FORMULATION AND EVALUATION OF DIPHENHYDRAMINE HYDROCHLORIDE LOZENGES FOR TREATMENT OF COUGH

Size: px
Start display at page:

Download "FORMULATION AND EVALUATION OF DIPHENHYDRAMINE HYDROCHLORIDE LOZENGES FOR TREATMENT OF COUGH"

Transcription

1 WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES Patel et al. Volume 3, Issue 5, Research Article ISSN FORMULATION AND EVALUATION OF DIPHENHYDRAMINE HYDROCHLORIDE LOZENGES FOR TREATMENT OF COUGH Dasharath M. Patel*, Rahul J. Patel, Hardik R. Shah and Chhagan N. Patel Department of Pharmaceutics and Pharmaceutical Technology, Shri Sarvajanik Pharmacy College, Mehsana , Gujarat, India Article Received on 25 February 2014, Revised on 24 March 2014, Accepted on 23 April 2014 *Correspondence for Author Dr. Dasharath M. Patel Department of Pharmaceutics and Pharmaceutical Technology, Shri Sarvajanik Pharmacy College, Mehsana, Gujarat, India ABSTRACT Objective: Diphenhydramine hydrochloride was formulated as lozenges to provide effective release for the management of cough. Many dosage forms like syrups, tablets, capsules are available in the market but still there is a need for new dosage forms which acts effectively and locally. Present investigation was undertaken to formulate and evaluate lozenges to meet the need of improved bioavailability by avoiding hepatic first pass metabolism of the drug. Experimental Work: The lozenges were formulated using various sugars like mannitol, dextrose, sucrose and isomalt. Polyethylene glycol 200, propylene glycol and glycerine were tested as plasticizer in formulation. The prepared formulations were subjected to various evaluation parameters. After completion of stability study for a period of 1 month, the optimized formulation was subjected to evaluation parameters. Results and Discussion: Lozenges formulated using isomalt and 0.1 ml glycerine remained as hard candy, while lozenges were not formed with any other sugar. The optimized formulation showed a hardness of around 15 kg/cm²; drug content and content uniformity of 97 % and in vitro drug release of more than 99 % within 20 min. After stability study, it was found that the lozenges were not altered in terms of above parameters and were stable. Conclusion: From the present work, it was concluded that the isomalt can be successfully used as tooth friendly sugar substitute in the formulation of medicated lozenges and glycerine can be used as a plasticizer to give better appearance. The molded lozenges can provide an attractive alternative formulation in the alleviation of cough. Keywords: Diphenhydramine hydrochloride, Lozenges, Hard candy, Cough, Isomalt Vol 3, Issue 5,

2 INTRODUCTION Amongst the different routes of drug delivery, oral route is widely preferred to the patient. However, oral administration of drugs has disadvantages such as hepatic first pass metabolism and enzymatic degradation within the gastrointestinal (GI) tract, that prohibit oral administration of certain classes of drugs especially peptides and proteins. Consequently, other absorptive mucosas are considered as potential sites for drug administration. Transmucosal routes of drug delivery (i.e., the mucosal linings of the nasal, rectal, vaginal, ocular and oral cavity) offer distinct advantages over oral administration for systemic drug delivery. These advantages include possible bypass of first pass effect, avoidance of presystemic elimination within the GI tract. [1] In case of the nasal cavity as a site for systemic drug delivery, the potential irritation and the irreversible damage to the ciliary action of the nasal cavity from chronic application of nasal dosage form limits its use in long term therapy. Even though the rectal, vaginal and ocular mucosa all offer certain advantages, the poor patient acceptability associated with these sites renders them reserved for local applications rather than systemic drug administration. [1] The parenteral route is not routinely used for self administration of medication. It is probable that at least 90 % of all drugs used to produce systemic effects are administered by the oral route. [2] On other hand, the oral cavity is highly acceptable by patients and the mucosa is relatively permeable with a rich blood supply. Furthermore, oral transmucosal drug delivery bypasses first pass effect and avoids pre-systemic elimination in the GI tract. [1] Lozenges can be used as an alternative dosage form to tablets and capsules when patients are unable to swallow. [3] Lozenges offer certain advantages like no need of water for administration, pleasant taste, patient acceptability, etc. [4] Lozenges historically have been used for the relief of minor sore throat pain and irritation and have been used extensively to deliver topical anesthetics and antibacterials. Today they are used for analgesics, anesthetics, antimicrobials, antiseptics, antitussives, aromatics, astringents, corticosteroids, decongestants, demulcents and other classes and combinations of drugs. [5] Vol 3, Issue 5,

3 Diphenhydramine hydrochloride, a histamine H 1 receptor antagonist, is widely used as antiallergic, antiemetic and antitussive drug in many dosage form. [6] Now a days, cough is a common disorder in patients like paediatrics and geriatrics. Diphenhydramine hydrochloride is available in conventional dosage form such as tablets, capsules, syrups. But, all these conventional dosage forms have their own limitations like first pass metabolism, need of water for administration, gastric irritancy and poor patient compliance. In the present research work an attempt was made to formulate and evaluate lozenges of Diphenhydramine hydrochloride using different sugars and plasticizers for optimization. MATERIALS AND METHODS Materials Diphenhydramine hydrochloride and isomalt were received as a gift sample from H. B. Chemicals, Vadodara, India. Propylene glycol (PG), polyethylene glycol 200 (PEG 200) and glycerine were procured from Finar Chemicals Ltd, Ahmedabad, India. Sucrose, dextrose and mannitol were procured from Yarrow Chem. Products, Mumbai, India. All other materials used were of pharmaceutical or analytical grade. Drug-Excipients Compatibility Study During the studies, possible interaction of drug with various ingredients proposed for use in final dosage form was checked. The drug-excipient compatibility study was carried out by using Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FTIR) spectroscopy. DSC study of pure drug and optimized batch was performed using DSC instrument (DSC-60, Shimadzu, Kyoto, Japan). In this process, samples (4 mg) were weighed into aluminum cell and scanned at 20 to 300 C, at 100 ml/min nitrogen flow rate against blank DSC aluminum cell as a reference. FTIR study was conducted using KBr mixing method on FTIR spectrophotometer (FTIR-8400, Shimadzu, Kyoto, Japan) and the spectrums were recorded in the wavelength region of cm -1. Analytical Method Development Calibration curve of Diphenhydramine hydrochloride was taken in phosphate buffer ph Accurately weighed 100 mg of Diphenhydramine hydrochloride was transferred to 100 ml volumetric flask and dissolved in phosphate buffer ph 6.8. The volume was adjusted up to 100 ml with respective solution to get 1000 µg/ml stock solution of drug. The stock solution Vol 3, Issue 5,

