with (PDD) 1 and without 2 dementia 80 PD with dementia PD without dementia (%) Patients NPI item 1 Aarsland et al. J Neurol Neurosurg Psychiatry 2007;78:36 42; 2 Kulisevsky et al. Mov Disord 2008;23: To view abstract, click Abstracts link above 4
5 Spectrum of PD cognitive impairment Predominantly subcortical items 1. Sustained attention 2. Working memory 3. Verbal memory Free and delayed recall 4. Verbal fluencies AF and action verbal fluency Predominantly cortical items: 1. Confrontation naming 2. Clock drawing (copy) 5
6 Cognitive impairment in PD Although precise identification of the impaired processes and their explanations in terms of cognitive models are debatable Impaired cognitive tasks in PD are very reminiscent of tasks impaired in processes affecting the frontal lobes 6
7 Types of cognitive impairment vary between newly diagnosed PD patients As a whole, lower cognitive performance in all tests vs control group Cortical and subcortical changes may occur simultaneously in some patients Patie ents (%) sh howing impa airment Memory and language g are more cortical than attention and visuospatial functions Muslimovic D. Neurology 2005;65: To view abstract, click Abstracts link above 7
8 The most important clinical predictors of global cognitive decline in PD (corrected for age) Neurological tasks with (a more posterior) cortical basis Semantic fluency Ability to copy Intersecting pentagons figure As well as a non-tremor dominant motor phenotype at the baseline assessment Profile of cognitive dysfunction amongst PD patients at baseline and at 3.5 (+/ 0.7) years from diagnosisi Pentagons: pentagon copying; PF: phonemic fluency; PRM: pattern recognition memory; SF: semantic fluency; SRM: spatial recognition memory; TOL: Tower of London Williams-Gray et al. Brain 2007;130: To view notes, click notes tab 8
9 Comparative progression of impairment of subcortical-type type (A,B) and cortical-type type (C,D) items Estimated Mar rginal Means Estimated Marg ginal Means selective decrease in cortical-type items scores in PDD TOTAL SCORES independently discriminated controls from PD without dementia as well as PD without t dementia from PDD (P<0.001) A. Alternating verbal fluency B. Working memory CG Cognitively intact MCI Dementia CORTICAL SCORES independently discriminated PDD from PD without dementia (P<0.01) Estimated Marg ginal Means CG Cognitively intact MCI Dementia C. Clock drawing task Copy part D. Confrontation naming CG Cognitively intact MCI Dementia PDD is characterised by the addition i of cortical dysfunction upon a predominant and progressive fronto- subcortical impairment rginal Means Estimated Mar CG Cognitively intact MCI Dementia Click for further details. Pagonabarraga et al. Mov Disord 2008;23: To view abstract, click Abstracts link above 9
10 Cognitive impairment in PD Cognitive impairment Normal Cognitive dysfunction Dementia Diagnosis of PD MCI * Time Age Phenotype Cortical deficits * Mild cognitive impairment Naming Pagonabarraga et al. Mov Disord 2008;23:
11 PD cognition: the boundaries between these 'systems' are not well defined Acetylcholine impairments in memory, attention, and frontal dysfunction Noradrenaline Contributing to impaired attention Glutamate? Serotonin Depressive mood Dopamine Partly responsible for dysexecutive syndrome 11
12 Heterogeneity of cognitive impairment in newly diagnosed PD PD patients had lower cognitive performance in all tests vs healthy controls Overall, the PD population suffered only mild cognitive impairment Dopamine agonist (DA) Cholinergic denervation? Muslimovic D. Neurology 2005;65:
13 Clinical features may reflect the extent of pathological burden Relatively subtle cognitive impairment i in PD (R-SCI) From visuo-perceptual and attentional-executive dysfunction PD with concurrent dementia PDD To visuo-perceptual and attentional-executive dementia Mainly dopaminergic deficits Crucial contribution of non-da systems How many legs? Hilker et al. Neurology 2005;65: To view abstract, click Abstracts link above. To view notes, click notes tab 13
14 DA medication appears to have little if any influence on the epidemiology of non-motor phenomena PD patients without dementia (n=1351) Current therapeutic combinations for PD Lev+DAs Lev+DAs 16% 3% Lev+DAs+ICOMT Lev+DAs+Anticholinergics 27% Lev+DAs+Other 44% 17% 64% 3% 0% 8% 16% 2% Monotherapy DAs* Lev alone Pramipexole Lev+ICOMT 4% Cabergoline Lev+(selegiline/amantadine/other AP) 22% Ropinirole DAs+ICOMTs Pergolide Monotherapy others 51% Monotherapy DAs 23% Lev+DAs No clear relationship between pharmacological data and: NPI items (including hallucinations) Executive dysfunction EDS (Epworth questionnaire) Levodopa (Lev) used by 74.2% of the patients, either alone (27%) or mainly in combination with dopamine agonists (DAs) Kulisevsky et al. Mov Disord 2008;23: To view abstract, click Abstracts link above 14
15 Evolving pharmacological response to Lev: three types of PD patients without dementia in whom DA cognitive response should be examined (1) Executive task perfor rmance Proper prefrontal cortex function De Stable responders Wearingoff PD novo PD Optimum patients (for PD) Too little DA receptor stimulation Too much Kulisevsky J. Drugs Aging 2000;16: To view abstract, click pause then click Abstracts link above 15
