Proper Medication Disposal.
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1 Proper Medication Disposal Leah Ann Lamb Assistant Director, Division of Water Quality Utah Department of Environmental Quality Overview Pharmaceuticals and Personal Care Products (PPCPs) are pollutants, we find them in low concentrations in our waterways. But their effect on the environment and human health is unknown, thus we are not regulating them. 1
2 Overview In addition to environmental concerns there are HUGE social issues to consider: Drug Sales Have Skyrocketed Low compliance = high accumulations Lots of unused drugs in people s homes Most home poisonings involve pharmaceuticals Pharms at Home Increase Drug Abuse Leftovers are routinely flushed Overview 2
3 Pharmaceuticals and Personal Care Products (PPCPs) as Pollutants PPCPs refers to: Products used by individuals for personal health or cosmetic reasons Products used by agribusiness to enhance growth or health of livestock. Pharmaceuticals and Personal Care Products as Pollutants PPCPs comprise a diverse collection of thousands of chemical substances including: Prescription and over-the counter drugs Veterinary drugs Fragrances Cosmetics Sun-screen products Diagnostic agents Nutraceuticals (e.g., vitamins) 3
4 PPCPs Enter The Environment Through Use and Disposal PPCPs have probably been present in the environment for as long as humans have been using them. Individuals add PPCPs to the environment through: Excretion Bathing Disposal of medications to sewers and trash. Unused/unwanted quantities as much as 50% of many prescriptions - 80% for antibiotics Common/historical recommendation was to flush; crush & flush is still widely practiced method Pharmaceuticals and Personal Care Products as Pollutants The drugs that we take may be excreted in a biologically active form into wastewater and ultimately released into lakes and rivers. Advances in technology have improved our ability to detect and quantify these chemicals. Their effect on the environment is now recognized as an important area of research. 4
5 PPCPs Are Present in Our Nation s Waterbodies National Stream Reconnaissance: U.S. Geological Survey (USGS), This study was the first national-scale examination of emerging contaminants in streams of the United States. Water samples were collected from a network of 139 streams across 30 states during 1999 and The sampling sites focused towards streams considered to be susceptible to contamination. Thus, the results of this study are not considered representative of all streams. PPCPs Are Present in Our Nation s Waterbodies RESULTS: One or more chemicals were detected in 80 percent of the streams sampled, and 82 of the 95 chemicals were detected at least once. Generally, these chemicals were found at very low concentrations (in most cases, less than 1 part per billion). Mixtures of the chemicals were common: 75 percent of the streams had more than one 50 percent had 7 or more 34 percent had 10 or more. 5
6 PPCPs Are Present in Our Nation s Waterbodies RESULTS: The most frequently detected chemicals (found in more than half of the streams) were: Coprostanol (fecal steroid) Cholesterol (plant and animal steroid) N-N-diethyltoluamide (insect repellent) Caffeine (stimulant) Triclosan (antimicrobial disinfectant) Tri (2-chloroethyl) phosphate (fire retardant) 4-nonylphenol (nonionic detergent metabolite). Steroids, nonprescription drugs, and insect repellent were the chemical groups most frequently detected. Detergent metabolites, steroids, and plasticizers generally were measured at the highest concentrations. PPCPs Are Present in Our Nation s Waterbodies Human and environmental effects: Knowledge of the potential human and environmental health effects of these 95 chemicals is highly varied. Drinking-water standards or other human or ecological health criteria have been established for 14. Measured concentrations rarely exceeded any of the standards or criteria. Thirty-three are known or suspected to be hormonally active. 46 are pharmaceutically active. Little is known about the potential health effects to humans or aquatic organisms exposed to the low levels of most of these chemicals or the mixtures commonly found in this study. 6
7 Some Pharmaceuticals are Endocrine Disrupting Chemicals* A group of chemicals, known as endocrine disruptor chemicals (EDCs), has been identified as having the potential to cause adverse health effects in humans and wildlife. Among this group DDT, PCBs, endosulfan, methoxychlor, diethylphthalate, diethylhexylphthalate, and bisphenol A may occur in drinking water. PPCPs May Cause Ecological Harm* Further research: Antibiotics, hormones, SSRIs are receiving the most attention. Boulder Creek, CO, study: 50:50 female:male ratio upstream, 90:10 downstream; ethynylestradiol measurably higher downstream. Male fish are producing eggs in the Potomac River. Bioassays of SSRIs are showing some sub-lethal effects at environmentally relevant levels Italian study found that a mixture of common drugs at very low (ng/l-environmentally-relevant) concentrations inhibited the growth of human embryonic cells 7
