RIVAL study: RadIal Vs. femoral access for coronary intervention in patients with acute coronary syndromes study. Sanjit Jolly MD, MSc FRCPC
|
|
|
- Brittany Park
- 5 years ago
- Views:
Transcription
1 RIVAL study: RadIal Vs. femoral access for coronary intervention in patients with acute coronary syndromes study Sanjit Jolly MD, MSc FRCPC
2 Rationale Prior small trials and meta-analyses have demonstrated that radial vs. femoral access reduces vascular access site complications Radial access remains underutilized with 6-12% procedures worldwide
3 Strong Independent Association with Bleeding and Death, MI and Stroke HR 5.37 ( ) HR 4.44 ( ) Analysis OASIS Registry, OASIS 2, CURE (N=34,126) HR 6.46 ( ) Eikelboom JW et al. Circulation 2006;114(8):
4 New Paradigms 1) Major bleeding is as important as MI, in terms of predicting subsequent mortality 2) Major Bleeding events may lead to death and Recurrent MI Ndrepepa G, et al. JACC. 2008;51(7): Eikelboom JW et al. Circulation 2006;114(8):
5 Updated Meta-analysis of Radial vs. Femoral RCTs Study name Radial Peto Femoral odds ratio ACCESS 0 / / Achenbach 0 / / Bodi 3 / / BRAFE 0 / 50 1 / FARMI 3 / 57 3 / Gorge 1 / / Mann / 68 2 / OCTOPLUS 1 / / OUTCLAS 0 / / RADIAL AMI 1 / 25 4 / RADIAMI 3 / 50 7 / TEMPURA 0 / 77 2 / Vazquez-Rodriguez 1 / / / / Heterogeneity Q=22.03, df=16, p=0.14 Major Bleeding Peto odds ratio and 95% CI OR 0.27 (95% CI 0.16, 0.45) p<0.001 Heterogeneity p=0.93, i 2 =0% Favours Radial Favours Femoral Jolly SS, et al. Am Heart J. 2009;157:
6 Updated Meta-analysis of Radial vs. Femoral RCTs Study name Peto Radial Femoral odds ratio ACCESS 11 / / Achenbach 0 / / Bodi 7 / / BRAFE 2 / 50 2 / Cooper 0 / / FARMI 6 / 57 6 / OCTOPLUS 7 / / OUTCLAS** 7 / / RADIAL AMI 0 / 25 1 / RADIAMI 1 / 50 2 / TEMPURA* 4 / 77 6 / Vazquez-Rodriguez 11 / / / / Heterogeneity Q=22.03, df=16, p=0.14 Death, MI or Stroke OR 0.71 (95% CI 0.49, 1.01) p=0.058 Peto odds ratio and 95% CI Heterogeneity p=0.59, i 2 =0% Favours Radial Favours Femoral Trend for a reduction in death, MI or stroke with radial Jolly SS, et al. Am Heart J. 2009;157:
7 Hypothesis Radial access site PCI will be associated with significantly less major bleeding and access site complications compared with a femoral approach This reduction in bleeding complications will translate into lower rates of death and ischemic complications
8 Study Objective To determine if radial compared to femoral access in patients with NSTEACS and STEMI can reduce the rate of death, MI, Stroke or major bleeding at 30 days
9 Non STEACS and STEMI (n=7000) Randomization Intent to treat Analysis Radial Access (n=3500) Femoral Access (n=3500) 30 day follow-up 30 day follow-up Primary Outcome: Death, MI, stroke or major bleeding at 30 days
10 Recruitment as of April 26, 2010 Started as a sub-study of the CURRENT trial in June 2006 Extended to a stand alone trial in March 2008 Study Arm CURRENT Substudy (Randomizing June 2006 June 2009) RIVAL Stand-alone (Randomizing March 2008 to present) CURRENT Substudy Extension (Randomizing December 2009 to present) Number of Patients Randomized Overall RIVAL Trial as of April 26,
11 Recruitment as of April 26, 2010
12 Top 12 Recruiting Countries as of April 26, 2010
13 Country Top 12 Recruiting Countries CURRENT Substudy as of April 26, 2010 RIVAL Stand-alone CURRENT Substudy Extension Overall RIVAL Program Canada Finland India Bulgaria Poland Spain China Israel Brazil Chile Czech Republic United States
14 Projected vs. Actual Recruitment as of April 26, 2010 Cumulative No. of Sites Cumulative Recruitment
15 Weekly Recruitment as of April 26, 2010
16 CIHR Funding Application Update Applied for CIHR funding in Sept 2009 with a number of co-applicants from the CANNECTIN network Not approved- feedback, will the trial change practice (KT) Re-applied for CIHR funding in March 2010 after performing a national survey to assess impact of our trial
