Neurociências e Saúde Mental Neuroscience and Mental Health May 11-15, 2015 Programme: Monday Welcome and Introduction to the course Seminar 1:

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1 Neurociências e Saúde Mental Neuroscience and Mental Health The PhD Programme in Health Sciences (PhDHS) and Interuniversitary PhD Programme in Aging and Chronic Diseases (PhDOC) Faculty of Medicine, University of Coimbra ( ) Dates (1 week): May 11-15, 2015 Local: IBILI Auditorium (Pólo III Pólo das Ciências da Saúde, Azinhaga de Santa Comba, Celas) Coordinators: Ana Cristina Rego (arego@fmed.uc.pt; a.cristina.rego@gmail.com) and António Freire (afreireg@hotmail.com) Programme: Monday (May 11) 14:00 14:30 Welcome and Introduction to the course (Ana Cristina Rego & António Freire) 14:30 15:15 Seminar 1: Language in the brain (Alexandre Castro-Caldas) 15:15 15:30 Discussion 15:30 16:15 (Neuro)psychiatric disorders (José Pio de Abreu) 16:15 16:30 Discussion 16:30 17:00 Break 17:00 17:45 Psychiatric diseases and behavior a genetic approach (António de Macedo) 17:45 18:30 The era of genomics in neuropsychiatric diseases (Joana Barbosa de Melo) 18:30 19:00 Discussion Tuesday (May 12) 14:00 14:45 Acidente Vascular Cerebral (Luís Cunha) 14:45 15:00 Discussion 15:00 15:45 Familial Amyloidotic Polyneuropathy (Maria João Saraiva) 15:45 16:00 Discussion 16:00 16:30 Break 16:30 17:15 Brain barriers and their modifications in disease states (Ana Paula Silva) 17:15 18:00 Discussion 18:00 18:30 Clinical aspects of demyelinating diseases the case of multiple sclerosis (Lívia Sousa) 18:30 19:00 Body fluid biomarkers in multiple sclerosis (Inês Baldeiras) 19:00 19:15 Discussion Wednesday (May 13) 14:00 14:30 Common molecular and cellular basis of neurodegenerative diseases (Catarina R. Oliveira) 14:30 14:45 Discussion 1

2 14:45 15:30 Molecular modifications in Alzheimer s disease (Cláudia F. Pereira) 15:30 16:15 Impact of diabetes in Alzheimer s disease (Paula Moreira) 16:15 16:30 Discussion 16:30 16:45 Break 16:45 17:30 Clinical aspects of polyglutamine disorders (Cristina Januário) 17:30 18:15 Molecular basis of Huntington s disease (Ana Cristina Rego) 18:15 18:30 Discussion 18:30 19:15 Challenging animal models of Machado-Joseph disease (Luís Pereira de Almeida) 19:15 19:30 Discussion Thursday (May 14) 14:00 15:00 Seminar 2: Translational research in Alzheimer s and Parkinson s diseases (Catarina R. Oliveira) 15:00 15:15 Discussion 15:15 15:30 Break 15:30 16:15 Clinical aspects of Parkinson s disease (António Freire) 16:15 17:00 Molecular aspects of Parkinson s disease (Sandra M. Cardoso) 17:00 17:15 Discussion 17:15 18:00 Deep brain stimulation: from the experience in Parkinson s disease to recent indications and future developments (Rui Vaz) 18:00 18:15 Discussion 18:15 19:00 Clinical trials in dementia (Isabel Santana) 19:00 19:45 Functional magnetic resonance imaging and multimodality in neurosciences (Sónia Gonçalves) 19:45 20:00 Discussion Friday (May 15) 14:00 15:00 Multiple choice questionnaire 15:00 15:30 Break 15:30 19:00 Student s assignment: papers presentation and project proposals (based on original papers) Student s assignments and distribution in Groups: The students (Groups 1-4) will be asked to present an original paper and critically analyze the data, as well as to propose additional relevant experiments and their specific rationale and objectives as a mini-project (orally presented). Each group will have 20 min for each presentation, which will be followed by ~10 min discussion. 2

3 Original papers and student s names (4 groups): Group 1: Ana Sofia Morgadinho Carvalho, Bruno Augusto Lourenço Costa, Carolina Maria de Oliveira Roque, Filipe Manuel Farto Palavra Paper: Varea O, Martin-de-Saavedra MD, Kopeikina KJ, Schürmann B, Fleming HJ, Fawcett- Patel JM, Bach A, Jang S, Peles E, Kim E, Penzes P. Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons. Proc Natl Acad Sci U S A Apr 27. pii: [Epub ahead of print] Group 2: Inês Pereira Dias Marques, Joana Carolina Teixeira Andrade, Joana Rita Ferreira Marques, Jorge Filipe Silva Henriques Paper: Shibuya Y, Niu Z, Bryleva EY, Harris BT, Murphy SR, Kheirollah A, Bowen ZD, Chang CC, Chang TY. Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage. Neurobiol Aging Apr 7. pii: S (15) doi: /j.neurobiolaging [Epub ahead of print] Group 3: José Carlos Pereira da Silva Cardoso, José Manuel Tereso Temótio, Luísa Nunes Dias Lagarto dos Santos, Maria João Santos Paper: Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, Stankowski J, Kim MS, Zhong J, Kumar M, Andrabi SA, Xiong Y, Dickson DW, Wszolek ZK, Pandey A, Dawson TM, Dawson VL. Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease. Cell Apr 10;157(2): doi: /j.cell Group 4: Paula Cristina Henriques Lopes Garrido, Sofia Andreia Domingues Viana, Susana Maria Nunes Renca, Sofia Morais Paper: Lim J, Lachenmayer ML, Wu S, Liu W, Kundu M, Wang R, Komatsu M, Oh YJ, Zhao Y, Yue Z. Proteotoxic stress induces phosphorylation of p62/sqstm1 by ULK1 to regulate selective autophagic clearance of protein aggregates. PLoS Genet Feb 27;11(2):e doi: /journal.pgen Evaluation: Students will be evaluated based on the oral presentation and on the ability to establish an interactive participation along the course, namely by frequently questioning the lecturers. The final grade in the course will also be based on mark obtained in the multiple choice questionnaire that will be held in the last day of the course. The evaluation criteria (max. 20 values) will include: - Presence (0-1; 0 will be given to less than 70% course attendance) - Participation (0-4) - Paper (0-10): * Data presentation (0-2); * Critical view (0-3);* Proposed experimental research (0-5). - MC Questionnaire (0-5) 3

