Unknown Case 6. Ann T. Moriarty, MD
|
|
- Phillip Goodman
- 5 years ago
- Views:
Transcription
1 Unknown Case 6 Ann T. Moriarty, MD
2 Unknown Case 6 61 year old male with an enlarged cervical lymph node. He has a history of lung carcinoma, renal cell carcinoma and lymphoma.
3 Case 6 Image 1: Fine needle biopsy of cervical lymph node. Romanowsky stained smear, 50x.
4 Case 6 Image 2: Fine needle biopsy of cervical lymph node. Papanicolaou stain 50x.
5 Case 6 What is your morphologic differential diagnosis?
6 Image 3: Compare the cell nuclei to the histiocyte nucleus (Thin Arrow). Most of the nuclei are larger than the histiocyte nuclei. The thick arrow demonstrates cytoplasmic fragments ( lymphoglandular bodies ).
7 Image 4: The arrow points to a histiocyte nucleus. The cells look smaller in ethanol fixed than air-dried preparations. The cells are also more monotonous appearing and there are only rare small lymphocytes present..
8 Morphologic Differential Neoplasms composed of single cells Large Cell Lymphoma Carcinoma Melanoma Small Round Blue Cell Tumor
9 Case 6 What additional information would you like?
10 Image 5: LCA (CD45Ra) immunostain positive in large cells (arrows)
11 Flow Cytometry Histograms of Case 6 A B Image 6: The cells have large side scatter and strong CD45 positivity indicating they are large lymphocytes(a). Histogram B shows the forward scatter versus side scatter characteristics. High forward scatter indicates big cells.
12 A B C D Image 7: Compare the scatter and CD45 characteristics of case 6 in A and B to the CD45 and side scatter characteristics of a small lymphocytic lymphoma in C and D. In C the cells have intense CD45 fluorescence and small side scatter and are not as spread out as those in A. This is accentuated in the forward scatter and side scatter plots, where the small lymphocytes are clustered to the left indicating small size (forward scatter) and little cytoplasmic complexity (side scatter).
13 Flow Cytometry Histograms of Case 6 Image 8: Arrow indicates that the entire population identified in the circled gate is exclusively kappa positive. This is a monoclonal B cell population.
14 Diagnosis: Large cell B cell lymphoma
15 Differential diagnosis Poorly differentiated Carcinoma Small cell undifferentiated carcinoma and other poorly differentiated carcinomas may present as single cells and in patients without a previously known primary. Most non-small cell carcinomas will have more abundant cytoplasm and will be much larger than the cells of large cell lymphoma. While small cell undifferentiated carcinomas may present as single cells, and may even shed cytoplasmic fragments in the background, the fragments are fewer and their nuclear chromatin pattern is coarsely granular compared to the vesicular chromatin and numerous lymphoglandular bodies of large cell lymphoma.
16 Poorly Differentiated Carcinoma Image 9: Small cell undifferentiated carcinoma will frequently fall apart into single cells. However, the nuclei of the cells are usually larger than large cell lymphoma, and the nuclei contain uniformly coarsely granular chromatin without the vesicular pattern and nuclei of large cell lymphomas. Romanowsky stain and Pap stain x 100.
17 Poorly Differentiated Carcinoma A B Image 10: Synaptophysin (A) and Epithelial markers (B) will be positive in most small cell undifferentiated carcinoma, while LCA (Image 6 ) will be negative in carcinomas. Synaptopysin and AE1/AE3 keratin stain x50.
18 Differential diagnosis Melanoma Melanoma can mimic any neoplasm, and should be part of the differential diagnosis of any neoplasm with a single cell pattern. The epithelioid variant of melanoma usually has cells 2 to 3 times the size of large cell lymphoma, has prominent nucleoli and are often binucleate. Helpful immunologic stains include HMB45 as well as melan A.
19 Melanoma Image 11: Romanowsky Stained smear, 50x. Notice how large the cells are and their abundant cytoplasm. The nuclei are several times larger than the histiocyte nuclei. Note the blue green melanin pigment in the histiocytes (arrow.)