17 Study Completion Based on current recruitment, RIVAL trial will be complete enrolment in November 2010 Plans to present at ACC in March 2011
18 Special Recognition for the Efforts of: RIVAL & CURRENT National Coordinators CANNECTIN collaborators RIVAL & CURRENT study team
19 RIVAL Project Office Study Team Principal Investigators: Dr. Sanjit Jolly MD, MSc, FRCPC Steering Committee Chairs: Dr. Salim Yusuf, MBBS, PhD, FRCPC Dr. Shamir Mehta MD, MSc, FRCPC, FACC Dr. John Cairns, MD, FRCPC Project Manager: Susan Chrolavicius Research Coordinators: Caley Cramp Adjudication Coordinator: Mitzi Lawrence, RN BScN Barbara Jedrzejowski
Methods Search strategy for identification of studies
Radial versus femoral access for coronary or intervention and the impact on major bleeding and ischemic events: A systematic review and meta-analysis of randomized trials Sanjit S. Jolly, MD, a Shoaib
Effect of Radial Versus Femoral Access on Radiation Dose and the Importance of Procedural Volume
JACC: CARDIOVASCULAR INTERVENTIONS VOL. 6, NO. 3, 2013 2013 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION ISSN 1936-8798/$36.00 PUBLISHED BY ELSEVIER INC. http://dx.doi.org/10.1016/j.jcin.2012.10.016
CORONARY: The Coronary Artery Bypass Grafting Surgery Off or On Pump Revascularization Study. Results at 1 Year
CORONARY: The Coronary Artery Bypass Grafting Surgery Off or On Pump Revascularization Study Results at 1 Year André Lamy Population Health Research Institute Hamilton Health Sciences McMaster University
STEMI update. Vijay Krishnamoorthy M.D. Interventional Cardiology
STEMI update Vijay Krishnamoorthy M.D. Interventional Cardiology OVERVIEW Current Standard of Care in Management of STEMI Update in management of STEMI Pre-Cath Lab In the ED/Office/EMS. Cath Lab Post
Overview of Trasradial Approach for Coronary Angiography and Intervention. A/Prof. Phạm Mạnh Hùng, MD.FACC., FESC
Overview of Trasradial Approach for Coronary Angiography and Intervention A/Prof. Phạm Mạnh Hùng, MD.FACC., FESC Outline Historical perspective and current trends Rationale for the radial approach Bleeding
Radial Artery Access Improving Outcomes and Decreasing Costs
Howard A. Cohen, MD, FACC, FSCAI Director, Division of Cardiac Intervention Co-Director, Cardiac Catheterization Laboratories Lenox Hill Heart & Vascular Institute Institute DISCLOSURE Nothing to disclose
ΚΕΡΚΙΔΙΚΗ ΠΡΟΠΕΛΑΗ ΑΝΑΚΟΠΗΗ ΣΕΛΕΤΣΑΙΩΝ ΔΕΔΟΜΕΝΩΝ
ΚΕΡΚΙΔΙΚΗ ΠΡΟΠΕΛΑΗ ΑΝΑΚΟΠΗΗ ΣΕΛΕΤΣΑΙΩΝ ΔΕΔΟΜΕΝΩΝ Dr ΝΙΚΟΛΑΟΣ ΚΑΥΚΑΣ MD, FESC Διεσθσνηής, Υπεύθσνος Αιμοδ/κού Εργαζηηρίοσ Καρδιολογική Κλινική Γεν. Νοζοκομείο Κ.Α.Τ. OUTLINE Introduction Radial in the world
ΓΙΑΚΔΡΚΙΓΙΚΗ ΠΡΟΠΔΛΑΗ ΚΑΙ ΑΓΓΔΙΟΠΛΑΣΙΚΗ: ΤΜΒΟΤΛΔ ΚΑΙ ΜΤΣΙΚΑ
ΓΙΑΚΔΡΚΙΓΙΚΗ ΠΡΟΠΔΛΑΗ ΚΑΙ ΑΓΓΔΙΟΠΛΑΣΙΚΗ: ΤΜΒΟΤΛΔ ΚΑΙ ΜΤΣΙΚΑ ΓΙΔΝΔΡΓΔΙΑ ΠΡΩΣΟΓΔΝΟΤ ΓΙΑΓΔΡΜΙΚΗ ΣΔΦΑΝΙΑΙΑ ΠΑΡΔΜΒΑΗ ΑΠΟ ΣΗΝ ΚΔΡΚΙΓΙΚΗ ΑΡΣΗΡΙΑ Λάμπρος Κ. Μόσιαλος Γιεσθσντής Δπεμβατικός Καρδιολόγος ΓΝΘ «Παπαγεωργίοσ»
TRANSRADIAL CARDIAC CATHETERIZATION. Amanda Ryan, DO, Interventional Cardiologist Heart Care Centers of Florida April 13, 2013
TRANSRADIAL CARDIAC CATHETERIZATION Amanda Ryan, DO, Interventional Cardiologist Heart Care Centers of Florida April 13, 2013 TOPICS Historical perspective and current trends Rationale Bleeding for the
Global Variations in the 1-year Rates of Death and Stroke in Patients Presenting to the Emergency Department with Atrial Fibrillation
Global Variations in the 1-year Rates of Death and Stroke in Patients Presenting to the Emergency Department with Atrial Fibrillation Results from the RE-LY AF Registry Presenter Disclosure Information
Aspirin at the Intersection of Antiplatelet and Anticoagulant Therapy An Act of Commission?
