Committee on National Alcohol Policy and Action 6th Meeting January Alcohol and Cancer. Dirk W. Lachenmeier
|
|
- Dayna Todd
- 5 years ago
- Views:
Transcription
1 Committee on National Alcohol Policy and Action 6th Meeting January 2010 Alcohol and Cancer Dirk W. Lachenmeier Chemisches und Veterinär- Untersuchungsamt Karlsruhe
2 Overview Summary of alcohol-related evaluations of the WHO International Agency for Research on Cancer (IARC) Mechanism for alcohol-associated carcinogenicity Quantitative data on alcohol-attributable cancer risk Policy implications
3 Alcohol-related evaluations of the WHO International Agency for Research on Cancer (IARC)
4 IARC Monographs Evaluation Process Cancer in humans Sufficient evidence Limited evidence Inadequate evidence Evidence suggesting lack of carcinogenicity Cancer in experimental animals Sufficient evidence Limited evidence Inadequate evidence Evidence suggesting lack of carcinogenicity Mechanistic and other relevant data Mechanistic data weak, moderate, or strong? Mechanism likely to be operative in humans? Overall evaluation Group 1 Group 2A Group 2B Group 3 Group 4 Carcinogenic to humans Probably carcinogenic to humans Possibly carcinogenic to humans Not classifiable as to its carcinogenicity to humans Probably not carcinogenic to humans
5 IARC Evaluations Cancer in humans Sufficient Limited Inadequate Sufficient Cancer in experimental animals Limited Inadequate Group 1 Group 1 Group 1 Group 2A Group 2B Group 2B Group 2B Group 3 Group 3 Group 1 Carcinogenic to humans 1: Ethanol, Acetaldehyde, Benzene Group 2A Probably carcinogenic to humans Group 2B Possibly carcinogenic to humans 2A: Acrylamide, Ethyl carbamate 2B: Ochratoxin, Pb, Furan Group 3 Not classifiable 3: Patulin, Nivalenol Group 4 Probably not carcinogenic to humans
6 Timeline of Alcohol-Related IARC Evaluations 1987 (Suppl. 7) 1988 (Vol. 44) 1999 (Vol. 71) 2007 (Vol. 96) 2009 (Vol. 100) Alcoholic beverages Group 1 Sites: oral cavity, pharynx, larynx, oesophagus and liver Group 1 Plus: colo-rectum and female breast Group 1 Plus: Pancreas (limited evidence) Ethanol in alcoholic bevereages (no evaluation, mechanism unclear) Group 1 Group 1 Acetaldehyde associated with alcohol consumption Group 2B (general evaluation) Group 2B (general evaluation) Group 1 Sites: Oesophagus, head and neck Ethyl carbamate (common contaminant in alcohol) Group 2B Group 2A
7 Summary of IARC evaluation There is sufficient evidence in humans for the carcinogenicity of alcoholic beverages. The occurence of malignant tumours of the oral cavity, pharynx, larynx, oesophagus, liver, female breast and colorectum is causally related to the consumption of alcoholic beverages. There is evidence suggesting lack of carcinogenicity in humans for alcoholic beverages and cancer of kidney and non-hodgkin lymphoma. Limited evidence for pancreas. There is substantial mechanistic evidence in humans with aldehyde dehydrogenase deficiency that acetaldehyde derived from the metabolism of ethanol in alcoholic beverages contributes to the causation of malignant oesophageal tumours. There is sufficient evidence in experimental animals for the carcinogenicity of ethanol. There is sufficient evidence in experimental animals for the carcinogenicity of acetaldehyde. Overall evaluation: Alcoholic beverages are carcinogenic to humans (Group 1). Ethanol in alcoholic beverages is carcinogenic to humans (Group 1). Acetaldehyde associated with alcohol consumption is carcinogenic to humans (Group 1).
8 Mechanism for alcohol-associated carcinogenicity
9 Two mechanisms for alcoholrelated carcinogenesis Ethanol Alcoholic beverages Acetaldehyde Alcohol dehydrogenase (ADH) DNA-Adducts Directly contained acetaldehyde and ethyl carbamate 1. Major mechanism: Ethanol and acetaldehyde from metabolism CANCER 2. Minor mechanism: Additive risk from carcinogens directly contained in the beverages
10 Ethanol metabolism and carcinogenesis Seitz&Stickel, Nat. Rev. Cancer 2007, 7, 599
11 Mechanisms of acetaldehyde-related carcinogenesis - DNA Adducts - Interstrand Crosslinks - DNA-Protein Crosslinks - Sister Chromatid Exchanges Seitz&Stickel, Nat. Rev. Cancer 2007, 7, 599
12 Mechanism of carcinogenesis caused by ethanol, acetaldehyde and ethyl carbamate Ethyl carbamate VC- Epoxid Seitz&Stickel, Nat. Rev. Cancer 2007, 7, 599
13 Dose-Response for Breast Cancer Relative Risk Worldwide evaluation: women with breast cancer and controls Usual linear risk relationship between average volume of alcohol consumption and cancer risk Source: Hamajima et al. (2002) BJC 87, 1234 Alcohol consumption [g/day] (number of drinks)
14 What happens to people, if alcohol consumption is stopped or reduced? Meta-analysis of epidemiological literature by Rehm et al. (Int J Cancer 121, , 2007) 13 epidemiological studies including over 5,000 cases indentified about the effects of drinking cessation on the risk for head and neck and oesophagus cancers. Stopping drinking indeed reduced the cancer risks but it took years, before the risks were as low as for lifetime abstainers.
