,, : Current Status in Drug Addiction and Addiction Memory Research WAN G Hao2Ran 1, GAO Xiang2 Rong 1, ZHAN G Kai2Gao 2, HAN Ji2Sheng 1 ( 1

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1 ( ) : R Current Status in Drug Addiction and Addiction Memory Research WAN G Hao2Ran 1 GAO Xiang2 Rong 1 ZHAN G Kai2Gao 2 HAN Ji2Sheng 1 ( 1 D rug Dependence Peki ng U niversity Beijing ) Neuroscience Research Instit ute 2 N ational Instit ute on Abstract The central feature of drug addiction is compulsive drug use loss of control over appar2 ently voluntary acts of drug seeking and drug taking. Drug addiction as a chronic brain disease may result f rom abnormal engagement of long2term associative memory. Addiction and memory are likely to share much in common in t he aspect s of neural adaptations synaptic plasticity and related molecular mechanisms. This paper reviews t he possible roles of learning mechanisms in t he develop ment of re2 lapse sensitization and drug addiction abnormal associative learning and compulsive behavior addic2 tion memory and addiction multiple memory systems and the development of addiction and empha2 size t he importance of synaptic plasticity and addiction memory in drug addiction. Addiction is charac2 terized by t he involvement of specific learning patterns of information. Addiction is closely related to t he disorder of associate learning t hat depends on dopamine. Hippocampus may play a key role in ad2 diction. At last we put forward the future directions for research. Key words Addiction memory Drug addiction Associate learning Neural circuits Molecular mech2 anisms : [13 ] CA1 ( V TA) addiction memory [4 5 ] aberrant memory [1 ] (L TP) [ : (L TD) ] V TA CA1 L TP ( ) : D1 (camp/ P KA/ CREB)

2 ( ) ( ) 2 2 [15 ] 2 (1) ( ) 1 2 D1 :D1 :D2 :D2 GPi/ SNr : / GPe : SNc/ V TA : / ( 1) L TP L TD [5 ] : [1 ] ( ) L TP 2 (AMPA) D1 D2 N2 2D2 ( NM2 DA) [2 ] AMPA AMPA [1 3 8 ] [9 ] [15 ] Nestler Total Recall the Memory of Addiction [5 ] : (1) [13 ] (2) [2 3 ] (3) camp/ P KA/ CREB [13 ] (4 ) camp (CREB) [13 ] (5) [1 2 ] (6) [2 3 ]

3 ( [9 ] ) [1 8 ] (psychostimulant s) [1 8 ] [13 ] D1 [14 ] [14 ] [8 ] ( ) ( non2associative sensitization) [10 ] CA1 [11 ] / [1 8 Alan Leshner ] : (laying down of memory trace) [12 ] [1 3 ] 2 [1 ] [1 3 ] [15 ]

4 [13 ] 2 ( multiple memory systems) [13 16 ] : [18 ] 2 (memory of addiction) 1972 Mello [17 ] [1 17 ] : 2 [4 ] : (1) (2) [4 ] 1 [1 19 ] (cross2sensitization) [1 5 ] : (1) (2) FosB CREB (3) (4)

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