20 Differential diagnosis Small round blue cell tumors Small, round, blue cell tumors(srbct) are mostly seen in children. They include, neuroblastoma, Ewing s/pnet tumor, rhabdomyosarcoma and desmoplastic small round cell tumor (DSRCT). Most are associated with characteristic clinical presentations and are most often characterized by distinctive chromosome abnormalities. The clinical presentation of case 6 would be unlikely for a SRBCT. In this 61 year old, Ewing s/pnet tumor and rhabdomyosarcoma may be a consideration. The pattern of expected immunologic reactivity may be seen on the next table. Although lymphoblastic lymphomas may be CD99 positive, they would not demonstrate the flow cytometric pattern in this case.
21 Small Round Blue Cell Tumors Tumor Site Age (yrs) Chromosome Desmin MSA CD99 MyoD/ Myogenin Epithelial Rhabdomyosarcoma (Alveolar) extremities Up to 25 9=mean 2 and 13 PAX3(FKHR) PAX7(FKHR) + + Rare weak + - (pos)* Rhabdomyosarcoma (Embryonal) Head/neck 7=mean Loss of 11,changes in 8,20, (pos)* Ewing's/PNET Lower limbs thorax Up to 40 20=mean q12 chrom 22 (EWS) rare scattered Desmoplastic Small Round Cell Tumor (DSRCT) abdomen Up to 48 22=mean t(11;22) (p13;q12) Neuroblastoma ** Adrenal Under 4 No consistent change * Epithelial markers are positive in less than 10% of cases ** Neuroblastoma associated with NSE positivity and serologic increase in catecholamines
22 Rhabdomyosarcoma Image 12: Romanowsky Stained smear, 50x. This is a biopsy from a neck mass in a child. The cells are single and demonstrate rare cytoplasmic fragments (arrow).
23 Rhabdomyosarcoma A B Image 13: (A) is an immunostain for Muscle Specific Actin showing positive cells (arrow) with negative lymphocytes below. (B) shows an LCA stain, reacting with the lymphocytes(arrow) but not the cells of the SRBCT.
24 Large Cell Lymphoma Large cell lymphoma is a morphologic descriptor, not a diagnostic entity. As cytologists, we are usually able to identify that the cells are abnormal, and larger than small lymphocytes. Further classification usually requires ancillary immunological and (sometimes) chromosomal studies. The WHO classification separates lymphocytic disorders into two large subgroups, 1)B cell neoplasms and 2) T cell/natural Killer (NK) cell neoplasms. Case 6 is a B cell neoplasm based upon the immunologic findings.
25 B Cell Lymphoma with Large Cell Size Of the B cell lymphomas, several subtypes have large cells, including: Follicular Lymphoma, Grade 3 Diffuse Large B cell Lymphoma Mediastinal large B cell lymphoma Intravascular Large B cell lymphoma Primary effusion lymphoma
26 B Cell Lymphoma with larger Cell Size Of the B cell lymphomas, several variants have larger cells than small lymphocytes, but are not as large as Large Cell Lymphomas. These are Precursor B lymphoblastic lymphoma Burkitt lymphoma
27 Follicular Lymphoma, Grade 3 Follicular lymphomas are identified by the presence of follicle formation on histologic sections. They are graded based upon the proportion of large cells ( centroblasts ) within neoplastic follicles. The number of large cells with prominent nucleoli are counted within the follicles. Ten follicles are counted. The number of centroblasts is expressed per 40x high power microscope field. Grade 1 follicular lymphoma has 0-5 centroblasts/hpf. Grade 2 follicular lymphoma has 6-15 centroblasts/hpf. Grade 3 has >15 centroblasts/hpf. Presently there is no analogous system for grading proportions of centroblasts in cytologic material.
28 Follicular Lymphoma, Grade 3 Image 14 : Hematoxylin and eosin stained smear, 40x. Grading follicular lymphoma requires counting the number of centroblasts per 40 x field over 10 fields. Centroblast is at arrow. Grade 3 demonstrates > 15 centroblasts/hpf.