16 Evolving pharmacological response to Lev: three types of PD patients without dementia in whom DA cognitive response should be examined (2) De-novo 1 Incomplete (below normal range) cognitive improvement Working memory various frontal tasks Declines at 18 months, lost significance at 24 months Advanced PD patients (acute challenge of Lev) Stable responders to oral Lev 2 Little, if any, modification in tasks covering a wide range of cognitive domains Wearing-off 3 Acute (reversible) worsening performance in highly demanding frontal tasks Wisconsin Card Sorting Test (WCST), Sternberg paradigm, or associative conditional learning 1 Kulisevsky et al. Mov Disord 2000;15: Kulisevsky J. Drugs Aging 2000;16: Kulisevsky et al. Brain 1996;119: To view abstract, click Abstracts link above. To view notes, click notes tab 16
17 Cognitive effects of pharmacological manipulation of the DA system Chronic DA replacement Acute DA challenge may have contrasting Improves motor and cognitive effects 1. Same task different motor response functions but is not enough to (e.g. WCST) compensate for Fuctuating patients worsening performance in On vs Off All motor deficits Returns to previous level of All cognitive deficits performance when plasma levels of LD decays Proper prefrontal cortex function 2. Same patients different tasks Executive ta ask performan nce De novo PD Too little Stable responders Wearing -off PD Optimum patients (for PD) DA receptor stimulation Kulisevsky J. Drugs Aging 2000;16: Too much Depending on frontal cortical regions with different DA depletion in PD 3. Same task - different polymorphisms Genes regulating g dopaminergic transmission COMT 4. Same patients rapid vs slower plasma increase in LD level Standard transient negative effects vs retard protecting effects 17
18 Cortical cholinergic activity is reduced in PD and PDD Mean Cortex Amygdata Hippocampus Inferior Temporal Superior Temporal Parietal Patients With Alzheimer Disease Patients With Parkinson Disease Without Dementia Patients With Parkinsonian Dementia Cerebral AChE activity correlates with neurological deficits in PDD Verbal memory Stroop colour word tests Trail-making test Digit it span Benton s Judgement of Line Orientation Frontal % Reduction in AChE Activity Hilker et al. Neurology 2005;65: ; Bohnen. J Neurol 2005;253: To view abstract, click Abstracts link above. To view notes, click notes tab 18
19 Rivastigmine versus placebo: changes from baseline on the Alzheimer s Disease Assessment Scale cognition (ADAS-cog) Change from baselin ne, ADAS-co og Rivastigmine (n=329) Placebo (n=161) * ** Improvement Baseline 1.0 Deterioration Week: *P = 0.002; **P < 0.001, efficacy analysis Emre et al. N Engl J Med 2004;351: To view abstract, click Abstracts link above. To view notes, click notes tab 19
20 Question 1. In Kulisevsky's 2008 study, what proportion of patients without dementia had at least one psychiatric symptom? A) 38% B) 58% C) 68% D) 97% Correct - Click anywhere to continue Incorrect, please try again Incorrect, You must please answer try again the question before continuing Submit Clear 20
21 Question 2: Impaired cognitive tasks in PD are very reminiscent of tasks impaired in processes affecting: A) Temporal lobes B) Occipital lobes C) Frontal lobes Correct - Click anywhere to continue Incorrect, please try again Incorrect, You must please answer try again the question before continuing Submit Clear 21
22 Copyright statements Slide 8 Slide 9 Slide 13 Slide , reproduced with permission from Oxford University Press 2008, reproduced with permission from John Wiley & Sons, Inc 2005, reproduced with permission from Wolters Kluwer, Inc 2004, reproduced with permission from Massachusetts Medical Society. All rights reserved 22
Chronic Effects of Dopaminergic Replacement on Cognitive Function in Parkinson s Disease: A Two-Year Follow-Up Study of Previously Untreated Patients
Movement Disorders Vol. 15, No. 4, 2000, pp. 613 626 2000 Movement Disorder Society Chronic Effects of Dopaminergic Replacement on Cognitive Function in Parkinson s Disease: A Two-Year Follow-Up Study
More informationClinical Features and Treatment of Parkinson s Disease
Clinical Features and Treatment of Parkinson s Disease Richard Camicioli, MD, FRCPC Cognitive and Movement Disorders Department of Medicine University of Alberta 1 Objectives To review the diagnosis and
More informationThe Spectrum of Lewy Body Disease: Dementia with Lewy Bodies and Parkinson's Disease Dementia
Disclosures Research support, Parkinson Society Canada, Canadian Institutes of Health Research, Ministry of Economic Development and Innovation, Teva Novartis clinical trial, Principal Investigator CME
More informationNeuropsychological Evaluation of
Neuropsychological Evaluation of Alzheimer s Disease Joanne M. Hamilton, Ph.D. Shiley-Marcos Alzheimer s Disease Research Center Department of Neurosciences University of California, San Diego Establish
More informationContinuous dopaminergic stimulation
