SUPPLEMENTAL MATERIAL
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1 SUPPLEMENTAL MATERIAL Cognitive impairment evaluated with Vascular Cognitive Impairment Harmonization Standards in a multicenter prospective stroke cohort in Korea Supplemental Methods Participants From October 2007 to August 2008, we screened 899 ischemic stroke patients with ischemic stroke among the consecutively enrolled to the multicenter hospital-based stroke register 1 from 12 hospitals in South Korea. All subjects were patients with ischemic stroke diagnosed using diffusion-weighted MRI within 7 days of symptom onset. Of these 899 patients, a total of 620 patients were enrolled for baseline assessment in this study, after excluding 79 patients with severe concomitant medical or neurological conditions (persistent impairment of consciousness or visual impairment), 14 with severe dysphasia, 8 who died within 2 weeks of stroke onset, 16 who were referred to other hospitals, and 162 who refused to give informed consent. The demographics, vascular risk factors, and clinical characteristics, including stroke subtypes, the severity of neurological symptoms, and functional status, were evaluated within 2 weeks after stroke onset during baseline evaluation. Of the 620 patients, 506 were followed up at 3 months after stroke onset, and 353 of them underwent comprehensive cognitive evaluations. This study was approved by the Institutional Review Board of each participating hospital, and all subjects provided written
2 informed consent. Evaluation of cognitive functions Three months after stroke, the patients cognitive functions were assessed using the 60-minute Korean version of the Vascular Cognitive Impairment Harmonization Standards neuropsychological (K-VCIHS-NP) protocol proposed by the National Institute of Neurological Disorders and Stroke and Canadian Stroke Network. 2, 3 The original version consists of 4 cognitive domains: 1) executive / activation: Animal naming, Controlled Oral Word Association Test (phonemic fluency), Digit Symbol Coding, and Trail Making Test; 2) language: Boston Naming Test; 3) visuospatial: Rey Complex Figure Test: Copy-; and 4) memory: Hopkins Verbal Learning Test. In addition, Korean Mini-Mental Status Examination (K-MMSE) for evaluating global cognitive dysfunctions and the Informant Questionnaire of Cognitive Decline in the Elderly (IQCODE) for assessing the patients pre-morbid history of cognitive dysfunctions were also included. All tests and scales in the original version were validated and standardized in Korea (Table S1) Diagnosis of dementia and cognitive impairment Dementia was diagnosed according to the Diagnostic and Statistical Manual (DSM) of Mental Disorders, Fourth Edition, criteria based on clinical interviews, cognitive functions assessed using the 60-minute K-VCIHS-NP, and social functioning status assessed on the scale of instrumental Activities of Daily Living (IADL) 3 months after stroke onset.
3 Cognitive functions were categorized as impaired when a decline was observed in at least 1 domain, where a score below the 10 th percentile for an individual domain. For frontal domains, which consisted of 4 tests, patients who scored below the 10 th percentile on more than 2 tests were identified as having abnormal frontal functions. Functional status and pre-stroke cognitive declines were classified as abnormal if the scores were above 0.43 on the Korean instrumental ADL scale 5 and 3.6 on the K- IQCODE, 12 in accordance with the validation studies conducted on the Korean versions of these tests. Patients were classified as having vascular dementia (VaD), vascular cognitive impairment with no dementia (VCIND), and normal cognition. VaD was defined as dementia in post-stroke survivors without regard to pre-stroke cognitive status, and VCIND was defined as cognitive impairment after stroke that does not meet the dementia criteria of DSM-IV. We also compared the rates of VCIND and VaD defined by the K-VCIHS-NP protocol with the rates determined using more established neuropsychological instruments, K-MMSE scores. The subjects had a score below the 2 nd percentile of the K-MMSE score of the norm group were defined as VaD, and between the 2 nd and 10 th 7, percentile were VCIND. Statistical Analysis The differences in demographics and clinical variables between study participants and patients who were excluded from the study were compared using the Chi-squared and the Mann-Whitney tests according to the characteristics of variables. The clinical determinants associated with VaD, VCIND, and normal cognition were assessed using logistic regression models, controlling for age, sex, level of education, various
4 vascular risk factors, and other detailed clinical variables, including subtypes of ischemic stroke. A two-sided p-value of less than 0.05 was defined as statistically significant.