Aspirin at the Intersection of Antiplatelet and Anticoagulant Therapy An Act of Commission? Ty J. Gluckman, MD, FACC, FAHA Medical Director, Center for Cardiovascular Analytics, Research and Data Science
GSK Medicine: Study Number: Title: Rationale: Phase: Study Period: Study Design: Centres: Indication: Treatment: Objectives:
The study listed may include approved and non-approved uses, formulations or treatment regimens. The results reported in any single study may not reflect the overall results obtained on studies of a product.
Transradial vs. Transfemoral Access in STEMI: Should We Randomize?
Transradial vs. Transfemoral Access in STEMI: Should We Randomize? Ajay J. Kirtane, MD, SM Center for Interventional Vascular Therapy Columbia University Medical Center / New York Presbyterian Hospital
Optimal Duration and Dose of Antiplatelet Therapy after PCI
Optimal Duration and Dose of Antiplatelet Therapy after PCI Donghoon Choi, MD, PhD Severance Cardiovascular Center Yonsei University College of Medicine Optimal Duration of Antiplatelet Therapy after PCI
Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin
Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin Marc S. Sabatine, MD, MPH on behalf of the PEGASUS-TIMI 54 Executive
Transfemoral access (TFA) through the percutaneous
Transradial Coronary Intervention in STEMI Patients The current status of this approach and future perspectives on its staying power. By Simone Biscaglia, MD, and Marco Valgimigli, MD, PhD, FESC Transfemoral
Is the role of bivalirudin established?
Is the role of bivalirudin established? Rob Henderson Consultant Cardiologist Trent Cardiac Centre Nottingham University Hospitals Conflicts of Interest: None Declarations: Member NICE Unstable Angina
Trial Update- TOTAL. Jonathan Byrne
Trial Update- TOTAL Jonathan Byrne No conflicts of interest Background- rationale for thrombectomy Major Limitation of primary PCI: distal embolisation and reduced flow Stonel JACC 2002;39:591-7 Henriques
Disclosure. Financial disclosure: National Advisory Board & Research Grant from Boehringer-Ingelheim
Randomised Dabigatran Etexilate Dose Finding Study In Patients With Acute Coronary Syndromes Post Index Event With Additional Risk Factors For Cardiovascular Complications Also Receiving Aspirin and Clopidogrel
Radial Artery Access: The Basics
Radial Artery Access: The Basics Jeffrey J. Popma, MD Professor of Medicine Harvard Medical School Director, Interventional Cardiology Beth Israel Deaconess Medical Center Boston, MA 1 Radial Artery Access:
ACUTE CORONARY SYNDROME PCI IN THE ELDERLY
ACUTE CORONARY SYNDROME PCI IN THE ELDERLY G.KARABELA MD.PhD ATHENS NAVAL HOSPITAL INTERVENTIONAL CARDIOLOGY DEPARTMENT NO CONFLICT OF INTEREST TO DECLAIRE Risk stratification in Αcute Coronary Syndrome.
M. Valgimigli, MD, PhD Swiss Cardiovascular Center Bern, Inselspital, Bern, Switzerland on behalf of the MATRIX Group NCT
Results From The Minimizing Adverse Haemorrhagic Events By Transradial Access Site And Systemic Implementation of Angiox-MATRIX Treatment Duration Program M. Valgimigli, MD, PhD Swiss Cardiovascular Center
Management of ST-elevation myocardial infarction Update 2009 Late comers: which options?
European Society of Cardiology Annual Session 2009 Management of ST-elevation myocardial infarction Update 2009 Late comers: which options? Antonio Abbate, MD Assistant Professor of Medicine Virginia Commonwealth
After acute coronary syndromes patients continue to have recurrent ischemic events despite revascularization and dual antiplatelet therapy
Randomised Dabigatran Etexilate Dose Finding Study In Patients With Acute Coronary Syndromes Post Index Event With Additional Risk Factors For Cardiovascular Complications Also Receiving Aspirin and Clopidogrel
Oral anticoagulation/antiplatelet therapy in the secondary prevention of ACS patients the cost of reducing death!