Continuous dopaminergic stimulation Angelo Antonini Milan, Italy GPSRC CNS 172 173 0709 RTG 1 As PD progresses patient mobility becomes increasingly dependent on bioavailability of peripheral levodopa
More informationCognitive-Motor Interference in Persons with Parkinson Disease
Cognitive-Motor Interference in Persons with Parkinson Disease Tara L. McIsaac, PhD, PT Associate Professor of Physical Therapy A.T. Still University Arizona School of Health Sciences October 11, 2014
More informationNEUROPSYCHOMETRIC TESTS
NEUROPSYCHOMETRIC TESTS CAMCOG It is the Cognitive section of Cambridge Examination for Mental Disorders of the Elderly (CAMDEX) The measure assesses orientation, language, memory, praxis, attention, abstract
More informationPD ExpertBriefing: Cognition and PD: What You ve Always Wanted to Know But Were Too Afraid to Ask. Presented By: Tuesday, March 22, 2011 at 1:00 PM ET
PD ExpertBriefing: Cognition and PD: What You ve Always Wanted to Know But Were Too Afraid to Ask Presented By: Alexander I. Tröster, PhD, ABPP University of North Carolina, Chapel Hill, NC Tuesday, March
More informationNon-motor symptoms as a marker of. Michael Samuel
Non-motor symptoms as a marker of progression in Parkinson s s disease Michael Samuel London, UK 1 Definitions and their problems Non-motor symptoms as a marker of progression Non-motor symptoms (NMS)
More informationDEMENTIA, THE BRAIN AND HOW IT WORKS AND WHY YOU MATTER
OVERCOMING THE CHALLENGES OF MANAGING CHRONIC DISEASES IN PERSONS WITH DEMENTIA DEMENTIA, THE BRAIN AND HOW IT WORKS AND WHY YOU MATTER LEARNING OBJECTIVES Be familiar with the diagnostic criteria for
More informationAGED SPECIFIC ASSESSMENT TOOLS. Anna Ciotta Senior Clinical Neuropsychologist Peninsula Mental Health Services
AGED SPECIFIC ASSESSMENT TOOLS Anna Ciotta Senior Clinical Neuropsychologist Peninsula Mental Health Services Issues in assessing the Elderly Association between biological, psychological, social and cultural
More informationParkinsonian Disorders with Dementia
Parkinsonian Disorders with Dementia George Tadros Consultant in Old Age Liaison Psychiatry, RAID, Heartlands Hospital Professor of Dementia and Liaison Psychiatry, Aston Medical School Aston University
More informationBehavioural Correlates of Cognitive Skill Learning in Parkinson s Disease
The Open Behavioral Science Journal, 2008, 2, 1-12 1 Behavioural Correlates of Cognitive Skill Learning in Parkinson s Disease M.H. Beauchamp 1, A. Dagher 2, M. Panisset 2,3 and J. Doyon *,1,2,4 1 Université
More informationAppendix N: Research recommendations
Appendix N: recommendations N.1 First-line treatment of motor symptoms recommendation 1 Interventions What is the effectiveness of initial levodopa monotherapy versus initial levodopa-dopamine agonist
More informationEvolution of cognitive dysfunction in an incident Parkinson s disease cohort
doi:10.1093/brain/awm111 Brain (2007), 130,1787^1798 Evolution of cognitive dysfunction in an incident Parkinson s disease cohort C. H. Williams-Gray, 1 T. Foltynie, 1 C. E. G. Brayne, 2 T. W. Robbins
More informationTreatment of sleep disorders in
Treatment of sleep disorders in Parkinson s s disease (PD) K. Ray Chaudhuri London, UK GPSRC CNS 176 0709 RTG 1 Managing insomnia in PD Onset/initiation Adjustment of anti-pd treatment Sleep hygiene Hypnotics
More informationThe Neuropsychology of
The Neuropsychology of Stroke Tammy Kordes, Ph.D. Northshore Neurosciences Outline What is the Role of Neuropsychology Purpose of Neuropsychological Assessments Common Neuropsychological Disorders Assessment
More informationM P---- Ph.D. Clinical Psychologist / Neuropsychologist
M------- P---- Ph.D. Clinical Psychologist / Neuropsychologist NEUROPSYCHOLOGICAL EVALUATION Name: Date of Birth: Date of Evaluation: 05-28-2015 Tests Administered: Wechsler Adult Intelligence Scale Fourth
More informationDementia in Parkinson s disease:
Dementia in Parkinson s disease: A 20 year Prospective Neuropsychological Study Sydney Multicentre Study Associate Professor Wayne GJ Reid PhD FAPS 149 newly diagnosed community living Parkinson s Disease
More informationProcess of a neuropsychological assessment
Test selection Process of a neuropsychological assessment Gather information Review of information provided by referrer and if possible review of medical records Interview with client and his/her relative
More informationOriginal Articles. Calne, resting tremor. Mortimer, Pirozzolo, Hansch, & Webster, postural disturbance III
2004 97-106 Original Articles 1 2 3 1 1 2 3 47 22 III I II muscular rigidity postural disturbance resting tremor bradykinesia Calne, 2001 Mortimer, Pirozzolo, Hansch, & Webster, 1982 Tel: 02-23627076 E-mail:
More informationCorrelation between motor and cognitive functions in the progressive course of Parkinson s disease
doi:10.1111/ncn3.53 ORIGINAL ARTICLE Correlation between motor and cognitive functions in the progressive course of Parkinson s disease Hidetomo Murakami,* Yoshiyuki Owan,* Yukiko Mori,* Kazuhisa Fujita,*
More informationLate Stage PD: clinical problems & management issues
Late Stage PD: clinical problems & management issues Miguel Coelho, MD Neurological Department, Hospital Santa Maria Clinical Pharmacology Unit, IMM, Lisbon Portugal 26 September 2014 Nothing to declare.
