Pulmonary Vein Isolation for AF RF or Cryo? Dr. Yuen Ho Chuen Princess Margaret Hospital
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1 Pulmonary Vein Isolation for AF RF or Cryo? Dr. Yuen Ho Chuen Princess Margaret Hospital
2 PV as a Source of Ectopic Activity Haissaguerre, et al. NEJM 1998
3 RF Ablation Gold standard Point by point ablation Largest experience worldwide
4 Cryoballoon Young technology Single shot approach Fast learning curve Aim: ablation faster and safer
5 Ideal AF Ablation Procedure Efficacy Safety Durability Ease of use
6 Meta-analysis of AF RF Ablation Ganesan, et al. J Am Heart Assoc2013
7 Meta-analysis of AF RF Ablation Ganesan, et al. J Am Heart Assoc2013
8 Outcomes of AF RF Ablation: 2 nd Worldwide Survey Cappato, et al. CircA&E 2010
9 Long-term Results for RF University of Pennsylvania Free from AF 1 year after ablation 123 patients ~7%/year late recurrence rate after the 1 st year Tzou, et al. CircA&E 2010
10 Long-term Results for RF Tzou, et al. CircA&E 2010
11 Very Long-term Results for RF New York, single centre Free from AF 1 year post-ablation (single procedure in 391 (87.9%)) 445 patients AF recurrence: 16.3% and 29.8% at 5 and 10 years respectively Steinberg, et al. HR 2014
12 Cryothermic Lesion Characteristics Less endothelial disruption than RF, thus less thrombus formation Smaller than RF lesions Dense, homogenous fibrosis Well demarcated border zone Underlying cellular matrix & tensile strength preserved Khairy, et al. Circulation 2003
13 Meta-analysis of AF Cryoballoon Ablation Andrade, et al. HR 2011
14 Long-term Results for Cryoballoon Germany, single centre, prospective observational 605 patients (579 PAF) At median FU of 30 months, freedom from AF: 61.6% Need for focal touch-up in 9% 23-mm CB: 26.7%, 28-mm CB: 25.6%, both: 47.7% Vogt, et al. JACC 2013
15 Challenge to Cryoballoon Ablation: Left Common Pulmonary Vein
16 Need for Touch-up
17 Complications of AF Ablation RF Ablation: 2 nd Worldwide Survey Cryoballoon: Germany, single centre Cappato, et al. CircA&E 2010 Vogt, et al. JACC 2013
18 Complications of AF Ablation Andrade, et al. HR 2011
19 Asymptomatic Brain Lesions Wissner, et al. Europace 2014
20 Post AF Ablation AT Stockholm, single centre, retrospective 630 patients with PAF RF=415, CB=215 Mean FU : 38+/-21 months Akerstrom, et al. JCE 2014
21 RF vs Cryoballoon United Kingdom, single centre, non-randomized 143 patients with PAF CB=90; RF=53 Kojodjojo, et al. Heart 2010
22 RF vs Cryoballoon Kojodjojo, et al. Heart 2010
23 RF vs Cryoballoon Belgium, single centre, retrospective 396 patients with PAF RF=260, CB=136 At mean FU 23+/-13 months, FFAF rates: 57.3% in RF vs 63.2% in CB (p=0.25) Mugnai, et at. Am J Cardiol2014
24 RF vs Cryoballoon Mugnai, et at. Am J Cardiol2014
25 RF vs Cryoballoon Cryoballoon Mugnai, et at. Am J Cardiol2014
26 Learning Curve for Cryoballoon Vogt, et al. JACC 2013
27 Germany Ablation Registry March September consecutive patients with PAF 55 centres CB=604 (26.8%), RF=1652 (73.2%) Schmidt, et al. JCE 2014
28 Germany Ablation Registry Longer ablation time due to lack of experience for cryoballoon in early stage? Schmidt, et al. JCE 2014
29 Germany Ablation Registry Schmidt, et al. JCE 2014
30 FreezeAF Germany, single centre, randomized 315 patients with PAF CB=156, RF=159 Redo procedures were permitted between 6 and 12 months using only the original energy source FFAF rates: At 6 months: 63% in CB vs 64% in RF At 12 months: 68% in CB vs 65% in RF Complication rates were significantly higher in CB group (driven by 5.1% PNP which all recovered within 12 months) Luik, et al. HRS 2015 Late-Breaking Session
31 Phrenic Nerve Monitoring by CMAP Franceschi, et al. HR 2011
