go the distance NEW AcrySof IQ ReSTOR +2.5 D It s a wide world. Help your patients and everywhere in between.

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1 NEW AcrySof IQ ReSTOR +2.5 D It s a wide world. Help your patients go the distance and everywhere in between. Now with ACTIVEFOCUS optical design for active-lifestyle patients. Recommend AcrySof IQ ReSTOR +2.5 D IOLs to take distance vision a step further. With fewer steps, a central refractive zone for distance and increased negative asphericity, the AcrySof IQ ReSTOR +2.5 D IOL s apodized diffractive optical design channels light to promote sharp distance vision. Designed to offer balanced near and intermediate vision as well, this IOL can help your patients enjoy a more active lifestyle. 1,2 AcrySof IQ ReSTOR PRESBYOPIA-CORRECTING IOL Advancing CATARACT SURGERY

2 More options to help your active-lifestyle patients see and do the things they love Many of today s cataract patients enjoy an active lifestyle, participating in activities that require intermediate and distance vision such as driving, golfing, shopping and playing tennis. With the AcrySof IQ ReSTOR +2.5 D and AcrySof IQ ReSTOR +3.0 D, your cataract patients have options for meeting their lifestyle needs. AcrySof IQ ReSTOR +2.5 D IOL Delivers sharp distance vision and more. 1 Designed to reduce spectacle dependence for a range of intermediate to distance vision. 1 Uses ACTIVEFOCUS : Apodized diffractive optical design. Central refractive zone channels more light to distance vision. Fewer steps. Increased negative asphericity. AcrySof IQ ReSTOR +3.0 D IOL Delivers the broadest range of vision across all ALCON IOLs. Designed to reduce spectacle dependence for near, intermediate and distance vision. 3

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4 An optical design for active-lifestyle patients AcrySof IQ ReSTOR +2.5 D vs. AcrySof IQ ReSTOR +3.0 D ACTIVEFOCUS reduces the AcrySof IQ ReSTOR IOL s add power from +3.0 D to +2.5 D by: Reducing diffractive steps from 9 to 7 and ReSTOR +2.5 ReSTOR +3.0 increased spacing Altering light distribution - Increasing distance function of the center zone from 40% to 100% - Reducing apodized diffractive area by 18% Center Distance Apodized Diffractive Multifocal Center Intermediate - Increasing the outer distance area by 6% Outer Distance Outer Distance

5 Offer your patients a wider range of quality vision AcrySof IQ ReSTOR +2.5 D IOL is designed to enhance vision quality for patients with more active lifestyles. 2 The lens offers superior near (40 cm) and intermediate vision (53 cm) by almost two lines over the AcrySof IQ monofocal lens. 1 Binocular Defocus Curve 2 67 cm (26 in) 50 cm (20 in) 40 cm (16 in) 33 cm (13 in) 67 cm (26 in) 50 cm (20 in) 40 cm (16 in) 33 cm (13 in) 20/ /20 Snellen 20/25 20/ LogMAR VA /25 20/32 Snellen 20/ /40 20/ Refraction (D) / Refraction (D) AcrySof IQ ReSTOR +2.5 D IOL AcrySof IQ Monofocal IOL AcrySof IQ ReSTOR +3.0 D IOL (n=116) AcrySof IQ ReSTOR +4.0 D IOL (n=114) Standard Deviation Binocular Mesopic Contrast Sensitivity 4-6 Months Post-op *,2 Mean Contrast Sensitivity (Log Units) cpd (n=127/130) 3 cpd (n=129/132) 6 cpd (n=116/128) 12 cpd (n=103/117) Spatial Frequency (Cycles per Degree) AcrySof IQ ReSTOR +2.5 D IOL AcrySof IQ Monofocal IOL Standard Deviation * With Glare

6 Quality-of-vision enhancements by design Simulated headlight images,4 AcrySof IQ ReSTOR +2.5 D IOL AcrySof IQ Monofocal IOL Crystalens HD500 IOL Pinhole images of AcrySof and competitor models using the 0.2 μm SA Modified ISO model eye and a 5 mm pupil at the IOL plane. Visual Disturbances 6 Months Postoperative Following Second Eye Implantation,1 Visual disturbance Glare/Flare AcrySof IQ ReSTOR +2.5 Model SV25T0 (n=153) AcrySof IQ Monofocal Model SN60WF (n=160) Patients implanted with AcrySof IQ ReSTOR +2.5 D IOLs experienced 3.3% severe glare. Patients implanted with AcrySof IQ Monofocal IOLs experienced 3.8% severe glare. None/Mild 75.8% 83.2% Moderate 20.9% 13.1% Severe 3.3% 3.8% Halos None/Mild 67.4% 88.8% Moderate 22.2% 7.5% Severe 10.5% 3.8% The safety of the AcrySof IQ ReSTOR +2.5 D Multifocal IOL Model SV25T0 is based in part on the safety demonstrated by parent models MA60D3 and SA60D3. No unanticipated serious adverse device effects were observed in any subjects implanted with Model SV25T0. There were no reports of explants during this clinical study.

