Job Title Name Signature Date. Director of Nursing Angela Wallace Signed Angela Wallace 30/6/2014
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1 PATIENT GROUP DIRECTIONS FOR SUPPLY OF VARENICLINE (CHAMPIX ) BY AUTHORISED COMMUNITY PHARMACISTS WORKING IN FORTH VALLEY Protocol Number 445 Version 1 Date protocol prepared: June 2014 Date protocol due for review: May 2016 This patient group direction must be signed by all health care professionals involved in its use. NHS Forth Valley should hold the original signed copy Organisation NHS Forth Valley Job Title Name Signature Date Director of Nursing Angela Wallace Signed Angela Wallace 30/6/2014 Medical Director Peter Murdoch Signed Peter Murdoch 26/6/2014 Director of Pharmacy Gail Caldwell Signed Gail Caldwell 1/7/2014 This document authorises the supply of Varenicline by appropriate practitioners to patients who meet the criteria for inclusion under the terms of the document. Practitioners seeking to supply Varenicline must ensure that they assess all clients to make sure they meet the criteria before supplying the product. The purpose of this Patient Group Direction is to help patients by ensuring that they have ready access to a quality assured service which provides a timely, consistent and appropriate supply of Varenicline.
2 Signatures of those developing the Patient Group Direction Job Title Name Signature Date Doctor Leslie Cruickshank Signed Leslie Cruickshank 1/7/2014 Pharmacist Chris Miller Signed Chris Miller 27/6/2014 Nurse Microbiologist (if appropriate) Paediatrician (if appropriate) Approval from Relevant* Advisory Committee/Group Committee/Group Chair Signed on behalf of committee Date Patient Group Directions Group Glynis Gordon Signed Glynis Gordon 26/6/2014 Primary Care D&T Committee Primary Care Prescribing Group Leslie Cruickshank Signed Leslie Cruickshank 26/6/2014 Primary Care Out of Hours Clinical Governance Committee Wound Management Group Acute Services D&T Committee Antimicrobial Management Team *Patient Group Directions Group and Primary Care Prescribing Group for services relating to the Primary Care setting Primary Care D&T Committee for services relating to the Care Groups Primary Care Out Of Hours Clinical Governance Committee for services relating to the Primary Care Out Of Hours service Wound Management Group for PGDs relating to wound management Acute Services Drug and Therapeutics Committee for services relating to the Acute Services Signature of one GP on behalf of Practice OR Head of Service OR Employer to indicate that other professionals may undertake the work within the confines of the Patient Group Direction Name Signature Date Varenicline PGD Protocol No 445 Version 1 2
3 PATIENT GROUP DIRECTION FOR SUPPLY OF VARENICLINE (CHAMPIX ) BY AUTHORISED COMMUNITY PHARMACISTS Indication Clients accessing the pharmacy smoking cessation service who have tried to stop through a recognised service using NRT with motivational support. Inclusion Criteria Dependent smoker (i.e. they smoke within 30minutes of waking up and /or find quitting unaided difficult) identified as sufficiently motivated to quit Clients over 18 years of age The client agrees to receive behavioural support according to the agreed protocol A full medical history is taken and documented and there are no contraindications or cautions for treatment with varenicline (see Criteria for exclusion and referral) No indication on the PMR that the patient is unsuitable for varenicline Exclusion Criteria Smokers not sufficiently motivated to quit Client under 18 years of age Pregnant or breastfeeding women Sensitivity to varenicline or any of its excipients Renal impairment (use with caution in elderly patients) End-stage renal disease Patients with a history of serious psychiatric illness such as schizophrenia, bipolar disorder and major depressive disorder. Previous psychiatric illness where pharmacotherapy or psychotherapy had been given Epilepsy Patient on theophylline or warfarin Not to be used in conjunction with other smoking cessation therapies PMR indicates that the patient is unsuitable for varenicline Referral criteria Caution Pharmacists should refer clients to their GP when client is considered eligible for varenicline but supply through pharmacy is not recommended through the exclusion criteria This may include any of the conditions referred to in the exclusion criteria above or previously unrecognised co-morbidities Patients on theophylline due to monitoring that is required Patients on warfarin Patients on Antipsychotics (typical and atypical) Patients with renal failure Patients on insulin may be supplied with varenicline. However patients should be advised to monitor their blood glucose level closely Varenicline PGD Protocol No 445 Version 1 3