15 Effect of drinking cessation on oesophageal cancer risk by duration Risk of oesophageal cancer significantly increased within the first 2 years following cessation and was 2.5 times higher than that of current drinkers. Following this, the risk started decreasing rapidly and reached the risk of never drinkers after more than 15 years of abstention. In total 63% of risk reduction was observed after 15 years of quitting drinking compared to current drinkers. Rehm et al. Int J Cancer 121, (2007)
16 Quantitative data on alcoholattributable cancer
17 Alcohol- attributable Mortality DEATH Disease Category EUR A M W T M% W% Maternal and perinatal conditions (low birth weight) ,0% 0,1% Cancer ,0% 41,4% Diabetes mellitus ,0% 0,0% Neuropsychiatric disorders ,2% 7,3% Cardiovascular diseases ,5% 9,5% Cirrhosis of the liver ,6% 21,7% Unintentional injuries ,8% 16,2% Intentional injuries ,8% 3,7% Total 'detrimental effects' attributable to alcohol ,0% 100,0% Diabetes mellitus ,2% 3,2% Cardiovascular diseases ,8% 96,8% Total 'beneficial effects' attributable to alcohol ,0% 100,0% All alcohol-attributable net death All deaths Percentage of all net deaths attributable to alcohol 3,5% -2,3% 0,6% Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., Patra, J. (2009): Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet 373: WHO. (2009): Global Health Risks. Mortality and burden of disease attributable to selected major risks. Geneva, Switzerland: WHO.
18 Net-effect of alcohol From: Alkohol in Europa,
19 Alcohol- attributable DALYs DALY Disease Category EUR A M W T M% W% Maternal and perinatal conditions (low birth weight) ,1% 0,2% Cancer ,0% 23,4% Diabetes mellitus ,0% 0,0% Neuropsychiatric disorders ,8% 39,8% Cardiovascular diseases ,5% 2,2% Cirrhosis of the liver ,1% 18,9% Unintentional injuries ,6% 11,4% Intentional injuries ,0% 4,1% Total 'detrimental effects' attributable to alcohol ,0% 100,0% Diabetes mellitus ,3% 9,8% Cardiovascular diseases ,7% 90,2% Total 'beneficial effects' attributable to alcohol ,0% 100,0% All alcohol-attributable net DALY All DALYs Percentage of all net DALYs attributable to alcohol 10,0% 2,4% 6,4% Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., Patra, J. (2009): Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet 373: WHO. (2009): Global Health Risks. Mortality and burden of disease attributable to selected major risks. Geneva, Switzerland: WHO.
20 Policy implications
21 Policy implications to reduce alcohol-related cancers Ethanol Alcoholic beverages Acetaldehyde Alcohol dehydrogenase (ADH) DNA-Adducts Directly contained Acetaldehyde and ethyl carbamate 1. Major mechanism (ethanol): General policy measures to reduce alcohol consumption CANCER 2. Minor mechanism: Improve alcohol quality, introduce maximum limits for contaminants into EU law
22 What about unrecorded alcohol? Unrecorded is an overview category for any kind of alcohol that is not taxed as beverage alcohol or registered in the jurisdiction where it is consumed Estimation for 2002: 30% of global alcohol is unrecorded (in EU generally lower, but with a gradient being highest in the Baltic countries) The FP7 AMPHORA project currently tests unrecorded alcohol for quality including carcinogenic contaminants First result: High concentrations of ethyl carbamate in certain unrecorded fruit spirits in Hungary, Poland & Romania (but also in legal fruit spirits; ethyl carbamate in alcohol is seen as health risk by JECFA/EFSA) Special policy measures required for unrecorded alcohol
23 Warning Labels?
24 Conclusions Alcoholic beverages are carcinogenic to humans (IARC Group 1). Linear dose-response relationship between volume of alcohol consumption and cancer risk No clear-cut threshold for drinking without cancer risk The development of cancer lags behind for 2-15 years, even after cessation of drinking Research is needed about the contribution of the different mechanisms (ethanol, acetaldehyde, ethyl carbamate) to cancer risk Contamination of alcoholic beverages with carcinogens is avoidable and should be subjected to improved regulatory control (EU-wide maximum limits needed) Policy measures should also include unrecorded alcohol, which might be especially prone to contamination with carcinogens
25 Thanks for your attention Chemisches und Veterinär- Untersuchungsamt Karlsruhe Thanks to: Robert Baan, IARC, for slides on IARC evaluation process Jürgen Rehm, CAMH, Toronto, for quantitative data on cancer burden and slides about drinking cessation
26 This paper was produced for a meeting organized by Health & Consumers DG and represents the views of its author on the subject. These views have not been adopted or in any way approved by the Commission and should not be relied upon as a statement of the Commission's or Health & Consumers DG's views. The European Commission does not guarantee the accuracy of the data included in this paper, nor does it accept responsibility for any use made thereof.