29 Follicular Lymphoma, Grade 3 Cytologically, we cannot reliably identify follicular structures, but expression of CD10 on the cells suggests that the neoplasm may have a follicular origin. A B C Image 15: There is weak fluorescent intensity of CD20 characterized as a shift of fluorescence that overlaps the baseline in A (arrow). Lambda chain expression is also of weak or low fluorescent intensity at arrow in B. CD10 in C is usually seen in follicular neoplasms.
30 Mediastinal Large B cell Lymphoma Mediastinal (thymic) large B cell lymphoma is also known as Mediastinal diffuse large cell lymphoma with sclerosis. Most patients are years old and there is a female predominance. Most mediastinal (thymic) B cell lymphomas are limited to the mediastinum upon presentation and may present with superior vena cava syndrome. The cytology and immunophenotyping studies demonstrate large lymphocytes with B cell markers. No CD10 is expressed. The findings of the mediastinal mass with sclerosis and compartmentalized growth pattern distinguishes this type of large cell lymphoma histologically. Cytologically, there are no distinguishing features. With extensive enveloping sclerosis, an inadequate specimen may be obtained with fine needle biopsy.
31 Mediastinal(thymic) Large B cell Lymphoma A B Image 16: Mediastinal large B cell lymphoma is composed of large cells with compartmentalizing fibrosis [A]. The flow cytometry histogram in [B] shows CD20 positive B-cells and no evidence of follicular origin indicated by lack of CD10 expression in C. C
32 Primary Effusion Lymphoma Body cavity based lymphomas are usually seen in immunosuppressed individuals and are composed of large cells, often with an immunoblastic or plasma cell appearance. The patients present with effusions and no other adenopathy. Image 17: There is a monotonous population of large cells in the fluid of this HIV positive male. The cells are large (compare them to the polymorphonuclear leukocytes at the arrow.) The cells have eccentric cytoplasm and an immunoblastic appearance. Pap stain,100x
33 Primary Effusion Lymphoma Primary effusion lymphomas are often CD45 positive and demonstrate wide side scatter, but frequently do not express pan B markers or surface light chains. Often, plasma cell markers (CD38) are seen on the surface. This lymphoma is associated with Herpes virus 8/Kaposi sarcoma herpes virus. Immunocytochemistry will demonstrate viral reactivity in the nuclei of the lymphoma cells. A B Image 18: Note the wide side scatter in [A] at arrow. The population is negative for any light chain in [B].
34 B Cell Lymphoma with larger Cell Size Precursor B lymphoblastic lymphoma is a malignant lymphoma which is identical in cell type to acute lymphoblastic leukemia. This lymphoma is usually a disease of children, although there is a second peak at the age of 70. This is an aggressive lymphoma with immature phenotype, no surface immunoglobulin and dim CD45 expression. They can express the Ewing's/PNET marker CD99. The cells are usually intermediate in size between small lymphocytic lymphomas and large cell lymphomas. Most lymphoblastic lymphomas are precursor T cell lymphoblastic lymphomas; 20% of those lymphomas with lymphoblastic features are precursor B lymphoblastic lymphoma. T and B cell lymphoblastic lymphoma are indistinguishable morphologically.
35 Lymphoblastic Lymphoma Image 19: The lymphocytes of lymphoblastic lymphoma are intermediate in size between large cell lymphoma and lymphomas of smaller size. (Compare the cell size to neutrophils or red cells). The cells have delicate blast like chromatin and inconspicuous nucleoli, similar to lymphoblastic leukemia. Romanowsky stain and Pap stain, x100.
36 Lymphoblastic Lymphoma A B C D E F Image 20: The cells of lymphoblastic lymphoma have dim CD45 intensity(b).the other blast characteristics are positivity for CD34 and HLADR(D). The dim CD20 (F)compared to CD19(E) is characteristic of B lymphoblasts as is the presence of CD10(C).