More informationA Longitudinal Evaluation of Health-Related Quality of Life of Patients with Parkinson s Disease
Volume 12 Number 2 2009 VALUE IN HEALTH A Longitudinal Evaluation of Health-Related Quality of Life of Patients with Parkinson s Disease Martine Visser, PhD, 1 Dagmar Verbaan, MSc, 1 Stephanie van Rooden,
More informationUse of the Pill Questionnaire to detect cognitive deficits and assess their impact on daily life in patients with Parkinson s disease
Neurology Asia 2013; 18(4) : 369 375 Use of the Pill Questionnaire to detect cognitive deficits and assess their impact on daily life in patients with Parkinson s disease 1 Ji Seon Kim MD, 2 Jong-Min Kim
More informationDementia and Alzheimer s disease
Since 1960 Medicine Korat โรงพยาบาลมหาราชนครราชส มา Dementia and Alzheimer s disease Concise Reviews PAWUT MEKAWICHAI MD DEPARTMENT of MEDICINE MAHARAT NAKHON RATCHASIMA HOSPITAL 1 Prevalence Increase
More informationUse a diagnostic neuropsychology HOW TO DO IT PRACTICAL NEUROLOGY
170 PRACTICAL NEUROLOGY HOW TO DO IT Pract Neurol: first published as 10.1046/j.1474-7766.2003.08148.x on 1 June 2003. Downloaded from http://pn.bmj.com/ Use a diagnostic neuropsychology on 16 October
More informationClinical Study A New Approach for the Quantitative Evaluation of the Clock Drawing Test: Preliminary Results on Subjects with Parkinson s Disease
Neurology Research International Volume 2010, Article ID 283890, 6 pages doi:10.1155/2010/283890 Clinical Study A New Approach for the Quantitative Evaluation of the Clock Drawing Test: Preliminary Results
More informationCHAPTER 5 NEUROPSYCHOLOGICAL PROFILE OF ALZHEIMER S DISEASE
CHAPTER 5 NEUROPSYCHOLOGICAL PROFILE OF ALZHEIMER S DISEASE 5.1 GENERAL BACKGROUND Neuropsychological assessment plays a crucial role in the assessment of cognitive decline in older age. In India, there
More informationIan McKeith MD, F Med Sci, Professor of Old Age Psychiatry, Newcastle University
Ian McKeith MD, F Med Sci, Professor of Old Age Psychiatry, Newcastle University Design of trials in DLB and PDD What has been learnt from previous trials in these indications and other dementias? Overview
More informationWHAT IS DEMENTIA? An acquired syndrome of decline in memory and other cognitive functions sufficient to affect daily life in an alert patient
DEMENTIA WHAT IS DEMENTIA? An acquired syndrome of decline in memory and other cognitive functions sufficient to affect daily life in an alert patient Progressive and disabling Not an inherent aspect of
More informationCognition in Parkinson's Disease and the Effect of Dopaminergic Therapy
Cognition in Parkinson's Disease and the Effect of Dopaminergic Therapy Penny A. MacDonald, MD, PhD, FRCP(C) Canada Research Chair Tier 2 in Cognitive Neuroscience and Neuroimaging Assistant Professor
More informationObjectives. RAIN Difficult Diagnosis 2014: A 75 year old woman with falls. Case History: First visit. Case History: First Visit
Objectives RAIN Difficult Diagnosis 2014: A 75 year old woman with falls Alexandra Nelson MD, PhD UCSF Memory and Aging Center/Gladstone Institute of Neurological Disease Recognize important clinical features
More informationNATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE. Health Technology Appraisal
NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE Health Technology Appraisal Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (Review of TA 111) Appraisal
More information02/04/2015. The structure of the talk. Dementia as a motor disorder. Movement, cognition & behaviour. Example 1. Example 2
The th Annual Memory Clinic Conference Dublin, Trinity College, 27 March 1 The structure of the talk Dementia as a motor disorder Thomas H. Bak Human Cognitive Neuroscience & Centre for Clinical Brain
More informationUniversity of Alberta
University of Alberta Longitudinal performance of Neuropsychological Assessments in Parkinson s Disease. by Taim Abdullah Muayqil A thesis submitted to the Faculty of Graduate Studies and Research in partial
More informationCognitive Function in Early and Advanced Parkinson s disease
Cognitive Function in Early and Advanced Parkinson s disease Lei Chen 1,2,, Xin Wang 1,2, Abstract Objective: To investigate the occurrence of mild cognitive impairment (MCI) in early and advanced Parkinson
More informationOverview. Overview. Parkinson s disease. Secondary Parkinsonism. Parkinsonism: Motor symptoms associated with impairment in basal ganglia circuits
