THE MICHAEL J. FOX FOUNDATION FOR PARKINSON S RESEARCH. Funding Opportunities

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1 THE MICHAEL J. FOX FOUNDATION FOR PARKINSON S RESEARCH Funding Opportunities

2 AGENDA 1. Brief Overview of MJFF Philosophy 2. MJFF Funding Programs 3. How to apply 4. What happens next? 5. Q&A Please feel free to submit questions in the field next to the slides on your screen. 2

3 INTRODUCTION TO MJFF

4 MJFF IS THE WORLD S LARGEST NONPROFIT FUNDER OF PD RESEARCH Our Mission To accelerate the development of improved therapies, and ultimately a cure, for people living with Parkinson s disease today. Vital Stats» Founded in 2000 by actor Michael J. Fox» Public charity» Nearly 70,000 donors in 2015 (individuals, corporations, nonprofits)» No chapters: team of 100 based in NYC» 3,300 grassroots fundraisers reaching 150,000 supporters worldwide in 2015» More than $600 million in research programs funded to date» $87.8 million in research programs funded in 2015» Nearly 2,100 projects funded to date» 550 active grants in current portfolio» 33% of funded projects are led by researchers outside the United States» Fund academics, biotechs and pharma 4

5 MJFF IS THE WORLD S LARGEST NONPROFIT FUNDER OF PD RESEARCH Our funding opportunities are open to both U.S. and non-u.s. industry and academic institutions. 5

6 VENTURE PHILANTHROPY DEFINES OUR ROLE IN DRUG DEVELOPMENT MJFF is focused on moving projects through the pipeline to ultimately de-risk the PD field for larger funders by» Addressing field-wide challenges» Aligning the field around priorities» Investing in riskier projects» Providing non-dilutive funding 6

7 OUR SCIENTIFIC TEAM WORKS CLOSELY WITH AWARDEES We invest more than just capital in to the success of your research.» Partners from the very beginning We can help you choose the right animal» When something goes wrong, we are here to help Things don t always work out, that s science With experience with over 1,750 grants, we can help address road blocks Sometime we don t have the specific expertise you need, but usually we know someone who does» We help foster collaborations and sharing of scientific ideas A connected scientific community is a productive scientific community At the conclusion of your grant, we bring in principle investigators of related projects to discuss their work and results 7

8 MJFF FUNDING PROGRAMS

9 MJFF FUNDING PROGRAMS ADDRESS CRITICAL NEEDS FOR PD THERAPEUTIC DEVELOPMENT Target Advancement Therapeutic Pipeline Program Improved Biomarkers & Outcome Measures Our Bi-Annual Core Funding Programs are open to all investigators interested in their work being considered for MJFF support.

10 TARGET ADVANCEMENT AN EDMOND J. SAFRA CORE PROGRAM FOR PD RESEARCH Our early stage targets program, Target Advancement supports investigators building robust evidence to rationalize targets for further translation into new Parkinson s treatments. Target Validation Awards Target Optimization Awards Support research characterizing promising, novel PD-relevant targets or continuing target biology work on established PD targets For the Fall 2016 cycle, MJFF has identified Dystonia related targets as a priority for further study 10

11 THERAPEUTIC PIPELINE PROGRAM AN EDMOND J. SAFRA CORE PROGRAM FOR PD RESEARCH The Therapeutic Pipeline Program supports industry and academic investigators with potential for fundamentally altering disease course and/or significantly improving treatment of symptoms above and beyond current standards of care. Disease-modifying Strategies Symptomatic Strategies Protect or restore degenerating and/or dysfunctional neurons affected in PD. Alleviate motor or non-motor symptoms of PD. Alleviate complications of PD treatments. 11

12 IMPROVED BIOMARKERS AND CLINICAL OUTCOME MEASURES The Improved Biomarkers and Clinical Outcomes program supports research that will develop improved biomarker tools and clinical outcome measures to assist in clinical trial design, execution and interpretation of results. Imaging Studies Clinical/Physiological Studies Biochemical assays Data Science 12

13 HOW TO APPLY 13

14 OUR CORE PROGRAMS ARE REVIEWED IN TWO STAGES: PRE-PROPOSAL A short 2-3 pages outlining your project and justifying why it is important for PD research FULL APPLICATION Pre-proposals of interest to MJFF are invited to submit a full application providing in-depth information on the project rationale, experimental plan, budget, and the team performing the research. 14

15 SUBMITTING A PRE-PROPOSAL Complete the pre-proposal template, and submit in our grant application portal. 15

16 IMPORTANT DEADLINES MAY 18 TH PRE-PROPOSALS DUE NOV 2016 ANTICIPATED FUNDING As a reminder, pre-proposal submissions are subject to administrative review and will not be accepted if incomplete. 16

17 APPLICANT BEST PRACTICES 1. Please read all the provided documents and visit our administrative guidelines and FAQ (links within the RFA) 2. Complete the pre-proposal checklist on the first page of the template 3. Please ensure you have provided a current address 4. Write down your username and password, you will need this to submit your full application if invited All MJFF correspondence about your application is completed via . 17

18 WHAT HAPPENS NEXT?

19 PRE-PROPOSAL STAGE Administrative Review Scientific Review FULL APPLICATION STAGE Administrative Review Applications reviewed by external experts Review meeting with experts to discuss applications

20 WE WANT TO WORK WITH YOU Come to us with your ideas to partner and collaborate. Sharing of risk will accelerate our common goal of getting new PD therapeutics to patients.» Partner with us on your research projects, whether with MJFF funding support or not» Launch joint funding program» Gain our perspective on: PD landscape Targets and pathways Specific MJFF awardee projects Your projects» List your trials on Fox Trial Finder» Join our precompetitive, public-private consortia» Attend scientific meetings Workshops PD Therapeutics Conference» Review and/or assess MJFF grants 20

21 QUESTIONS? For more information, please visit michaeljfox.org/funding

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