8 More Issues To Consider Too Many Pharmaceuticals Go Unused* PhRMA uses an estimate of 3% of all meds go unused Recent British survey showed: 82% of antibiotics go unused 50% of antidepressants 50% of beta-blockers 20% of pain meds Compliance/adherence rates for some medications are under 20% Patient t compliance goes down as # of medications goes up: polypharmacy Medicare Part D now requires 30-day supply billings, regardless of need and without ability to refund unused expenses (or to return unused product) Too Many Pharmaceuticals Go Unused* Rampant non-compliance and poor adherence to medication regimens, coupled with medication errors, present a significant health care issue, especially for the elderly Accumulations of unused meds have become a national burden, both in health care cost and in potential for diversion and abuse Hospice nurses, nursing homes and medical examiners are faced with large accumulations of medicines, including potent controlled substances, when patients die Catch 22 for handling the leftovers no easy, safe, legal or environmentally acceptable answers 8
9 Drug Sales Have Skyrocketed* U.S. sales have more than doubled in last 5 yrs (Ref: National Drug Intelligence Center, 2005, via Ilene Ruhoy, 2006) Drug Sales Have Skyrocketed* Between 1992 and 2002: U.S. population grew 13% # non-controlled prescriptions increased 57% # controlled drug prescriptions increased 154% (ref: CASA, via Irene Ruhoy, 2006) Thi i d d il bilit i k t th This increased use and availability is one key to the current concerns over what to do with the left-overs. 9
10 Most Poisonings Involve Pharmaceuticals Of all calls to U.S. poison control centers in 2004: 2,438,644 total exposures reported 1,389,156 (57%) were pharmaceutical exposures 581,488 (42%) of the pharm exposures were to children under 6 years of age Poisonings Unintentional ti injuries i were 5th leading cause of death overall in the U.S. and the leading cause for those under age 45. (Does not include suicides or homicides) Of all unintentional injuries that resulted in death, poisonings accounted for 16.4% Of all poisonings, 93.4% were drug-relatedrelated 10
11 Unintentional Deaths In 2007, more Utahns died from unintentional prescription pain medication overdoses than in motor vehicle crashes, making it the number one cause of injury death in Utah. Unintentional Deaths A study of deaths between 1999 and 2004 shows that 47 percent of those deaths due to non-illicit drug overdoses had an active prescription for the opioid drug that was determined to be their cause of death. Seventy five percent had a valid prescription for that drug in the past year (365 days). Only 15 percent of deaths had no record of a prescription being filled for the opioid found in their system at the time of death. The average age of deaths, which had a valid prescription at time of death, is 41 years old, with the largest age grouping For deaths where no active prescription was found, the average age is 39.6, with the largest age group at
12 Pharms at Home Increase Drug Abuse* Between 1992 and 2003: U.S. population grew 14% # of teens (12 to 17 yrs of age) who abused controlled prescription drugs jumped 212% # of adults (18 and older) abusing such drugs climbed 81% # of all Americans who abuse controlled prescription drugs nearly doubled, from 7.8 million to 15.1 million Pharms at Home Increase Drug Abuse The # (15 1 million) of controlled The # (15.1 million) of controlled prescription drug abusers exceeds the combined # of Schedule I (illegal) drug abusers: Cocaine = 5.9 million Hallucinogens = 4.0 million Inhalants = 2.1 million Heroin = 0.3 million 12
13 Pharms at Home Increase Drug Abuse Pharming is latest craze among teens Generation Rx One in five teens says he or she has been offered prescription drugs to get high In 2003, 15% of all American teens abused or were addicted to controlled drugs Summary of the Problem* Lots of unused drugs in people s homes Low compliance = high h accumulations Poisoning and abuse concerns Leftovers are routinely flushed Pharms are showing up in the environment No safe, legal, environmentally-acceptable options 13
14 Resource Conservation and Recovery Act (RCRA) The Resource Conservation and Recovery Act (RCRA) is a federal law controlling the management and disposal of solid and hazardous wastes produced by a wide variety of industries and sources. The RCRA program regulates the management and disposal of hazardous pharmaceutical wastes produced by pharmaceutical manufacturers and the health care industry. Under RCRA, a waste is a hazardous waste if it is specifically listed by the EPA or if it exhibits one or more of the following four characteristics: ignitability, corrosivity, reactivity and toxicity. RCRA does not regulate any household waste, which includes medications/pharmaceutical waste generated in a household. CONTROLLED SUBSTANCE ACT* Schedule I illegal drugs (ex., heroin, LSD) Schedule II morphine, OxyContin, codeine, Demerol, Ritalin, amphetamines Schedule III Tylenol with codeine, Vicodin Schedule IV benzodiazepines, Valium, Darvon Schedule V codeine cough syrups 14
