Martindale Pharma is a UK pharmaceutical manufacturing company supplying niche products to over 50 countries worldwide.

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1 INTERNATIONAL

2 Martindale Pharma is a UK pharmaceutical manufacturing company supplying niche products to over 50 countries worldwide. Our vision Making Lives Better drives every action and decision of the company. This applies to everyone involved with our company, from our employees to our distributors, our customers in local hospitals and government agencies, and most importantly, the patients using our medicines. With a history tracing back to the 18th century, we continue to be a leading UK supplier of injectables, oral solutions, suppositories and ophthalmic drops and ointments. Our History 1787: James Macarthy founded a retail pharmacy in Romford, later to become Macarthy Ltd 1873: William Martindale bought a pharmacy in central London 1933: W. Martindale was acquired by Savory & Moore Ltd 1967: Savory & Moore Ltd was acquired by Macarthy Ltd 1990: Martindale Pharmaceuticals launched as a trading style for Macarthys Laboratories Ltd 1991: Martindale Pharmaceuticals move to purpose built facility in Harold Hill, within a few kilometres of where James Macarthy founded his original pharmacy 1992: Macarthy plc acquired by Lloyds Chemists plc 1994: Martindale acquires Daniels Pharmaceuticals and enters the ophthalmics market 1995: Further acquisitions lead to the launch of the Martindale Specials business 1999: Aurum acquired and Martindale enters the Pre Filled Syringe sector 2000: Brentwood facility commissioned 2003: Acquired by Cardinal Health 2009: Methadone launched into multiple markets 2010: AAC Capital acquires Martindale from Cardinal Health 2014: Martindale relocates headquarters to High Wycombe in Buckinghamshire. Martindale Pharma has a comprehensive network of local and international specialist distributors, with particular strength in the Middle East, Australia, Africa, selected markets in Europe, Asia and the Caribbean. Customer service is crucial to our success and hearing a familiar voice on the phone or a swift reply to an from your Martindale Pharma contact are integral to our approach to serving our customers. Our international team has the experience and depth of knowledge to manage the shipment of our goods, including Controlled Drugs (Narcotics), to our export customers across the globe.

3 Martindale Pharma supplies critical care injections to hospital in over 30 countries across five continents

4 Pain Relief/CNS Drugs To many international customers, the name Martindale Pharma is synonymous with Controlled Drugs (CDs) or Narcotics. In several countries, the supply of opioid analgesics has been central to the growth of the business partnership. Whilst the mix of products from an ever increasing portfolio may have broadened, the detailed adherence and understanding of the import and export processes for Controlled Drugs (CDs) across international borders remains a cornerstone to the Martindale Pharma export business. In the WHO three-step analgesic ladder, opioids are divided into those used for mild to moderate pain, including Codeine and Dihydrocodeine and those for moderate to severe pain, including Morphine, Pethidine and Fentanyl. The ones from the first group are distinguished by the existence of a ceiling effect and are often used with non opioid analgesics. Repeated administration of these drugs may cause dependence and tolerance and treatment should always be supervised by a specialist and the patient assessed at regular intervals. The Martindale Pharma range includes CDs in a number of dosage forms, which dependent on sufficient volume can be manufactured to country specific strengths and supplied in local packaging. INTERNATIONAL JOB NUMBER: MART/02/ 2017/022 DATE OF PREPARATION: FEB / 06

5 Pain Relief/CNS Drugs Fentanyl 01 Morphine 02 50mcg/ml in 2ml 50mcg/ml in 10mg/ml in 1ml 15mg/ml in 1ml 20mg/ml in 1ml 30mg/ml in 1ml Pethidine 03 Phenobarbital 04 50mg/ml in 1ml 50mg/ml in 2ml 30mg/ml in 1ml 60mg/ml in 1ml 200mg/ml in 1ml Building A2, Glory Park Glory Park Avenue, Wooburn Green High Wycombe. HP10 0DF United Kingdom t +44 (0) f +44 (0) e connect@martindalepharma.co.uk w martindalepharma.co.uk

