Glen A Lutchman, MD. Clinical Associate Professor, Medicine - Gastroenterology & Hepatology. Bio

Transcription

1 Clinical Associate Professor, Medicine - Gastroenterology & Hepatology Curriculum Vitae available Online CLINICAL OFFICES Stanford Gastroenterology and Digestive Health Clinic 450 Broadway St Bio Pav D 2nd Fl Pod 2 and 3 Redwood City, CA Tel (650) Fax (650) CLINICAL FOCUS Liver Transplantation Gastroenterology ACADEMIC APPOINTMENTS Clinical Associate Professor, Medicine - Gastroenterology & Hepatology HONORS AND AWARDS Honors in Biochemistry, University of the West Indies (1996) Honors in Pharmacology, University of the West Indies (1996) Honors in Obstetrics and Gynecology, University of the West Indies (1996) Chin Yee Prize for Surgery, University of the West Indies (1996) NIH Intramural Fellows Travel Award, National Institutes of Health (2003) AASLD Advanced Hepatology Fellowship,, American Association for the Study of Liver Diseases ( ) PROFESSIONAL EDUCATION Board Certification: Internal Medicine, American Board of Internal Medicine (2001) Fellowship: UCSF Div of Gastroenterology (2008) CA Fellowship: UCSF Div of Gastroenterology (2007) CA Residency: SUNY at Brooklyn School Of Medicine (2002) NY Board Certification: Transplant Hepatology, American Board of Internal Medicine (2008) Board Certification: Gastroenterology, American Board of Internal Medicine (2007) Board Certification, American Board of Internal Medicine, Transplant Hepatology (2008) Fellowship: National Institutes of Health (2005) MD Page 1 of 5

2 Medical Education: University of the West Indies (1996) West Indies Fellow, UCSF Medical Center, Transplant Hepatology (2008) Research Fellow, National Institutes of Health, Hepatology Research (2005) MHSc, Duke University, Clinical Research (2005) Chief Resident, SUNY Downstate Medical Center, Internal Medicine (2002) Resident, SUNY Downstate Medical Center, Internal Medicine (2001) MBBS, University of the West Indies, Medicine (1996) Research & Scholarship CURRENT RESEARCH AND SCHOLARLY INTERESTS My primary research interest is in metabolic liver disease primarily non-alcoholic steatohepatitis. I also have an interest in transplant outcomes for patients with chronic hepatitis C. CLINICAL TRIALS Once-Daily Oral Avatrombopag Tablets Used in Subjects With Chronic Liver Diseases and Thrombocytopenia Prior to Elective Surgical or Diagnostic Procedures, Recruiting Teaching GRADUATE AND FELLOWSHIP PROGRAM AFFILIATIONS Medicine (Masters Program) Publications PUBLICATIONS OUTCOME OF EN-BLOC COMBINED HEART AND LIVER TRANSPLANTATION IN THE ADULT FAILING FONTAN Vaikunth, S., Concepcion, W., Daugherty, T., Fowler, M., Lutchman, G., Maeda, K., Rosenthal, D., Teuteberg, J., Woo, Y., Lui, G. K. ELSEVIER SCIENCE INC.2018: 539 Safety and Efficacy of Velpatasvir and Sofosbuvir-based Regimens for the Treatment of HCV Genotype 1-6: Results of the HCV-TARGET Study Landis, C. S., Sulkowski, M. S., Reau, N., Lutchman, G. A., Vainorius, M., Welzel, T. M., Zeuzem, S., Khalili, M., Nelson, D. R., Lok, A. S., Fried, M. W., Terrault, N., HCV-TAR-Get Network WILEY.2017: 587A Real-world experience with interferon-free, direct acting antiviral therapies in Asian Americans with chronic hepatitis C and advanced liver disease. Medicine Chang, C. Y., Nguyen, P., Le, A., Zhao, C., Ahmed, A., Daugherty, T., Garcia, G., Lutchman, G., Kumari, R., Nguyen, M. H. 2017; 96 (6) Effectiveness and tolerability of simeprevir and sofosbuvir in nontransplant and post-liver transplant patients with hepatitis C genotype 1. Alimentary pharmacology & therapeutics Lutchman, G., Nguyen, N. H., Chang, C. Y., Ahmed, A., Daugherty, T., Garcia, G., Kumari, R., Gupta, S., Doshi, D., Nguyen, M. H. 2016; 44 (7): Lower response to simeprevir and sofosbuvir in HCV genotype 1 in routine practice compared with clinical trials. BMJ open gastroenterology Yee, B. E., Nguyen, N. H., Jin, M., Lutchman, G., Lim, J. K., Nguyen, M. H. 2016; 3 (1) Tolerability and effectiveness of sofosbuvir and simeprevir in the post-transplant setting: systematic review and meta-analysis. BMJ open gastroenterology Nguyen, N. H., Yee, B. E., Chang, C., Jin, M., Lutchman, G., Lim, J. K., Nguyen, M. H. 2016; 3 (1) Page 2 of 5