37 B Cell Lymphoma with larger Cell Size Burkitt lymphoma is another lymphoma with cells smaller than large cells, that might be considered in the morphologic differential diagnosis of large cell lymphoma. This lymphoma occurs endemically in Africa and is associated with the jaw and face. The sporadic cases usually seen in the United States are associated with the gastrointestinal tract and abdomen. The sporadic Burkitt lymphoma occurs in children and young adults. Immunodeficiency states are also associated with Burkitt lymphoma. Burkitt lymphoma is an aggressive neoplasm with a rapid growth rate. The cells are medium size, have classic midnight blue cytoplasm with vacuoles and coarse chromatin with multiple chromocenters. It is a B cell lymphoma with brilliant light chain fluorescence.
38 Burkitt Lymphoma Image 21: The lymphocytes of Burkitt lymphomas are intermediate in size between large cell lymphoma and lymphomas of smaller size. The cells have coarse chromatin and deep blue cytoplasm with vacuoles. The multiple chromocenters are more easily seen on Pap stain. Romanowsky stain and Pap stain, x100. (Histiocyte nucleus at arrow.)
39 Large Cell Lymphoma Large cell lymphomas also occur in the T cell/nk cell lymphomas. The T cell/nk disorders usually have characteristic clinical syndromes and are more difficult to define immunologically. Frequently T cell gene rearrangement studies are performed to confirm the diagnosis of a T cell lymphoma if aberrant T cell phenotyping studies are not seen. T cell Lymphomas that may fall into the large cell category include: Peripheral T cell lymphoma,nos Adult T cell leukemia/lymphoma syndrome Extranodal NK/T cell lymphoma, nasal type Anaplastic large cell lymphoma
40 Peripheral T cell lymphoma, NOS This category is a wastebasket of T cell lymphoma. Histologically, there is effacement of the lymph node with a mixture of cells. Although large cells may predominate, there are usually a spectrum of cell sizes. Eosinophils, histiocytes and plasma cells may also be present which can be confused as Hodgkin s Lymphoma. This is the most common type of T cell lymphoma seen in the Western Hemisphere. It occurs in adults and is associated with advanced disease and poor response to therapy. Immunologically the cells display mature T cell antigens. CD3 is positive. There may be loss of normal antigen expression ( aberrant phenotype.)
41 Peripheral T cell Lymphoma, NOS Image 22 : The cytologic spectrum of Peripheral T cell lymphoma is wide. Usually there is a mixture of small and large cells, epithelioid histiocytes may be abundant and there are few normal appearing lymphocytes. Morphologically, most of these are confused with a reactive lymph node because of the spectrum of cell size. Romanowsky and Pap stain x 100.
42 Peripheral T cell Lymphoma, NOS Image 23 : CD3 is strongly positive in the malignant cells. Notice the size and shape variation. CD3 antibody stain x 100 (Cell block material).
43 Anaplastic Large cell Lymphoma A cutaneous and a systemic form of Anaplastic Large Cell Lymphoma (ALCL) exist. Although B cell lymphomas may have anaplastic morphology, the characterization of a lymphoma as ALCL is reserved for those lymphomas of T cell or Null cell type. These lymphomas are characterized by large, hyperlobated cells that are Ki-1 (CD30) positive and and express anaplastic large cell lymphoma kinase (ALK). The systemic variety of ALCL occurs in young patients (the first three decades of life) and is more aggressive than the cutaneous variety. The cutaneous form is recurrent, occurs later in life and is more often ALK negative. Variants of anaplastic large cell lymphoma have been described (including a small cell variant.) These variants are characterized by the same immunologic features. Confusingly, anaplastic large cell lymphomas are usually epithelial membrane antigen positive, and may be LCA negative. A panel of immunologic markers, including ALK and CD30 should be performed on cases with hyperlobated cells.
44 Anaplastic Large Cell Lymphoma A B Image 24: A demonstrates Ki1(CD30) positivity in ALCL in the typical cytoplasmic and golgi distribution. B is a Papanicolaou stained fine needle aspirate demonstrating the large size and nuclear lobulations. CD30 antibody and Pap stain x 100.