Oral anticoagulation/antiplatelet therapy in the secondary prevention of ACS patients the cost of reducing death! Robert C. Welsh, MD, FRCPC Associate Professor of Medicine Director, Adult Cardiac Catheterization
Ischemic and bleeding risk stratification in NSTE ACS. Andrzej Budaj Postgraduate Medical School Grochowski Hospital, Warsaw, Poland
Ischemic and bleeding risk stratification in NSTE ACS Andrzej Budaj Postgraduate Medical School Grochowski Hospital, Warsaw, Poland Disclosure Andrzej Budaj, MD, PhD, reports the following potential conflicts
Experiences with interim trial monitoring, particularly with early stopped trials
Experiences with interim trial monitoring, particularly with early stopped trials 1 Robert J Glynn, ScD Divisions of Preventive Medicine and Pharmacoepidemiology & Pharmacoeconomics, Brigham & Women s
The worldwide overview: updated (2005-6) meta-analyses of hormonal treatment trials
The worldwide overview: updated (2005-6) meta-analyses of hormonal treatment trials Richard Gray, for the Early Breast Cancer Trialists Collaborative Group (EBCTCG) Main questions, 2005-6 1) 5 years of
Transfer in D2B. Scott D Friedman, MD FACC Medical Director, Cardiology Services Shore Health System of Maryland. The Problem
Transfer in D2B Scott D Friedman, MD FACC Medical Director, Cardiology Services Shore Health System of Maryland The Problem NRMI-5: North Carolina, July 2003- June 2004 NC Nation Guidelines N 2,738 79,927
Ischemic Heart Disease Interventional Treatment
Ischemic Heart Disease Interventional Treatment Cardiac Catheterization Laboratory Procedures (N = 89) is a regional and national referral center for percutaneous coronary intervention (PCI). A total of
Kenneth W. Mahaffey, MD and Keith AA Fox, MB ChB
Once-daily oral direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation Kenneth W. Mahaffey, MD and Keith AA Fox, MB ChB on behalf
John J.P. Kastelein MD PhD Professor of Medicine Dept. of Vascular Medicine Academic Medial Center / University of Amsterdam
Latest Insights from the JUPITER Study John J.P. Kastelein MD PhD Professor of Medicine Dept. of Vascular Medicine Academic Medial Center / University of Amsterdam Inflammation, hscrp, and Vascular Prevention
Culprit PCI vs MultiVessel PCI for Acute Myocardial Infarction
Culprit PCI vs MultiVessel PCI for Acute Myocardial Infarction Dipti Itchhaporia, MD, FACC, FESC Trustee, American College of Cardiology Director of Disease Management, Hoag Hospital Robert and Georgia
PROlonging Dual antiplatelet treatment after Grading stent-induced Intimal hyperplasia study
ESC, Hotline III, Paris, August, 30, 2011 PROlonging Dual antiplatelet treatment after Grading stent-induced Intimal hyperplasia study M. Valgimigli, MD, PhD University of Ferrara, ITALY On behalf of the
Surveying the Landscape of Oral Antiplatelet Therapy in Acute Coronary Syndrome Management
Surveying the Landscape of Oral Antiplatelet Therapy in Acute Coronary Syndrome Management Jeffrey S Berger, MD, MS Assistant Professor of Medicine and Surgery Director of Cardiovascular Thrombosis Disclosures
Clopidogrel vs New Antiplatelet Therapy (Prasugrel) Adnan Kastrati, MD Deutsches Herzzentrum, Technische Universität München, Germany
Clopidogrel vs New Antiplatelet Therapy () Adnan Kastrati, MD Deutsches Herzzentrum, Technische Universität München, Germany Seoul, April 3, 21 Dual Antiplatelet Therapy for Stenting MACE, % 12 1 8 6 In
Complete Revascularization: The Future Mode of Revascularization in STEMI
Complete Revascularization: The Future Mode of Revascularization in STEMI Alan C. Yeung, MD Li Ka Shing Professor of Medicine Chief, Division of Cardiovascular Medicine Stanford University School of Medicine
La terapia antiaggregante nel paziente con stroke
La terapia antiaggregante nel paziente con stroke Paolo Gresele Dipartimento di Medicina, Sez. Medicina Interna e Cardiovascolare Università di Perugia XXVII Congresso Nazionale FCSA Milano, 20-22 Ottobre
Ischemic Heart Disease Interventional Treatment
Ischemic Heart Disease Interventional Treatment Cardiac Catheterization Laboratory Procedures (N = 11,61) is a regional and national referral center for percutaneous coronary intervention (PCI). A total
DECLARATION OF CONFLICT OF INTEREST. Lecture fees: AstraZeneca, Ely Lilly, Merck.