4 Faculty names and affiliations: External to the University of Coimbra Alexandre Castro-Caldas (MD, PhD) - Instituto de Ciências da Saúde, Universidade Católica Portuguesa, Palma de Cima, Lisboa, Portugal acastrocaldas@ics.lisboa.ucp.pt Maia João Saraiva (PhD) Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal mjsaraiv@ibmc.up.pt Rui Vaz (MD, PhD) - Neurosurgery Service of S. João Hospital, Faculty of Medicine, University of Porto, Porto, Portugal ruimcvaz@gmail.com From the University of Coimbra Ana Cristina Rego (PhD) - Faculty of Medicine, and Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal a.cristina.rego@gmail.com; acrego@cnc.uc.pt; arego@fmed.uc.pt Ana Paula Silva (PhD) - Faculty of Medicine, University of Coimbra, Coimbra, Portugal apmartins@fmed.uc.pt António de Macedo (MD, PhD) - Faculty of Medicine, University of Coimbra, Coimbra, Portugal amacedo@ci.uc.pt António Freire (MD, PhD) - University Hospital of Coimbra (HUC), Neurology Service, and Faculty of Medicine, University of Coimbra, Coimbra, Portugal afreireg@hotmail.com Catarina R. Oliveira (MD, PhD) - Faculty of Medicine and CNC, University of Coimbra, Coimbra, Portugal catarina.n.oliveira@gmail.com Cláudia F. Pereira (PhD) - Faculty of Medicine and CNC, University of Coimbra, Coimbra, Portugal claudia.mf.pereira@gmail.com; cpereira@fmed.uc.pt Cristina Januário (MD, PhD) - HUC, Neurology Service, and Faculty of Medicine, University of Coimbra, Coimbra, Portugal cristinajanuario@gmail.com Inês Baldeiras (PhD) Lab. Neurochemistry, HUC, and CNC, University of Coimbra, Coimbra, Portugal ines.baldeiras@sapo.pt Isabel Santana (MD, PhD) - HUC, Neurology Service, and Faculty of Medicine, University of Coimbra, Coimbra, Portugal isabeljsantana@gmail.com Joana Barbosa de Melo (PhD) - Faculty of Medicine, University of Coimbra, Coimbra, Portugal mmelo@fmed.uc.pt José Pio de Abreu (MD, PhD) - Faculty of Medicine, University of Coimbra, Coimbra, Portugal pioabreu@netcabo.pt 4

5 Lívia Sousa (MD) - HUC, Neurology Service, Coimbra, Portugal livia.sousa@netcabo.pt Luís Cunha (MD, PhD) - HUC, Neurology Service, and Faculty of Medicine, University of Coimbra, Coimbra, Portugal cunhaluis0@gmail.com Luís Pereira de Almeida (PhD) - CNC and Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal lpereiradealmeida@gmail.com Paula Isabel Moreira (PhD) - Faculty of Medicine and CNC, University of Coimbra, Coimbra, Portugal pismoreira@gmail.com Sandra M. Cardoso (PhD) - Faculty of Medicine and CNC, University of Coimbra, Coimbra, Portugal cardoso.sandra.m@gmail.com Sonia I. Gonçalves (PhD) - Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal sigoncalves@uc.pt; sonia.isabel.goncalves@gmail.com Students participating at the Neuroscience and Mental Health course (2014/15 edition): PhD/Master programme NAME Programa de Doutoramento em Ciências da Saúde Ana Sofia Morgadinho Carvalho Bruno Augusto Lourenço Costa Carolina Maria de Oliveira Roque Filipe Manuel Farto Palavra Inês Pereira Dias Marques Joana Carolina Teixeira Andrade Joana Rita Ferreira Marques Jorge Filipe Silva Henriques José Carlos Pereira da Silva Cardoso José Manuel Tereso Temótio Luísa Nunes Dias Lagarto dos Santos Maria João Santos Paula Cristina Henriques Lopes Sofia Andreia Domingues Viana Susana Maria Nunes Renca amorgadinho@gmail.com brunolourencocosta@gmail.com cmoroque@gmail.com filipepalavra@gmail.com inespdmarques@yahoo.com joana.teixeira.andrade@gmail.com joanaritamarques@live.com.pt silvahenriques@gmail.com jose.c.cardoso@gmail.com josetemotio@gmail.com luisalagarto123@gmail.com mjfcsantos@gmail.com paulacgarrido@hotmail.com sofia_viana@estescoimbra.pt susana.renca@gmail.com MIB Sofia Morais sofiamorais86@gmail.com 5