SUBCUTANEOUS AS REQUIRED & SYRINGE PUMP PRESCRIPTION & ADMINISTRATION RECORD (SPAR) Name: Address: Postcode: Date of Birth: NHS Number:

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1 FILE IN PATIENT S COMMUNITY HEALTH RECORD FOLDER : SUBCUTANEOUS AS REQUIRED & SYRINGE PUMP PRERIPTION & ADMINISTRATION RECORD (SPAR) Abbreviations used in this document to be listed here with the full description CI Continuous subcutaneous infusion JiCD Just in case four core drugs PRN As required PO By mouth Subcutaneously SPAR Subcutaneous as required & syringe pump prescription & administration record STAT Immediately Address: General Practitioner Important Contacts : Address: Write patient details or affix Identification label Hospital Number: : Address: Postcode: Date of Birth: NHS Number: Syringe pump serial code: SPAR booklet number: (Circle relevant number above) Next of Kin Telephone number: : Address: Telephone number: District Nurse Telephone number: Specialist Palliative Care Advice Line For Blackpool, Fylde and Wyre: Trinity Hospice on (24 hours) For Lancaster, Morecambe and Carnforth: St John s Hospice, Hospice at home hub (24hours) RELEVANT ALLERGIES/DRUG SENSITIVITIES or STATE NO KNOWN ALLERGIES JUST IN CASE 4 CORE DRUGS (JiCD) DRUG Morphine Levomepromazine Midazolam Glycopyrronium Water for Injection QUANTITY SUPPLIED 5 x 10 mg/ml 5 x 25 mg/ml 5 x 10 mg/2 ml 5 x 200 microgram/ml 10 x 10 ml When pack opened, state if any discrepancies found between supplied and checked quantities, and reasons for discrepancy Date JiCD Bag opened & contents checked District Nurse ( Print ) QUANTITY CHECKED (initial) District Nurse Signature Expiry date PRERIPTION RECORDS PAGE DRUG Date started Date stopped 6 7 Water for Injection 8 9 Morphine Midazolam Levomepromazine Glycopyrronium Alternative opioid Non 4 core drug prescription Specialist medication Specialist medication SPAR version 8.0 (October 2018) Review due September 2021 Pharmacist check: : Signature: VS2142 Approved by the Health Records Consultation Group Procedural Document ID: CORP/PROC/592

2 JUST IN CASE FOUR CORE DRUGS (JiCD) Anticipatory Prescribing for End of Life Care The provision of JiCD at the end of life can support proactive symptom control by promoting anticipatory prescribing, which ensures common symptoms are anticipated and responded to in a timely fashion. Patients may be prescribed different end of life drugs anticipatory medications if they are intolerant of these recommended first line medications. For further information, please contact local Specialist Palliative Care Team for advice. Pain Nausea and Vomiting Agitation and Restlessness Respiratory Tract Secretions Morphine 10 mg/ml *Supply: 5 x 1mL Levomepromazine 25 mg/ml *Supply: 5 x 1mL Midazolam 10 mg/2ml *Supply: 5 x 2mL Glycopyrronium 200 micrograms/ml *Supply: 5 x 1mL Initial PRN dose **2.5 mg 1 hourly PRN Initial PRN dose 2.5mg mg 6 hourly PRN Initial PRN dose 2.5mg - 5 mg 4 hourly PRN Initial PRN dose 200 micrograms 4 hourly PRN Initial CI dose **5-10 mg over 24 hours Initial CI dose 6.25mg mg over 24 hours Initial CI dose 5mg - 10mg over 24 hours Initial CI dose 0.6mg mg Over 24 hours Water for Injections 10 x 10 ml (to dilute CI to a volume of at least 10mL ideally to maximum 17mL in a 20mL syringe or to maximum 22mL in a 30mL syringe) Dilution can be brand specific so always check * These quantities have been designed to cover the longest possible scenario of being needed over a bank holiday weekend, so please ensure adequate amount prescribed to ensure supply for 5 days (usually at least enough for 2 doses per day). ** For patients established on oral morphine or oxycodone, follow guidance on page 3 for conversion of oral to equivalent subcutaneous dose. For patients on buprenorphine or fentanyl patches, follow guidance on page 3 and discuss with Specialist Palliative Care Service for advice regarding further analgesia (see page 1 for contact numbers). If a patient is receiving an alternative opioid, discuss with Specialist Palliative Care Service for advice.. 2