Alcohol and cancer. Peter Anderson MD, MPH, PhD
Alcohol and cancer Peter Anderson MD, MPH, PhD Professor, Substance Use, Policy and Practice, Institute of Health and Society, Newcastle University, England Professor, Alcohol and Health, Faculty of Health,
More informationJürgen Rehm 1,2,3, Robert Mann 1,2 & Jayadeep Patra 1 1 Centre for Addiction and Mental Health, Toronto, Canada 2 Dalla Lana School of Public Health,
Jürgen Rehm,2,3, Robert Mann,2 & Jayadeep Patra Centre for Addiction and Mental Health, Toronto, Canada 2 Dalla Lana School of Public Health, University of Toronto, Canada 3 TU Dresden, Germany Based on
More informationwhat s new? CONFERENCE ALCOHOL AND HEALTH Amsterdam, 23 September 2010
CONFERENCE ALCOHOL AND HEALTH Amsterdam, 23 September 2010 Alcohol drinking and cancer risk: what s new? Dr Paule LATINO-MARTEL UMR U 557 Inserm, U 1125 Inra, Cnam, Université Paris 13; CRNH-IdF, France
More informationAlcohol and Cancer: Defining the Exposure and Key Milestones in Establishing the Relationship
Alcohol and Cancer: Defining the Exposure and Key Milestones in Establishing the Relationship Susan M. Gapstur, PhD, MPH Vice President, Epidemiology American Cancer Society 1 Disclosure Information SUSAN
More informationUpdate on alcohol and cancer epidemiology Is the evidence getting clearer? Dr. Isabelle Romieu
Update on alcohol and cancer epidemiology Is the evidence getting clearer? Dr. Isabelle Romieu Key Facts Alcohol is the world s third largest risk factor for disease burden More than 1.9 billion adults
More informationThe burden caused by alcohol
The burden caused by alcohol Presentation at REDUCING THE HARM CAUSED BY ALCOHOL: A COORDINATED EUROPEAN RESPONSE Tuesday, November 13 Jürgen Rehm Centre for Addiction and Mental Health, Toronto, Canada
More informationAlcoholic beverages no ordinary food commodities
Alcoholic beverages no ordinary food commodities V. Poznyak, MD, PhD Coordinator, Management of Substance Abuse Department of Mental Health and Substance Abuse Codex Committee on Food Labelling 17 October
More informationTHE abuse of alcohol is the leading risk factor for disability and premature death in the world.
THE abuse of alcohol is the leading risk factor for disability and premature death in the world. Besides tobacco an other harmful agents, alcohol is the most common cause of many illnesses in our midst,
More informationGlobal Survey on Alcohol and Health. and. Global Information System on Alcohol and Health
Global Survey on Alcohol and Health and Global Information System on Alcohol and Health Management of Substance Abuse www.who.int/substance_abuse/ WHO Department of Mental Health and Substance Abuse The
More informationInternational Agency for Research on Cancer Lyon, France
Global Burden of Cancer in Attributable to Alcohol Consumption International Agency for Research on Cancer Lyon, France Kevin D Shield (Shieldk@fellow.iarc.fr), Pietro Ferrari, Jacques Ferlay, Freddie
More informationALCOHOL S BURDEN (with special attention to Africa and the NCDs)
ALCOHOL S BURDEN (with special attention to Africa and the NCDs) Isidore S. Obot, PhD, MPH Professor of Psychology, University of Uyo Director, Centre for Research and Information on Substance Abuse (CRISA),
More informationAlcohol consumption and non-communicable diseases: epidemiology and
Alcohol consumption and non-communicable diseases: epidemiology and policy implications Charles Parry 1,2, Jayadeep Patra 3,4 & Jürgen Rehm 3-6 Alcohol & Drug Abuse Research Unit, Medical Research Council,
More informationA L C O H O L A N D H E A LT H ALCOHOL AND CANCER RISK
TABLE OF CONTENTS Preface 1 Introduction 2 Alcohol use and relative cancer risk 3 How alcohol acts on the body to affect cancer risk 6 Risk factors affecting the association between alcohol and cancer
More informationHarmful Use of Alcohol A Global Public Health Perspective
GLOBAL ALCOHOL POLICY CONFERENCE COEX Congress Centre, Seoul, Republic of Korea, 7 October 2013 Harmful Use of Alcohol A Global Public Health Perspective Mr Dag Rekve Department of Mental Health and Substance
More informationThe Global Burden of Alcohol Misuse: New Epidemiological Data
The Global Burden of Alcohol Misuse: New Epidemiological Data Jürgen Rehm (1) & Robin Room (2) (1) Centre for Addiction and Mental Health, Toronto, Canada University of Toronto WHO Collaborating Centre
More informationA global strategy to reduce the harmful use of alcohol