7 The power of a proven platform Like all AcrySof IQ lenses, AcrySof IQ ReSTOR +2.5 D IOLs also provide the benefits of: 14 BioMaterial: Clear Capsules 5-7 Unique material property bonds with the capsule, which can help block cell migration onto the optic BioMechanics: Refractive Predictability 8-11 STABLEFORCE haptics facilitate precise centration within the capsular bag Axial and rotational stability enable excellent long-term refractive predictability Durable, single-piece IOL design allows ease of delivery through a small incision BioMaterial BioMechanics BioOptics: Improved Functional Vision 12,3,13 AcrySof Natural chromophore and aspheric optics improve functional vision Portfolio of IQ Monofocal, IQ Toric and IQ ReSTOR lenses for correction of distance vision, astigmatism and presbyopia lens to promote ocular health BioOptics AcrySof IQ ReSTOR +2.5 D IOL Specifications Model Number Model Number +2.5 SV25T mm 6.0 mm Anterior Apodized Diffractive Aspheric Surface With a Central Refractive Posterior Optic Surface Add-power D Add-power Spectacle Plane D Number of Diffractive Steps 7 Filtration UV and Blue-Light Filtering Optic Material Acrylate/Methacrylate Copolymer Central Optic Refractive Optic Diameter 6.0 mm Overall Length 13.0 mm Suggested A-Constant Front View Provided as a guideline only. A-Constant measured with optical coherence. Side View Index of Refraction 1.55 Haptic Angulation 0 Haptic Configuration STABLEFORCE Haptics

8 Recommend the lenses that give your patients more than just sharp distance vision: AcrySof IQ ReSTOR +2.5 D IOLs. For useful tools to help you get started, contact your Alcon sales representative today. AcrySof IQ ReSTOR Family of IOLs Important Product Information CAUTION: Federal (USA) law restricts this device to the sale by or on the order of a physician. INDICATIONS: The AcrySof IQ ReSTOR Posterior Chamber Intraocular Lens (IOL) is intended for primary implantation for the visual correction of aphakia secondary to removal of a cataractous lens in adult patients with and without presbyopia, who desire near, intermediate and distance vision with increased spectacle independence. The lens is intended to be placed in the capsular bag. WARNINGS/PRECAUTIONS: Careful preoperative evaluation and sound clinical judgment should be used by the surgeon to decide the risk/benefit ratio before implanting a lens in a patient with any of the conditions described in the Directions for Use labeling. Physicians should target emmetropia, and ensure that IOL centration is achieved. Care should be taken to remove viscoelastic from the eye at the close of surgery. Some patients may experience visual disturbances and/or discomfort due to multifocality, especially under dim light conditions. As with other multifocal IOLs, visual symptoms may be significant enough that the patient will request explant of the multifocal IOL. Spectacle independence rates vary with all multifocal IOLs; as such, some patients may need glasses when reading small print or looking at small objects. Clinical studies with the AcrySof ReSTOR lens indicated that posterior capsule opacification (PCO), when present, developed earlier into clinically significant PCO. Prior to surgery, physicians should provide prospective patients with a copy of the Patient Information Brochure available from Alcon for this product informing them of possible risks and benefits associated with the AcrySof IQ ReSTOR IOLs. Studies have shown that color vision discrimination is not adversely affected in individuals with the AcrySof Natural IOL and normal color vision. The effect on vision of the AcrySof Natural IOL in subjects with hereditary color vision defects and acquired color vision defects secondary to ocular disease (e.g., glaucoma, diabetic retinopathy, chronic uveitis, and other retinal or optic nerve diseases) has not been studied. Do not resterilize; do not store over 45 C; use only sterile irrigating solutions such as BSS or BSS PLUS Sterile Intraocular Irrigating Solutions. ATTENTION: Reference the Directions for Use labeling for a complete listing of indications, warnings and precautions. 1. AcrySof IQ ReSTOR +2.5 D IOL Directions for Use. 2. C Clinical Study Report: Clinical Investigation of AcrySof IQ ReSTOR +2.5 D Multifocal IOL. Effective date 07 Aug AcrySof IQ IOL Directions for Use. 4. Alcon data on file. 5. Linnola RJ, Sund M, Ylonen R, et al. Adhesion of soluble fibronectin, laminin, collagen type IV to intraocular lens materials. J Cataract Refract Surg. 1999; Boureau C, et al. Incidence of Nd:YAG laser capsulotomies after cataract surgery: comparison of 3 square edge lenses of different composition. Can J Ophthalmol. 2009;44: AcrySof IQ ReSTOR IOL Directions for Use. 8. Wirtitsch MG, et al. Effect of haptic design on change in axial lens position after cataract surgery. J Cataract Refract Surg. 2004;30(1): Koshy JJ, Nishi Y, Hirnschall N, et al. Rotational stability of a single-piece toric acrylic intraocular lens. J Cataract Refract Surg. 2010;36(10): Nejima R, et al. Prospective intrapatient comparison of 6.0-millimeter optic single-piece and 3-piece hydrophobic acrylic foldable intraocular lenses. Ophthalmology. 2006;113(4): Kohnen T, et al. Incision sizes before and after implantation of SN60WF intraocular lenses using the Monarch injector system with C and D cartridges. J Cataract Refract Surg. 2008;34: AcrySof IQ +3.0 D Directions for Use. 13. AcrySof IQ Toric IOL Directions for Use. 14. Alcon internal sales data on file. AcrySof IQ ReSTOR PRESBYOPIA-CORRECTING IOL Advancing CATARACT SURGERY 2015 Novartis 4/15 RES15027SA