PUBLIKATIONEN ORIGINALARBEITEN

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1 PUBLIKATIONEN ORIGINALARBEITEN Wei-Min Tong, Enikö Kallay, Harald Hofer, Wolfgang Hulla, Theresa Manhardt, Meinrad Peterlik and Heide S. Cross. Growth regulation of human colon cancer cells by epidermal growth factor and 1,25-dihydroxyvitamin D 3 is mediated by mutual modulation of receptor expression. Eu J Cancer 1998, 34,(13): Wei-Min Tong, Harald Hofer, Meinrad Peterlik, Heide S. Cross. Mechanism of antimitogenic action of Vitamin D in Human Colon Carcinoma Cells: Relevance for Suppression of Epidermal Growth Factor stimulated Cell Growth. Oncology Research 1999; 11, (2): Harald Hofer, Guan-Min Ho, Meinrad Peterlik, Milan R. Uskokovic, Jae Kyoo Lee, M Christina White, Gary H. Posner, and Heide S. Cross. Biological effects of 1alpha-hydroxy- and 1beta- (hydroxymethyl)-vitamin D compounds relevant for potential colorectal cancer therapy. J Pharm Exp Ther, 1999, 291(2): , Heide S. Cross, Petra Bareis, Harald Hofer, Martin G Bischof, Erika Bajna, Stefan Kriwanek, Elisabeth Bonner; Meinrad Peterlik. 25- Hydroxyvitamin D3-1-alpha-hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis. Steroids 2001, 66: Petra Bareis, Martin G. Bischof, Givanna Bises, Harald Hofer, Christian Pötzi, Teresa Manhardt, Rosemary Bland, Heide S. Cross. Clonal differences in expression of 25- hydroxyvitamin D 3-1-hydroxylase, of 25-hydroxyvitamin D 3-24-hydroxylase and of the vitamin D receptor in human colon carcinoma cells: effects of epidermal growth factor and 1 a,25- dihydroxyvitamin D 3 Exp Cell Res. 2002,10;276(2): Wolfgang Jessner, Michael Gschwandtler, Petra Steindl-Munda, Harald Hofer, Thomas Watkins, Friedrich Wrba, Christian Müller, Alfred Gangl, Peter Ferenci A pilot study on primary interferon resistance as predictor of non response to treatment in chronic hepatitis virus genotype 1 infection. Lancet. 2001,13;358(9289): Peter Ferenci, Harald Brunner, Karin Nachbaur, Christian Datz, Michael Gschwandtler, Harald Hofer, Petra Steindl-Munda, Wolfgang Vogel Combination of interferon induction therapy and ribavirin in chronic hepatitis c. Hepatology. 2001;34(5): Harald Hofer, Hans C Bankl, Friedrich Wrba, Petra Steindl-Munda, Markus Peck- Radosavljevic, Christoph Österreicher, Christian Mueller, Alfred Gangl, Peter Ferenci Hepatocellular fat accumulation in patients with chronic hepatitis C due to genotype 3a - role of impaired cholesterol synthesis, Am J Gastroenterol. 2002;97(11):

2 Markus Peck-Radosavljevic, Martina Wichlas, Monika Homoncik-Kraml, Anna Kreil, Harald Hofer, Wolfgang Jessner, Alfred Gangl, Peter Ferenci Rapid suppression of Hematopoiesis by standard or pegylated Interferon. Gastroenterology. 2002;123(1): Kramer L, Bauer E, Funk G, Hofer H, Jessner W, Steindl-Munda P, Wrba F, Madl C, Gangl A, Ferenci P. Subclinical impairment of brain function in chronic hepatitis C infection. J Hepatol 2002;37(3): Harald Hofer, Thomas Watkins-Riedel, Oskar Janata, Edward Penner, Heidemarie Holzmann, Petra Steindl-Munda, Alfred Gangl, Peter Ferenci Spontaneous viral clearance in patients with acute hepatitis C can be predicted by repeated measurements of serum viral load, Hepatology. 2003;37(1):60-4. Jessner W, Stauber R, Hackl F, Datz C, Watkins-Riedel T, Hofer H, Gangl A, Kessler H, Ferenci P. Early viral kinetics on treatment with pegylated interferon-alpha-2a in chronic hepatitis C virus genotype 1 infection. J Viral Hepat 2003;10(1):37-42 Harald Hofer, Fritz Wrba, Christoph Österreicher, Alfred Gangl, Peter Ferenci, Edward Penner Centrilobular necrosis in autoimmune hepatitis: A histological feature associated with an acute onset of disease. Submitted 2003 Steindl-Munda P, Ferenci P, Brunner H, Nachbaur K, Datz C, Gschwantler M, Hofer H, Stauber R, Hackl F, Jessner W, Rosenbeiger M, Gangl A, Vogel W; Austrian Hepatitis Study Group. Impact of high-dose interferon induction and ribavirin therapy in patients with chronic hepatitis C relapsing after or not responding to interferon monotherapy. Liver Int Aug;23(4): Stauber, R., E., Hofer, H., Hackl, F., Schütze, K., Datz, C., Hegenbarth, K., Jessner, W., Steindl- Munda, P., Ferenci, P.,for the Austrian Hepatitis Study Group Retreatment of patients with chronic hepatitis C not responding to interferon/ribavirin combination therapy with daily interferon plus ribavirin plus amantadine. Wiener Klin Wochenschrift 2004; 116 Harald Hofer, Christoph Österreicher, Wolfgang Jessner, Melitta Penz, Petra Steindl-Munda, Friedrich Wrba, Peter Ferenci. Hepatic iron concentration does not predict response to standard and pegylated-ifn/ribavirin therapy in patients with chronic hepatitis C. J Hep (6): Harald Hofer, Julius Benjamin Neufeld, Christoph Oesterreicher, Paul Grundtner, Fritz Wrba, Alfred Gangl, Peter Ferenci, and Christoph Gasche. Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection Genes Immun. 2005;6(3): Osterreicher CH, Datz C, Stickel F, Hellerbrand C, Penz M, Hofer H, Wrba F, Penner E, Schuppan D, Ferenci P. Association of myeloperoxidase promotor polymorphism with cirrhosis in