A global strategy to reduce the harmful use of alcohol Endorsed by the World Health Assembly in May 2010 Global strategy to reduce the harmful use of alcohol Developed through a long and intense collaboration
More informationBasis. Many peerreviewed. publications on details in the last three years
Mortality and burden of disease due to alcohol in Europe and in the Netherlands Ziekte en sterfte als gevolg van alcoholgebruik in Europa en in Nederland J. Rehm Social and Epidemiological Research (SER)
More informationAlcohol and cancer March 2013
Alcohol and cancer March 2013 Contents Introduction 1 The relationship between alcohol and cancer 3 > What is the evidence that drinking alcohol can cause cancer? 3 > How does alcohol cause cancer? 3
More informationBurden and cost of alcohol, tobacco and illegal drugs globally and in Europe
Burden and cost of alcohol, tobacco and illegal drugs globally and in Europe Jürgen Rehm 1-4 Kevin D. Shield 1,2,3 1) Centre for Addiction and Mental Health, Toronto, Canada 2) University of Toronto, Canada
More informationOutline. Background on the American Institute for Cancer Research (AICR) and Continuous Update Project (CUP)
Alcohol and Cancer: State of the Science Christine L. Sardo Molmenti PhD, MPH, RD AICR Science Analyst Assistant Professor Hofstra-Northwell School of Medicine Northwell Health April 25, 2017 Outline Background
More informationEffective actions to reduce the harmful use of alcohol
Effective actions to reduce the harmful use of alcohol Dag Rekve, Senior Technical Officer, World Health Organization Dag Rekve Senior Technical Officer WHO HQ/NMH Switzerland www.who.int/substance_abuse/en/
More informationROMANIA. Upper-middle Income Data source: United Nations, data range
ROMANIA SOCIOECOMIC CONTEXT Total population 21,532,000 Annual population growth rate -0.5% Population 15+ years 85% Adult literacy rate 97.3% Population in urban areas 54% Income group (World bank) Upper-middle
More informationSubmission on a National Cancer Strategy
Submission on a National Cancer Strategy July 2015 Alcohol Action Ireland Alcohol Action Ireland is the national charity for alcohol related issues. We are an independent voice for advocacy and policy
More informationNIH Public Access Author Manuscript Alcohol Res Health. Author manuscript; available in PMC 2012 March 19.
NIH Public Access Author Manuscript Published in final edited form as: Alcohol Res Health. 2011 ; 34(2): 135 143. The Risks Associated With Alcohol Use and Alcoholism Jürgen Rehm, Ph.D. Director of the
More informationProfessor Jennie Connor. Department of Preventive and Social Medicine University of Otago, Dunedin
Professor Jennie Connor Department of Preventive and Social Medicine University of Otago, Dunedin New Zealand Population Health Congress 2014 acute and chronic effects benefits and harms pattern and volume
More informationAMPHORA Alcohol Public Health Research Alliance Deliverable D1.5 Report of the toxicological assessment of untaxed alcohol in Europe Annex:
AMPHORA Alcohol Public Health Research Alliance Deliverable D1.5 Report of the toxicological assessment of untaxed alcohol in Europe Annex: Recommendations on unrecorded alcohol AMPHORA WP7 Drinking environments
More informationDraft global strategy to reduce harmful use of alcohol
Draft global strategy to reduce harmful use of alcohol Luxembourg January 27, 2010 Leading causes of attributable global mortality and burden of disease, 2004 Attributable Mortality % 1. High blood pressure
More informationAlcol e tumori con focus sulle basse dosi
Alcol e tumori con focus sulle basse dosi Carlo La Vecchia Department of Epidemiology, Istituto Mario Negri Department of Clinical Sciences and Community Health, Università degli Studi di Milano 1 Cancers
More informationKAZAKHSTAN. Upper-middle Income Data source: United Nations, data range
KAZAKHSTAN SOCIOECOMIC CONTEXT Total population 15,314,000 Annual population growth rate -0.3% Population 15+ years 76% Adult literacy rate 99.5% Population in urban areas 58% Income group (World bank)
More informationThe relationship between different dimensions of alcohol use and the burden of disease an update
REVIEW doi:10.1111/add.13757 The relationship between different dimensions of alcohol use and the burden of disease an update Jürgen Rehm 1,2,3,4,5,6,GerhardE.GmelSr 1,7,8,9, Gerrit Gmel 1, Omer S. M.