6 Addiction Martindale Pharma is one of the leading UK suppliers of Methadone for the treatment of Opioid Drug addiction. Our Methadone is currently registered in Ireland, Malta, Kenya and South Africa, with further registration applications submitted in Europe and the Middle East. With over 15 years experience in manufacturing Methadone to a precise and consistent formulation, all our products are manufactured under GMP conditions. Formulations include Alcohol free, Sugar free, Lycosine free and orange flavoured variants. In 2013 Martindale Pharma increased its portfolio for the treatment of Opioid Drug Addiction and launched the first presentation of Naloxone to be licensed for emergency use in the home or other nonmedical setting. In 2017, Martindale Pharma added Espranor to the group of Addiction products. Espranor oral lyophilisate is a freeze-dried wafer, which dissolves rapidly on the tongue. This represents another first-in-class development, and demonstrates the commitment of Martindale Pharma to this therapy area. INTERNATIONAL JOB NUMBER: MART/02/ 2017/022 DATE OF PREPARATION: FEB / 06

7 Addiction Methadone 01 The presentations available are: Oral solutions Injections Tablets Latest formulation: Martindale Pharma has developed a 2mg/ml methadone formulation with the following benefits. Sugar free Alcohol free Lycosine free Orange flavor 3 year shelf-life Prenoxad (Naloxone Hydrochloride) 02 Prenoxad Injection (naloxone hydrochloride 1mg/1ml solution for injection) contains 2 ml naloxone hydrochloride 1 mg/ml. Espranor 03 Espranor 2 mg oral lyophilise. Each oral lyophilisate contains 2 mg of buprenorphine (as hydrochloride). Each oral lyophilisate contains 0.50 mg aspartame. Espranor 8 mg oral lyophilise. Each oral lyophilisate contains 8 mg of buprenorphine (as hydrochloride). Each oral lyophilisate contains 2.00 mg aspartame. Building A2, Glory Park Glory Park Avenue, Wooburn Green High Wycombe. HP10 0DF United Kingdom t +44 (0) f +44 (0) e connect@martindalepharma.co.uk w martindalepharma.co.uk

8 Hospital Specialty Specialist Parenteral Injections supplied in oules or vials remain core to Martindale Pharma s business. In addition to the Narcotics detailed in the previous section, the range of niche injectables available support the treatment of many medical conditions and surgical procedures. As well as products from its in house manufacturing capability, Martindale Pharma has entered into partnerships with a number of other specialist cgmp manufacturers, offering an enhanced spectrum of products and presentations, for exle, 50 ml vials and aseptically filled oules. INTERNATIONAL JOB NUMBER: MART/02/ 2017/022 DATE OF PREPARATION: FEB / 06

9 Hospital Specialty Acetylcysteine 01 Ephedrine mg/ml in 30mg/ml in 1ml 30m/ml in 30mg/ml in PFS Adrenaline 03 Glycopyrronium Bromide 04 1 in 1,000 in 1ml 1 in 1,000 in 0.5ml 1 in 1,000 in 5ml 1 in 10,000 in 1 in 10,000 in 1ml 1 in 10,000 in 5ml 1 in 1,000 in 1ml Anaphylaxis PFS 1 in 1,000 in 1 ml Paediatric PFS 1 in 10,000 in PFS 0.2mg/ml in 1ml 0.2mg/ml in 3ml Glycopyrronium Bromide 0.5mg/ml and Neostigmine Metilsulfate 2.5mg/ml Cardioplegia 05 Magnesium Sulphate 06 Infusion Concentrate 20ml 1g in 2ml (50%) 5g in 10m (50%) 2.5g in 5ml (50%) 10% in Building A2, Glory Park Glory Park Avenue, Wooburn Green High Wycombe. HP10 0DF United Kingdom t +44 (0) f +44 (0) e connect@martindalepharma.co.uk w martindalepharma.co.uk

10 Oral Suspensions Martindale Pharma has a strong background in the Unlicensed or Specials business. Specials are medicinal products prescribed, administered and supervised by doctors for a specific indication, either when a licensed product does not exist or is not currently available on the market. Martindale Pharma has licensed some of its oral suspensions, making these molecules the first licensed oral liquid suspensions in the UK. INTERNATIONAL JOB NUMBER: MART/02/ 2017/022 DATE OF PREPARATION: FEB / 06

