obstructive sleep apnea : OSA OSA obstructive sleep apnea : OSA Verga nasal continuous positive airway pressure ; CPAP OSA OSA OSA CPAP CPAP 3D OSA

Transcription

1 obstructive sleep apnea : OSA OSA OSA OSA OSA nasal continuous positive airway pressure ; CPAP OSA obstructive sleep apnea : OSA OSA OSA OSA the International Classification of Sleep Disorders 3rd. : ICSD 3 OSA OSA OSA 1 OSA OSA OSA OSA AHI Apnea hypopnea index OSA Verga nasal continuous positive airway pressure ; CPAP OSA CPAP CPAP 3D PVT psychomotor vigilance task OSA Lapses Slope AHI OSA OSA OSA 25

2 the International Classification of Sleep Disorders 3rd. : ICSD 3 polysomnography : PSG out of center sleep testing : OCST RE- RAs PSG OCST PSG OCST RERAs RERA Respiratory effort related arousal 2 OSA Z score OSA AHI 30 Z score AHI AHI 30 AHI 30 :p 2 OSA OSA OSA OSA Sharafkhaneh OSA OSA OSA Yaffe apnea hypopnea index : AHI OSA Chang OSA OSA OSA Aoki OSA OSA OSA OSA MRI OSA OSA Elwood 26

3 VT psychomotor vigilance task AHI Lapses Slope AHI AHI Adjusted β CoefficientCl p Adjusted β CoefficientCl p meanrt Lapses Slope BMI meanrtlapses Slope RT OSA Buratti OSA OSA OSA Gelber MRI OSA OSA OSA Eε4 APOEε4 OSA 3 CPAP OSA CPAP CPAP ADNI OSA MCI AD CPAP MCI AD OSA CPAP MCI AD OSA MCI OSA AD OSA OSA CPAP MCI AD Canessa OSA MRI OSA CPAP OSA QOL OSA OSA CPAP CPAP 27

4 30 1 OSA CPAP CPAP OSA CPAP OSA Bixler E Vgontzas A Ten Have T et al Effectsofage on sleep apnea in men I Prevalence and severity Am J Respir Crit Care Med American Academy of Sleep Medicine International classification of sleep disorders 3rd ed American Academy of Sleep Medicine editor 2014 Martin M Sforza E Roche F et al Sleep breathing disorders and cognitive function in the elderly an 8 year follow up study the proof synapse cohort Sleep Varga AW Kishi A Mantua J et al Apnea induced rapid eye movement sleep disruption impairs human spatial navigational memory J Neurosci Koo BB Patel SR Strohl K et al Rapid eye movement related sleep disordered breathing influence of age and gender Chest Yamauchi M Fujita Y Kumamoto M et al Nonrapid Eye Movement Predominant Obstructive Sleep Apnea Detection and Mechanism J Clin Sleep Med Sharafkhaneh A Giray N Richardson P et al Association of psychiatric disorders and sleep apnea in a large cohort Sleep Yaffe K Laffan AM Harrison SL et al l Sleep Disordered Breathing Hypoxia and Risk of Mild Cognitive Impairment and Dementia in Older Women JAMA Chang W P Liu M E Chang W C et al Sleep apnea and the risk of dementia a population based 5 year follow up study in Taiwan PLoS One e78655 Aoki K Matsuo M Takahashi M et al Association of sleep disordered breathing with decreased cognitive function among patients with dementia J Sleep Res Thomas RJ Rosen BR Stern CE et al Functional imaging of working memory in obstructive sleep disordered breathing J Appl Physiol Elwood PC Bayer AJ Fish M et al Sleep disturbance and daytime sleepiness predict vascular dementia J Epidemiol Community Health Zimmerman ME Aloia MS Sleep disordered breathing and cognition in older adults Curr Neurol Neurosci Rep Buratti L Viticchi G Falsetti L et al Vascular impairment in Alzheimer s disease the role of obstructive sleep apnea J Alzheimers Dis Gelber RP Redline S Ross GW et al Associations of brain lesions at autopsy with polysomnography features before death Neurology Kim H Yun C H Thomas RJ et al Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle aged and older general population Sleep B Canessa N Castronovo V Cappa SF et al Obstructive Sleep Apnea Brain Structural Changes and Neurocognitive Function before and after Treatment Am J Respir Crit Care Med Macey PM Is brain injury in obstructive sleep apnea reversible? Sleep Kadotani H Young T Peppard PE et al Association between apolipoprotein E epsilon4 and sleep disordered breathing in adults JAMA Osorio RS Gumb T Pirraglia E et al Sleep disordered breathing advances cognitive decline in the elderly Neurology

5 30 1 Sleep disordered breathing and cognitive dysfunction Takuro Kitamura, Soichiro Miyazaki and Hideaki Suzuki Department of Otorhinolaryngology Head and Neck Surgery, University of Occupational and Environmental Health Research Institute of Life and Sciences, Chubu University Key words : obstructive sleep apnea, sleep disordered breathing, cognitive dysfunction, dementia 29