More informationARMENIA. Lower-middle Income Data source: United Nations, data range
ARMENIA SOCIOECOMIC CONTEXT Total population 3,010,000 Annual population growth rate -0.5% Population 15+ years 80% Adult literacy rate 99.4% Population in urban areas 64% Income group (World bank) Lower-middle
More informationLITHUANIA. Upper-middle Income Data source: United Nations, data range
LITHUANIA SOCIOECOMIC CONTEXT Total population 3,408,000 Annual population growth rate -0.6% Population 15+ years 84% Adult literacy rate 99.6% Population in urban areas 66% Income group (World bank) Upper-middle
More informationUNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (the)
UNITED KINGDOM OF GREAT BRITAIN AND RTHERN IRELAND (the) SOCIOECOMIC CONTEXT Total population 60,512,000 Annual population growth rate 0.4% Population 15+ years 82% Adult literacy rate - - Population in
More informationNORWAY. Recorded adult (15+) alcohol consumption by type of alcoholic beverage (in % of pure alcohol), Other 2% Wine 31%
RWAY SOCIOECOMIC CONTEXT Total population 4,669,000 Annual population growth rate 0.6% Population 15+ years 81% Adult literacy rate - - Population in urban areas 77% Income group (World bank) High Income
More informationGERMANY. Recorded adult (15+) alcohol consumption by type of alcoholic beverage (in % of pure alcohol), Spirits 20%
GERMANY SOCIOECOMIC CONTEXT Total population 82,641,000 Annual population growth rate 0.1% Population 15+ years 86% Adult literacy rate - - Population in urban areas 75% Income group (World bank) High
More informationNational response to harmful use of alcohol. A presentation By Dr. Sheila Ndyanabangi Principal Medical Officer In charge- Alcohol Control Programme
National response to harmful use of alcohol A presentation By Dr. Sheila Ndyanabangi Principal Medical Officer In charge- Alcohol Control Programme Introduction Alcohol is widely used in all societies
More informationBEHAVIORS ASSOCIATED WITH ALCOHOL
BEHAVIORS ASSOCIATED WITH ALCOHOL CONSUMPTION AMONG STUDENTS OF THE FACULTY OF MEDICAL SCIENCES IN STIP 1 Marina Danilova, Vaska Zdravkova University Goce Delcev, Stip Although we know much about alcohol,
More informationAlcohol's Effects on the Body
Alcohol's Effects on the Body Drinking too much on a single occasion or over time can take a serious toll on your health. Here s how alcohol can affect your body: Brain: Alcohol interferes with the brain
More informationInfluence of unrecorded alcohol consumption on liver cirrhosis mortality
Submit a Manuscript: http://www.wjgnet.com/esps/ Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx DOI: 10.3748/wjg.v20.i23.7217 World J Gastroenterol 2014 June 21; 20(23): 7217-7222 ISSN 1007-9327 (print)
More informationSLOVENIA. Recorded adult (15+) alcohol consumption by type of alcoholic beverage (in % of pure alcohol), Spirits 13%
SLOVENIA SOCIOECONOMIC CONTEXT Total population 2,001,000 Annual population growth rate 0.2% Population 15+ years 86% Adult literacy rate 99.7% Population in urban areas 51% Income group (World bank) High
More informationThe burden of death, disease and disability due to alcohol in New Zealand
The burden of death, disease and disability due to alcohol in New Zealand Research summary September 2004 Jennie Connor, Joanna Broad, Rod Jackson School of Population Health, University of Auckland Stephen
More informationALL CANCER (EXCLUDING NMSC)
ALL CANCER (EXCLUDING NMSC) AVERAGE NUMBER OF CASES PER YEAR (2011-2015) AVERAGE NUMBER OF DEATHS PER YEAR (2011-2015) Male Female Both sexes Male Female Both sexes 4,557 4,516 9,073 1 2,196 1,984 4,180
More informationHospital admissions, deaths and overall burden of disease attributable to alcohol consumption in Scotland
Hospital admissions, deaths and overall burden of disease attributable to alcohol consumption in Scotland This resource may also be made available on request in the following formats: 0131 314 5300 nhs.healthscotland-alternativeformats@nhs.net
More informationAlcohol-related harm in Europe Key data
MEMO/06/397 Brussels, 24 October 2006 Alcohol-related harm in Europe Key data Alcohol-related harm in the EU: 55 million adults are estimated to drink at harmful levels in the EU (more than 40g of alcohol
More informationStockholm World Health Organization. Avenue Appia Geneva 27 Switzerland
Stockholm 2012-04-17 World Health Organization Avenue Appia 20 1211 Geneva 27 Switzerland Comments on the second WHO Discussion Paper, dated 22 March 2012, on global monitoring, indicators and targets
More informationALCOHOL AND SOCIETY ALCOHOL AND CANCER
ALCOHOL AND SOCIETY 30% of all alcohol-attributable cancer cases in Sweden are caused by moderate or low levels of alcohol consumption. THEME 2016/2017: ALCOHOL AND CANCER If you re too tired to take your
More informationALL CANCER (EXCLUDING NMSC)
ALL CANCER (EXCLUDING NMSC) AVERAGE NUMBER OF CASES PER YEAR (2012-2016) AVERAGE NUMBER OF DEATHS PER YEAR (2012-2016) Male Female Both sexes Male Female Both sexes 4,607 4,632 9,240 1 2,238 2,036 4,274
More informationCreative Commons: Attribution 3.0 Hong Kong License
Title Tobacco and alcohol control: why drink a carcinogen to protect the heart? Author(s) Lam, TH Citation The RACMA/HKCCM International Conference on 'Healthcare Reforms in Comparative Health Systems',
