Responding to the Prescription Opioid and Heroin Crisis: An Epidemic of Addiction
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1 Responding to the Prescription Opioid and Heroin Crisis: An Epidemic of Addiction Andrew Kolodny, MD Co-Director, Opioid Policy Research Collaborative Institute for Behavioral Health Schneider Institutes for Health Policy Heller School for Social Policy and Management Brandeis University
2 Conflict of Interests I have no relevant financial relationships to disclose. 2
3 Opium 3
4 Death rate per 100,000 Unintentional Drug Overdose Deaths United States, ,404 drug overdose deaths in Heroin Cocaine 0 '70 '72 '74 '76 '78 '80 '82 '84 '86 '88 '90 '92 '94 '96 '98 '00 '02 '04 '06 Year National Vital Statistics System,
5 Death rate per 100,000 Unintentional Drug Overdose Deaths United States, ,404 drug overdose deaths in Heroin Cocaine 0 '70 '72 '74 '76 '78 '80 '82 '84 '86 '88 '90 '92 '94 '96 '98 '00 '02 '04 '06 Year National Vital Statistics System,
6 Death rate per 100,000 Unintentional Drug Overdose Deaths United States, ,404 drug overdose deaths in Heroin Cocaine 0 '70 '72 '74 '76 '78 '80 '82 '84 '86 '88 '90 '92 '94 '96 '98 '00 '02 '04 '06 Year National Vital Statistics System,
7 Death rate per 100,000 Unintentional Drug Overdose Deaths United States, ,404 drug overdose deaths in Heroin Cocaine 0 '70 '72 '74 '76 '78 '80 '82 '84 '86 '88 '90 '92 '94 '96 '98 '00 '02 '04 '06 Year National Vital Statistics System,
8 Death rate per 100,000 Unintentional Drug Overdose Deaths United States, ,404 drug overdose deaths in Heroin Cocaine 0 '70 '72 '74 '76 '78 '80 '82 '84 '86 '88 '90 '92 '94 '96 '98 '00 '02 '04 '06 Year National Vital Statistics System,
9 Death rate per 100,000 Unintentional Drug Overdose Deaths United States, ,404 drug overdose deaths in Heroin Cocaine 0 '70 '72 '74 '76 '78 '80 '82 '84 '86 '88 '90 '92 '94 '96 '98 '00 '02 '04 '06 Year National Vital Statistics System,
10 Death rate per 100,000 Unintentional Drug Overdose Deaths United States, ,404 drug overdose deaths in Heroin Cocaine 0 '70 '72 '74 '76 '78 '80 '82 '84 '86 '88 '90 '92 '94 '96 '98 '00 '02 '04 '06 Year National Vital Statistics System,
11 Death rate per 100,000 Unintentional Drug Overdose Deaths United States, ,404 drug overdose deaths in Heroin Cocaine 0 '70 '72 '74 '76 '78 '80 '82 '84 '86 '88 '90 '92 '94 '96 '98 '00 '02 '04 '06 Year National Vital Statistics System,
12 Death rate per 100,000 Unintentional Drug Overdose Deaths United States, ,404 drug overdose deaths in Heroin Cocaine 0 '70 '72 '74 '76 '78 '80 '82 '84 '86 '88 '90 '92 '94 '96 '98 '00 '02 '04 '06 Year National Vital Statistics System,
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14 Heroin treatment admissions : SOURCE: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration, Treatment Episode Data Set (TEDS). Data received through
15 Death rates from overdoses of heroin or prescription opioid pain relievers (OPRs), by age group SOURCE: CDC. Increases in Heroin Overdose Deaths 28 States, 2010 to 2012 MMWR. 2014, 63:
16 Primary non-heroin opiates/synthetics admission rates, by State (per 100,000 population aged 12 and over) 16
17 Primary non-heroin opiates/synthetics admission rates, by State (per 100,000 population aged 12 and over) 17
18 Primary non-heroin opiates/synthetics admission rates, by State (per 100,000 population aged 12 and over) 18
19 Primary non-heroin opiates/synthetics admission rates, by State (per 100,000 population aged 12 and over) 19
20 Primary non-heroin opiates/synthetics admission rates, by State (per 100,000 population aged 12 and over) 20
21 Primary non-heroin opiates/synthetics admission rates, by State (per 100,000 population aged 12 and over) 21
22 Unintentional overdose deaths involving opioid analgesics parallel per capita sales of opioid analgesics in morphine equivalents by year, U.S., Number of Deaths '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 * Opioid sales (mg/person) Source: National Vital Statistics System, multiple cause of death dataset, and DEA ARCOS * 2007 opioid sales figure is preliminary.