Overview Overview Parkinsonism: Motor symptoms associated with impairment in basal ganglia circuits The differential diagnosis of Parkinson s disease Primary vs. Secondary Parkinsonism Proteinopathies:
More informationBiological Risk Factors
Biological Risk Factors Ms Angelina Crea Provisional Psychologist Academic Child Psychiatry Unit Royal Children s Hospital Professor Alasdair Vance Head Academic Child Psychiatry Department of Paediatrics
More informationSCIENTIFIC DISCUSSION
London, 2 March 2006 Product name: Prometax Procedure number: EMEA/H/C/255/II/33 SCIENTIFIC DISCUSSION 7 Westferry Circus, Canary Wharf, London, E14 4HB, UK Tel. (44-20) 74 18 84 00 Fax (44-20) 74 18 86
More informationTHE ROLE OF ACTIVITIES OF DAILY LIVING IN THE MCI SYNDROME
PERNECZKY 15/06/06 14:35 Page 1 THE ROLE OF ACTIVITIES OF DAILY LIVING IN THE MCI SYNDROME R. PERNECZKY, A. KURZ Department of Psychiatry and Psychotherapy, Technical University of Munich, Germany. Correspondence
More informationThe Frontal Lobes. Anatomy of the Frontal Lobes. Anatomy of the Frontal Lobes 3/2/2011. Portrait: Losing Frontal-Lobe Functions. Readings: KW Ch.
The Frontal Lobes Readings: KW Ch. 16 Portrait: Losing Frontal-Lobe Functions E.L. Highly organized college professor Became disorganized, showed little emotion, and began to miss deadlines Scores on intelligence
More information21/05/2018. Today s webinar will answer. Presented by: Valorie O Keefe Consultant Psychologist
Today s webinar will answer. 1. What is the RBANS, and how is the updated version different than the original version? 2. What are the neurocognitive areas assessed by the RBANS and what scores are available?
More informationDementia Update. October 1, 2013 Dylan Wint, M.D. Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas, Nevada
Dementia Update October 1, 2013 Dylan Wint, M.D. Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas, Nevada Outline New concepts in Alzheimer disease Biomarkers and in vivo diagnosis Future trends
More informationDementia. Aetiology, pathophysiology and the role of neuropsychological testing. Dr Sheng Ling Low Geriatrician
Dementia Aetiology, pathophysiology and the role of neuropsychological testing Dr Sheng Ling Low Geriatrician Topics to cover Why is dementia important What is dementia Differentiate between dementia,
More informationSOCIABLE - NEXT GENERATION COGNITIVE TRAINING USING MULTI-TOUCH SURFACE COMPUTERS
SOCIABLE - NEXT GENERATION COGNITIVE TRAINING USING MULTI-TOUCH SURFACE COMPUTERS Dr Paraskevi Sakka Neurologist - Psychiatrist Athens Association of Alzheimer s Disease and Related Disorders Neurodegenerative
More informationHallucinations and conscious access to visual inputs in Parkinson s disease
Supplemental informations Hallucinations and conscious access to visual inputs in Parkinson s disease Stéphanie Lefebvre, PhD^1,2, Guillaume Baille, MD^4, Renaud Jardri MD, PhD 1,2 Lucie Plomhause, PhD
More informationErin Cullnan Research Assistant, University of Illinois at Chicago
Dr. Moises Gaviria Distinguished Professor of Psychiatry, University of Illinois at Chicago Director of Consultation Liaison Service, Advocate Christ Medical Center Director of the Older Adult Program,
More informationTable 1: Summary of measures of cognitive fatigability operationalised in existing research.
Table 1: Summary of measures of cognitive fatigability operationalised in existing research. Candidate Mmeasures Studies Procedure Self-reported fatigue measure Key Findings The auditory As and auditory
More informationDEMENTIA 101: WHAT IS HAPPENING IN THE BRAIN? Philip L. Rambo, PhD
DEMENTIA 101: WHAT IS HAPPENING IN THE BRAIN? Philip L. Rambo, PhD OBJECTIVES Terminology/Dementia Basics Most Common Types Defining features Neuro-anatomical/pathological underpinnings Neuro-cognitive
More informationCANTAB Test descriptions by function
CANTAB Test descriptions by function The 22 tests in the CANTAB battery may be divided into the following main types of task: screening tests visual memory tests executive function, working memory and
More informationPharmacological Treatments for Neuropsychiatric Symptoms in Dementia 3/22/2018
Pharmacological Treatments for Neuropsychiatric Symptoms in Dementia 3/22/2018 Mary Ellen Quiceno, MD, FAAN Associate Professor of Neurology UNTHSC Center for Geriatrics 855 Montgomery Street, PCC 4, Ft.