More informationConclusions of the BioInitiative Report. Michael Kundi Medical University of Vienna BioInitiative Organizing Committee
Conclusions of the BioInitiative Report Michael Kundi Medical University of Vienna BioInitiative Organizing Committee Preamble...it is impossible to derive...a proposal for a policy from a sentence stating
More informationBladder and genitourinary tumours
Oxford Scholarship Online You are looking at 2751-2760 of 3042 items for: keywords : stasis pubepi Bladder and genitourinary tumours Claudio Pelucchi and Carlotta Galeone Published in print: Published
More informationEditorial Process: Submission:12/04/2017 Acceptance:04/02/2018
DOI:10.22034/APJCP.2018.19.7.1845 RESEARCH ARTICLE Editorial Process: Submission:12/04/2017 Acceptance:04/02/2018 Estimating the Burden of Cancer and Treatment Cost Related to Alcohol Consumption in Indonesia:
More information5. Summary of Data Reported and Evaluation 5.1 Exposure data
5. Summary of Data Reported and Evaluation 5.1 Exposure data Smoking of tobacco is practised worldwide by over one thousand million people. However, while smoking prevalence has declined in many developed
More informationNational level ICD 9-3 digit Nuts II european shortlist Croatia 1999/2000 From WHO ICD-10, 4 digit. 1999/2000 From WHO ICD-10, 4 digit
Gleb Denissov Reference Period Transmission to Eurostat Data Albania 1999/2000 From WHO ICD-9, 3 digit Bulgaria 1999/2000 National level from WHO Nuts II level by e-mail National level ICD 9-3 digit Nuts
More informationJ Clin Oncol by American Society of Clinical Oncology INTRODUCTION
JOURNAL OF CLINICAL ONCOLOGY A S C O S P E C I A L A R T I C L E Alcohol and Cancer: A Statement of the American Society of Clinical Oncology Noelle K. LoConte, Abenaa M. Brewster, Judith S. Kaur, Janette
More informationAlcohol and Cancer Risks
Alcohol and Cancer Risks A guide for health professionals Scottish Health Action on Alcohol Problems Introduction Alcohol and Cancer Risks: A Guide for Health Professionals This guide has been produced
More informationCancer in Ontario. 1 in 2. Ontarians will develop cancer in their lifetime. 1 in 4. Ontarians will die from cancer
Cancer in Ontario 1 in 2 Ontarians will develop cancer in their lifetime 1 in 4 Ontarians will die from cancer 14 ONTARIO CANCER STATISTICS 2016 1 Cancer in Ontario An overview Cancer is a group of more
More informationEuropean Status report on Alcohol and Health
European Status report on Alcohol and Health Dr Lars Moller Regional Advisor a.i. WHO Regional Office for Europe Main killers in the WHO European Region Source: Preventing chronic diseases. A vital investment.
More informationWhat the AMPHORA project says for European alcohol policy
AMPHORA NEWSLETTER DECEMBER 2012 What the AMPHORA project says for European alcohol policy Potential impact The main outcomes of the scientific work of the AMPHORA project drive the need for stepped-up
More informationNational burden of colorectal cancer in Lithuania and the ranking of Lithuania within the 45 European nations
ONCOLOGY LETTERS 10: 433-438, 2015 National burden of colorectal cancer in Lithuania and the ranking of Lithuania within the 45 European nations RAIMUNDAS LUNEVICIUS 1,2, TOMAS POSKUS 2 and NARIMANTAS
More informationESTONIA. Recorded adult per capita consumption (age 15+) Lifetime abstainers
ESTONIA Recorded adult per capita consumption (age 15+) 12 1 Litres of pure alcohol 8 6 4 Beer Spirits Wine 2 1961 1965 1969 1973 1977 1981 1985 1989 1993 1997 21 Year Sources: FAO (Food and Agriculture
More informationDoes Europe have a drinking problem? The Amphora project perspective
Does Europe have a drinking problem? The Amphora project perspective Antoni Gual, MD, PhD. Firenze, December 6 th 2013 Alcohol Measures for Public Health Research Alliance 2009 2012 Who are the AMPHORA
More informationTHE BURDEN OF HEALTH AND DISEASE IN SOUTH AFRICA
THE BURDEN OF HEALTH AND DISEASE IN SOUTH AFRICA BRIEFING TO SELECT COMMITTEE ON SOCIAL SERVICES 15 March 216 Prof Debbie Bradshaw, Dr Pillay-van Wyk, Ms Ntuthu Somdyala and Dr Marlon Cerf PRESENTATION
More informationPatterns of binge drinking among adults in urban and rural areas of Pha-An township, Myanmar
Patterns of binge drinking among adults in urban and rural areas of Pha-An township, Myanmar Saw Morgan Soe Win 1, Chitlada Areesantichai 2. 1 College of Public Health Sciences, Chulalongkorn University,
More informationExecutive Summary... vii. 1 Introduction Methods Alcohol attributable conditions... 3
Acknowledgements In addition to the authors of the report we would like to acknowledge the contribution of Lynn Deacon and Sacha Wyke of the North West Public Health Observatory. We also wish to thank
More information"Submission to the Law Commission on the Alcohol in our lives report
Liquor Project Co-ordinator Law Commission P O Box 2590 Wellington 29 October 2009 "Submission to the Law Commission on the Alcohol in our lives report This submission is from The Cancer Society of New
More informationAlcohol and Cancer Risk
Many Hearts Many Minds One Goal Volume 4 Number 5 Spring 2013 Alcohol and Cancer Risk Overview The link between alcohol consumption and many cancers is supported by a growing body of evidence. What is
