December 2, Taube Foundation Huntington s Disease Symposium. Course Chair Stanley B. Prusiner, MD Course Fee $25

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1 University of California San Francisco Taube Foundation Huntington s Disease Symposium Kanbar Hall, Jewish Community Center 3200 California Street San Francisco, California Course Chair Stanley B. Prusiner, MD Course Fee $25

2 where This course will be held at the Jewish Community Center (JCC) of San Francisco in Kanbar Hall. The address is 3200 California Street, San Francisco, CA 8:30 am 6:00 pm lodging For your convenience, a small block of rooms has been reserved across the street at the Laurel Inn, 444 Presidio Avenue. Until November 1, 2005 a special conference rate of $ per night is available. After this date, rooms will be provided on a spaceavailable basis only. Please contact the hotel directly to make a reservation: telephone: (800) or (415) ; fax: (415) When placing reservations by phone or by fax with the hotel, please mention that you are attending the UCSF Huntington s Disease Symposium. transportation and parking Parking is available at the JCC at the rate of: $1.25/half hour for the first four hours; $1.75/half hour after 4 hours, daily maximum: $25 Limited parking is available at the UCSF Laurel Heights Campus (across the street) for $10/day on Friday. The campus is located at 3333 California Street, between Presidio Avenue and Laurel Street. Muni buses: #1 California, #2 Clement, #3 Jackson, #4 Sutter (weekdays only), and #43 Masonic. Muni Information Cabs: Yellow Cab DeSoto Cab Co Luxor Cab Street Parking is difficult and limited to 2 hours. Please note that you must enter the JCC from the main entrance on California Street. registration information Registration fee: $25 All Attendees Preregistration is preferred to ensure that registrants receive a syllabus and CME Certificate at the course. Payments may be made by Visa, MasterCard, American Express or check. Register via: Online: Mail: Complete course registration form and send with payment to: UCSF Office of CME P.O. Box San Francisco, CA Fax: Fax completed registration form to: (415) (be sure to include your credit card number) To register by phone or to inquire about registration status, please call UCSF s CME Registration Office at (415) Refunds: No refunds. On-Site Registration Time: 7:30-8:00 am Date: Friday, general information

3 Course Co-Chairs (University of California, San Francisco, unless otherwise noted) Stanley B. Prusiner, MD Director, Institute for Neurodegenerative Diseases Professor of Neurology and Biochemistry Stephen L. Hauser, MD Chair and Robert A. Fishman Distinguished Professor Department of Neurology UCSF Faculty Fred Cohen, MD, D Phil, FACP Professor, Cellular and Molecular Pharmacology and Biochemistry and Biophysics Marc Diamond, MD Assistant Professor in Residence Department of Neurology Department of Cellular and Molecular Pharmacology Steven Finkbeiner, MD, PhD Associate Professor in Residence of Neurology and Physiology Cynthia Kenyon, PhD American Cancer Society Professor Director, Hillblom Center for the Biology of Aging, Department of Biochemistry and Biophysics Bruce L. Miller, MD A.W. & Mary Margaret Clausen Distinguished Chair Professor of Neurology Jonathan Weissman, PhD Investigator, Howard Hughes Medical Institute Professor, Department of Cellular and Molecular Biochemistry Visiting Faculty James Gusella, PhD Bullard Professor of Neurogenetics, Harvard Medical School Director, Molecular Neurogenetics Unit and Center for Human Genetic Research, Massachusetts General Hospital accreditation The University of California, San Francisco School of Medicine (UCSF) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. UCSF designates this educational activity for a maximum of 7 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity. Nursing Credit For the purpose of recertification, the American Nurses Credentialing Center accepts AMA PRA category 1 credit issues by organizations accredited by the ACCME.

