Directorate of Laboratory Medicine

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1 Directrate f Labratry Medicine Presenting The Clinical Sciences Labratry Centre Prviding a mdern cmprehensive Pathlgy Service fr the ppulatins f Greater Manchester and beynd Clinical Sciences Building 1 Clinical Sciences Building 2 Artists Impressin f Clinical Sciences Building 3 (due t pen 2009) A cntinuing develpment f a Labratry Village t accmmdate crprate mdern technlgies and a cntinuus analytical service

2 Abut the Directrate f Labratry Medicine (DLM) The Directrate f Labratry Medicine is a single, managed unit within the Trust with a Clinical Directr, Crprate Supprt Team and Clinical and Business Managers. The strategic planning is fr a cmpsite, patient fcused service perating frm a substantially single-site Labratry Village creating a mre efficient rganisatin based n shared equipment and technlgy. The key aims and bjectives f the Directrate f Labratry Medicine are t prvide: Integrated children s and adult analytical and diagnstic services; A safe, mdern, apprpriate and cmfrtable envirnment; A service, which is cmprehensive, interpretative, accredited and apprpriate, and respnsive t user needs; Apprpriate educatin and training t all staff and students; A quality lead and managed service; Fully perating services within all the prvisins f Clinical Gvernance; Cnditins t initiate, facilitate and undertake research and develpment; Full cperatin with Universities and ther apprpriate bdies t strengthen research. The Clinical Sciences Buildings are lcated in the Suth West crner f the CMMC site and cmprise:- CSB1 - cmmissined during 1994 prviding mdern accmmdatin fr Histpathlgy and a large Mrtuary, Clinical Research and service and university departments f Micrbilgy and Virlgy. A university student teaching area and museum is prvided n the grund flr. CSB2 - erected during 2002, huses Autlab (prviding 24hr rapid bld analyses and bld transfusin prducts), the Manchester Cytlgy Centre (incrprating the cytlgy departments f Christie Hspital and MRI), the Manchester Cytlgy Training Centre and the Manchester Medical Micrbilgy Partnership (cmprising an amalgamatin f the service and university departments f Micrbilgy and Virlgy frm CMMC, Christie Hspital, PHLS and Suth Manchester University Hspital Trust). (CSB3 planning is in an advanced stage fr an extensin t CSB2 that will cmplete the cnslidatin f all labratry disciplines within the Trust.) Further infrmatin can be btained frm the Directrate website

3 AUTOLAB Directrate f Labratry Medicine Cntinuus Pathlgy Prcessing 24/7 Over 5 millin test results per year Rapid turnarund times Fully rbtic Bichemistry and Haematlgy analysers Numerus bld parameters prvided frm Frm this ne sample n tw analysers Immunassay units included t this (July 2003) Autmated cagulatin analysers Autmated bld grup and antibdy testing Increased specimen thrughput STAT service in all areas Over 30,000 units f bld crss-matched per annum General rm view Bld Transfusin Bichemistry analyser Haematlgy bld cunts analyser Autmated bld gruper Cagulatin analyser Specimen receptin Micrscpical bld analysis

4 Directrate f Labratry Medicine Clinical Research Liver and Islet Cell service wrk and research perfrmed Trust, Reginal and supra-reginal assay service Assessment f partial hepatic functins Nn-invasive assessment f hepatic fibrsis (P111NP) Oxidant stress in liver disease Clinical trials f new treatments in liver disease Assessment f pancreatic beta cell functin Measurement f immun-reactive insulin Clinical Research Labratry DLM Client Services Centre Main Visitr Receptin Hspital and GP liaisn Results ht-line Curier service t GP surgeries and health centres Reprt printing and distributin User guides and infrmatin DLM Curier Vehicle Designated parking area CSB Receptin Office

5 Electrn Micrscpy Suite Directrate f Labratry Medicine Enhanced, refurbished and equipped t prvide a Unified Electrn Micrscpy Service Clinical, Public Health and Academic service Diagnstic ultrastructural analysis Fully integrated with Histlgy, Micrbilgy and Virlgy Transmissin Electrn Micrscpe with digital imaging system Print Rm Specimen Preparatin EM Phtmicrgraphs Micrspridian apprx 2.5 x 1.5 µm Helicbacter pylri apprx 5 x 0.5 µm Glmerular capillary lp apprx 500 nm thick

6 Immunlgy Directrate f Labratry Medicine

7 Histpathlgy and Mrtuary Cmprehensive service t MRI, SMH, REH & GPs Gynaeclgical pathlgy tertiary referral centre Ophthalmic pathlgy tertiary referral centre Cmprehensive renal bipsy service Immuncytchemistry and muscle bipsy Directrate f Labratry Medicine service Develping mlecular bitechnlgy Mrtuary service fr Trust & City deaths Facilities fr GMP frensic autpsies Integratin with Bereavement Centre Cmprehensive museum and student teaching Grund & 1st Flr, CSB1 Specimen dissectin facilities Pst Mrtem Rm Immuncytchemistry Lab Histlgy Labratry Tumur Bard Meeting Histlgy Office Reprting/Teaching Rm Sectin f keratinising squamus carcinma

8 Manchester Cytlgy Centre & Manchester Cytlgy Training Centre Directrate f Labratry Medicine Largest fully integrated Cytlgy unit in the cuntry Prcessing abut cervical smears annually Dedicated fine needle aspirate service Centre fr Liquid Based Cytlgy (LBC) and wart virus testing. State f the art facilities At the frefrnt f the intrductin f new techniques; The Manchester Cytlgy Training Centre is situated in custm-built accmmdatin n the grund flr. Delegates attend frm labratries and clinics thrughut the NW Regin and UK Frm this Smear screening Grup discussin and this t this (Sep 2002) LBC Preparatin Cnventinal Smear, x10 mag LBC Smear, x10 mag

9 Manchester Medical Micrbilgy Partnership Directrate f Labratry Medicine Unified micrbilgy service fr Central Manchester and Manchester Children s University Hspitals NHS Trust, University Hspital f Suth Manchester, Christie Hspital and ther Trusts acrss NW Regin Cmprehensive Bacterilgy repertire, including specialist respiratry and enteric services. Rapid TB Culture Meningcccal Reference Unit natinally appinted specialist reference centre ( Vaccine Evaluatin Unit Large Virlgy labratry prviding reference services fr the Nrth West f England and specialist testing fr the UK Extensive Mlecular Diagnstic labratries cntaining state f the art equipment fr Rapid Plymerase Chain Reactin (PCR) assays fr bacterial, fungal and viral pathgens and sequencing facilities fr gentyping and resistance mnitring. Majr fcus fr training f Medical Micrbilgists FE500 Pre-analytical Analyser Autmated Viral Serlgy Culture plates Sensitivities Randm Access Serlgy Bld culture instrumentatin

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