More information6/14/2017. Alcohol and Cancer: The Risk Factor We Aren t Talking About. Public Health Impact THE SCOPE OF THE PROBLEM
Alcohol and Cancer: The Risk Factor We Aren t Talking About Noelle K. LoConte, MD Associate Professor of Medicine University of Wisconsin Madison, WI THE SCOPE OF THE PROBLEM Public Health Impact 3 1 Alcohol
More informationA Local Mechanism by which Alcohol Consumption Causes Cancer
Essay A Local Mechanism by which Alcohol Consumption Causes Cancer Miguel López-Lázaro Department of Pharmacology, Faculty of Pharmacy, University of Seville, C/ Profesor Garcia Gonzalez 2, 41012 Sevilla,
More informationThe Risk of Alcohol in Europe. Bridging the Gap June 2004
The Risk of Alcohol in Europe Bridging the Gap 16-19 June 2004 1. What is the relationship between alcohol and the risk of heart disease? 2. What is the relationship between alcohol and the risk of other
More informationTable Case-control studies on consumption of alcoholic beverages and cancer of the oesophagus
Vioque et al. (2008), Spain, 1995 99 Oesophagus 202 (187 men, 15 women), histologically confirmed; 160 (79.2%) squamous-cell carcinomas, 42 adenocarcinoma; Participation rate, 95.8%. Face-to-face interview
More informationLATVIA. Recorded adult per capita consumption (age 15+) Lifetime abstainers
LATVIA Recorded adult per capita consumption (age 15+) 14 12 Litres of pure alcohol 1 8 6 4 Beer Spirits Wine 2 1961 1965 1969 1973 1977 1981 1985 1989 1993 1997 21 Year Sources: FAO (Food and Agriculture
More informationScientific Facts on. Alcohol
page 1/5 Scientific Facts on Alcohol Source document: WHO (2004) Summary & Details: GreenFacts Context - Alcohol is not an ordinary commodity. It has been part of human civilization for thousands of years,
More informationCentre for Addiction and Mental Health, Toronto, Canada; 2. Department of Public Health Sciences, University of Toronto, Canada; 3
African Journal of Drug & Alcohol Studies, 7(1), 2008 Copyright 2008, CRISA Publications VOLUME OF ALCOHOL CONSUMPTION, PATTERNS OF DRINKING AND BURDEN OF DISEASE IN SUB-SAHARAN AFRICA, 2002 Michael Roerecke
More informationRecent Results from the IARC Monographs: Carcinogenicity of Consuming Red & Processed Meat, Coffee and Very Hot Beverages
Recent Results from the IARC Monographs: Carcinogenicity of Consuming Red & Processed Meat, Coffee and Very Hot Beverages Dana Loomis, PhD & Kurt Straif MD, PhD Conflict of Interest Statement I declare
More informationA review of human carcinogens -Part F: Chemical agents and related occupations
A review of human carcinogens -Part F: Chemical agents and related occupations In October 2009, 23 scientists from 6 countries met at the International Agency for Research on Cancer (IARC) to re-assess
More informationAlcohol abuse. Tomáš Zima. Meeting the needs of Mediterranean nations: Mediterranean diet and the area s specific diseases
Meeting the needs of Mediterranean nations: Mediterranean diet and the area s specific diseases This is a Platinum Open Access Journal distributed under the terms of the Creative Commons Attribution Non-Commercial
More informationAlcohol consumption, harm and policy responses in Europe. Dr Lars Møller Programme Manager World Health Organization Regional Office for Europe
Alcohol consumption, harm and policy responses in Europe Dr Lars Møller Programme Manager World Health Organization Regional Office for Europe Burden of NCD in Europe Burden of disease by broad cause group
More informationNew scientific study: no safe level of alcohol
1 sur 7 25/08/2018 à 00:36 healthdata.org New scientific study: no safe level of alcohol 7-9 minutes Originally posted August 23, 2018. 3 million deaths in 2016 attributed to alcohol; Massive health risks
More informationVolume of alcohol consumption, patterns of drinking and burden of disease in the European region 2002
Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2006 Volume of alcohol consumption, patterns of drinking and burden of disease
More informationVasilis Vasiliou. Q. Max Guo. Alcohol and Cancer
Alcohol and Cancer Samir Zakhari Editors Vasilis Vasiliou Q. Max Guo Alcohol and Cancer Editors Samir Zakhari, Ph.D. Director Division of Metabolism and Health Effects National Institute on Alcohol Abuse
More informationTwo Topics: Tobacco Control and Dietary Chemoprevention Stephen S. Hecht, Ph.D. February 3-5, 2016 Lansdowne Resort, Leesburg, VA
Two Topics: Tobacco Control and Dietary Chemoprevention Stephen S. Hecht, Ph.D. February 3-5, 2016 Lansdowne Resort, Leesburg, VA Outline Tobacco Control Policy Research Dietary Chemoprevention Percentage
More informationCancer Mortality, Recent Trends And Perspectives
& Cancer Mortality, Recent Trends And Perspectives Dragana Nikšić¹*, Amira Kurspahić-Mujičić¹, Aida Pilav², Haris Nikšić³ 1. Social Medicine Institute, Faculty of Medicine, University of Sarajevo, Čekaluša
More informationA meta-analysis of alcohol drinking and cancer risk
British Journal of Cancer (200) 85(), 700 705 doi: 0.054/ bjoc.200.240, available online at http://www.idealibrary.com on http://www.bjcancer.com A meta-analysis of alcohol drinking and cancer risk V Bagnardi,
More informationFACT SHEET Alcohol and Price. Background. 55 million European adults drink to dangerous levels.