4 Taube Foundation Huntington s Disease Symposium Kanbar Hall, Jewish Community Center 3200 California Street San Francisco, California who should attend this course This course is intended for practicing physicians in the areas of neurology, psychiatry, geriatrics, and pediatrics. Topics are also intended for clinicians and basic scientists in genetic counseling, nursing, neuroscience, biochemistry, and molecular genetics. Attendees from the Bay Area and Northwestern United States are anticipated. Educational Objectives Participants will learn about progress in the basic sciences and in the clinic relevant to the basic biology of Huntington's disease and the quest for a cure. Dr. James Gusella will describe the successful search for the genetic basis of the disease and current thoughts regarding its pathophysiology. Additional speakers will discuss cellular and molecular substrates of the disease, including protein structure, folding, and the impact of aging on these processes. In addition, behavioral approaches to Huntington's disease and strategies for the development of potential therapies will be discussed. AT THE CONCLUSION OF THE COURSE, PARTICIPANTS WILL BE ABLE TO: Describe the genetic basis of Huntington's disease. Describe the biochemical basis through which the Huntington's disease mutation alters protein structure. Describe cellular mechanisms through which Huntington protein misfolding leads to neurodegeneration. Describe mechanisms through which aging facilitates neurodegeneration. Describe behavioral approaches to Huntington's disease. Identify emerging therapies for Huntington's disease.

5 Friday, program 8:30 am Registration and Breakfast 9:00 am Opening Remarks Stanley B. Prusiner, MD 9:15 am The Challenges of Huntington s Disease Stephen L. Hauser, MD 9:30 am The Use of Genetics to Define Targets for Huntington s Disease Treatment James Gusella, PhD 10:30 am Behavioral Approaches to Huntington's Disease Bruce L. Miller, MD 11:15 am Cellular and Molecular Mechanisms of Huntington's Disease Steven Finkbeiner, MD, PhD 12 noon Lunch on your own 1:15 pm Taube Foundation Award Winner Announcement and Presentation 1:45 pm Common Structural Themes in Neurodegenerative Diseases - Implications for the Treatment of Huntington's Disease Fred Cohen, MD, D Phil, FACP

6 2:30 pm Discovery and Characterization of a Novel Potential Therapy for Huntington's Disease Marc Diamond, MD 3:15 pm Break 3:45 pm Pathways that Couple the Normal Aging Process to Age-related Protein-aggregation Disease in C. elegans Cynthia Kenyon, PhD 4:30 pm Novel Genetic and Biochemical Approaches for Studying the Misfolding of the Huntington Protein Jonathan Weissman, PhD 5:15 pm Summary of Progress James Gusella, PhD 5:45 pm Closing remarks Stanley B. Prusiner, MD

7 Taube Foundation Huntington s Disease Symposium Friday, Jewish Community Center, San Francisco MNR06002 Kanbar Hall Mail to : UCSF Office of CME P.O. Box San Francisco, CA Fax: (415) Phone: (415) Dr. Mr. Ms. Mrs. Last Name First M.I. Degree Specialty Address City State Zip Daytime Phone Fax Would you like to be on our priority list? Yes No Would you like to be on our priority fax list? Yes No Date of birth to be used as OCME registrant number / / Month Day Year Please indicate if you have any special needs: Registration Fee: $25 Make checks payable to UC Regents X X course registration form Please charge my credit card Visa MasterCard American Express for $ Name on Card (Please Print) Card # _ Expiration Date Authorized Signature Refund Policy: No refunds.

8 0569 Office of Continuing Medical Education Box 0742, LH-450 San Francisco, CA Taube Foundation Huntington s Disease Symposium REGISTER TODAY! For more information or to register online, visit our website at You may also reach us by calling the Office of Continuing Medical Education at (415) or info@ocme.ucsf.edu. NON-PROFIT U.S. POSTAGE P A I D PERMIT #470 SANTA ROSA CA upcoming cme courses 39th Annual Recent Advances in Neurology February 15-17, 2006 San Francisco, California 5th International Conference on Frontotemporal Dementias September 6-8, 2006 San Francisco, California Kanbar Hall, Jewish Community Center 3200 California St, San Francisco, CA

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