3 PAIN MANAGEMENT If the patient has moderate to severe renal impairment (Chronic Kidney Disease 4 i.e. egfr of 30mL/min or less), discuss with the Specialist Palliative Care Service for advice regarding further analgesia. If the patient is on a buprenorphine or fentanyl patch, leave the patch in situ, change as usual and discuss with the Specialist Palliative Care Service for advice regarding further analgesia For opioid naïve patients or those established on oral morphine Yes Is the patient taking oral morphine? No Stop oral morphine Convert to a 24 hour CI of morphine, by dividing the total daily dose of oral morphine by 2 e.g. Yes Patient in pain? No Total daily oral CI morphine morphine dose 60 mg 30 mg Prescribe a rescue dose of morphine 1 hourly PRN. (Dose should be 1/6th of the calculated total CI morphine dose.) Consider giving morphine 2.5 mg Consider starting CI with morphine 5mg - 10 mg over 24 hours Rescue dose of morphine 2.5 mg 1 hourly PRN ENSURE PRN morphine 2.5 mg 1 hourly prescribed Titrate dose as necessary; discuss with the Specialist Palliative Care Service if pain not controlled on 60 mg morphine over 24 hours. For patients who are opioid naïve but need oxycodone such as patients with significant renal impairment (GFR 30mL/min or less) Use rescue oxycodone dose 1.25mg - 2.5mg 4 hourly PRN. Consider starting a CI with oxycodone 5mg - 10mg over 24 hours if frequent episodes of pain For patients established on oral oxycodone Follow the initial steps of the algorithm for morphine. Convert oral oxycodone to dose as shown below Stop regular oral oxycodone Use a 3:2 conversion to determine the oral: CI dose Divide the oral dose by 1.5 to obtain the CI dose Total daily oral oxycodone CI oxycodone dose 40 mg 25 mg Prescribe a rescue dose of oxycodone 1 hourly PRN. (Dose should be a 1/6th of the calculated total CI oxycodone dose.) Titrate dose as necessary; discuss with the Specialist Palliative Care Service if pain not controlled on 60 mg oxycodone over 24 hours. *Some references recommend a 2:1 conversion from oral to subcutaneous oxycodone. For end of life care use the value of 3:2 as shown above. 3

4 NAUSEA AND VOMITING If the symptoms are not controlled on levomepromazine 25 mg over 24 hours, contact the Specialist Palliative Care Service for advice. Yes Is the patient nauseated? No Consider giving levomepromazine 2.5mg mg (Use clinical judgement as to dose) Consider CI levomepromazine 6.25mg mg over 24 hours Titrate as needed to max 25 mg over 24 hours ENSURE PRN levomepromazine 2.5mg mg 6 hourly prescribed (Use clinical judgement as to dose) AGITATION AND TERMINAL RESTLESSNESS If patient remains restless on midazolam 30 mg over 24 hours, contact the Specialist Palliative Care Service for advice Yes Agitation/restlessness No Exclude reversible causes: Constipation Urinary retention Nicotine withdrawal ENSURE PRN midazolam 2.5mg - 5 mg 4 hourly prescribed Consider midazolam 2.5mg - 5 mg Consider CI midazolam 5mg - 10 mg over 24 hours If starting CI above 10mg over 24 hours, seek specialist advice. Titrate dose as necessary up to a max 30 mg over 25 hours. Max dose 60 mg (on specialist advice) over 24 hours 4