45 Hodgkin's Lymphoma Although Hodgkin s lymphoma is not high on the differential diagnosis of Large Cell Lymphoma, it may be a consideration when entertaining the diagnosis of ALCL. Reed Sternberg (RS) cells are usually relatively rare in aspirates of Hodgkin's lymphoma. There is a background of reactive follicles and eosinophils, histiocytes and plasma cells may accompany the follicular hyperplasia. Flow cytometry is not helpful in the diagnosis of Hodgkin s Lymphoma. Immunochemical stains are most important. The classic RS cells should be LCA negative, LeuM1(CD15) positive and CD30 positive. Image 25 : This cytospin demonstrates the RS cells with a background of eosinophils and lymphocytes. The immunostain demonstrates the characteristic LeuM1 positivity in a Golgi distribution (Arrow). Cytospin Pap stain and CD30 stain x 50.
46 Summary In summary, unknown Case 6 is a case of Diffuse large B cell lymphoma. The cells are larger than histiocyte nuclei, with vesicular chromatin and nucleoli. Numerous lymphoglandular bodies(cytoplasmic fragments) were present in the background. An LCA stain(cd45ra) was positive, confirming the lymphocytic origin. Although, the diagnosis of Large cell lymphoma is descriptive, the flow cytometric analysis demonstrated a B cell origin without evidence of follicular derivation (CD10 negative.) With the full complement of morphology, immunocytochemistry and flow cytometry, a diagnosis of Large B Cell lymphoma, most likely Diffuse B cell lymphoma could be entertained. There are numerous lymphomas of both T/NK cell and B cell which may appear large morphologically
47 Summary Diffuse Large B cell Lymphoma comprise 30-40% of all lymphomas in the United States. The median age group is 60 years, but the age range is wide. Usually patients present with isolated node or extranodal involvement. The histology demonstrates diffuse replacement of the node without follicle formation. There are several morphologic variants described. These include: centroblastic, immunoblastic, T cell rich B cell, and anaplastic lymphoma. Although these types are recognizable as a Large B cell lymphoma, interobserver variability is broad and the prognostic differences between these types is not established.
48 References Harris NJ, Jaffe ES, Stein H et al. Revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood. 1994;84: Harris NJ, Jafffe ES, Diebold J et al. Lymphoma Classification-from controversy to consensus: The REAL and WHO classification of lymphoid neoplasms. Ann Oncol 2000;11(Suppl 1): Isaacson PG. The current status of lymphoma classification. Br J Haematol 2000;109: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds.) Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues. International Agency for Research on Cancer (IARC) Press; Lyon, Kempson Rl, Fletcher CD, Evans HL, Hendrickson MR, Sibley RK. Tumors of the Soft Tissues. Atlas of Tumor Pathology Series, no 30, third series. AFIP: Washington DC, Young NA, Al-Saleem T. Diagnosis of lymphoma by fine-needle aspiration cytology using the Revised European-American classification of lymphoid neoplasms. Cancer(Cytopathol) 1999;87:
Case 3. Ann T. Moriarty,MD
Case 3 Ann T. Moriarty,MD Case 3 59 year old male with asymptomatic cervical lymphadenopathy. These images are from a fine needle biopsy of a left cervical lymph node. Image 1 Papanicolaou Stained smear,100x.