3 A glass half full: Implications of screening for hepatitis C virus in the era of highly effective antiviral therapy. Hepatology Lutchman, G., Kim, W. R. 2015; 61 (5): Recurrent Hepatocellular Carcinoma and Poorer Overall Survival in Patients Undergoing Left-sided Compared With Right-sided Partial Hepatectomy. Journal of clinical gastroenterology Valenzuela, A., Ha, N. B., Gallo, A., Bonham, C., Ahmed, A., Melcher, M., Kim, L. H., Esquivel, C., Concepcion, W., Ayoub, W. S., Lutchman, G. A., Daugherty, T., Nguyen, et al 2015; 49 (2): Safety and efficacy of entecavir in adefovir-experienced patients JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Nguyen, N. H., Trinh, H. N., Nguyen, T. T., Do, S. T., Tran, P., Nguyen, H. A., Nguyen, K. K., Garcia, R. T., Lutchman, G. A., Nguyen, M. H. 2015; 30 (1): Sustained virological response and its treatment predictors in hepatitis C virus genotype 4 compared to genotypes 1, 2, and 3: a meta-analysis. BMJ open gastroenterology Yee, B. E., Nguyen, N. H., Zhang, B., Lin, D., Vutien, P., Wong, C. R., Lutchman, G. A., Nguyen, M. H. 2015; 2 (1) Treatment of Acute Hepatitis C Infection with Pegylated Interferon and Ribavirin in Patients Coinfected with Human Immunodeficiency Virus: A Systematic Review and Meta-Analysis INTERVIROLOGY Zhang, B., Nguyen, N. H., Yee, B. E., Yip, B., Ayoub, W. S., Lutchman, G. A., Nguyen, M. H. 2015; 58 (4): Meta-analysis: influence of host and viral factors in patients with chronic hepatitis C genotype 4 treated with pegylated interferon and ribavirin EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY Yee, B. E., Nguyen, N. H., Zhang, B., Vutien, P., Wong, C. R., Lutchman, G. A., Nguyen, M. H. 2014; 26 (11): Meta-analysis: influence of host and viral factors in patients with chronic hepatitis C genotype 4 treated with pegylated interferon and ribavirin. European journal of gastroenterology & hepatology Yee, B. E., Nguyen, N. H., Zhang, B., Vutien, P., Wong, C. R., Lutchman, G. A., Nguyen, M. H. 2014; 26 (11): Mutations in HBV DNA polymerase associated with nucleos(t)ide resistance are rare in treatment-naive patients. Clinical gastroenterology and hepatology Vutien, P., Trinh, H. N., Garcia, R. T., Nguyen, H. A., Levitt, B. S., Nguyen, K., da Silveira, E., Daugherty, T., Ahmed, A., Garcia, G., Lutchman, G. A., Nguyen, M. H. 2014; 12 (8): Mutations in HBV DNA Polymerase Associated With Nucleos(t)ide Resistance Are Rare in Treatment-naive Patients. Clinical gastroenterology and hepatology Vutien, P., Trinh, H. N., Garcia, R. T., Nguyen, H. A., Levitt, B. S., Nguyen, K., da Silveira, E., Daugherty, T., Ahmed, A., Garcia, G., Lutchman, G. A., Nguyen, M. H. 2014; 12 (8): Primary surgical resection versus liver transplantation for transplant-eligible hepatocellular carcinoma patients. Digestive diseases and sciences Wong, R. J., Wantuck, J., Valenzuela, A., Ahmed, A., Bonham, C., Gallo, A., Melcher, M. L., Lutchman, G., Concepcion, W., Esquivel, C., Garcia, G., Daugherty, T., Nguyen, et al 2014; 59 (1): Both HCV and HBV are Major Causes of Liver Cancer in Southeast Asians. Journal of immigrant and minority health Lin, H., Ha, N. B., Ahmed, A., Ayoub, W., Daugherty, T. J., Lutchman, G. A., Garcia, G., Nguyen, M. H. 2013; 15 (6): Incidence of Hepatocellular Carcinoma Among US Patients With Cirrhosis of Viral or Nonviral Etiologies CLINICAL GASTROENTEROLOGY AND HEPATOLOGY Mair, R. D., Valenzuela, A., Ha, N. B., Ayoub, W. S., Daugherty, T., Lutchman, G. A., Garcia, G., Ahmed, A., Nguyen, M. H. 2012; 10 (12): Risk factors for hepatocellular carcinoma in patients with chronic liver disease: a case-control study CANCER CAUSES & CONTROL Ha, N. B., Ha, N. B., Ahmed, A., Ayoub, W., Daugherty, T. J., Chang, E. T., Lutchman, G. A., Garcia, G., Cooper, A. D., Keeffe, E. B., Nguyen, M. H. Page 3 of 5