4 (1000 µg/ml) was further diluted to get concentration of Diphenhydramine hydrochloride in the range of µg/ml. These solutions were scanned for the maximum absorbance using Shimadzu UV/Vis double beam spectrophotometer. The absorbance of these drug solutions were estimated at 258 nm. Preparation of Lozenges The lozenges were prepared by heating and congealing technique. Syrupy base was prepared in a beaker by dissolving the required amounts of sugar in water and kept for heating on a hot plate. Temperature was maintained at C till it became thick. The drug and other excipients (except plasticizer) were added manually and mixed thoroughly after 30 min with continue process of heating. The prepared mass was further heated for 45 min and then plasticizer was added into it. Then above syrupy base was poured into pre-cooled and prelubricated mold and the mold was kept aside for min. Lozenges were removed from mold and were kept for air drying. In the case of batches without plasticizer, a step of plasticizer addition was omitted from procedure. These prepared lozenges were further subjected to various evaluation parameters. The formulations of batches prepared with different sugars are shown in Table 1. Table 1: Composition of batches for sugar optimization Ingredients Quantity (10 Lozenges) R1 R2 R3 R4 Diphenhydramine HCl 125 mg 125 mg 125 mg 125 mg Mannitol g Sucrose g Dextrose g -- Isomalt g Sodium citrate 500 mg 500 mg 500 mg 500 mg Menthol 15 mg 15 mg 15 mg 15 mg Color (Sunset yellow) q.s. q.s. q.s. q.s. Mango flavor q.s. q.s. q.s. q.s. Water 70 ml 70 ml 70 ml 70 ml Once the sugar was selected, further batches were formulated to select the plasticizer. The compositions of batches are shown in Table 2. Vol 3, Issue 5,

5 Table 2: Composition of batches for plasticizer selection Ingredients Quantity (10 Lozenges) R5 R6 R7 Diphenhydramine HCl 125 mg 125 mg 125 mg Isomalt gm gm gm Sodium citrate 500 mg 500 mg 500 mg Propylene glycol 1 ml PEG ml -- Glycerine ml Menthol 15 mg 15 mg 15 mg Color (Sunset yellow) q.s. q.s. q.s. Mango flavor q.s. q.s. q.s. Water 70 ml 70 ml 70 ml Once the plasticizer was selected, further batches were formulated to optimize its quantity. The compositions of batches are shown in Table 3. Table 3: Composition of batches for plasticizer optimization Ingredients Quantity (10 Lozenges) R8 R9 R10 Diphenhydramine HCl 125 mg 125 mg 125 mg Isomalt gm gm gm Sodium citrate 500 mg 500 mg 500 mg Glycerine 0.5 ml 0.3 ml 0.1 ml Menthol 15 mg 15 mg 15 mg Color (Sunset yellow) q.s. q.s. q.s. Mango flavor q.s. q.s. q.s. Water 70 ml 70 ml 70 ml Evaluation of Lozenges The prepared lozenges were evaluated for various parameters. The diameter and thickness of lozenges were determined using Vernier Calipers. Thickness was measured at a center of lozenges. The hardness of lozenges was determined by using Pfizer type hardness tester, where the force required to break the lozenges was noted. The weight variation was conducted by weighing 20 lozenges individually and calculating the average weight and comparing the individual lozenges weight to the average value. The friability of the lozenges was determined using Roche friabilator. Weighed lozenges were placed in the friabilator and operated for 4 min at 25 rpm. The lozenges were then made free from dust and reweighed. The percentage weight loss was recorded and friability was calculated. Vol 3, Issue 5,

6 The mouth dissolving time was determined by in-house method. The time taken by the lozenge to dissolve completely was determined by placing each lozenge in separate beaker containing 100 ml phosphate buffer ph 6.8 at 50 rpm using mechanical stirrer and time was noted at 37 C. For determination of drug content, five lozenges were weighed individually and crushed in a mortar. Drug was extracted with 100 ml of distilled water. The drug content was determined spectrophotometrically at 258 nm with blank standard as the reference. For content uniformity, three lozenges were weighed individually and dissolved in a beaker containing 50 ml distilled water separately. The drug content was determined spectrophotometrically at 258 nm with blank standard as the reference. Moisture content determination was done by gravimetric method. Each lozenge was weighed and placed in vacuum oven at 70 C for 16 hr. Final weight was subtracted from initial and the difference in moisture content was calculated. [4] In Vitro Dissolution Study The modified dissolution test apparatus USP type II (paddle) was used and 100 ml of the dissolution medium phosphate buffer ph 6.8 was placed in the beaker containing the lozenge and stirred at 100 rpm. Five ml aliquot samples were withdrawn at 5 min interval and replaced immediately with an equal volume of fresh medium i.e., phosphate buffer ph 6.8. Each aliquot was diluted and analyzed at 258 nm using blank, by Shimadzu UV-Visible spectrophotometer. The amount of drug release was determined from the standard calibration curve of pure drug. [7] Stability Studies Optimized formulation was subjected to stability study at temperature 40 º C/75 % relative humidity (RH) for a period of 1 month. The optimized formulation sealed in aluminum foil was kept at above mentioned temperature and humidity condition. At the end of studies, samples were analyzed for the in vitro drug release, content uniformity and % drug content and other parameters such as hardness and friability. [8] RESULTS AND DISCUSSION Drug- Excipients Compatibility Study FTIR spectrums of drug and drug in combination with excipients are shown in Figure 1 and Figure 2, respectively. It was observed that there were no changes in main peaks in the FTIR Vol 3, Issue 5,

7 spectra of a mixture of drug and excipients. The FTIR study demonstrate that no physical or chemical interactions of Diphenhydramine hydrochloride with other excipients. C-O-C Stretchin C-H Stretch Figure 1: FT-IR spectra of Diphenhydramine hydrochloride C-O-C Stretching C-H Stretch Figure 2: FT-IR spectra of Diphenhydramine hydrochloride and excipients DSC thermogram of drug and drug in combination with excipients are shown in Figure 3 and Figure 4, respectively. It is evident from DSC thermograms that sharp endothermic peak obtained in pure drug was retained without any measure shift in composite mixture, indicating absence of any physical incompatibility of drug with excipients used in lozenges formulation. Vol 3, Issue 5,