5 Supplemental Table 1. Korean version of the 60-minute Vascular Cognitive Impairment Harmonization Standards-Neuropsychology Protocol proposed by the National Institute of Neurological Disorders and Stroke and Canadian Stroke Network Cognitive domains and neuropsychological test Executive/Activation Korean version of VCIHS-NP protocol Sources Animal naming (semantic fluency) Animal naming Kang, Y et al. (2000) 8 Controlled Oral Word Association Test (COWAT) Korean-COWAT ( ㄱ, ㅇ, ㅅ ) Kang, Y et al. (2000) 8 Digit Symbol Coding Digit Symbol Coding Yum, TH et al. (1992) 6 Trail Making Test Korean-Trail Making Test- Elderly s version Yi, H et al. (2007) 18 List learning test strategies Seoul Verbal Learning Test Kang, Y et al. (2003) 10 Language / Lexical Retrieval Boston Naming Test Visuospatial Rey Complex Figure Test: Copy Memory Korean-Boston Naming test: Short form A Rey Complex Figure Test: Copy Kang, Y et al. (1999) 9 Kang, Yet al. (2003) 10 Others Hopkins Verbal Learning Test Seoul Verbal Learning Test Kang, Y et al. (2003) 10 Informant Questionnaire of Cognitive Decline in the Elderly (IQCODE): Short form Mini-Mental State Examination (MMSE) Instrumental Activities of Daily Living (ADL) IQCODE-Korean Korean-MMSE Korean-Instrumental ADL Lee, DW et al. (2005) 12 Kang, Y (2006) 7 Kang, SJ et al. (2002) 5 VCIHS-NP: Vascular Cognitive Impairment Harmonization Standards neuropsychological
6 Supplemental Table 2. Comparison of the clinical characteristics of patients whose cognitive function was evaluated with those of patients who dropped out at the 3- month follow-up Baseline assessment (N=620) Cognitive function evaluated (N=353) Dropped out (N=267) P value Age, years ± SD 65.6 ± ± ± 12.3 <0.001 Sex (women), % (N) 44.4 (275) 38.8 (137) 51.7 (138) Education, years ± SD 4.5 ± ± ± 1.8 <0.001 Risk Factors, % (N) Hypertension 66.3 (411) 62.9 (222) 70.8 (189) Diabetes 32.9 (204) 32.6 (115) 33.3 (89) Hyperlipidemia 24.5 (151) 22.9 (80) 26.6 (71) Smoking 43.2 (268) 45.9 (162) 39.7 (106) prior stroke 23.2 (144) 18.7 (66) 29.2 (78) Atrial fibrillation 17.6 (109) 15.9 (56) 19.9 (53) NIH Stroke Scale score at admission (median*) Poor pre-morbid status, % (N) (modified Rankin Score 3) < (61) 7.6 (27) 12.7 (34) Pre-stroke IQCODE score, median* 3.07 (N=594) 3.07 (N=346) 3.11 (N=248) SD: standard deviation; N: number; NIH: National Institutes of Health; IQCODE: Informant Questionnaire of Cognitive Decline in the Elderly; * Mann-Whitney U test 0.003
7 Supplemental Table 3. Clinical characteristics and determinants of cognitive impairment in post-stroke survivors at 3 months after ischemic stroke Uni-variable analysis Multi-variable analysis Normal cognition (N=132) VCI (N=221) P value Adjusted OR P value Men, % Age, years (SD) 59.9 (13.2) 66.5 (11.7) <0.001 Low education, 6 years % Vascular risk factors 0.77 ( ) 1.03 ( ) Hypertension, % <0.001 * 1.71 ( ) Diabetes, % * 1.47 ( ) Hyperlipidemia, % Smoking, % Prior stroke, % Ischemic Stroke subtypes, % Large artery atherosclerosis * 1.42 ( ) Small vessel occlusion <0.001 * 0.36 ( ) Cardioembolism Other or undetermined causes Neurological severity on admission by NIH Stroke Scale, mean (SD) 3.45 (3.76) 4.57 (4.65) ( ) Poor functional status at 3 months by modified Rankin Scale 3, % <0.001 * 3.59 ( ) 0.029