DECLARATION OF CONFLICT OF INTEREST Lecture fees: AstraZeneca, Ely Lilly, Merck. Risk of stopping dual therapy. S D Kristensen, FESC Aarhus Denmark Acute coronary syndrome: coronary thrombus Platelets
Quale terapia antiaggregante nello STEMI? Prasugrel vs ticagrelor
Quale terapia antiaggregante nello STEMI? Prasugrel vs ticagrelor Leonardo Bolognese Cardiovascular Department, Arezzo, Italy Platelet Reactivity in Patients with STEMI Undergoing Primary PCI Campo G et
Recommendations for criteria for STEMI systems of care: A focus on pharmacoinvasive strategies
Recommendations for criteria for STEMI systems of care: A focus on pharmacoinvasive strategies Mohammad Zubaid, MB, ChB, FRCPC, FACC Professor of Medicine, Kuwait University Chairman, Faculty of Cardiology,
INDIVIDUALIZED MEDICINE
CENTER FOR INDIVIDUALIZED MEDICINE Clopidogrel Pharmacogenetics Can We Impact Clinical Practice? Michael E. Farkouh, MD, MSc Peter Munk Cardiac Centre University of Toronto Naveen Pereira MD Mayo Clinic
OBJECTIVES. New Twist To Old Disease: Cardiovascular Update /9/2017. Prevention Pre-operative Coronary Artery Disease
New Twist To Old Disease: Cardiovascular Update 2017 Sridevi R Pitta, M.D.,MBA, F.S.C.A.I., R.P.V.I Medical Director for STEMI, Medical Director for CV Quality Council, Interventional Cardiologist & Endovascular
Clopidogrel has been evaluated in clinical trials that included cardiovascular patients
REVIEW ARTICLE Comparative Benefits of Clopidogrel and Aspirin in High-Risk Patient Populations Lessons From the CAPRIE and CURE Studies Jack Hirsh, CM, MD, FRCPC, FRACP, FRSC, DSc; Deepak L. Bhatt, MD,
Prof. Jindřich Špinar, MD
Prof. Jindřich Špinar, MD Head of the Internal Cardiology dpt., University Hospital Brno Focuses on clinical cardiology, acute and chronic heart failure, ischemic heart gisease, hypertension Vice head
Στεφανιαίος ασθενής με μη βαλβιδική Κολπική Μαρμαρυγή - Νέες στρατηγικές
4 ο ΠΑΝΕΛΛΗΝΙΟ ΑΡΡΥΘΜΙΟΛΟΓΙΚΟ ΣΥΝΕΔΡΙΟ 21-22 ΣΕΠΤΕΜΒΡΙΟΥ 2018 HILTON, ΑΘΗΝΑ Στεφανιαίος ασθενής με μη βαλβιδική Κολπική Μαρμαρυγή - Νέες στρατηγικές Ι. Κανακάκης MD, PhD Διευθυντής Αιμοδυναμικού Τμήματος
Transcatheter Aortic Valve Implantation. SSVQ November 23, 2012 Centre Mont-Royal 15:40
Transcatheter Aortic Valve Implantation SSVQ November 23, 2012 Centre Mont-Royal 15:40 Nicolo Piazza MD, PhD, FRCPC, FESC, FACC McGill University Health Center German Heart Center Munich 1 First-in-Human
Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombosis
Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombosis NCT00526474; Trial funded by Merck David A. Morrow, MD, MPH On behalf of the TRA 2 P-TIMI 50 Steering Committee and Investigators
Li J, Li X, Ross JS, Wang Q, Wang Y, Desai NR, Xu X, Nuti SV, Masoudi FA, Spertus JA, Krumholz HM, Jiang L; China PEACE Collaborative Group.
Fibrinolytic therapy in hospitals without percutaneous coronary intervention capabilities in China from 2001 to 2011: China PEACE-retrospective AMI study. Li J, Li X, Ross JS, Wang Q, Wang Y, Desai NR,
Abbott Vascular. PROTOCOL EXCEL Clinical Trial
Abbott Vascular PROTOCOL Clinical Trial Evaluation of XIENCE PRIME or XIENCE V versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization PCI (1 st gen DES) vs. CABG for Left
Increasing Prevalence of Atrial Fibrillation and Flutter in the United States
Increasing Prevalence of Atrial Fibrillation and Flutter in the United States The present retrospective study estimated the current and projected prevalence of AF and atrial flutter (AFL) in the United
No conflict of interest to declare
Switch and Non-Switch in P2Y12 Inhibition: The Real-Life Use of Clopidogrel and Prasugrel in Patients with Acute Myocardial Infarction. Insights from the FAST MI 2010 Registry. F. Schiele (Besançon), E.
Recognizing the High Risk NSTEMI Patient for Early Appropriate Therapy
Recognizing the High Risk NSTEMI Patient for Early Appropriate Therapy Learning Objectives Learn to recognize the high risk patient Discuss effective management of a high risk NSTEMI patient Review CCS
How to approach non-infarct related artery disease in patients with STEMI in a limited resource setting
How to approach non-infarct related artery disease in patients with STEMI in a limited resource setting Ahmed A A Suliman, MBBS, FACP, FESC Associate Professor, University of Khartoum Interventional Cardiologist,
The Role of NOACs in AF: What do We Know 4 Years After the RE-LY Study?