More informationNon Alzheimer Dementias
Non Alzheimer Dementias Randolph B Schiffer Department of Neuropsychiatry and Behavioral Science Texas Tech University Health Sciences Center 9/11/2007 Statement of Financial Disclosure Randolph B Schiffer,,
More informationUniversity of Groningen. Visual hallucinations in Parkinson's disease Meppelink, Anne Marthe
University of Groningen Visual hallucinations in Parkinson's disease Meppelink, Anne Marthe IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
More informationBasal ganglia motor circuit
Parkinson s Disease Basal ganglia motor circuit 1 Direct pathway (gas pedal) 2 Indirect pathway (brake) To release or augment the tonic inhibition of GPi on thalamus Direct pathway There is a tonic inhibition
More informationHill, Elisabeth L Executive dysfunction in autism. Trends in Cognitive Sciences, 8(1), pp ISSN [Article]
Hill, Elisabeth L.. 2004. Executive dysfunction in autism. Trends in Cognitive Sciences, 8(1), pp. 26-32. ISSN 13646613 [Article] http://research.gold.ac.uk/2558/ The version presented here may differ
More informationUniversity of Zagreb Medical School Repository
Središnja medicinska knjižnica Relja, M., Klepac, N. (2006) A dopamine agonist, pramipexole, and cognitive functions in Parkinson's disease. Journal of the Neurological Sciences, 248 (1-2). pp. 251-254.
More informationMild cognitive impairment in Parkinson s disease: a distinct clinical entity?
Wen et al. Translational Neurodegeneration (2017) 6:24 DOI 10.1186/s40035-017-0094-4 REVIEW Mild cognitive impairment in Parkinson s disease: a distinct clinical entity? Ming-Ching Wen 1,2*, Ling Ling
More informationScreening and Management of Behavioral and Psychiatric Symptoms Associated with Dementia
Screening and Management of Behavioral and Psychiatric Symptoms Associated with Dementia Measure Description Percentage of patients with dementia for whom there was a documented screening* for behavioral
More informationSECTION 1: as each other, or as me. THE BRAIN AND DEMENTIA. C. Boden *
I read all the available books by other [people with] Alzheimer s disease but they never had quite the same problems as each other, or as me. I t s not like other diseases, where there is a standard set
More informationCoordinating Care Between Neurology and Psychiatry to Improve the Diagnosis and Treatment of Parkinson s Disease Psychosis
Coordinating Care Between Neurology and Psychiatry to Improve the Diagnosis and Treatment of Parkinson s Disease Psychosis Jeff Gelblum, MD Senior Attending Neurologist Mt. Sinai Medical Center Miami,
More informationAcetylcholinesterase inhibitors: donepezil, rivastigmine, tacrine or galantamine for non-alzheimer s dementia
STEER 2002; Vol 2: No.2 Acetylcholinesterase inhibitors: donepezil, rivastigmine, tacrine or galantamine for non-alzheimer s dementia Bunmi Fajemisin Evidence search date: November 2001 www.signpoststeer.org
More informationAlzheimer s disease dementia: a neuropsychological approach
Alzheimer s disease dementia: a neuropsychological approach Dr. Roberta Biundo, PhD Neuropsychology Coordinator at Parkinson s disease and movement disorders unit of San Camillo rehabilitation hospital
More informationshows syntax in his language. has a large neocortex, which explains his language abilities. shows remarkable cognitive abilities. all of the above.
Section: Chapter 14: Multiple Choice 1. Alex the parrot: pp.529-530 shows syntax in his language. has a large neocortex, which explains his language abilities. shows remarkable cognitive abilities. all
More informationWorking memory in medicated patients with Parkinson's disease: the central executive seems to work
J7ournal of Neurology, Neurosurgery, and Psychiatry 1996;60:313-317 Working memory in medicated patients with Parkinson's disease: the central executive seems to work Nathalie Fournet, Olivier Moreaud,
More informationBehavioral Aspects of Parkinson s Disease
Behavioral Aspects of Parkinson s Disease Joseph H. Friedman, MD Director, Movement Disorders Program Butler Hospital Dept of Neurology Alpert Medical School of Brown University 1 Disclosures Drugs will
More informationDementia Training Session for Carers. By Dr Rahul Tomar Consultant Psychiatrist
Dementia Training Session for Carers By Dr Rahul Tomar Consultant Psychiatrist Dementia in the UK: Facts & Figures National Dementia strategy launched in 2009 800,000 people living with dementia (2012)
More informationDEMENTIA and BPSD in PARKINSON'S DISEASE. DR. T. JOHNSON. NOVEMBER 2017.