11 Oral Suspensions Tapclob (Clobazam) 01 Noyada (Captopril) 02 5mg/5ml in 150ml bottle 10mg/5ml in 150ml bottle 5mg/5ml in 100ml bottle 25mg/5ml in 100ml bottle Martapan (Dexamethasone) 03 Dexamfetamine 04 2mg/5ml in 150ml bottle 1mg/ml in 500ml bottle Building A2, Glory Park Glory Park Avenue, Wooburn Green High Wycombe. HP10 0DF United Kingdom t +44 (0) f +44 (0) e connect@martindalepharma.co.uk w martindalepharma.co.uk

12 Retail Specialty and Critical Care Martindale Pharma continues to invest in additional products to compliment and strengthen the range for both the UK and our international markets. Obstetrics Caffeine Citrate Caffeine Citrate 10mg/ml. Each 1ml of solution contains, 10mg Caffeine citrate, equivalent to 5mg of Caffeine. Sodium Citrate Sodium Citrate 0.3M Oral Solution g of Sodium Citrate in 30ml of Oral Solution INTERNATIONAL JOB NUMBER: MART/02/ 2017/022 DATE OF PREPARATION: FEB / 06

13 Retail Specialty and Critical Care Pre-filled s PRTC (Plastic Rigid Tip Cap) Emergency Range 03 Ophthalmology Our range of products cover the leading ophthalmic diseases: Glaucoma, Conjunctivitis and Dry eye. 04 Our PFS are latex-free, Luer Lock compatible and designed to reduce tip breakage. Adrenaline Atropine Ephedrine Amiodarone Naloxone Calcium Chloride (intravenous infusion) Chlorhenicol Timolol Vista Methasone Hypromellose Pilocarpine Atropine Latanoprost Dorzolamide / Timolol Carmellose Ear, Nose and Throat 05 Suppositories 06 Lidocaine Hydrochloride 5% & Phenylephrine Hydrochloride 0.5% BIPP (Bismuth subnitrate and iodoform paste) Morphine Paracetamol Aspirin Building A2, Glory Park Glory Park Avenue, Wooburn Green High Wycombe. HP10 0DF United Kingdom t +44 (0) f +44 (0) e connect@martindalepharma.co.uk w martindalepharma.co.uk