23 Rate 8 Rates of Opioid Sales, OD Deaths, and Treatment, Opioid Sales KG/10,000 Opioid Deaths/100,000 Opioid Treatment Admissions/10, Year CDC. MMWR 2011
24 Opioid prescribing in the U.S. peaked ~ 2011 Prescribing has declined slightly since 2011 Prescribing levels in 2015 were 3 times higher than 1999 Source: Guy GP Jr., Zhang K, Bohm MK, et al. Vital Signs: Changes in Opioid Prescribing in the United States, MMWR Morb Mortal Wkly Rep 2017;66:
25 Opioid Prescribing by Morphine Mg Equivalents by County 2015 Source: MMWR / July 7, 2017 / Vol. 66 / No. 26 US Department of Health and Human Services/Centers for Disease Control and Prevention
26 Estimated Age-adjusted Death Rates for Drug Poisoning by County, United States: 2015 Source: Rossen LM, Bastian B, Warner M, Khan D, and Chong Y. Drug poisoning mortality: United States, National Center for Health Statistics
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28 28
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30 Dollars Spent Marketing OxyContin ( ) Source: United States General Accounting Office: Dec. 2003, OxyContin Abuse and Diversion and Efforts to Address the Problem.
31 Industry-funded educational messages Physicians are needlessly allowing patients to suffer because of opiophobia. Opioid addiction is rare in pain patients. Opioids can be easily discontinued. Opioids are safe and effective for chronic pain. 31
32 Industry-funded organizations campaigned for greater use of opioids Pain Patient Groups Professional Societies The Joint Commission The Federation of State Medical Boards 32
33 The risk of addiction is much less than 1% Porter J, Jick H. Addiction rare in patients treated with narcotics. N Engl J Med Jan 10;302(2):123 Cited 824 times (Google Scholar) 33
34 N Engl J Med Jan 10;302(2):
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38 CDC Opioid Guideline (2016) Nonpharmacologic therapy and nonopioid pharmacologic therapy are preferred for chronic pain.
39 CDC Opioid Guideline (2016) Developed without input from experts with ties to opioid makers Rejected use of so-called risk assessment tools Defined > 50mg ME as high dose and > 90mg ME to be avoided. For acute pain: Three days or less will often be sufficient.
40 VA/DOD Guideline (2017) We recommend against initiation of long-term opioid therapy for chronic pain Risks for overdose and death significantly increase at a range of mg morphine equivalent daily dose We recommend against opioid doses over 90 mg morphine equivalent daily dose for treating chronic pain
41 Controlling the epidemic: A Three-pronged Approach Prevent new cases of opioid addiction. Treat people who are already addicted. Reduce supply from pill mills and the blackmarket. 41
42 How the opioid lobby frames the problem: Source: Slide presented by Dr. Lynn Webster at FDA meeting on hydrocodone upscheduling, Jan 25 th, 2013.
43 This is a false dichotomy Opioid harms are not limited to so-called drug abusers 35% met DSM V criteria for an opioid use disorder 1 Pain Patients Drug Abusers 92% of opioid OD decedents were prescribed opioids for chronic pain Boscarino JA, Rukstalis MR, Hoffman SN, et al. Prevalence of prescription opioid-use disorder among chronic pain patients: comparison of the DSM-5 vs. DSM-4 diagnostic criteria. J Addict Dis. 2011;30: Johnson EM, Lanier WA, Merrill RM, et al. Unintentional Prescription Opioid-Related Overdose Deaths: Description of Decedents by Next of Kin or Best Contact, Utah, J Gen Intern Med Oct 16.
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45 Buprenorphine Experience in France Introduced in the mid 90s 79% decline in OD deaths in 6 years Use of mono product (not formulated with naloxone) associated with diversion and injection use Source: Auriacombe et al. French field experience with buprenorphine. Am J Addict. 2004
46 Summary The U.S. is in the midst of a severe epidemic of opioid addiction To bring the epidemic to an end: We must prevent new cases of opioid addiction We must ensure access to treatment for people already addicted
47 Andrew Kolodny, M.D., Co-Director Peter Kreiner, Ph.D., Co-Director Contact Us: 47
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