4 2012; 23 (3): Ethnic Differences in Viral Dominance Patterns in Patients with Hepatitis B Virus and Hepatitis C Virus Dual Infection HEPATOLOGY Nguyen, L. H., Ko, S., Wong, S. S., Tran, P. S., Trinh, H. N., Garcia, R. T., Ahmed, A., Lutchman, G. A., Keeffe, E. B., Nguyen, M. H. 2011; 53 (6): Screening for Hepatocellular Carcinoma After HBsAg Clearance Age Before Cirrhosis? JOURNAL OF CLINICAL GASTROENTEROLOGY Lutchman, G. A., Nguyen, M. A. 2011; 45 (1): 4-5 Endoscopic Management of a Spontaneous Gallbladder Perforation and Bile Leak DIGESTIVE DISEASES AND SCIENCES Munroe, C., Padilla-Thornton, A. E., Triadafilopoulos, G., Van Dam, J., Lutchman, G. 2010; 55 (10): Ribavirin Improves Early Responses to Peginterferon Through Improved Interferon Signaling GASTROENTEROLOGY Feld, J. J., Lutchman, G. A., Heller, T., Hara, K., Pfeiffer, J. K., Leff, R. D., Meek, C., Rivera, M., Ko, M., Koh, C., Rotman, Y., Ghany, M. G., Haynes-Williams, et al 2010; 139 (1): 154-U239 Reactivation of Hepatitis B With Reappearance of Hepatitis B Surface Antigen After Chemotherapy and Immunosuppression CLINICAL GASTROENTEROLOGY AND HEPATOLOGY Palmore, T. N., Shah, N. L., Loomba, R., Borg, B. B., Lopatin, U., Feld, J. J., Khokhar, F., Lutchman, G., Kleiner, D. E., Young, N. S., Childs, R., Barrett, A. J., Liang, et al 2009; 7 (10): Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis ALIMENTARY PHARMACOLOGY & THERAPEUTICS Loomba, R., Lutchman, G., Kleiner, D. E., Ricks, M., Feld, J. J., Borg, B. B., Modi, A., Nagabhyru, P., Sumner, A. E., Liang, T. J., Hoofnagle, J. H. 2009; 29 (2): The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis HEPATOLOGY Lutchman, G., Modi, A., Kleiner, D. E., Promrat, K., Heller, T., Ghany, M., Borg, B., Loomba, R., Liang, T. J., Premkumar, A., Hoofnagle, J. H. 2007; 46 (2): Mutation rate of the hepatitis C virus NS5B in patients undergoing treatment with ribavirin monotherapy GASTROENTEROLOGY Lutchman, G., Danehower, S., Song, B., Liang, T. J., Hoofnagle, J. H., Thomson, M., Ghany, M. G. 2007; 132 (5): Changes in serum adipokine levels during pioglitazone treatment for nonalcoholic steatohepatitis: Relationship to histological improvement CLINICAL GASTROENTEROLOGY AND HEPATOLOGY Lutchman, G., Promrat, K., Kleiner, D. E., Heller, T., Ghany, M. G., Yanovski, J. A., Liang, T. J., Hoofnagle, J. H. 2006; 4 (8): Steatosis and progression of fibrosis in untreated patients with chronic hepatitis C infection HEPATOLOGY Perumalswami, P., Kleiner, D. E., Lutchman, G., Heller, T., Borg, B., Park, Y., Liang, T. J., Hoofnagle, J. H., Ghany, M. G. 2006; 43 (4): Pilot study of interferon gamma for chronic hepatitis C JOURNAL OF HEPATOLOGY Soza, A., Heller, T., Ghany, M., Lutchman, G., Liang, T. J., Germain, J., Hsu, H. H., Park, Y., Hoofnagle, J. H. 2005; 43 (1): Pushing the treatment envelope for chronic hepatitis C - Is more necessarily better? HEPATOLOGY Lutchman, G., Ghany, M. 2005; 41 (2): A pilot study of ploglitazone treatment for nonalcoholic steatohepatitis HEPATOLOGY Promrat, K., Lutchman, G., Uwaifo, G. I., Freedman, R. J., Soza, A., Heller, T., Doo, E., Ghany, M., Premkumar, A., Park, Y., Liang, T. J., Yanovski, J. A., Kleiner, et al 2004; 39 (1): Viral kinetics in hepatitis C HEPATOLOGY Lutchman, G., Hoofnagle, J. H. Page 4 of 5

5 2003; 37 (6): Page 5 of 5