14 Therapeutic groups & alphabetical list of products Therapeutic class Code Product Strength Presentation Pack Size ACE inhibitor Noyada (Captopril) 5mg/5ml Oral Solution 100ml ACE inhibitor Noyada (Captopril) 25mg/5ml Oral Solution 100ml Alkalinizer Sodium Bicarbonate BP 8.4%w/v Anaesthetic Cardioplegia Infusion Concentrate Anaesthetic Cocaine Hydrochloride Anaesthetic Lidocaine Hydrochloride 5% & Phenylephrine 0.5% 20ml 10% nasal spray 2.5ml nasal spray Analgesic Aspirin 150mg suppository Analgesic Aspirin 300mg suppository Analgesic Paracetamol 120mg suppository Analgesic Paracetamol 240mg suppository Analgesic Paracetamol 500mg suppository Analgesic Paracetamol 1000mg suppository Analgesic/Antidote for methanol poisoning Analgesic/Antidote for methanol poisoning Ethanol BP (Dehydrated Alcohol) Ethanol BP (Dehydrated Alcohol) Antiarrhythmic agent Amiodarone 300mg in 2.5ml 100% 2ml 100% 5ml Antibiotic Chlorhenicol BP 1%w/w eye ointment Antibiotic Chlorhenicol BP 10%w/v ear drop Antibiotic Chlorhenicol BP 5%w/v ear drop Antibiotic Chlorhenicol BP 0.5%w/v eye drop Anticholinergic Glycopyrronium Bromide Anticholinergic Glycopyrronium Bromide Anticholinergic Hyoscine Hydrobromide BP Anticholinergic Hyoscine Hydrobromide BP Anticholinesterases Glycopyrronium Bromide and Neostigmine Metilsulfate Antidote for Paracetamol overdose Antidote in methaemoglobinemia 4g 0.2mg/ml 1ml 0.2mg/ml 3ml 400mcg/ ml 600mcg/ ml 0.5mg/ml 2.5mg/ml 1ml 1ml 1ml Acetylcysteine 200mg/ml Methylthioninium Chloride PROVEBLUE 5mg/ml Antimuscarinic agent Atropine Sulfate 1mg in 5ml Antimuscarinic agent Atropine Sulfate 3mg in Antimuscarinic agent Atropine Sulfate 600mcg/ ml 5ml Antimuscarinic agent Atropine Sulfate BP 1%w/v eye drop Antimuscarinic agent Atropine Sulfate BP 400mcg/ ml Antimuscarinic agent Atropine Sulfate BP 600mcg/ ml Antimuscarinic agent Atropine Sulfate BP 1mg/ml 1ml Antiseptic BIPP pouch 30g Antiseptic BIPP 1.25 x 100cm gauze Antiseptic BIPP 1.25 x 200cm gauze 1ml 1ml 1ml Therapeutic class Code Product Strength Presentation Pack Size Antiseptic BIPP 1.25 x 300cm gauze Antiseptic BIPP 2.5 x 100cm gauze Antiseptic BIPP 2.5 x 200cm gauze Antiseptic BIPP 2.5 x 300cm gauze Barbiturate Phenobarbitone Sodium BP Barbiturate Phenobarbitone Sodium BP Barbiturate Phenobarbitone Sodium BP Benzodiazepine Midazolam 50mg in 50ml Benzodiazepine Midazolam 100mg in 50ml Benzodiazepine 14891/ Benzodiazepine 14892/ Tapclob Oral Suspension (Clobazam) Tapclob Oral Suspension (Clobazam) CNS Stimulant Dexamfetamine Sulfate 200mg/ml 1ml 30mg/ml 1ml 60mg/ml 1ml 5mg/5ml 10mg/5ml vial vial Oral Suspension Oral Suspension 50ml 50ml 150ml 150ml 1mg/ml Oral Solution 500ml Corticosteroid Vista Methasone TM eye drop Corticosteroid Vista Methasone TM eye drop 5ml replacement replacement replacement replacement replacement/ anticonvulsant replacement/ anticonvulsant replacement/ anticonvulsant replacement/ anticonvulsant replacement/ anticonvulsant Calcium Chloride 10mmol Calcium Chloride 5mmol 5ml Calcium Chloride Intravenous Infusion Potassium Acid Phosphate 100mg in 1ml (10%) Magnesium Sulfate 1g in 2ml (50%) Magnesium Sulfate 5g in (50%) Magnesium Sulfate 4g in 20ml (20%) Magnesium Sulfate 2.5g in 5ml (50%) 10mmol 2ml 20ml 5ml Magnesium Sulfate 10%w/v Glucocorticoid Dexamethasone Sodium Phosphate (Martapan) 2mg/5ml solution 150ml K+ supplement Potassium Chloride 20%w/v Laxative / Lubricant Glycerol BP Adult suppository 4g Laxative / Lubricant Glycerol BP Children's suppository 2g Laxative / Lubricant Glycerol BP Infant suppository 1g Lubricant Carmellose (Melophthal) Lubricant Carmellose (Melophthal) 0.5% UDV eye drop 0.4ml 1% UDV eye drop 0.4ml Lubricant Hypromellose BPC 0.3%w/v eye drop Lubricant Melophthal (Carmellose) Lubricant Melophthal (Carmellose) 0.5% UDV eye drop 0.4ml 1% UDV eye drop 0.4ml Please note: Not all products are licensed or available in all countries. INTERNATIONAL JOB NUMBER: MART/02/ 2017/022 DATE OF PREPARATION: FEB / 06