8 NIH: National Institutes of Health; SD: Standard deviation; VCI: vascular cognitive impairment, * Chi-square test, Mann-Whitney test, OR: odds ratio (95% confidence interval) after adjusting for age, sex, hypertension, diabetes, NIH Stroke scale, modified Rankin Scale, large artery atherosclerosis, and small vessel occlusion Supplemental References 1. Lee BC, Roh JK. International experience in stroke registries: Korean Stroke Registry. Am J Prev Med. 2006;31:S Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42: Hachinski V, Iadecola C, Petersen RC, Breteler MM, Nyenhuis DL, Black SE, et al. National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards. Stroke. 2006;37: Kang Y, Jahng SM, Na DL. Seoul neuropsychological screening battery II (SNSB-II). Seoul, Korea: Human Brain Research and Consulting; Kang SJ, Choi SH, Lee BH, Kwon JC, Na DL, Han S-H, et al. The Reliability and Validity of the Korean Instrumental Activities of Daily Living (K-IADL). J Korean Neurol Assoc. 2002;20: Yum TH, Park YS, Oh KJ, Kim JH, Lee YH. Manual for Korean-Wechsler Adult Intelligence Scale. Seoul: Korea Guidance; Kang Y. A Normative Study of the Korean-Mini Mental State Examination(K- MMSE) in the Elderly. Korean J Psych. 2006;25: Kang Y, Chin JH, Na DL, Lee JH, Park JS. A normative study of the Korean
9 version of Controlled Oral Word Association Test (COWAT) in the elderly Korean J Clin Psychol. 2000;19: Kang Y, Kim HH, Na DL. A Short form of the Korean-Boston Naming Test (K- BNT) for using in dementia patients. korean J Clin Psych. 1999;18: Kang Y, Na DL. Professional manual; Seoul neuropsychological screening battery. Seoul, Korea: Human brain research and consulting; Kang Y, Na DL, Hahn SH. A validity study on the korean mini-mental state examination (K-MMSE) in dementia patients. Korean J Neurol. 1997;15: Lee D-W, Lee J-Y, Ryu S-G, Cho S-Jin, Hong C-H, Lee J-H, et al. Validity of the Korean Version of Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). J Korean Geriatr Soc. 2005;9: Seo EH, Lee DY, Kim KW, Lee JH, Jhoo JH, Youn JC, et al. A normative study of the Trail Making Test in Korean elders. International Journal of Geriatric Psychiatry. 2006;21: Bour A, Rasquin S, Boreas A, Limburg M, Verhey F. How predictive is the MMSE for cognitive performance after stroke? J Neurol. 2010;257: Ganguli M, Belle S, Ratcliff G, Seaberg E, Huff FJ, von der Porten K, et al. Sensitivity and specificity for dementia of population-based criteria for cognitive impairment: the MoVIES project. J Gerontol. 1993;48:M Williams-Russo P, Sharrock NE, Mattis S, Szatrowski TP, Charlson ME. Cognitive effects after epidural vs general anesthesia in older adults. A randomized trial. JAMA. 1995;274: Gregg EW, Yaffe K, Cauley JA, Rolka DB, Blackwell TL, Narayan KM, et al. Is diabetes associated with cognitive impairment and cognitive decline among older women? Study of Osteoporotic Fractures Research Group. Arch Intern Med.
10 2000;160: Yi H, Chin J, Lee BH, Kang Y, Na DL. Development and validation of korean version of trail making test for elderly persons. Dementia and Neurocognitive Disorders. 2007;6:54-66
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