8 Figure 3: DSC thermogram of Diphenhydramine hydrochloride Figure 4: DSC thermogram of Diphenhydramine hydrochloride and excipients Analytical Method Development The drug was analyzed using UV visible spectrophotometer. The UV spectrum of drug solution in phosphate buffer ph 6.8 is shown in Figure 5. The drug exhibited λ max at 258 nm. The calibration curve was generated using different concentration ( µg/ml) of drug solutions in the Beer-Lambert law. The data for calibration curve are shown in Table 4 and calibration curve is shown in Figure 6. Table 4: Calibration curve data of drug in phosphate buffer ph 6.8 Sr. Concentration Absorbance Mean Absorbance ± No. (µg/ml) I II III S. D. (n=3) ± ± ± ± ± ± ± ± Vol 3, Issue 5,

9 Figure 5: UV spectrum of different solutions of drug Figure 6: Calibration curve of Diphenhydramine hydrochloride Formulation Optimization of Lozenges After performing formulation of batches for sugar selection (R1 to R4), the observations are reported here. Mannitol was easily dissolved in water, but the mass formulated with mannitol was stuck on the wall of beaker during heating and thick viscous mass was not obtained. The batches formulated with dextrose and sucrose showed re-crystallization of sugars. Batch formulated with isomalt showed hard candy type lozenges, but the appearance was not good. Due to lack of physical appearance, it was decided to add plasticizer in further formulations. Formulations were prepared by incorporating a plasticizer as shown in Table 2. Batches formulated with PG and PEG 200 showed soft semisolid type lozenges while that with Vol 3, Issue 5,

10 glycerine showed a hard semisolid type lozenges formed after keeping aside for half an hour. So, glycerine was selected for further batches and its quantity was varied to check the effect on the quality of lozenges. The batches formulated with varying quantity of glycerine (batches R8 to R10) showed that as the quantity of glycerine was reduced, the hardness and transparency of the lozenges were improved. With higher concentration of glycerine, the lozenges were remained as semisolid type after keeping aside for half an hour. With lower concentration of glycerine, the lozenges were remained as hard candy type with good appearance and transparency. Hence batch R10 was selected as optimized batch. The photograph of optimized batch is shown if Figure 7. Figure 7: Photograph of optimized formulation Evaluation of Lozenges The detailed data for evaluation of optimized batch are shown in Table 5. Diameter and thickness was found to be 18 mm and 8 mm, respectively. Hardness was found to be 15 kg/cm 2. Weight variation was within the limit of average weight ± 10 %. Friability was found to be ± %. Time taken to dissolve lozenges was found be around 18 min. Drug content and content uniformity of lozenges were found to be around 97 %. Hence, it can be concluded that drug was distributed uniformly throughout the lozenges. No significant difference in the drug content among the lozenges indicated good content uniformity. Moisture content was found to be 0.665± % which was in the limit %. The evaluation results showed that the optimized formulation showed acceptable properties in terms of various parameters. Vol 3, Issue 5,

11 Table 5: Results of evaluation study of optimized formulation Result (n=3) Evaluation Parameter* After stability study 0 day of 1 month Hardness ± kg/cm ± Diameter 18 mm 18 ± 0 Thickness 8 mm 8 ± 0 Weight Variation 1.95 % 2.41 % % Friability ± % ± Mouth Dissolving Time 1105 ± sec 1168 ± Drug Content ± % ± Content Uniformity ± ± Moisture Content 0.665± % ± *Values are expressed as mean ± S.D for three determinations Table 6: % CPR of optimized formulation Time (min) Average % CPR ± S. D. 0 day After stability study of 1 month ± ± ± ± ± ± ± ± ± ± ± ± * Values are expressed as mean ± S.D for three determinations Figure 8: % drug release profile of optimized formulation Vol 3, Issue 5,

12 In Vitro Dissolution Study In vitro dissolution data for the optimized formulation are shown in Table 6 before and after stability study carried out for 1 month. In vitro dissolution for lozenges was found to be around 99% within 20 min. After stability study for 1 month, there was not so much difference in results. So, the optimized formulation was stable (Figure 8). CONCLUSION The present study was focused on the formulation and evaluation of Diphenhydramine hydrochloride lozenges by utilizing mannitol, sucrose, dextrose and isomalt as a base among which lozenges were prepared only by using isomalt as base. The physical appearance of lozenges was not attractive. So, PG, PEG 200 and glycerine were used as plasticizer in various concentration among which lozenges prepared using 0.1 ml glycerine were very attractive in look with required properties. The stability studies carried for period of 1 month proved that the prepared lozenges were found stable and there wasn t any substantial interaction between the drug, color and flavor. From the present work, it can be concluded that the isomalt can be successfully used as the tooth friendly sugar substitute in the formulation of medicated lozenges and owing to its low caloric value and its ability to withstand formation of plaques, it could be used safely for pediatric patient concerns. Due to low caloric value of isomalt, diabetic patients also can consume medicated lozenge prepared using isomalt as base. ACKNOWLEDGEMENT Authors are also thankful to H. B. Chemicals for providing drug and isomalt as gift sample. Authors are very much thankful to Principal of Shri Sarvajanik Pharmacy College, Mehsana for extending laboratory and instrumental facilities to carry out the work. REFERENCES 1. Shojaei AH. Buccal mucosa as a route for systemic drug delivery: A review. J Pharm Pharm Sci, 1998; 1(1): Hooda R, Tripathi M, Kapoor K. A review on oral mucosal drug delivery system. The Pharma Innovation, 2012; 1(1): Batheja P, Thakur R, Michniak B. Basic biopharmaceutics of buccal and sublingual absorption. In: Touitou E, Barry BW, editors. Enhancement in drug delivery. London, New York: CRC Press, Taylor and Francis Group; p Vol 3, Issue 5,

13 4. Jain V, Maheshwari R, Ansari R, Mahajan SC, Joshi GA. Review on lozenges. British Biomedical Bulletin, 2013; 1(1): Allen LV. Troches and lozenges. Cited 2013 Oct 15. Available from 6. Mario DLM, Vanna S, Alessandra TP. Development of new topical formulations of Diphenhydramine hydrochloride: In vitro diffusion and in vivo preliminary studies. Int J Pharm Tech Res, 2010; 2(1): Das S, Pattanayak D. Formulation development and optimization of medicated lozenges for pediatric use. Int J of Pharm Sci & Res, 2011; 3(1): Nagoba SN, Purushotham RK, Zakaullah S. Formulation of clotrimazole as lozenge tablet for improved delivery to oral thrush. J of Pharm & Biomed Sci, 2011; 12(17): Vol 3, Issue 5,

STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS

STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS Int. J. Chem. Sci.: 8(1), 2010, 405-414 STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS V. L. NARASAIAH, T. KARTHIK KUMAR, D. SRINIVAS, K. SOWMYA, P. L. PRAVALLIKA and Sk. Md. MOBEEN

More information

Patel B et al. IRJP 1 (1)