More informationFrom Morphology to Molecular Pathology: A Practical Approach for Cytopathologists Part 1-Cytomorphology. Songlin Zhang, MD, PhD LSUHSC-Shreveport
From Morphology to Molecular Pathology: A Practical Approach for Cytopathologists Part 1-Cytomorphology Songlin Zhang, MD, PhD LSUHSC-Shreveport I have no Conflict of Interest. FNA on Lymphoproliferative
More informationDETERMINATION OF A LYMPHOID PROCESS
Chapter 2 Applications of Touch Preparation Cytology to Intraoperative Consultations: Lymph Nodes and Extranodal Tissues for Evaluation of Hematolymphoid Disorders INTRODUCTION As discussed in Chap. 1,
More informationDifferential diagnosis of hematolymphoid tumors composed of medium-sized cells. Brian Skinnider B.C. Cancer Agency, Vancouver General Hospital
Differential diagnosis of hematolymphoid tumors composed of medium-sized cells Brian Skinnider B.C. Cancer Agency, Vancouver General Hospital Lymphoma classification Lymphoma diagnosis starts with morphologic
More informationPresentation material is for education purposes only. All rights reserved URMC Radiology Page 1 of 98
Presentation material is for education purposes only. All rights reserved. 2011 URMC Radiology Page 1 of 98 Radiology / Pathology Conference February 2011 Brooke Koltz, Cytopathology Resident Presentation
More information7 Omar Abu Reesh. Dr. Ahmad Mansour Dr. Ahmad Mansour
7 Omar Abu Reesh Dr. Ahmad Mansour Dr. Ahmad Mansour -Leukemia: neoplastic leukocytes circulating in the peripheral bloodstream. -Lymphoma: a neoplastic process in the lymph nodes, spleen or other lymphatic
More information, , 2011 HODGKIN LYMPHOMA
European Federation of Cytology Societies 4tu Annual Tutorial in Cytopathology Trieste, June 6-10, 2011 HODGKIN LYMPHOMA Classification The World Health Organization Classification of Lymphomas (2001)
More informationImmunopathology of Lymphoma
Immunopathology of Lymphoma Noraidah Masir MBBCh, M.Med (Pathology), D.Phil. Department of Pathology Faculty of Medicine Universiti Kebangsaan Malaysia Lymphoma classification has been challenging to pathologists.
More informationNon-Hodgkin lymphomas (NHLs) Hodgkin lymphoma )HL)
Non-Hodgkin lymphomas (NHLs) Hodgkin lymphoma )HL) Lymphoid Neoplasms: 1- non-hodgkin lymphomas (NHLs) 2- Hodgkin lymphoma 3- plasma cell neoplasms Non-Hodgkin lymphomas (NHLs) Acute Lymphoblastic Leukemia/Lymphoma
More informationAnaplastic Large Cell Lymphoma (of T cell lineage)
Anaplastic Large Cell Lymphoma (of T cell lineage) Definition T-cell lymphoma comprised of large cells with abundant cytoplasm and pleomorphic, often horseshoe-shaped nuclei CD30+ Most express cytotoxic
More informationContents. vii. Preface... Acknowledgments... v xiii
Contents Preface... Acknowledgments... v xiii SECTION I 1. Introduction... 3 Knowledge-Based Diagnosis... 4 Systematic Examination of the Lymph Node... 7 Cell Type Identification... 9 Cell Size and Cellularity...
More informationIncidence. Bimodal age incidence 15-40, >55 years Childhood form (0-14) more common in developing countries M:F=1.5:1; in all subtypes except NS
Hodgkin Lymphoma Hodgkin Lymphoma 30% of all lymphomas Absolute incidence unchanged Arise in lymph node, cervical region Neoplastic tissues usually contain a small number of tumor cells Incidence Bimodal
More informationWHO Classification. B-cell chronic lymphocytic leukemia/small T-cell granular lymphocytic leukemia
Blood Malignancies-II Prof. Dr. Herman Hariman, a Ph.D, SpPK (KH). Prof. Dr. Adikoesoema Aman, SpPK (KH) Dept. of Clinical Pathology, School of Medicine, University of North Sumatra WHO classification
More informationLymphoma: What You Need to Know. Richard van der Jagt MD, FRCPC
Lymphoma: What You Need to Know Richard van der Jagt MD, FRCPC Overview Concepts, classification, biology Epidemiology Clinical presentation Diagnosis Staging Three important types of lymphoma Conceptualizing