DEMENTIA and BPSD in PARKINSON'S DISEASE. DR. T. JOHNSON. NOVEMBER 2017. Introduction. Parkinson's disease (PD) has been considered largely as a motor disorder. It has been increasingly recognized that
More informationUNIVERSITY OF BOLTON SCHOOL OF EDUCATION AND PSYCHOLOGY PSYCHOLOGY PATHWAYS SEMESTER 2 EXAMINATIONS 2015/2016
EDP07 UNIVERSITY OF BOLTON SCHOOL OF EDUCATION AND PSYCHOLOGY PSYCHOLOGY PATHWAYS SEMESTER 2 EXAMINATIONS 2015/2016 COGNITIVE AND BIOPSYCHOLOGICAL PERSPECTIVES MODULE NO: PSC4003 Date: Wednesday 18 th
More informationPPMI Cognitive-Behavioral Working Group. Daniel Weintraub, MD
PPMI Cognitive-Behavioral Working Group Daniel Weintraub, MD PPMI Annual Meeting - May 6-7, 2014 Membership Daniel Weintraub WG Chair Tanya Simuni Steering Committee Shirley Lasch IND Chris Coffey, Chelsea
More informationASHI 712. The Neuroscience of Human Memory. Dr. Olave E. Krigolson LECTURE 2: Short Term Memory and Sleep and Memory
ASHI 712 The Neuroscience of Human Memory Dr. Olave E. Krigolson krigolson@uvic.ca LECTURE 2: Short Term Memory and Sleep and Memory Working / Short Term Memory Sunglasses Chair Dress Earrings Boots Bed
More informationUDS version 3 Summary of major changes to UDS form packets
UDS version 3 Summary of major changes to UDS form packets from version 2 to VERSION 3 february 18 final Form A1: Subject demographics Updated question on principal referral source to add additional options
More informationCognitive and Behavioural Changes After Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson s Disease
17 Cognitive and Behavioural Changes After Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson s Disease Antonio Daniele, Pietro Spinelli and Chiara Piccininni Istituto di Neurologia, Università
More informationIII./3.1. Movement disorders with akinetic rigid symptoms
III./3.1. Movement disorders with akinetic rigid symptoms III./3.1.1. Parkinson s disease Parkinson s disease (PD) is the second most common neurodegenerative disorder worldwide after Alzheimer s disease.
More informationEARLY ONSET FRONTOTERMPORAL DEMENTIA AND ALZHEIMERS DISEASE: DIAGNOSIS, TREATMENT AND CARE
EARLY ONSET FRONTOTERMPORAL DEMENTIA AND ALZHEIMERS DISEASE: DIAGNOSIS, TREATMENT AND CARE John Rudge, BA Hons This thesis is presented as partial requirement for the degree of Doctor of Psychology at
More informationA Neuropsychiatric, Neuroradiological, and Neuropsychological Profile of a Cohort of Patients with Vascular Dementia
A Neuropsychiatric, Neuroradiological, and Neuropsychological Profile of a Cohort of Patients with Vascular Dementia Moises Gaviria, MD University of Illinois at Chicago Advocate Christ Medical Center
More informationWhy Cognition Matters: Impact of Cognitive Impairment on Safety and Independent Living Skills
Why Cognition Matters: Impact of Cognitive Impairment on Safety and Independent Living Skills Presented by: Dr. William Mansbach CEO & Founder Mansbach Health Tools, LLC www.thebcat.com Highlights on Prevalence
More informationProf Tim Anderson. Neurologist University of Otago Christchurch
Prof Tim Anderson Neurologist University of Otago Christchurch Tim Anderson Christchurch Insidious cognitive loss From subjective memory complaints (SMC) to dementia Case 1. AR. 64 yrs Male GP referral
More informationThe Effect of Pramipexole on Depressive Symptoms in Parkinson's Disease.
Kobe J. Med. Sci., Vol. 56, No. 5, pp. E214-E219, 2010 The Effect of Pramipexole on Depressive Symptoms in Parkinson's Disease. NAOKO YASUI 1, KENJI SEKIGUCHI 1, HIROTOSHI HAMAGUCHI 1, and FUMIO KANDA
More informationMANAGING YOUR COGNITIVE SYMPTOMS. Dr. Valerie Suski University of Pittsburgh Medical Center HDSA COE Director
MANAGING YOUR COGNITIVE SYMPTOMS Dr. Valerie Suski University of Pittsburgh Medical Center HDSA COE Director The information provided by speakers in workshops, forums, sharing/networking sessions and any
More informationRevised criteria for the clinical diagnosis of dementia with Lewy. Dementia with Lewy bodies. (Dementia with Lewy Bodies)
Dementia with Lewy bodies First described: Okazaki H, 1961, Diffuse intracytoplasmic ganglionic inclusions (Lewy type) associated with progressive dementia and quadriparesis in flexion. J Neuropathol Exp
More informationAssessment Toolkits for Lewy Body Dementia
Study : Assessment Toolkits for Lewy Body Dementia There are two toolkits, depending on whether the patient is presenting with a primary cognitive problem or with cognitive decline in the context of established
More informationParkinson e decadimento cognitivo. Stelvio Sestini
Parkinson e decadimento cognitivo Stelvio Sestini Patients with PD can develop a spectrum of cognitive symptoms Heterogeneity of cognitive deficits The cognitive symptoms can evolve to dementia (Mov Disorder
More informationDementia. Assessing Brain Damage. Mental Status Examination
Dementia Assessing Brain Damage Mental status examination Information about current behavior and thought including orientation to reality, memory, and ability to follow instructions Neuropsychological