5 RESPIRATORY TRACT SECRETIONS If the symptoms are not controlled, contact the Specialist Palliative Care Service for advice. Treatment must be started as soon as symptoms appear. Drugs cannot remove already-present secretions. Consider positional change or use of suction. Yes Secretions present? No Consider stat glycopyrronium 200 micrograms Consider CI glycopyrronium 0.6mg mg over 24 hours Titrate dose as necessary; max dose 1.2 mg over 24 hours. If requires higher dose, seek specialist advice. ENSURE PRN glycopyrronium 200 micrograms 4 hourly prescribed OTHER DRUGS THAT MAY BE USED IN CIs LOCALLY INCLUDE: Drug Dose Indication Diamorphine If opioid naïve: 5 10 mg/24 hour Pain (reserved for high doses) Oxycodone If opioid naïve: 5 10 mg/24 hour Pain Hyoscine butylbromide (Buscopan) mg/24 hour Gastrointestinal colic/respiratory (Higher doses may be used on specialist advice) tract secretions Metoclopramide 30 mg/24 hour (Higher doses on specialist advice) Nausea & vomiting Haloperidol mg/24 hour (max 10mg/24 hour) Nausea & vomiting (Haloperidol 5 30 mg/24 hour Agitation) Cyclizine mg/24 hour (max 150 mg/24 hour) Nausea & vomiting Hyoscine Hydrobromide mg/24 hour (max 2.4 mg/24 hour) Respiratory tract secretions Sodium chloride 0.9% for injection not with cyclizine Diluent THE FOLLOWING DRUGS ARE TO BE USED ONLY ON THE RECOMMENDATION OF SPECIALIST PALLIATIVE CARE Levomepromazine 25 75mg/24 hour Agitation/Delirium (Higher doses may be used on specialist advice) Octreotide micrograms/24 hour Obstructive vomiting Ondansetron 8 24 mg/24 hour (max 32 mg/24 hour) Refractory vomiting Tramadol mg/24 hour Pain Dexamethasone 2mg 16 mg/24 hour Multiple uses, e.g. pain, nausea THE FOLLOWING DRUGS ARE TO BE USED ONLY WITH THE DIRECT GUIDANCE OF A SPECIALIST IN PALLIATIVE CARE Alfentanil Ketorolac Pain Methadone Levetiracetam (Keppra) Epileptic Seizures Sodium Valproate Compatibility of Medicines in a Syringe Pump Always base the prescription of the medication in the syringe pump on a face to face clinical assessment of the patient and their current symptoms. Most patients do not need all 4 Just in case drugs in a syringe pump in order to keep them comfortable. The four core drugs recommended in this guidance are compatible to be used together in a syringe pump. Other drugs may or may not be compatible for use together. An online syringe pump compatibility tool is available at If unsure, please seek further advice from local specialist palliative care team or hospice advice line. 5

6 Hospital number: Patient date of birth: For continuous subcutaneous infusion via syringe pump PLEASE SIGN FOR ALL PATIENTS IN ANTICIPATION OF THE NEED TO SET UP A SYRINGE PUMP OUT OF HOURS Date Medication Dosage Frequency Print Signature AS REQUIRED 24 HOURS Date Time of Drug DRUG ADMINISTRATION AND STOCK CONTROL RECORD & Exp Date Initial Print Print 6

7 Date Time of Drug & Exp Date Initial Print Print 7

8 : JUST IN CASE PRERIPTION FOR A PATIENT NOT ON OR OTHER OPIOID FOR PAIN Date Medication Dosage Frequency Print Signature (Just in Case Prescription) If opioid naïve: 2.5mg Hourly STAT PRN for pain : JUST IN CASE PRERIPTION DOSE AND AS REQUIRED DOSE IF ALREADY ON OPIOIDS - AIM to PRERIBE 1/6 th of the 24 hour dose : FOR CONTINUOUS SUBCUTANEOUS INFUSION VIA SYRINGE PUMP IF NOT ON OR OTHER OPIOIDS FOR PAIN Date Medication Dosage Frequency Print Signature If opioid naïve: 5mg 10 mg 24 HOURS or : CONTINUOUS SUBCUTANEOUS INFUSION DOSE RANGE OVER 24 HOURS IF ALREADY ON OPIOID Dose ranges prescribed should be clinically appropriate but no bigger than a 50% dose increase between the lower dose and the higher dose. New dose ranges should be rewritten in a new box and previous dose range discontinued 24 HOURS 24 HOURS 24 HOURS 24 HOURS 24 HOURS 24 HOURS 24 HOURS 8

9 Date Time of Drug Strength of CONTROLLED DRUG ADMINISTRATION AND STOCK CONTROL RECORD & Exp Date Initial Dose Given 9

10 : JUST IN CASE PRERIPTION AND FOR USAGE AS REQUIRED Date Medication Dosage Frequency Print Signature (prescriber) (Just in Case Prescription) 2.5mg - 5mg 4 hourly STAT PRN for agitation & restlessness : FOR CONTINUOUS SUBCUTANEOUS INFUSION VIA SYRINGE PUMP Date Medication Dosage Frequency Print Signature 5mg 10mg 24 HOURS 24 HOURS 24 HOURS 24 HOURS 24 HOURS CONTROLLED DRUG ADMINISTRATION AND STOCK CONTROL RECORD Date Time of Drug Strength of & Exp Date Initial Dose Given 10