Patel B et al. IRJP 1 (1) INTERNATIONAL RESEARCH JOURNAL OF PHARMACY Available online http://www.irjponline.com Research Article IMPROVEMENT OF SOLUBILITY OF CINNARIZINE BY USING SOLID DISPERSION TECHNIQUE Patel Bipin*, Patel Jayvadan,

More information

Formulation and Evaluation

Formulation and Evaluation Chapter-5 Formulation and Evaluation 5.1 OBJECTIVE After successful taste masking and solubility enhancement of drugs in preliminary studies, by using Mannitol Solid Dispersion, next step includes the

More information

FORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS

FORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 974-434 Vol.2, No.1, pp 341-347, Jan-Mar 1 FORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS Kothawade S. N. 1 *, Kadam

More information

Formulation and evaluation of sublingual tablets of lisinopril

Formulation and evaluation of sublingual tablets of lisinopril Journal of GROVER Scientific & Industrial AGARWAL: Research FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF LISINOPRIL Vol. 71, June 2012, pp. 413-417 413 Formulation and evaluation of sublingual tablets

More information

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium Available online on www.ijddt.com International Journal of Drug Delivery Technology 214; (3); 98-13 Research Article ISSN: 97 441 Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast

More information

DEVELOPMENT AND IN-VITRO EVALUATION OF NICOTINE HARD CANDY LOZENGES FOR SMOKING CESSATION. Received: 16 Dec 2013, Revised and Accepted: 11 Feb 2014

DEVELOPMENT AND IN-VITRO EVALUATION OF NICOTINE HARD CANDY LOZENGES FOR SMOKING CESSATION. Received: 16 Dec 2013, Revised and Accepted: 11 Feb 2014 Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 6, Suppl 2, 2014 Research Article DEVELOPMENT AND IN-VITRO EVALUATION OF NICOTINE HARD CANDY LOZENGES

More information

CHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR

CHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR CHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR Efavirenz and ritonavir, two widely prescribed anti retroviral

More information

Formulation and Evaluation of Lidocaine Lozenges

Formulation and Evaluation of Lidocaine Lozenges Formulation and Evaluation of Lidocaine Lozenges MadusudhanRaoYamsani *,Shravan Kumar Y,Sandeep P, NareshNomula, andavinash M. Department of Pharmaceutics, Vaagdevi College of Pharmacy, Naimnagar, Hanamkonda,

More information

Global College of Pharmacy, Kahnpur Khui, Tehsil Anandpur Sahib, Distt.- Ropar, Punjab, India

Global College of Pharmacy, Kahnpur Khui, Tehsil Anandpur Sahib, Distt.- Ropar, Punjab, India IJPSR (2012), Vol. 3, Issue 09 (Research Article) Received on 19 May, 2012; received in revised form 25 June, 2012; accepted 27 August, 2012 IN-VITRO EVALUATION OF TWO MARKETED BRANDS OF PARACETAMOL TABLETS

More information

STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS

STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS Int. J. Chem. Sci.: 10(4), 2012, 1934-1942 ISSN 0972-768X www.sadgurupublications.com STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS K. VENUGOPAL * and K. P. R. CHOWDARY a Nirmala College

More information

Research Article of Formulation and Evaluation of Lozenges for Oral Bacterial Infection

Research Article of Formulation and Evaluation of Lozenges for Oral Bacterial Infection Human Journals Research Article August 2016 Vol.:7, Issue:1 All rights are reserved by Surbhi Choursiya et al. Research Article of Formulation and Evaluation of Lozenges for Oral Bacterial Infection Keywords:

More information

EVALUATION OF EFFERVESCENT FLOATING TABLETS. 6.7 Mathematical model fitting of obtained drug release data

EVALUATION OF EFFERVESCENT FLOATING TABLETS. 6.7 Mathematical model fitting of obtained drug release data EVALUATION OF EFFERVESCENT FLOATING TABLETS 6.1 Technological characteristics of floating tablets 6.2 Fourier transform infrared spectroscopy (FT-IR) 6.3 Differential scanning calorimetry (DSC) 6.4 In

More information

Research Article Derivative Spectrophotometric Method for Estimation of Metformin Hydrochloride in Bulk Drug and Dosage Form

Research Article Derivative Spectrophotometric Method for Estimation of Metformin Hydrochloride in Bulk Drug and Dosage Form Research Article Derivative Spectrophotometric Method for Estimation of Metformin Hydrochloride in Bulk Drug and Dosage Form Gowekar NM, Lawande YS*, Jadhav DP, Hase RS and Savita N. Gowekar Department

More information

World Journal of Pharmaceutical Research

World Journal of Pharmaceutical Research World Journal of Pharmaceutical ReseaRch Volume 3, Issue 3, 4527-4535. Research Article ISSN 2277 715 DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF RAMOSETRON Zarana

More information

Asian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012

Asian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012 STUDIES ON EFFECT OF SUPERDISINTEGRANTS ON ETORICOXIB TABLET FORMULATIONS Chowdary K. P. R 1, Venugopal. K *2 1 College of Pharmaceutical Sciences, Andhra University, Vishakapattanam. 2 * Nirmala college

More information

FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS

FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS Int. J. Chem. Sci.: 7(4), 2009, 2555-2560 FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS HINDUSTAN ABDUL AHAD *, B. PRADEEP KUMAR, C.

More information

pharmaceutical formulations. Anagliptin shows absorption maximum at 246 nm and obeys beer s law in the

pharmaceutical formulations. Anagliptin shows absorption maximum at 246 nm and obeys beer s law in the ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR ESTIMATION OF ANAGLIPTIN IN TABLET DOSAGE FORM BY U.V. SPECTROPHOTOMETRIC

More information

J Pharm Sci Bioscientific Res (4): ISSN NO

J Pharm Sci Bioscientific Res (4): ISSN NO Development and Validation of Analytical Methods for Simultaneous Estimation of Pregabalin and Amitriptyline Hydrochloride in their Combined Marketed Dosage form ABSTRACT: Nikhilkumar Patel, Gurjit Kaur,

More information

Formulation and evaluation of fast dissolving tablet of aceclofenac

Formulation and evaluation of fast dissolving tablet of aceclofenac International Journal of Drug Delivery 2 (2010) 93-97 http://www.arjournals.org/ijdd.html Research article ISSN: 0975-0215 Formulation and evaluation of fast dissolving tablet of aceclofenac Sudhir Bhardwaj

More information

PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES

PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES ULTRA VIOLET AND DERIVATIVE SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF METOLAZONE IN PHARMACEUTICALS Shobha Manjunath, S. Appala

More information

Biowaiver Study on Prednisolone Tablets 5 mg in Three Different Brands. Marketed in Sudan. Safaa Mohamed *, Tilal Elsaman

Biowaiver Study on Prednisolone Tablets 5 mg in Three Different Brands. Marketed in Sudan. Safaa Mohamed *, Tilal Elsaman Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2017, 9 [4]:8-114 [http://scholarsresearchlibrary.com/archive.html] ISSN 0975-5071 USA CODEN: DPLEB4

More information

ENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE

ENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES ENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE Kantilal B. Narkhede *1, R. B. Laware 2, Y. P.