4 Action if patient declines Action if Included Action if excluded Discuss alternative products if suitable and/or offer a referral to the Specialist Smoking Cessation service for further assessment Supply varenicline (Champix ) 0.5mg and 1mg tablets. Refer to GP or Specialist Smoking Cessation Service Details of treatment course Drug name Strength and form Route Varenicline (Champix ) Tablets 0.5mg and 1mg film coated tablets Oral Treatment regime Legal status POM Prescription only medicine Black Triangle Dose(s) Days 1-3: 500 mcg (white tablets) once daily Days 4 7: 500 mcg tablets twice daily Day 8 to the end of the treatment: 1mg (blue tablets) twice daily for 11 weeks. (Reduce to 0.5mg twice daily if not tolerated) Maximum single dose 1mg Maximum daily dose 2mg Client should set a date to stop smoking. Client should start taking varenicline 1-2 weeks before this date. Tablets should be swallowed whole with plenty of water and can be taken with or without food Patients who cannot tolerate the adverse effects of varenicline may have the dose lowered temporarily or permanently to 0.5mg twice daily 1 st consultation (Assessment) Client should set a quit date between the next 8-14 days. Supply 14 day starter pack (11 x 0.5mg tabs with 14 X 1mg tablets) Set a formal quit date between one and two weeks after starting varenicline Take a CO reading Varenicline PGD Protocol No 445 Version 1 4
5 2 nd Consultation (before quit date) Confirm quit date. Monitor carbon monoxide reading. Supply 1mg varenicline tablets as required. 3 rd consultation (First follow up). Monitor carbon monoxide reading and confirm abstinence. Supply varenicline tablets as required. (Refer to Appendix 1) Subsequent consultations Supply varenicline tablets if patient has stopped smoking and carbon monoxide reading confirms abstinence. (Refer to Appendix 1) Final consultation (week 10 12) Discuss coping strategies when the support service finished. Supply varenicline tablets (if required) if patient has stopped smoking and carbon monoxide reading confirms abstinence. (Refer to Appendix 1) Drug Interactions No clinical meaningful drug interactions have been reported. Since metabolism of varenicline represents less than 10% of its clearance, active substances known to affect the cytochrome P450 system are unlikely to alter the pharmacokinetics of varenicline and therefore a dose adjustment of varenicline would not be required. Side Effects Nausea Sleep disorders/ abnormal dreams Headache Appetite changes Dry mouth /taste disturbances Drowsiness Dizziness For less common side effects please refer to BNF Advice and Support Advice to clients should include specific product advice on dosage, method of administration and side effects If client experiences any extreme side effects they should seek medical advice - Varenicline should be discontinued immediately if agitation, depressed mood or changes in behaviour that are of concern for the pharmacist, patient s family or caregiver are observed or if the patient develops suicidal thoughts or suicidal behaviour The major reasons for varenicline failure are: - Unrealistic expectations; - Lack of preparation for the fact that tablets may cause nausea; - Insufficient support from trained smoking cessation advisor It is important to make sure that the client understands the following points: 1. Varenicline is not a magic cure: effort and determination are crucial Varenicline PGD Protocol No 445 Version 1 5
6 Informed Consent 2. Varenicline works by acting on the parts of the brain which are affected by nicotine in cigarettes 3. Varenicline does not remove all the temptation to smoke, but it does make abstinence easier (it takes the edge of the discomfort by reducing the severity of tobacco withdrawal symptoms such as craving to smoke, irritability, poor concentration and low mood) 4. Varenicline is safe, but about a third of clients may experience mild nausea usually about 30 minutes after taking it. This reaction often diminishes gradually over the first few weeks, and most patients tolerate it without problems; The following general advice should also be given: Follow-up and obtaining further supplies Possible changes in the body on stopping smoking e.g. weight gain Effects on driving or using machinery Patient on insulin should monitor blood glucose closely At the end of treatment, discontinuation of varenicline has been associated with an increase in irritability, urge to smoke, and/or insomnia in up to 3% of patients. The pharmacist should inform the patient accordingly Clients must be informed that information relating to the supply of varenicline under a PGD needs to be passed to other health service organisations in particular their GP and the NHS Scotland to ensure proper record keeping and patient safety. Records Patient s name, address, date of birth and GP details; Date supplied & name of the pharmacist who supplied the medication; Reason for inclusion; Advice given to patient; Details of any adverse drug reaction and actions taken including documentation in the patient s medical record via GP; Since varenicline is a black triangle drug all adverse reactions should be reported to the CHM using the Yellow Card reporting system The varenicline clinical risk assessment form should be completed for each client and retained in the pharmacy for a minimum of 3 years. References British National Formulary (BNF) Summary of Product Characteristics (SPC) for Champix. National Institute for Health and Clinical Excellence. Varenicline for smoking cessation. NICE technology appraisal 123, July Medicines and Health Product regulatory Agency (MHRA) safety alert: November 2008 Varenicline PGD Protocol No 445 Version 1 6
7 Authorisation These Patient Group Directions give authority for: (PRINT NAME of APPROVED PHARMACIST) To supply varenicline (Champix ) 0.5mg and 1mg to clients (PHARMACY) Requirements for a participating pharmacist To have satisfactorily completed the approved training: To have been accredited as an approved practitioner within this scheme To have been advised to have indemnity insurance To maintain clinical knowledge appropriate to their practice by attending relevant study days, courses and to make themselves aware of appropriate current literature To act as an approved practitioner within the terms of the Patient Group Direction and Proformas and to supply accordingly To work in an approved pharmacy Authorising signature Date: I have received, read and fully understand my Health Board s policy on patient group directions I have received the training which approved practitioners must undertake before being authorised to supply varenicline under the relevant patient group direction I agree to act as an approved practitioner within the terms of the patient group direction and proforma and to supply accordingly I understand that by agreeing to act as an approved practitioner under the patient group direction and service level agreement I am adjusting my scope of professional practice Pharmacist s Signature: Date: Varenicline PGD Protocol No 445 Version 1 7
8 Treatment Plan Appendix 1 Consultations Treatment plan 1 st week- Assessment week Client should set a quit date between the next 8-14 days. Supply 14 day starter pack (11 x 500 mcg tabs with 14 X 1mg tablets) *Make arrangement to see client again before tablets run out i.e. between days rd week Client should have set a quit date. Monitor carbon monoxide level. If client is still smoking, he/she should be informed that treatment with varenicline would have to be stopped if he/she continued to smoke. Supply 1mg varenicline tablets if required Make arrangement to see client the following week 4 th - 12 th week Monitor carbon monoxide level and check if client has stopped smoking. If client is still smoking, treatment with varenicline should be stopped. If client has quit smoking supply 1mg varenicline tablets as required. If side effects are tolerable then continue supplying Varenicline 1mg tablets as required. If client is troubled by side effects assess whether they are tolerable or whether supply should be stopped. Here you may discuss the option to dose taper at week 10 with aim of stopping varenicline after 12 weeks of treatment. Note: A 14 day starter pack (11 x 500mcg tabs with 14 x 1mg tabs) can be supplied for the last two weeks of treatment. Ensure the patient has clear instructions to take the tablets in the starter pack in reverse order to facilitate tapered discontinuation. Varenicline PGD Protocol No 445 Version 1 8
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