More informationPearls and pitfalls in interpretation of lymphoid lesions in needle biopsies
Pearls and pitfalls in interpretation of lymphoid lesions in needle biopsies Megan S. Lim MD PhD University of Pennsylvania October 8, 2018 Objectives To understand how the trend toward less invasive lymph
More informationDuring past decades, because of the lack of knowledge
Staging and Classification of Lymphoma Ping Lu, MD In 2004, new cases of non-hodgkin s in the United States were estimated at 54,370, representing 4% of all cancers and resulting 4% of all cancer deaths,
More information3/24/2017 DENDRITIC CELL NEOPLASMS: HISTOLOGY, IMMUNOHISTOCHEMISTRY, AND MOLECULAR GENETICS. Disclosure of Relevant Financial Relationships
DENDRITIC CELL NEOPLASMS: HISTOLOGY, IMMUNOHISTOCHEMISTRY, AND MOLECULAR GENETICS Jason L. Hornick, M.D., Ph.D. Director of Surgical Pathology and Immunohistochemistry Brigham and Women s Hospital Professor
More informationBurkitt lymphoma. Sporadic Endemic in Africa associated with EBV Translocations involving MYC gene on chromosome 8
Heme 8 Burkitt lymphoma Sporadic Endemic in Africa associated with EBV Translocations involving MYC gene on chromosome 8 Most common is t(8;14) Believed to be the fastest growing tumor in humans!!!! Morphology
More informationCase 2. Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset
Case 2 Dr. Sathima Natarajan M.D. Kaiser Permanente Medical Center Sunset History 24 year old male presented with a 3 day history of right flank pain, sharp in nature Denies fever, chills, hematuria or
More informationAggressive B-Cell Lymphomas
Aggressive B-cell Lymphomas Aggressive B-Cell Lymphomas Stephen Hamilton Dutoit Institute of Pathology Aarhus Kommunehospital B-lymphoblastic lymphoma Diffuse large cell lymphoma, NOS T-cell / histiocyte-rich;
More informationClassification of Hematologic Malignancies. Patricia Aoun MD MPH
Classification of Hematologic Malignancies Patricia Aoun MD MPH Objectives Know the basic principles of the current classification system for hematopoietic and lymphoid malignancies Understand the differences
More informationNon-Hodgkin Lymphoma. Protocol applies to non-hodgkin lymphoma involving any organ system except the gastrointestinal tract.
Non-Hodgkin Lymphoma Protocol applies to non-hodgkin lymphoma involving any organ system except the gastrointestinal tract. Protocol revision date: January 2005 No AJCC/UICC staging system Procedures Cytology
More informationPrimary Cutaneous CD30-Positive T-cell Lymphoproliferative Disorders
Primary Cutaneous CD30-Positive T-cell Lymphoproliferative Disorders Definition A spectrum of related conditions originating from transformed or activated CD30-positive T-lymphocytes May coexist in individual
More informationHematopathology Lab. Third year medical students
Hematopathology Lab Third year medical students Objectives Identify the lesion Know the specific name of the lesion Know associated disease Know relevant pathologic background Spherocytes: appear small,
More informationAlmost any suspected tumor can be aspirated easily and safely. Some masses are more risky to aspirate including:
DOES THIS PATIENT HAVE CANCER? USING IN-HOUSE CYTOLOGY TO HELP YOU MAKE THIS DIAGNOSIS. Joyce Obradovich, DVM, Diplomate, ACVIM (Oncology) Animal Cancer & Imaging Center, Canton, Michigan Almost every
More information2010 Hematopoietic and Lymphoid ICD-O Codes - Alphabetical List THIS TABLE REPLACES ALL ICD-O-3 Codes
Acute basophilic leukemia 9870/3 Acute biphenotypic leukemia [OBS] 9805/3 Acute erythroid leukemia 9840/3 Acute megakaryoblastic leukemia 9910/3 Acute monoblastic and monocytic leukemia 9891/3 Acute myeloid