15 What Should I do with my Unused Medications? DO NOT FLUSH! DO NOT POUR! What Should I do with my Unused Medications? DO NOT FLUSH! DO NOT POUR! DISPOSAL GUIDELINES: First, check with your police department to see if they have a drug collection program. Both the Salt Lake City Police Department and the Salt Lake County Sherriff s Office each have established a proper disposal program, go to: for locations 15
16 What Should I do with my Unused Medications? DO NOT FLUSH! DO NOT POUR! DISPOSAL GUIDELINES: Second, check to see if your community household hazardous waste program collects medications (they must have law enforcement officials present). We try to list sites at What Should I do with my Unused Medications? DO NOT FLUSH! DO NOT POUR! DISPOSAL GUIDELINES: Lastly, if no collection options exist, follow these steps: Remove all personal identification from prescription bottles; Mix all unused drugs with coffee grounds, kitty litter, or another undesirable substance, and/or Place this mixture in a sealed container before disposing in the trash, on the day of pick-up. 16
17 Proper Disposal Pilot Currently in Utah, there are two types of formal residential collection options for unused medications: At law enforcement agencies, or At household hazardous waste collection events (which must have law enforcement present). FUNDING Grants are available to Law Enforcement Agencies to Establish a Drug Collection for Proper Disposal Program The Department of Environmental Quality is offering law enforcement agencies a one-time grant, up to $1,000, to establish a Drug Collection for Proper Disposal program. This funding can be used to pay for: collection boxes, signage, evidence handling, incineration, advertising or associated expenses. 17
18 FUNDING Requirements to secure this funding include: Establishment of a Drug Collection for Proper Disposal policy which uses evidence handling protocols with final destruction of the collected drugs through incineration at an approved hazardous waste disposal facility; DEA letter of approval Placement of clearly marked, secured and locked collection bins in an accessible areas which are monitored by the agency; FUNDING Requirements to secure this funding include: Residents will not be required to provide personal information or pay for disposal service; Reporting to DEQ of the pounds of medications collected; Advertising of the program through normal communications with the pubic. 18
19 DAVIS COUNTY LAYTON CITY LOCATIONS SALT LAKE COUNTY SALT LAKE CITY Both Police Stations 1040 West 700 South 315 East 200 South LOCATIONS SALT LAKE COUNTY SHERIFF S OFFICE COTTONWOOD HEIGHTS HERRIMAN HOLLADAY KEARNS MAGNA MILLCREEK 19
20 SUMMIT COUNTY LOCATIONS Park City Police Department Summit County Sheriff s Office TOOELE COUNTY TOOELE STANSBURY PARK WENDOVER GRANTSVILLE UINTAH COUNTY VERNAL UTAH COUNTY SALEM CITY SANTAQUIN/GENOLA LOCATIONS UTAH COUNTY SHRIFF S S OFFICE TWO LOCATIONS EVIDENCE BUILDING EAGLE MOUNTAIN SUBSTATION 20
21 LOCATIONS WASHINGTON COUNTY HURRICANE Other inquires but no grant applications: Woods Cross City Logan City Emery County Sheriff s Office Sandy City Heber City Wasatch County Sheriff s Office Salina City Mapleton City 21
22 PROPER DISPOSAL OF PHARMACEUTICALS WORK GROUP Salt Lake City Public Utilities: Florence Reynolds, Water Quality and Treatment Administrator Salt S Lake City Police Department: t Jim Hill, Manager Police - Crime Lab/Ruthanne Ogletree, Evidence Board of Pharmacy: Roger B. Fitzpatrick, Chairperson DOPL: Noel Taxin, Manager DEA: Lynettte Wingert, Investigator Salt Lake Valley Health Department: Dorothy Adams, Manager Household Hazardous Waste Disposal Utah Department of Health: Iona M. Thraen, Patient Safety Director Health Systems Improvement Utah Poison Control Center /University of Utah College of Pharmacy Barbara Insley Crouch, PharmD, MSPH Director, Utah Poison Control Center Utah Department of Environmental Quality: Leah Ann Lamb, Assistant Director Utah Division of Water Quality 22
23 PROPER DISPOSAL OF PHARMACEUTICALS WORK GROUP Web Site Proper Medication Disposal: Other resources: Product Stewardship Institute: Teleosis Institute: Green Health Pharmacy Program: Sources of Information Contained in this Presentation References: Pharmaceuticals and Personal Care Products as Pollutants (PPCPs), EPA Web Site: * Information in slides with an * was used with permission from Dave Galvin with the Local Hazardous Waste Management Program in King County, Washington and was taken from a presentation he gave to the Product Stewardship Institute. 23
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