Alcohol and Price Background In much of the European Union drinking is part of the culture and although rates and patterns vary across countries, the EU has the highest rate of alcohol consumption in the
More informationSmoking and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)
Smoking and Mortality SECTION 6 Smoking and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC) Kotaro Ozasa Abstract In the JACC study, risk of death with all cancers and
More informationOverview of 2010 Hong Kong Cancer Statistics
Overview of 2010 Hong Kong Cancer Statistics Cancer Registration in Hong Kong The Hong Kong Cancer Registry has since the 1960s been providing population-based cancer data for epidemiological research
More informationInformation Services Division NHS National Services Scotland
Cancer in Scotland April 2013 First published in June 2004, revised with each National Statistics publication Next due for revision October 2013 Information Services Division NHS National Services Scotland
More informationIJC International Journal of Cancer
IJC International Journal of Cancer Comparative risk assessment of carcinogens in alcoholic beverages using the margin of exposure approach Dirk W. Lachenmeier 1,2, Maria C. Przybylski 2 and Jürgen Rehm
More informationThe future of cancer prevention: setting realistic goals and timeframe
The future of cancer prevention: setting realistic goals and timeframe Dr Christopher P Wild PhD International Agency for Research on Cancer Lyon, France We cannot treat our way out of the cancer problem
More informationCancer & Excessive Alcohol Use Laura Tomedi, PhD, MPH Alcohol Epidemiologist New Mexico Cancer Council November 15, 2017
Cancer & Excessive Alcohol Use Laura Tomedi, PhD, MPH Alcohol Epidemiologist New Mexico Cancer Council November 15, 2017 What Am I Going to Talk About Today? Alcohol Alcohol and Cancer What Can We Do?
More informationCancer Risk Factors in Ontario. Alcohol
Cancer Risk Factors in Ontario Alcohol Prepared by Stephanie Young, Elisa Candido, Beth Theis and Loraine Marrett, Prevention and Surveillance, Prevention and Cancer Control, Cancer Care Ontario. The authors
More informationAcrylamide in Foods: An Important International Issue
Acrylamide in Foods: An Important International Issue 2013 Fera-JIFSAN Annual Symposium FDA, Harvey W. Wiley Bldg Auditorium College Park, MD June 12-13, 2013 Acrylamide in Foods Acrylamide - industrial
More informationThe WHO global strategy to reduce the harmful use of alcohol NORDISK RUSMIDDELSEMINAR REYKJAVIK, ICELAND 26 AUGUST 2010
The WHO global strategy to reduce the harmful use of alcohol NORDISK RUSMIDDELSEMINAR REYKJAVIK, ICELAND 26 AUGUST 2010 WHO governing structure UN specialized agency 193 Member States The World Health
More informationALCOHOL IS CARCINOGENIC. ALCOHOL CAUSES CANCER
ALCOHOL IS CARCINOGENIC. ALCOHOL CAUSES CANCER Ethanol, which is the main component of all alcoholic beverages, is carcinogenic. EVIDENCE OF THE CANCER ALCOHOL LINK IS OVERWHELMING from various sources
More informationBEER AND CARDIOVASCULAR HEALTH: EFFECTS ON MORBIDITY AND MORTALITY. Simona Costanzo THE 7 TH EUROPEAN BEER AND HEALTH SYMPOSIUM
BEER AND CARDIOVASCULAR HEALTH: EFFECTS ON MORBIDITY AND MORTALITY Simona Costanzo Department of Epidemiology and Prevention IRCCS Mediterranean Neurological Institute Pozzilli (IS), Italy simona.costanzo@neuromed.it
More informationAlcohol. Alcohol. Alcohol and cancer:
The relationship between alcohol consumption and certain types of cancers is well established. In general, two approaches to reducing alcohol consumption can be distinguished: supply reduction and demand
More informationCancer in the Northern Territory :
Cancer in the Northern Territory 1991 21: Incidence, mortality and survival Xiaohua Zhang John Condon Karen Dempsey Lindy Garling Acknowledgements The authors are grateful to the many people, who have
More informationPart 2. Chemical and physical aspects
Part 2. Chemical and physical aspects 12. Chemical and physical aspects: introduction 12.1 Background information used The assessment of the toxicity of drinking-water contaminants has been made on the
More informationWHO methodology. Alcohol consumption
Alcohol consumption WHO methodology Dr Alexandra Fleischmann, Mr Dag Rekve and Dr Vladimir Poznyak Management of Substance Abuse Unit (MSB) Department of Mental Health and Substance Abuse, WHO, Geneva
More informationColorectal Cancer Screening
Colorectal Cancer Screening December 5, 2017 Connecticut Cancer Partnership 14th Annual Meeting Xavier Llor, M.D., PhD. Associate Professor of Medicine Co-Director, Cancer Genetics and Prevention Program
More information