More information

DESIGN AND CHARACTERIZATION OF TRAMADOL HCL MEDICATED HARD LOLLIPOPS

DESIGN AND CHARACTERIZATION OF TRAMADOL HCL MEDICATED HARD LOLLIPOPS INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article DESIGN AND CHARACTERIZATION OF TRAMADOL HCL MEDICATED HARD LOLLIPOPS P. Jagadeesh*, Padmasetty

More information

A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS

A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS Research Article A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS K. P. R. Chowdary *, Tanniru Adinarayana, T. Vijay, Mercy. R. Prabhakhar

More information

Comparative study of different solubility enhancement techniques on dissolution rate of zaltoprofen

Comparative study of different solubility enhancement techniques on dissolution rate of zaltoprofen World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers All Rights Reserved Available online at: http://www.wjpsonline.org/ Original

More information

IJRPC 2011, 1(4) Rohan et al. ISSN: INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY

IJRPC 2011, 1(4) Rohan et al. ISSN: INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article ABSORPTION CORRECTION METHOD AND SIMULTANEOUS EQUATION METHOD FOR THE SIMULTANEOUS ESTIMATION

More information

Development and Validation of Area Under Curve Method for Simultaneous Estimation of Thiocolchicoside and Lornoxicam in Tablet Dosage Form

Development and Validation of Area Under Curve Method for Simultaneous Estimation of Thiocolchicoside and Lornoxicam in Tablet Dosage Form Development and Validation of Area Under Curve Method for Simultaneous Estimation of Thiocolchicoside and Lornoxicam in Tablet Dosage Form ABSTRACT: A Patel* 1, B Shah 2 1 Research Scholar, Dpt. of Pharmacy,

More information

Available Online through Research Article

Available Online through Research Article ISSN: 0975-766X Available Online through Research Article www.ijptonline.com SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF FROVATRIPTAN SUCCINATE MONOHYDRATE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

More information

3.1 Background. Preformulation Studies

3.1 Background. Preformulation Studies Preformulation Studies 3.1 Background Delivery of any drug requires a suitable dosage form to get optimum therapeutic effects. The development of such dosage forms fundamental properties of the drug molecule

More information

Mixed Hydrotropy: Novel Science of Solubility Enhancement

Mixed Hydrotropy: Novel Science of Solubility Enhancement Research Paper Mixed Hydrotropy: Novel Science of Solubility Enhancement R. K. MAHESHWARI* AND Y. JAGWANI Shri G. S. Institute of Technology and Science, 23-Park Road, Indore-452 003, Madhya Pradesh, India

More information

FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN

FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN Ms. Jyoti Rathore 1*, Mr. Hitesh Kumar Parmar 1 Ujjain Institute of Pharmaceutical Sciences, Ujjain. Email- hkparmar7@rediffmail.com ABSTRACT

More information

Karnataka Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Gulbarga, Karnataka ABSTRACT KEYWORDS:

Karnataka Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Gulbarga, Karnataka ABSTRACT KEYWORDS: 335 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 4(6): November-December 2015 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY

More information

International Journal of Biopharmaceutics. Journal homepage:

International Journal of Biopharmaceutics. Journal homepage: 59 e- ISSN 0976-1047 Print ISSN 2229-7499 International Journal of Biopharmaceutics Journal homepage: www.ijbonline.com IJB FORMULATION AND EVALUATION OF PROMETHAZINE HCl FAST DISINTEGRATING SUBLINGUAL

More information

Validated UV Spectrophotometric Method Development And Stability Studies Of Acamprosate Calcium In Bulk And Tablet Dosage Form

Validated UV Spectrophotometric Method Development And Stability Studies Of Acamprosate Calcium In Bulk And Tablet Dosage Form International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.5, No.3, pp 1241-1246, July-Sept 2013 Validated UV Spectrophotometric Method Development And Stability Studies Of Acamprosate

More information

Formulation and evaluation of Orodispersible tablets to enhance dissolution rate of Lamotrigine by using Solid Dispersion Technique

Formulation and evaluation of Orodispersible tablets to enhance dissolution rate of Lamotrigine by using Solid Dispersion Technique 35 Formulation and evaluation of Orodispersible tablets to enhance dissolution rate of Lamotrigine by using Solid Dispersion Technique Bhumi B. Patel 1 *, Chainesh N. Shah 2, Rumit M. Shah 3 1 Department

More information

7. SUMMARY, CONCLUSION AND RECOMMENDATIONS

7. SUMMARY, CONCLUSION AND RECOMMENDATIONS 211 7. SUMMARY, CONCLUSION AND RECOMMENDATIONS Drug absorption from the gastro intestinal tract can be limited by various factors with the most common one being poor aqueous solubility and poor permeability

More information

DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF EZETIMIBE FROM TABLET FORMULATION

DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF EZETIMIBE FROM TABLET FORMULATION Int. J. Chem. Sci.: 13(2), 2015, 1051-1056 ISSN 0972-768X www.sadgurupublications.com DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF EZETIMIBE FROM TABLET FORMULATION KHEMCHAND GUPTA

More information

Volume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL

Volume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Volume: 2: Issue-3: July-Sept -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Ajaykumar Patil*, Ashish Pohane, Ramya Darbar, Sharanya Koutika, Alekhya

More information

MEDAK DIST. ANDHRA PRADESH STATE, INDIA. Research Article RECEIVED ON ACCEPTED ON

MEDAK DIST. ANDHRA PRADESH STATE, INDIA. Research Article RECEIVED ON ACCEPTED ON Page67 Available Online through IJPBS Volume 1 Issue 2 APRIL- JUNE 2011 SIMPLE QUANTITATIVE METHOD DEVELOPMENT AND VALIDATION OF VALSARTAN IN PUREFORM AND PHARMACEUTICAL DOSAGE FORMS BYUV SPECTROSCOPY

More information

FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING AGENTS

FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING AGENTS Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 4, Suppl 1, 2012 Research Article FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING

More information

COMPARATIVE IN VITRO EVALUATION OF COMMERCIALLY AVAILABLE PANTOPRAZOLE DELAYED RELEASE TABLETS

COMPARATIVE IN VITRO EVALUATION OF COMMERCIALLY AVAILABLE PANTOPRAZOLE DELAYED RELEASE TABLETS 343 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 3(4): July-August 2014 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO

More information

Available Online through Research Article

Available Online through Research Article ISSN: 0975-766X Available Online through Research Article www.ijptonline.com DESIGN AND EVALUATION OF GASTRORETENTIVE TABLETS FOR CONTROLLED DELIVERY OF NORFLOXOCIN Ganesh Kumar Gudas*, Subal Debnath,

More information

Optimization of Atenolol Core Tablet CHAPTER 5: OPTIMIZATION OF FORMULATION OF ATENOLOL CORE TABLETS

Optimization of Atenolol Core Tablet CHAPTER 5: OPTIMIZATION OF FORMULATION OF ATENOLOL CORE TABLETS CHAPTER 5: OPTIMIZATION OF FORMULATION OF ATENOLOL CORE TABLETS 5.1. AIM OF THE STUDY The pulsatile type press coated colon targeted atenolol tablet release drug after 6 hr lag time. The compression coated

More information

Formulation and Evaluation of Tinidazole Syrup Made by Mixed Solvency Concept Technique

Formulation and Evaluation of Tinidazole Syrup Made by Mixed Solvency Concept Technique Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3 (6):266-271 (http://scholarsresearchlibrary.com/archive.html) ISSN 0974-248X USA CODEN: DPLEB4

More information

Journal of Pharmaceutical and Scientific Innovation

Journal of Pharmaceutical and Scientific Innovation Journal of Pharmaceutical and Scientific Innovation www.jpsionline.com Research Article ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF ROSUVASTATIN BY USING SOLID DISPERSION TECHNIQUE Swathi T 1 *,

More information

Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums

Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums 1368 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue 1 April-June 211 Research Paper International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue

More information

DEVELOPMENT OF NON SODIUM EFFERVESCENT TABLET OF PARACETAMOL USING ARGININE CARBONATE

DEVELOPMENT OF NON SODIUM EFFERVESCENT TABLET OF PARACETAMOL USING ARGININE CARBONATE IJPSR (2013), Vol. 4, Issue 5 (Research Article) Received on 17 July, 2012; received in revised form, 23 February, 2013; accepted, 14 April, 2013 DEVELOPMENT OF NON SODIUM EFFERVESCENT TABLET OF PARACETAMOL

More information

Formulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants

Formulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants ISSN: 2231-3354 Received on: 13-11-2011 Revised on: 18:11:2011 Accepted on: 22-11-2011 Formulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants Leela

More information

Formulation and Evaluation of Doxofylline Lozenges

Formulation and Evaluation of Doxofylline Lozenges 43 Kothagattu Nandini, Arsham Priyadarshini, Shravan Kumar Yamsani* Department of Pharmaceutics, Vaagdevi College of Pharmacy, Kakatiya University, Warangal-506009, Telangana, India. *For Correspondence

More information

FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE FAST DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES

FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE FAST DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES Research Article Deshmukh ND,, 2012; Volume 1(5): 364-378 ISSN: 2277-8713 FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE FAST DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES *N. D. DESHMUKH, R. R.

More information

FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD

FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD Int. J. Chem. Sci.: 6(3), 2008, 1270-1275 FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD K. P. R. CHOWDARY, P. TRIPURA SUNDARI and K. SURYA

More information

Formulation and Development of Sustained Release Tablets of Valsartan Sodium

Formulation and Development of Sustained Release Tablets of Valsartan Sodium INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Research Article Formulation and Development of Sustained Release Tablets of Valsartan Sodium G. Sandeep * and A. Navya Department of

More information

Formulation and evaluation of immediate release salbutamol sulphate

Formulation and evaluation of immediate release salbutamol sulphate 5 Formulation, optimization and evaluation of immediate release layer of salbutamol sulphate Salbutamol is moderately selective beta (2)-receptor agonist similar in structure to terbutaline and widely

More information

Design and in Vitro Evaluation Studies of Tramadol Hydrochloride Lozenzes for Treatment of Pain in Childreans

Design and in Vitro Evaluation Studies of Tramadol Hydrochloride Lozenzes for Treatment of Pain in Childreans Science Innovation 2015; 3(6): 100-107 Published online October 9, 2015 (http://www.sciencepublishinggroup.com/j/si) doi: 10.11648/j.si.20150306.16 ISSN: 2328-7861 (Print); ISSN: 2328-787X (Online) Design

More information

FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS

FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS G. Subba Rao

More information

Design and In-vitro Evaluation of Silymarin Bilayer Tablets

Design and In-vitro Evaluation of Silymarin Bilayer Tablets CODEN (USA)-IJPRUR, e-issn: 2348-6465 International Journal of Pharma Research and Health Sciences Available online at www.pharmahealthsciences.net Original Article Design and In-vitro Evaluation of Silymarin

More information

Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with other Superdisintegrants

Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with other Superdisintegrants International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol. 3, No.3, pp 1119-1124, July-Sept 2011 Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with

More information

DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS

DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS Volume: 2: Issue-4: Oct - Dec -2011 ISSN 0976-4550 DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS Chinmaya Keshari Sahoo* 1, Tanmaya Keshari Sahoo 2 and

More information

The present manuscript describes simple, sensitive, rapid, accurate, precise and cost effective First derivative

The present manuscript describes simple, sensitive, rapid, accurate, precise and cost effective First derivative ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF

More information

Formulation and evaluation of oro-dispersible tablets of lafutidine

Formulation and evaluation of oro-dispersible tablets of lafutidine Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (5):226-235 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

PHARMACEUTICS I صيدالنيات 1 UNIT 1 INTRODUCTION

PHARMACEUTICS I صيدالنيات 1 UNIT 1 INTRODUCTION PHARMACEUTICS I صيدالنيات 1 UNIT 1 INTRODUCTION 1 PHARMACEUTICS Pharmaceutics is the science of dosage form design. The general area of study concerned with the formulation, manufacture, stability, and

More information

ISSN: X CODEN: IJPTFI Available Online through Research Article

ISSN: X CODEN: IJPTFI Available Online through Research Article ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com NEW SPECTROPHOTOMETRIC ESTIMATION OF NAPROXEN TABLETS FORMULATIONS EMPLOYING MIXED SOLVENCY CONCEPT (AT 331NM)

More information

Journal of Chemical and Pharmaceutical Research, 2015, 7(5): Research Article

Journal of Chemical and Pharmaceutical Research, 2015, 7(5): Research Article Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2015, 7(5):1225-1231 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Formulation and evaluation of raft forming sustained