11 Date Time of Drug Strength of CONTROLLED DRUG ADMINISTRATION AND STOCK CONTROL RECORD & Exp Date Initial Dose Given Print Print 11

12 : JUST IN CASE PRERIPTION AND FOR USAGE AS REQUIRED Date Medication Dosage Frequency Print Signature (Just in Case Prescription) 2.5 mg mg 6 Hourly STAT PRN for nausea & vomiting : FOR CONTINUOUS SUBCUTANEOUS INFUSION VIA SYRINGE PUMP Date Medication Dosage Frequency Print Signature 6.25mg 12.5 mg 24 HOURS 24 HOURS 24 HOURS 24 HOURS 24 HOURS DRUG ADMINISTRATION AND STOCK CONTROL RECORD Date Time of Drug Strength of & Exp Date Initial Dose Given Print Print 12

13 DRUG ADMINISTRATION AND STOCK CONTROL RECORD cont Date Time of Drug Strength of & Exp Date Initial Dose Given Print Print 13

14 : JUST IN CASE PRERIPTION AND FOR USAGE AS REQUIRED Date Medication Dosage Frequency Print Signature (Just in Case Prescription) 200 micrograms (0.2mg) 4 hourly STAT PRN for respiratory secretions : FOR CONTINUOUS SUBCUTANEOUS INFUSION VIA SYRINGE PUMP Date Medication Dosage Frequency Print Signature 0.6mg 1.2mg 24 HOURS 24 HOURS 24 HOURS 24 HOURS 24 HOURS Date Time of Drug Strength of DRUG ADMINISTRATION AND STOCK CONTROL RECORD & Exp Date Initial Dose Given Print Print 14

15 DRUG ADMINISTRATION AND STOCK CONTROL RECORD cont Date Time of Drug Strength of & Exp Date Initial Dose Given Print Print 15

16 PRERIPTION OF ALTERNATIVE STRONG OPIOID AS REQUIRED JUST IN CASE Date Medication Dosage Frequency Print Signature ALTERNATIVE STRONG OPIOID FOR CONTINUOUS SUBCUTANEOUS INFUSION VIA SYRINGE PUMP Dose ranges prescribed should be clinically appropriate but no bigger than a 50% dose increase between the lower dose and the higher dose. New dose ranges should be rewritten in a new box and previous dose range discontinued Date Medication Dosage Frequency Print Signature 24 HOURS 24 HOURS 24 HOURS 24 HOURS 24 HOURS CONTROLLED DRUG ADMINISTRATION AND STOCK CONTROL RECORD Date Time of Drug Strength of & Exp Date Initial Dose Given 16

17 CONTROLLED DRUG ADMINISTRATION AND STOCK CONTROL RECORD cont Date Time of Drug Strength of & Exp Date Initial Dose Given 17

18 END OF LIFE DRUG PRERIPTION RECORD FOR MEDICATION OTHER THAN THE JUST IN CASE FOUR CORE DRUGS NAME OF MEDICATION SYMPTOM BEING MANAGED Dose range (mg) FOR USAGE AS REQUIRED ONLY Date Medication Dosage Frequency Print Signature (Prescriber) FOR CONTINUOUS SUBCUTANEOUS INFUSION VIA SYRINGE PUMP Date Medication Dosage Frequency Print 24 HOURS 24 HOURS 24 HOURS 24 HOURS Signature (Prescriber) Date Time of Drug Strength of DRUG ADMINISTRATION AND STOCK CONTROL RECORD & Exp Date Initial Dose Given HCP 2(if applicable) 18