The Role of NOACs in AF: What do We Know 4 Years After the RE-LY Study? Michael Glikson, MD, FACC, FESC Davidai Arrhythmia Center Leviev Heart Center Israel June 2013 Disclosures No relevant Disclosures
scores in acute coronary syndrome
ESC CONGRESS 212 Comparing the predictive validity of three contemporary bleeding risk 1 scores in acute coronary syndrome 1 José Ramón González-Juanatey University Clinical Hospital of Santiago de Compostela.
An international, double-blind, phase III randomized trial. Main Results
An international, double-blind, phase III randomized trial Main Results Robert Hart on behalf of the NAVIGATE ESUS Steering Committee and Investigators Sponsorship & Disclosures NAVIGATE ESUS was sponsored
Impact of CYP2C19 and ABCB1 SNPs on outcomes with ticagrelor versus clopidogrel in acute coronary syndromes: a PLATO genetic substudy
Impact of CYP2C19 and ABCB1 SNPs on outcomes with ticagrelor versus clopidogrel in acute coronary syndromes: a PLATO genetic substudy Lars Wallentin, Stefan James, Robert F Storey, Martin Armstrong, Bryan
Approach to Multi Vessel disease with STEMI
Approach to Multi Vessel disease with STEMI MANAGEMENT OF ST-ELEVATION MYOCARDIAL INFARCTION Dr. Thomas Alexander, M.D; D.M; F.A.C.C. Senior Consultant and Interventional Cardiologist Kovai Medical Centre
and Treatment in Emergency Care) Trial: Intravenous Glucose, Insulin & Potassium (GIK) in Emergency Medical Services
Results of the IMMEDIATE (Immediate Myocardial Metabolic Enhancement DuringInitial Assessment and Treatment in Emergency Care) Trial: A Double Blinded Randomized Controlled Trial of Intravenous Glucose,
TICAGRELOR VERSUS CLOPIDOGREL AFTER THROMBOLYTIC THERAPY IN PATIENTS WITH ST- ELEVATION MYOCARDIAL INFARCTION: A RANDOMIZED CLINICAL TRIAL
TICAGRELOR VERSUS CLOPIDOGREL AFTER THROMBOLYTIC THERAPY IN PATIENTS WITH ST- ELEVATION MYOCARDIAL INFARCTION: A RANDOMIZED CLINICAL TRIAL Otavio Berwanger, MD, PhD - On behalf of the TREAT Trial Steering
New Generation Drug- Eluting Stent in Korea
New Generation Drug- Eluting Stent in Korea Young-Hak Kim, MD, PhD Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Purpose To briefly introduce the
The Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) Trial
Benefits and Risks of the Combination of Clopidogrel and Aspirin in Patients Undergoing Surgical Revascularization for Non ST-Elevation Acute Coronary Syndrome The Clopidogrel in Unstable angina to prevent
Neurologic complications after transradial or transfemoral approach for diagnostic and interventional cardiac catheterization.
Neurologic complications after transradial or transfemoral approach for diagnostic and interventional cardiac catheterization Dr Paolo Buja Trend Patients undergoing PCI in UK FEMORAL RADIAL Ratib JACC
Prasugrel vs. Ticagrelor in ACS/PCI Which one to choose? V. Voudris MD FESC FACC 2 nd Cardiology Division Onassis Cardiac Surgery Center
Prasugrel vs. Ticagrelor in ACS/PCI Which one to choose? V. Voudris MD FESC FACC 2 nd Cardiology Division Onassis Cardiac Surgery Center Hospitalizations in the U.S. Due to ACS Acute Coronary Syndromes
Access Issues and Bleeding Complications
Cardiovascular Trends 2011: Nursing and Cath Lab Symposia ITS 2011 Access Issues and Bleeding Complications Mauricio G. Cohen, MD, FACC, FSCAI Director, Cardiac Catheterization Lab Associate Professor
Craig Laferriere. The selection of pneumococcal serotypes for a developing-world vaccine: A metaregression analysis of immunogenicity
Craig Laferriere The selection of pneumococcal serotypes for a developing-world vaccine: A metaregression analysis of immunogenicity I have no actual or potential conflict of interest in relation to this
Upstream P2Y 12 RB. Stefano Savonitto Divisione di Cardiologia Arcispedale S. Maria Nuova Reggio Emilia
Upstream P2Y 12 RB Stefano Savonitto Divisione di Cardiologia Arcispedale S. Maria Nuova Reggio Emilia Dio può essere dimostrato Le dimostrazioni dell esistenza di Dio IA Dio non può essere dimostrato
Switching from femoral to radial access for coronary angiography in ACS
ORIGINAL ARTICLE 169 Feasability, bleeding events and impact on door-to-balloon times Switching from femoral to radial access for coronary angiography in ACS Ivano Reho, Martin Sprenger, David Tueller,
Heart Outcomes Prevention Evaluation (HOPE) Study
Final Heart Outcomes Prevention Evaluation (HOPE) Study P.J. Devereaux, MD, PhD McMaster University, Population Health Research Institute Final Disclosure I was not involved with HOPE Study I am not Salim
Timing of Intervention in Non ST Elevation Acute Coronary Syndromes: And the VERDICT is? Sanjit S. Jolly, M.D., M.Sc., Shamir R. Mehta, M.D., M.Sc.