More information

Formulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets

Formulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets Formulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets M. Sunitha Reddy 1, B. Sharath Reddy 1, S. Muhammed Fazal Ul Haq 1 Centre of Pharmaceutical Sciences, Jawaharlal Nehru Technological

More information

Development and validation of spectrophotometric method for simultaneous estimation of Sumatriptan and Naproxen sodium in tablet dosage form

Development and validation of spectrophotometric method for simultaneous estimation of Sumatriptan and Naproxen sodium in tablet dosage form Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2010, 1 (1): 36-41 Development and validation of spectrophotometric method for simultaneous estimation of Sumatriptan and Naproxen

More information

Comparative study of analytical method development of fluconazole in tablets and capsule by ultraviolet spectrophotometric method

Comparative study of analytical method development of fluconazole in tablets and capsule by ultraviolet spectrophotometric method Research Article Comparative study of analytical method development of fluconazole in tablets and capsule by ultraviolet spectrophotometric method Shital S. Patil*, Ubhale Ravindra, Yeole Tejal, Tayade

More information

Volume: I: Issue-2: Aug-Oct ISSN NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE

Volume: I: Issue-2: Aug-Oct ISSN NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE Volume: I: Issue-2: Aug-Oct -2010 ISSN 0976-4550 NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE * Hindustan Abdul Ahad, Anuradha CM, Chitta Suresh

More information

Venkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online)

Venkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online) Design and development of Metformin hydrochloride Tried sustained release tablets Venkateswara Rao T 1 *, Bhadramma N 1, Raghukiran CVS 2 and Madubabu K 3 Bapatla College of Pharmacy, Bapatla, Guntur-522101

More information

DESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF NEBIVOLOL HCL

DESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF NEBIVOLOL HCL DESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF NEBIVOLOL HCL Isha Shah, Alpesh Yadav, Shailendra Bhatt Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India-3000. Abstract

More information

Spectrophotometric Method for Estimation of Sitagliptin Phosphate in Bulk...

Spectrophotometric Method for Estimation of Sitagliptin Phosphate in Bulk... Spectrophotometric Method for Estimation of Sitagliptin Phosphate in Bulk... I J P F A International Science Press Spectrophotometric Method for Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage

More information

Comparative Dissolution Study of Glipizide by Solid Dispersion Technique

Comparative Dissolution Study of Glipizide by Solid Dispersion Technique Comparative Dissolution Study of Glipizide by Solid Dispersion Technique Dehghan M H G 1, Saifee M 1, Hanwate R M 2 1 Y.B.Chavan College of Pharmacy,Dr. Rafiq Zakaria campus, Aurangabad-431001, Maharashtra,

More information

Department Of Quality Assurance Techniques, Modern College of Pharmacy Nigdi, Pune Maharashtra, India

Department Of Quality Assurance Techniques, Modern College of Pharmacy Nigdi, Pune Maharashtra, India IJPSR (2013), Vol. 4, Issue 1 (Research Article) Received on 20 September, 2012; received in revised form, 06 November, 2012; accepted, 22 December, 2012 DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING

More information

Preformulation Study. CHAPTER 3 Preformulation Study. 3.0 Introduction

Preformulation Study. CHAPTER 3 Preformulation Study. 3.0 Introduction CHAPTER 3 3.0 Introduction As per Sir Arthur Conan Doyle, It is a capital mistake to theorize before one has data. Preformulation work is the foundation for development of any robust formulations (G. Banker

More information

The Nitrofurantoin Capsules Revision Bulletin supersedes the currently official monograph.

The Nitrofurantoin Capsules Revision Bulletin supersedes the currently official monograph. Nitrofurantoin Capsules Type of Posting Revision Bulletin Posting Date 28 Dec 2018 Official Date 01 Jan 2019 Expert Committee Chemical Medicines Monographs 1 Reason for Revision Compliance In accordance

More information

Impact factor: 3.958/ICV: 4.10 ISSN: REVIEW ARTICLE ON MEDICATED LOLLIPOP Kalpesh Patil*, Namrata Patil, S.A.Tadvi, S.P.

Impact factor: 3.958/ICV: 4.10 ISSN: REVIEW ARTICLE ON MEDICATED LOLLIPOP Kalpesh Patil*, Namrata Patil, S.A.Tadvi, S.P. Impact factor: 3.958/ICV: 4.10 ISSN: 0976-7908 47 Pharma Science Monitor 8(2), Apr-Jun 2017 PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES Journal home page: http://www.pharmasm.com

More information

skim milk as carrier by kneading method. They were evaluated for percentage yield, drug content, FT-IR

skim milk as carrier by kneading method. They were evaluated for percentage yield, drug content, FT-IR Available Online through ISSN: 0975-766X CODEN: IJPTFI Research Article www.ijptonline.com ENHANCEMENT OF SOLUBILITY & DISSOLUTION RATE OF LAMOTRIGINE BY KNEADING METHOD Gadhave M.V*, Mahakal A. J., Gaikwad

More information

FORMULATION RELEASE STUDY OF SOME IMPORTANT DRUGS FROM SUPPOSITORY

FORMULATION RELEASE STUDY OF SOME IMPORTANT DRUGS FROM SUPPOSITORY FORMULATION RELEASE STUDY OF SOME IMPORTANT DRUGS FROM SUPPOSITORY Mohammed Younus Ali*, Sadat Ali JJT University, Churu-Bisau Road, Jhunjhunu Rajasthan ABSTRACT: The purpose of this study was to formulate

More information

Scholars Research Library. Formulation and evaluation of buccoadhesive tablet of Atenolol

Scholars Research Library. Formulation and evaluation of buccoadhesive tablet of Atenolol Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3(2): 34-38 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

Validated Spectrophotometric Method for Simultaneous Estimation of Atorvastatin and Nicotinic acid in Combined Pharmaceutical dosage form

Validated Spectrophotometric Method for Simultaneous Estimation of Atorvastatin and Nicotinic acid in Combined Pharmaceutical dosage form International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 974-434 Vol.4, No.3, pp 999-3, July-Sept Validated Spectrophotometric Method for Simultaneous Estimation of Atorvastatin and Nicotinic

More information

Method Development and Validation of Emtricitabine in Bulk by UV Spectroscopy

Method Development and Validation of Emtricitabine in Bulk by UV Spectroscopy Human Journals Research Article February 2019 Vol.:14, Issue:3 All rights are reserved by Gandi Anusha et al. Method Development and Validation of Emtricitabine in Bulk by UV Spectroscopy Keywords: Emtricitabine,

More information

International Journal of Pharmacy

International Journal of Pharmacy International Journal of Pharmacy Journal Homepage: http://www.pharmascholars.com Research Article CODEN: IJPNL6 FORMULATION AND EVALUATION OF ZOLMITRIPTAN FAST DISSOLVING TABLET USING SYNTHETIC SUPERDISINTEGRANTS