15 Therapeutic class Code Product Strength Presentation Pack Size Lubricant Simple BP eye ointment Miotic Pilocarpine BP 1%w/v eye drop Miotic Pilocarpine BP 2%w/v eye drop Miotic Pilocarpine BP 4%w/v eye drop Non-selective betablocker Non-selective betablocker Neuromuscular blocking agent 74437/ / Timolol 0.25%w/v eye drop 5ml Timolol 0.5%w/v eye drop 5ml Suxamethonium Chloride 4g 50mg/ml 2ml Opioid analgesic Codeine Phosphate BP 60mg/ml 1ml Opioid analgesic DF118 TM forte 40mg tablet Opioid analgesic Diamorphine 10mg tablet Opioid analgesic Dihydrocodeine Elixir 10mg/5ml liquid 150ml Opioid analgesic Dihydrocodeine Injection BP Opioid analgesic Fentanyl Citrate 100mcg/ 2ml Opioid analgesic Fentanyl Citrate 500mcg/ Opioid analgesic Morphine Oral Solution Opioid analgesic Morphine Oral Solution Opioid analgesic Morphine Oral Solution 50mg/ml 1ml 10mg in 5ml 10mg in 5ml 10mg in 5ml Opioid analgesic Morphine Sulfate 50mg in 50ml Opioid analgesic Morphine Sulfate 100mg in 50ml liquid liquid liquid Opioid analgesic Morphine Sulfate 10mg suppository Opioid analgesic Morphine Sulfate BP 10mg/ml 1ml Opioid analgesic Morphine Sulfate BP 15mg/ml 1ml Opioid analgesic Morphine Sulfate BP 30mg/ml 1ml Opioid analgesic Morphine Sulfate BP 20mg/ml 1ml Opioid analgesic Pethidine BP 50mg tablet Opioid analgesic 77812/ Opioid analgesic 77813/ vial vial 2ml 100ml 300ml 500ml 50ml 50ml Pethidine BP 50mg/ml 2ml Pethidine BP 50mg/ml 1ml Opioid analgesic Pethidine BP 10mg/ml 5ml Opioid analgesic / Addiction Opioid analgesic / Addiction Opioid analgesic / Addiction Opioid analgesic / Addiction Methadone Oral Solution DTF Methadone Oral Solution DTF Methadone Oral Solution Sugar Free Methadone Oral Solution Sugar Free Opioid antagonist Naloxone Hydrochloride Opioid antagonist Prenoxad 1mg/ml injection (Naloxone Hydrochloride) 1mg/ml liquid 500ml 1mg/ml liquid 2.5ltr 1mg/ml liquid 500ml 1mg/ml liquid 2.5ltr 2mg in 2ml 1mg/ml 2ml 2ml Therapeutic class Code Product Strength Presentation Pack Size Opioid partial agonist-antagonist Opioid partial agonist-antagonist Espranor 2mg wafer Espranor 8mg wafer Oral care Dentural - Denture Cleanser Parenteral Parenteral Prostaglandin analogue Respiratory Analeptic Respiratory Analeptic liquid 250ml Sodium Chloride 30% w/v vial 50ml Sodium Chloride BP 30%w/v Latanoprost 0.005% eye drop 2.5ml Caffeine Citrate Solution for Injection Caffeine Citrate Oral Solution 10mg/ml 1ml 10mg/ml bottle 5ml Stimulant laxative Bisacodyl BP 10mg suppository amine amine amine Treatment of glaucoma Treatment of glaucoma Ephedrine Hydrochloride Ephedrine Hydrochloride Ephedrine Hydrochloride Adrenaline (Epinephrine) Adrenaline (Epinephrine) Adrenaline (Epinephrine) Anaphylaxis Adrenaline (Epinephrine) Paediatric 30mg in 30mg in 30mg/ml 1ml 1mg in (1:10,000) 1mg in (1:10,000) 1mg in 1ml (1:1,000) 1mg in 1ml (1:1,000) 1ml 1ml Adrenaline BP 1:10,000 1ml Adrenaline BP 1:10,000 5ml 17082/ / Adrenaline BP 1:10,000 Adrenaline BP 1:1000 5ml Adrenaline BP 1: ml 17002/ Adrenaline BP 1:1000 1ml Dorzolamide/Timolol 20mg/ml + 5mg/ml Latanoprost/Timolol 50mcg/ml + 5mg/ml eye drop eye drop 5ml 2.5ml Urinary Alkaliniser Sodium Citrate 0.3M liquid 30ml Adverse events should be reported. Reporting forms and information can be found at Adverse events should also be reported to Martindale Pharma. Tel: Fax: drugsafety@martindalepharma.co.uk Please note: Not all products are licensed or available in all countries. Building A2, Glory Park Glory Park Avenue, Wooburn Green High Wycombe. HP10 0DF United Kingdom t +44 (0) f +44 (0) e connect@martindalepharma.co.uk w martindalepharma.co.uk

16 Building A2, Glory Park Glory Park Avenue Wooburn Green High Wycombe HP10 0DF United Kingdom t +44 (0) f +44 (0) e connect@martindalepharma.co.uk w martindalepharma.co.uk Adverse events should be reported. Reporting forms and information can be found at Adverse events should also be reported to Martindale Pharma Tel: Fax: drugsafety@martindalepharma.co.uk MART/02/ 2017/022 DATE OF PREPARATION: FEB 2017