19 DRUG ADMINISTRATION AND STOCK CONTROL RECORD cont Date Time of Drug Strength of & Exp Date Initial Dose Given 19

20 SPECIALIST PALLIATIVE CARE PRERIPTION RECORD Date Medication Symptom(s) being managed Dose range (mg) Indication for increase in dose Size of incremental dose (mg) Time between each increase in dose (days) ADDITIONAL COMMENTS SIGNIFICANT ADVERSE EFFECTS OF MEDICATION TO BE AWARE OF: SPECIALIST LEAD (Print ) CONTACT NUMBER PRERIBED BY (Print name) SIGNATURE & DATE If ceiling dose is being approached, or patient experiences significant adverse effects, please contact Trinity Hospice to discuss next steps. During weekdays ring and ask to speak to the doctor on call for clinical advice. Out of hours or at weekends please phone in patient unit and speak to the nurse in charge. FOR USAGE AS REQUIRED SEE ADVICE ABOVE Date Medication Dosage Frequency Print FOR CONTINUOUS SUBCUTANEOUS INFUSION VIA SYRINGE PUMP SEE ADVICE ABOVE Signature (Prescriber) Date Medication Dosage Frequency Print Signature 24 HOURS 24 HOURS 24 HOURS 24 HOURS 20

21 DRUG ADMINISTRATION AND STOCK CONTROL RECORD Date Time of Drug Strength of & Exp Date Initial Dose Given 21

22 SPECIALIST PALLIATIVE CARE PRERIPTION RECORD Date Medication Symptom(s) being managed Dose range (mg) Indication for increase in dose Size of incremental dose (mg) Time between each increase in dose (days) ADDITIONAL COMMENTS SIGNIFICANT ADVERSE EFFECTS OF MEDICATION TO BE AWARE OF: SPECIALIST LEAD (Print ) CONTACT NUMBER PRERIBED BY (Print name) SIGNATURE & DATE If ceiling dose is being approached, or patient experiences significant adverse effects, please contact Trinity Hospice to discuss next steps. During weekdays ring and ask to speak to the doctor on call for clinical advice. Out of hours or at weekends please phone in patient unit and speak to the nurse in charge FOR USAGE AS REQUIRED SEE ADVICE ABOVE Date Medication Dosage Frequency Print FOR CONTINUOUS SUBCUTANEOUS INFUSION VIA SYRINGE PUMP SEE ADVICE ABOVE Date Medication Dosage Frequency Print 24 HRS 24 HRS 24 HRS 24 HRS Signature (Prescriber) Signature (Prescriber) 22

23 DRUG ADMINISTRATION AND STOCK CONTROL RECORD Date Time of Drug Strength of & Exp Date Initial Dose Given 23

24 Community Pharmacies Participating in Anticipatory Supply of JiCD in Tamper Evident Bag Blackpool Cohens Pharmacy Moor Park Health Centre Bristol Avenue Blackpool FY2 0JG Telephone Mon-Fri Sat Sun Blackpool MedicX Pharmacy Whitegate Primary Care Centre 150 Whitegate Drive Blackpool FY3 9ES Telephone Mon-Sun Blackpool Co-op Pharmacy Cleveleys/ Thornton Boots Pharmacy 9 11 All Hallows Road Bispham Blackpool FY2 0AS Telephone Mon-Fri Sat Victoria Road Cleveleys, FY5 1BS Telephone Blackpool Lytham Road Pharmacy Kirkham Co-op Pharmacy South Shore Primary Care Centre Lytham Road Blackpool FY4 1TJ Telephone Mon - Thur Fri Market Square, Kirkham PR4 2SD Telephone Mon-Sat Sun Mon-Fri Sat Fleetwood Warburtons Pharmacy Lord Street Fleetwood FY7 6JZ Telephone Poulton/Carleton Carleton Pharmacy 5 Poulton Road Carleton FY6 7NH Telephone Freckleton Well Pharmacy Great Eccleston Great Eccleston Health Centre ThePharmacy Mon-Fri Sat Douglas Drive Health Centre Freckleton PR4 1RY Telephone Mon-Fri Sat Raikes Road Great Eccleston PR3 0ZA Telephone St Anne s/lytham MedicX Pharmacy Hambleton Hambleton Pharmacy Mon, Tue, Thur, Fri Wed Sat Lytham Primary Care Centre Warton Street Lytham FY8 5EE Telephone Mon-Fri Kiln Lane Poulton le Fylde Hambleton FY6 9AH Telephone Mon Tue-Fri Sat Closed daily for lunch Mon - Fri Sat Out Of Hours Access to End of Life Drugs (for use in EMERGENCIES only) Fylde Coast Medical Services via Urgent Care Centre at Blackpool Teaching Hospital, Whinney Heys Road, Blackpool Preston Primary Care Centre Royal Preston Hospital Sharoe Green Lane, Preston