Timing of Intervention in Non ST Elevation Acute Coronary Syndromes: And the VERDICT is? Sanjit S. Jolly, M.D., M.Sc., Shamir R. Mehta, M.D., M.Sc. From the Population Health Research Institute and Departments
Resolute in Bifurcation Lesions: Data from the RESOLUTE Clinical Program
Resolute in Bifurcation Lesions: Data from the RESOLUTE Clinical Program Prof. Ran Kornowski, MD, FESC, FACC Director - Division of Interventional Cardiology Rabin Medical Center and Tel Aviv University,
Psychosocial issues and Type D personality: Effects on rehabilitation Susanne S. Pedersen (PhD), Tilburg University, The Netherlands
Psychosocial issues and Type D personality: Effects on rehabilitation Susanne S. Pedersen (PhD), Tilburg University, The Netherlands Affiliations 1. Department of Medical Psychology and Neuropsychology,
Myocardial Infarction In Dr.Yahya Kiwan
Myocardial Infarction In 2007 Dr.Yahya Kiwan New Definition Of Acute Myocardial Infarction The term of myocardial infarction should be used when there is evidence of myocardial necrosis in a clinical setting
STATINS EVALUATION IN CORONARY PROCEDURES AND REVASCULARIZATION
STATINS EVALUATION IN CORONARY PROCEDURES AND REVASCULARIZATION Otávio Berwanger, MD, FACS - On behalf of the SECURE Steering Committee and Investigators Trial Organization Trial Steering Committee Dr.
Folate and prevention of neural tube defects: Tracking red blood cell concentrations will help guide policy decisions about fortification
Folate and prevention of neural tube defects: Tracking red blood cell concentrations will help guide policy decisions about fortification Derrick Bennett, University of Oxford, UK 8 October, 2014 IXth
INR as a Biomarker: Anticoagulation in Atrial Fib, Heart Failure, and Cardiovascular Disease Daniel Blanchard, MD, FACC, FAHA
INR as a Biomarker: Anticoagulation in Atrial Fib, Heart Failure, and Cardiovascular Disease Daniel Blanchard, MD, FACC, FAHA Professor of Medicine Director, Cardiology Fellowship Program Sulpizio Cardiovascular
Primary Angioplasty and Thrombolysis for the Treatment of Acute ST- Segment Elevated Myocardial Infarction
Ontario Health Technology Assessment Series 2010; Vol. 10, No. 17 Primary Angioplasty and Thrombolysis for the Treatment of Acute ST- Segment Elevated Myocardial Infarction An Evidence Update Presented
Angioplastica coronarica nel paziente anziano ad alto rischio emorragico
Attualità in Cardiologia Aprilia, Enea Hotel 22 ottobre 2011 Angioplastica coronarica nel paziente anziano ad alto rischio emorragico Fabrizio Tomai, MD, FACC, FESC Dept. of Cardiovascular Sciences - Interventional
2. If prasugrel is found to be both more costly and more effective than clopidogrel, to assess its costeffectiveness
Cost-Effectiveness of Prasugrel vs. Clopidogrel for PCI Patients with Acute Coronary Syndromes: Results from the TRITON-TIMI TIMI 38 Trial David J. Cohen, M.D., M.Sc. Director of Cardiovascular Research
Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial [HYVET] R. Peters
![Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial [HYVET] R. Peters](/thumbs/74/71463454.jpg "Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial [HYVET] R. Peters")
Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial [HYVET] R. Peters ClinicalTrials.gov: NCT00122811 Backgound The prevalence of dementia rises with increasing
Improving on AUC. Presenter Disclosure Information. Objectives 3/13/2014. Cornelia Anderson BSN, RN. No Disclosures
Improving on AUC Presenter Disclosure Information Cornelia Anderson BSN, RN To following relationships exist related to this presentation: No Disclosures Objectives Discuss History & Purpose of AUC Discuss
Clinical Seminar. Which Diabetic Patient is a Candidate for Percutaneous Coronary Intervention - European Perspective
Clinical Seminar Which Diabetic Patient is a Candidate for Percutaneous Coronary Intervention - European Perspective Stephan Windecker Department of Cardiology Swiss Cardiovascular Center and Clinical
How Long Patietns Will Be on Dual Antiplatelet Therapy?