3 patients with hereditary hemochromatosis. J Hepatol Jun;42(6): Epub 2005 Apr 2. Osterreicher CH, Datz C, Stickel F, Hellerbrand C, Penz M, Hofer H, Wrba F, Penner E, Schuppan D, Ferenci P. TGF-beta1 codon 25 gene polymorphism is associated with cirrhosis in patients with hereditary hemochromatosis. Cytokine Jul 21;31(2): Kramer L, Hofer H, Bauer E, Funk G, Formann E, Steindl-Munda P, Ferenci P. Relative impact of fatigue and subclinical cognitive brain dysfunction on health-related quality of life in chronic hepatitis C infection. AIDS. 2005;19, S3:S Formann E, Steindl-Munda P, Hofer H, Jessner W, Bergholz U, Gurguta C, Ferenci P. Longterm follow-up of chronic hepatitis C patients with sustained virological response to various forms of interferon-based anti-viral therapy. Aliment Pharmacol Ther Feb 15;23(4): Hofer H, Oesterreicher C, Wrba F, Ferenci P, Penner E. Centrilobular necrosis in autoimmune hepatitis: a histological feature associated with acute clinical presentation. J Clin Pathol Mar;59(3): Hofer H, Gurguta C, Bergholz U, Steindl-Munda P, Ferenci P. Standard interferon-alpha in combination with ribavirin for hepatitis C patients with advanced liver disease and thrombocytopenia. Wien Klin Wochenschr. 2006;118(19-20): Scherzer TM, Staufer K, Hofer H, Novacek G, Ferenci P, Vogelsang H Efficacy and safety of antiviral therapy in patients with crohn s disease and chronic hepatitis C. Aliment Pharm Therapeut 2008 in press. Scherzer TM, Rajender KR, Staufer K, Hofer H, Steindl-Munda P, Ferenci F. Hepatocellular carcinoma in long-term sustained virologic responders to antiviral treatment for chronic hepatitis C. Am J Gastroenterol 2008 in press Elke M. Hennes, Mikio Zeniya, Albert. J. Czaja, Albert Parés, George N. Dalekos, Edward L. Krawitt, Paulo L. Bittencourt, Gilda Porta, Kirsten M. Boberg, Harald Hofer, Francesco B. Bianchi, Minoru Shibata, Christoph Schramm, Barbara Eisenmann de Torres, Peter R. Galle, Ian McFarlane,Hans-Peter Dienes, Ansgar W. Lohse The International Autoimmune Hepatitis Group Simplified criteria for the diagnosis of autoimmune hepatitis, Hepatology 2008 in press Peter Ferenci, Harald Brunner, Hermann Laferl, Thomas-Matthias Scherzer, Andreas Maieron, Michael Strasser, Gabriele Fischer, Harald Hofer, Martin Bischof, Rudolf Stauber, Michael

4 Gschwantler, Petra Steindl-Munda, Karin Löschenberger for the Austrian Hepatitis Study Group A Randomized, Prospective Trial of Ribavirin 400 mg/day versus 800 mg/day in Combination with Peginterferon alfa-2a for Chronic Hepatitis C Genotypes 2 and 3 Hepatology 2008 in press

5 II) BUCHBEITRÄGE & KONSENSUSREPORTS H.S. Cross, W.-M. Tong, H. Hofer, Y. Sheinin, M. Peterlik. The intrinsic 1,25(OH) 2 D3/VDR system of human colonic epithelial cells: Upregulation during tumor progression. IN: Vitamin D Chemistry, Biology and Clinical Applications of the Steroid Hormone. Eds.; Norman AW, Bouillon R, Thomasset M, University of California, Riverside, pp , 1997 Heide S. Cross, Harald Hofer, Petra Bareis, Giovanna Bises, Gary H. Posner, Meinrad Peterlik. Vitamin D Compounds and colorectal cancer: A rationale for their use in prevention and therapy. Proceedings of the tenth workshop of vitamin D, May 2000 Harald Hofer, Therapie der akuten Hepatitis C. In: Leitfaden der Infektionskrankheiten der Leber, 2006 Hofer H, Penner E. Diagnose, Klassifikation und Therapie der Autoimmunhepatitis und Overlap Syndrome. ÖGGH Konsensus 2007 Hofer H. Therapie der akuten Hepatitis B. Konsensus der ÖGGH zur Diagnostik und Therapie der Hepatitis B, 2008