More information

Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011

Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011 ISSN: 223-7346 Research Article Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp -394-43, Oct -Dec 211 FORMULATION AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIMEPIRIDE

More information

FACTORIAL STUDIES ON THE EFFECTS OF HYDROXY PROPYL β- CYCLODEXTRIN AND POLOXAMER 407 ON THE SOLUBILITY AND DISSOLUTION RATE OF BCS CLASS II DRUGS

FACTORIAL STUDIES ON THE EFFECTS OF HYDROXY PROPYL β- CYCLODEXTRIN AND POLOXAMER 407 ON THE SOLUBILITY AND DISSOLUTION RATE OF BCS CLASS II DRUGS JChrDD Vol 2 Issue 2 2011: 89-93 ISSN 2249-6785 Journal of Chronotherapy and Drug Delivery Received: August 06, 2011 Accepted: Sep 12, 2011 Original Research Paper FACTORIAL STUDIES ON THE EFFECTS OF HYDROXY

More information

Received: ; Accepted: MEDICATED LOLLIPOPS OF KETOCONAZOLE FOR PEDIATRIC ORAL THRUSH PATIENTS

Received: ; Accepted: MEDICATED LOLLIPOPS OF KETOCONAZOLE FOR PEDIATRIC ORAL THRUSH PATIENTS International Journal of Institutional Pharmacy and Life Sciences 1(3): November-December 2011 INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES Dental Sciences Research Article!!! Received:

More information

RP-HPLC Method Development and Validation of Abacavir Sulphate in Bulk and Tablet Dosage Form

RP-HPLC Method Development and Validation of Abacavir Sulphate in Bulk and Tablet Dosage Form RP-HPLC Method Development and Validation of Abacavir Sulphate in Bulk and Tablet Dosage Form S. LAVANYA* 1, SK. MANSURA BEGUM 1, K. NAGAMALLESWARA RAO 2, K. GAYATHRI DEVI 3 Department of pharmaceutical

More information

FORMULATION AND EVALUATION OF SUBLINGUAL TABLET FOR NARATRIPTA

FORMULATION AND EVALUATION OF SUBLINGUAL TABLET FOR NARATRIPTA Brahmbhatt et al Journal of Drug Delivery & Therapeutics; 2014, 4(4), 19-23 19 Available online on 15.07.2014 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open access to Pharmaceutical

More information

Formulation and Evaluation of Acyclovir Liposomes

Formulation and Evaluation of Acyclovir Liposomes Krishna Mohan Chinnala and Rabinarayan Panigrahy., 217/ Formulation and evaluation of acyclovir RESEARCH ARTICLE International Research Journal of Pharmaceutical and Biosciences Pri -ISSN: 2394-5826 http://www.irjpbs.com

More information

A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac

A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac Asian Journal of Chemistry Vol. 22, No. 6 (2010), 4239-4244 A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac K.P.R. CHOWDARY*

More information

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE BY CYCLODEXTRINS, POLOXAMER AND PVP

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE BY CYCLODEXTRINS, POLOXAMER AND PVP Int. J. Chem. Sci.: 9(2), 20, 637-646 ISSN 0972-768X www.sadgurupublications.com ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE BY CYCLODEXTRINS, POLOXAMER AND PVP K. P. R. CHOWDARY *, K.

More information

Pharmaceutical Studies on Formulation and Evaluation of Sustained Release Tablets Containing Certain Drugs

Pharmaceutical Studies on Formulation and Evaluation of Sustained Release Tablets Containing Certain Drugs Mansoura University Faculty of Pharmacy Department of Pharmaceutics Pharmaceutical Studies on Formulation and Evaluation of Sustained Release Tablets Containing Certain Drugs Thesis presented by Ali Saeed

More information

Formulation, Optimization and Evaluation of Mouth Dissolving Tablet of Zidovudine

Formulation, Optimization and Evaluation of Mouth Dissolving Tablet of Zidovudine Formulation, Optimization and Evaluation of Mouth Dissolving Tablet of Zidovudine Mayur V. Chinchore*, Sanjay P. Aher, Chetan P. Mahajan, Ghanshyam J. Yadav, Avish D. Maru Department of Pharmaceutics,

More information

Improving Micromeritic Properties of Ibuprofen: An Agglomeration Approach

Improving Micromeritic Properties of Ibuprofen: An Agglomeration Approach Bangladesh Pharmaceutical Journal 20(1): 90-98, 2017 Improving Micromeritic Properties of Ibuprofen: An Agglomeration Approach Md. Sazzadul Islam and Md. Saiful Islam Pathan Department of Pharmacy, State

More information

Development and validation of UV-visible spectrophotometric method for estimation of rifapentine in bulk and dosage form

Development and validation of UV-visible spectrophotometric method for estimation of rifapentine in bulk and dosage form Available online at www.derpharmachemica.com Scholars Research Library Der Pharma Chemica, 2013, 5(2):251-255 (http://derpharmachemica.com/archive.html) ISSN 0975-413X CODEN (USA): PCHHAX Development and

More information

Journal of Chemical and Pharmaceutical Research, 2018, 10(2): Research Article

Journal of Chemical and Pharmaceutical Research, 2018, 10(2): Research Article Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2018, 10(2):84-90 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Development and Validation of Q-Absorbance Ratio

More information

Maisammaguda, Dulapally, Secundrabad.

Maisammaguda, Dulapally, Secundrabad. 121 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 3(6): November-December 2014 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY

More information

FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES

FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES Int. J. Chem. Sci.: 10(1), 2012, 297-305 ISSN 0972-768X www.sadgurupublications.com FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES K. P.

More information

for Methotrexate. The result of analysis has been validated statistically and recovery studies confirmed the accuracy of

for Methotrexate. The result of analysis has been validated statistically and recovery studies confirmed the accuracy of ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF LEFLUNOMIDE AND METHOTREXATE IN

More information

Routes of drug administration

Routes of drug administration Routes of drug administration Definition:- A route of administration in pharmacy is the path by which a drug is taken into the body. Classification:- The various routes of administrations are classified

More information

World Journal of Pharmaceutical Research SJIF Impact Factor 5.990

World Journal of Pharmaceutical Research SJIF Impact Factor 5.990 SJIF Impact Factor 5.990 Volume 4, Issue 5, 277-289. Research Article ISSN 2277 7105 COMPARATIVE EVALUATION OF PREDNISOLONE 5MG TABLETS MARKETED IN BANGLADESH Nabila Morshed 1 and Shahana Sharmin 2* 1

More information