How Long Patietns Will Be on Dual Antiplatelet Therapy? Ron Waksman,, MD, FACC Professor of Medicine (Cardiology) Georgetown University Associate Director, Division of Cardiology, Washington Hospital Center
Apixaban Versus ASA To Reduce the Risk Of Stroke. Coordinated by Population Health Research institute Hamilton, Ontario, Canada
AVERROES Apixaban Versus ASA To Reduce the Risk Of Stroke Coordinated by Population Health Research institute Hamilton, Ontario, Canada Sponsors: Bristol-Myers Squibb Co. & Pfizer, Inc. S. Connolly Disclosure:
Evolving Challenges in the Evaluation and Treatment of Lower Extremity PAD -- The Peripheral Academic Research Consortium (PARC)
Evolving Challenges in the Evaluation and Treatment of Lower Extremity PAD -- The Peripheral Academic Research Consortium (PARC) W. Schuyler Jones, MD FACC Director, Adult Cardiac Catheterization Laboratory
Decision for fibrinolysis or primary PCI in the prehospital phase
Decision for fibrinolysis or primary PCI in the prehospital phase Nicolas Danchin, Hôpital Européen Georges Pompidou, Paris, France Disclosures Research grants: Astrazeneca, Eli-Lilly, GSK, Merck, Novartis,
Cindy L. Grines MD FACC FSCAI
Cindy L. Grines MD FACC FSCAI Hofstra Northwell School of Medicine Chair, Cardiology Academic Chief of Cardiology, Northwell Health North Shore University Hospital, Manhasset NY Multivessel Disease in
Update on the NOAC s: 2018 Daniel Blanchard, MD, FACC, FAHA
Update on the NOAC s: 2018 Daniel Blanchard, MD, FACC, FAHA Professor of Medicine Director, Cardiology Fellowship Program Sulpizio Cardiovascular Center UC San Diego The NOACS, chronologically Dabigatran:
SYNOPSIS. International co-ordinating investigator Redacted
Drug product: Drug substance(s): AZD6140 Document No.: D5130C00002 Edition No.: 01 Study code: D5130C00002 Date: 12 October 2005 SYNOPSIS A Double-blind, Double-dummy, Parallel Group Randomised Dose Confirmation
Optimal lenght of DAPT in different clinical scenarios
Optimal lenght of DAPT in different clinical scenarios After PCI with DES in the light of recent and ongoing studies Dr Grégoire Rangé / CH Chartres / France DAPT duration depend on the evolution of risk
Thrombectomy. how? For whom?
Thrombectomy how? For whom? Marco Zimarino, MD, PhD Institute of Cardiology - University G. d Annunzio, Chieti (Italy) Why Manual Thrombectomy? Pros 1 Extraction of thrombotic material, acute reduction
Long-term safety, tolerability and efficacy of alirocumab in high cardiovascular risk patients: ODYSSEY LONG TERM
Long-term safety, tolerability and efficacy of alirocumab in high cardiovascular risk patients: ODYSSEY LONG TERM Efficacy by subgroup, and safety when LDL-C
MULTIcentre evaluation of Single high-dose. acute myocardial infarction study
MULTIcentre evaluation of Single high-dose Tirofiban bolus TiRofiban vs. versus with sirolimus eluting stent or barein metal stent in during primary PCI STEMI acute myocardial infarction study M. Valgimigli,
Saudi Arabia February Pr Michel KOMAJDA. Université Pierre et Marie Curie Hospital Pitié Salpétrière
Prevention of Cardiovascular events with Ivabradine: The SHIFT Study Saudi Arabia February 2011 Pr Michel KOMAJDA Université Pierre et Marie Curie Hospital Pitié Salpétrière Paris FRANCE Declaration Of
The Polypill for Secondary Prevention Is Entering the Cardiovascular Field: Worldwide Interest Based on Better Adherence and Economics
The Polypill for Secondary Prevention Is Entering the Cardiovascular Field: Worldwide Interest Based on Better Adherence and Economics Jose M. Castellano, MD, PhD Clinical Trials Coordinator, CNIC, Madrid,
Clinical Investigation and Reports
Clinical Investigation and Reports Relationship of Activated Partial Thromboplastin Time to Coronary Events and Bleeding in Patients With Acute Coronary Syndromes Who Receive Heparin Sonia S. Anand, MD,
HIP ATTACK Trial: Can we improve outcomes after a hip fracture with accelerated surgery? PJ Devereaux, MD, PhD
HIP ATTACK Trial: Can we improve outcomes after a hip fracture with accelerated surgery? PJ Devereaux, MD, PhD Disclosure Member of research group with policy of not accepting honorariums or other payments
ICSS Safety Results NOT for PUBLICATION. June 2009 ICSS ICSS ICSS ICSS. International Carotid Stenting Study: Main Inclusion Criteria
Safety Results NOT for The following slides were presented to the Investigators Meeting on 22/05/09 and most of them were also presented at the European Stroke Conference on 27/05/09 They are NOT for in