More informationCapacity and Older Adults. Kenneth I. Shulman
Capacity and Older Adults Kenneth I. Shulman Increased Requests for Contemporaneous Assessments of Testamentary Capacity Increase in challenges to testamentary capacity Demographics/Economics Prevalence
More informationMethod. NeuRA Schizophrenia and bipolar disorder April 2016
Introduction Schizophrenia is characterised by positive, negative and disorganised symptoms. Positive symptoms refer to experiences additional to what would be considered normal experience, such as hallucinations
More informationWhat APS Workers Need to Know about Frontotemporal, Lewy Body and Vascular Dementias
What APS Workers Need to Know about Frontotemporal, Lewy Body and Vascular Dementias Presenter: Kim Bailey, MS Gerontology, Program & Education Specialist, Alzheimer s Orange County 1 1 Facts About Our
More informationNeuropsychiatric Symptoms of Patients With Progressive Supranuclear Palsy and Parkinson s Disease
Neuropsychiatric Symptoms of Patients With Progressive Supranuclear Palsy and Parkinson s Disease Dag Aarsland, M.D., Ph.D. Irene Litvan, M.D. Jan P. Larsen, M.D., Ph.D. Neuropsychiatric symptoms are common
More informationImaging of Alzheimer s Disease: State of the Art
July 2015 Imaging of Alzheimer s Disease: State of the Art Neir Eshel, Harvard Medical School Year IV Outline Our patient Definition of dementia Alzheimer s disease Epidemiology Diagnosis Stages of progression
More informationProgram Highlights. Michael Pourfar, MD Co-Director, Center for Neuromodulation New York University Langone Medical Center New York, New York
Program Highlights David Swope, MD Associate Professor of Neurology Mount Sinai Health System New York, New York Michael Pourfar, MD Co-Director, Center for Neuromodulation New York University Langone
More informationCronicon EC NEUROLOGY. Mini Review. Alzheimer s Living with the Disease- Understanding the Brain. Caron Leid* Aspen University, Aspen, Colorado, USA
Cronicon OPEN ACCESS EC NEUROLOGY Mini Review Alzheimer s Living with the Disease- Understanding the Brain Caron Leid* Aspen University, Aspen, Colorado, USA *Corresponding Author: Caron Leid, Aspen University,
More informationNeuropsychology and Parkinson s Disease. Erin Holker, Ph.D., ABPP Neuropsychology Laboratory
Neuropsychology and Parkinson s Disease Erin Holker, Ph.D., ABPP Neuropsychology Laboratory Parkinson s disease and cognition Parkinson s disease is not just a disorder of movement The same circuits associated
More informationParkinson s Disease Psychosis: Hallucinations Delusions and Paranoia
Parkinson s Disease Psychosis: Hallucinations Delusions and Paranoia Christopher G. Goetz, MD Professor of Neurological Sciences Professor of Pharmacology Rush University Medical Center Parkinson s Foundation
More informationUpdate on functional brain imaging in Movement Disorders
Update on functional brain imaging in Movement Disorders Mario Masellis, MSc, MD, FRCPC, PhD Assistant Professor & Clinician-Scientist Sunnybrook Health Sciences Centre University of Toronto 53 rd CNSF
More informationTable 7.2B: Summary of Select Screening Tools for Assessment of Vascular Cognitive Impairment in Stroke Patients
Table 7.2B: Summary of Select Screening Tools for Assessment of Vascular Cognitive Impairment in Stroke Patients Recommended First Line Screening and s Montreal Cognitive (MoCA) The MoCA is available for
More informationCognitive Neuroscience of Memory
Cognitive Neuroscience of Memory Types and Structure of Memory Types of Memory Type of Memory Time Course Capacity Conscious Awareness Mechanism of Loss Sensory Short-Term and Working Long-Term Nondeclarative
More informationPalliative Approach to the Person with Advanced Dementia
Mid North Coast Rural Palliative Care Project Link Nurse Education 2004 Palliative Approach to the Person with Advanced Dementia Anne Sneesby CNC - ACAT To care for the dying is a very human opportunity
More informationHDSA Annual Convention June 2013 Behavior Issues: Irritability and Depression Peg Nopoulos, M.D.
HDSA Annual Convention June 2013 Behavior Issues: Irritability and Depression Peg Nopoulos, M.D. Professor of Psychiatry, Neurology, and Pediatrics University of Iowa, Iowa City, Iowa The information provided
More informationWorking Memory: Critical Constructs and Some Current Issues. Outline. Starting Points. Starting Points
Working Memory: Critical Constructs and Some Current Issues Edward E. Smith Columbia University Outline Background Maintenance: Modality specificity and buffers Interference resolution: Distraction and
More informationFunctional Neuroanatomy. IBRO ISN African Neuroscience School 4-13 th Dec 2014 Nairobi, Kenya
Functional Neuroanatomy IBRO ISN African Neuroscience School 4-13 th Dec 2014 Nairobi, Kenya What is/are the function(s) of the nervous system? Sensation Perception Visceral activities (Homeostasis) Behavior
More information