32 2 nd Generation Cryoballoon
33 Reduction in Need for Touch-up Study Packer, et al JACC 2013 with 2 nd Gen CB PVI by CB only Noof CB applications 83% Mean 12.5 per patient Sizeof CB used CB generation Both sizes: 20.8% of PV 1st Chun, et al EHJ % >4 per vein in 44% 28mm only 1st Kojodjojo, et al Heart % Limit 2 per vein 28mm only 1st Straube, et al Circ A&E % Mean 2.82 per vein Mean 11.6 per patient Bothsizes: 21% 2nd
34 1 st Gen CB vs 2 nd Gen CB (With a 3-month blanking) Belgium, single centre, nonrandomized 100 patients with PAF 50 CB1 vs 50 CB2 12-month FU AF-free survival: CB1 66% vs CB2 84% (with a 3-month blanking) (p=0.038) Di Giovani, et al. JCE 2014
35 Efficacy of 2 nd Gen CB Freedom from AF at 1 year; Single centre studies; No AADs
36 Higher incidence of PNP with 2 nd Gen CB Prospective observational study in a single centre in Belgium 1 st gen CB compared with 2 nd gen CB 1 st gen CB: 80 patients (Group 1) 2 nd gen CB: 41 patients (Group 2) Evaluated incidence of phrenic nerve paralysis PNP occurred in 13 (10.7%) of patients 5/80 (6.25%) in Group 1 vs 8/41 (19.5%) in Group 2 (p=0.033) At 7 months, PNP persisted in only 1 patient (2.5%) in Group 2 Casado-Arroyo, et al. HR 2013
37 Atrioesophageal Fistula with 2 nd Gen CB 3 patients in 3 different institutes in US 1 st gen CB in 1 patient and 2 nd gen CB in 2 patients All used 28mm balloon 1 patient had LET which recorded <20 C at LIPV ablation 2 patients underwent surgical repair All died Kawasaki, et al. JCE 2014
38 RF vs 2 nd Gen CB US, multicentre, non-randomized 1196 patients with AF (76% paroxysmal AF) 2 nd gen CB=773, RF=423 In CB group, only 1.6% PVs needed RF touch-up 1-year FFAF rates for paroxysmal AF: 78.4% in 2 nd gen CB vs 60.8% in RF (p<0.001) Aryana, et al. JCE 2015
39 RF vs 2 nd Gen CB Proceduraldata RF 2 nd Gen CB P value Ablation time (min) 66+/ /-14 <0.001 Procedural time (min) 188+/ /-49 <0.001 Fluoroscopic time (min) 23+/ /-13 <0.001 Complications RF 2 nd Gen CB P value Transient PNP 0% 7.6% <0.001 Persistent PNP 0% 1.2% Other adverse events 2.6% 1.6% FU RF 2 nd Gen CB P value Re-do ablation 24.1% 14.6% NA Patients with PV reconnection at redo ablation 65.7% 44.2% Aryana, et al. JCE 2015
40 Durability of PVI by 2 nd Gen CB Czech Republic 21 patients with PAF Ablated with 2 nd gen CB Remapped at 3 months 90% of PVs showed durable PVI (lowest 83% in RIPV, mostly inferior border) Reddy, et al. JCE 2015
41 Contact Force Technologies TactiCath, St. Jude Medical SmartTouch, Biosense Webster
42 Durability of PVI by CF 3 centre study EFFICAS I: Operator blinded to contact force information EFFICAS II: Operator NOT blinded & actively using contact force at ablation Neuzil, et al. CircA&E 2013
43 Improved Durable PVI by CF (26 patients) (24 patients) Kautzner, et al. Europace 2015
44 CF guided RF Montreal, non-randomized 75 patients with PAF SmartTouch=25, control=50 After PVI, adenosine testing for dormant PV conduction 1-year FFAF rates: CFguided group 88% vs control group 66% (p=0.047) Andrade, et al. HR 2014
45 CF-guided RF vs 2 nd Gen CB France, single centre, nonrandomized 150 patients with PAF Smart touch=75, 2 nd gen CB=75 In RF group, mean CF: 19.7g In CB group, PVI was achieved without touch-up in 100% patients, persistent PNP 0% Jourda, et al. Europace 2015
46 Conclusions Outcomes are comparable between RF and cryoballoon ablation for AF Cryoballoon ablation is associated with higher incidence of PNP but may cause less cardiac tamponade Cryoballoon ablation may be faster than RF ablation 2 nd Gen CB and CF-guided RF ablation are promising technologies which may improve outcomes of AF ablation
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