More information2012 Hematopoietic and Lymphoid ICD-O Codes - Numerical List THIS TABLE REPLACES ALL ICD-O-3 Codes
Malignant lymphoma, NOS 9590/3 Non-Hodgkin lymphoma, NOS 9591/3 B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma 9596/3 Primary
More informationHODGKIN LYMPHOMA DR. ALEJANDRA ZARATE OSORNO HOSPITAL ESPAÑOL DE MEXICO
HODGKIN LYMPHOMA DR. ALEJANDRA ZARATE OSORNO HOSPITAL ESPAÑOL DE MEXICO HODGKIN LYMPHOMA CLASSIFICATION Lukes & Butler Rye WHO-2016 Linphocytic and/or histiocytic Nodular & diffuse Nodular Sclerosis Lymphocyte
More informationLEUKAEMIA and LYMPHOMA. Dr Mubarak Abdelrahman Assistant Professor Jazan University
LEUKAEMIA and LYMPHOMA Dr Mubarak Abdelrahman Assistant Professor Jazan University OBJECTIVES Identify etiology and epidemiology for leukemia and lymphoma. Discuss common types of leukemia. Distinguish
More informationCase Report A case of EBV positive diffuse large B-cell lymphoma of the adolescent
Int J Clin Exp Med 2014;7(1):307-311 www.ijcem.com /ISSN:1940-5901/IJCEM1311029 Case Report A case of EBV positive diffuse large B-cell lymphoma of the adolescent Qilin Ao 2, Ying Wang 1, Sanpeng Xu 2,
More informationHepatic Lymphoma Diagnosis An Algorithmic Approach
Hepatic Lymphoma Diagnosis An Algorithmic Approach Ryan M. Gill, M.D., Ph.D. University of California, San Francisco PLEASE TURN OFF YOUR CELL PHONES Disclosure of Relevant Financial Relationships USCAP
More informationCINtec p16 INK4a Staining Atlas
CINtec p16 INK4a Staining Atlas Rating Rating Positive The rating positive will be assigned if the p16 INK4a -stained slide shows a continuous staining of cells of the basal and parabasal cell layers of
More informationDiplomate of the American Board of Pathology in Anatomic and Clinical Pathology
A 33-year-old male with a left lower leg mass. Contributed by Shaoxiong Chen, MD, PhD Assistant Professor Indiana University School of Medicine/ IU Health Partners Department of Pathology and Laboratory
More informationA Practical Guide To Diagnose B-Cell Lymphomas on FNAs. Nancy P. Caraway, M.D.
A Practical Guide To Diagnose B-Cell Lymphomas on FNAs Nancy P. Caraway, M.D. Major Factors Impacting Dx Lymphomas on Small Bxs Classification systems Immunophenotyping by multiprobe flow cytometry and
More informationMimics of Lymphoma in Routine Biopsies. I have nothing to disclose regarding the information to be reported in this talk.
Mimics of Lymphoma in Routine Biopsies Patrick Treseler, MD, PhD Professor of Pathology University of California San Francisco I have nothing to disclose regarding the information to be reported in this
More informationRole of immunohistochemistry in the differential diagnosis of malignant small round cell tumor: a study of 38 cases
International Journal of Research in Medical Sciences Patel A et al. Int J Res Med Sci. 2015 Dec;3(12):3833-3839 www.msjonline.org pissn 2320-6071 eissn 2320-6012 Research Article DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20151452
More informationCombinations of morphology codes of haematological malignancies (HM) referring to the same tumour or to a potential transformation
Major subgroups according to the World Health Organisation (WHO) Classification Myeloproliferative neoplasms (MPN) Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or
More informationAbstract. Anatomic Pathology / DIAGNOSIS AND SUBCLASSIFICATION OF PRIMARY AND RECURRENT LYMPHOMA
Anatomic Pathology / DIAGNOSIS AND SUBCLASSIFICATION OF PRIMARY AND RECURRENT LYMPHOMA Diagnosis and Subclassification of Primary and Recurrent Lymphoma The Usefulness and Limitations of Combined Fine-Needle
More informationCutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement
Cutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchcock Medical Center
More informationA Report of a Rare Case of Anaplastic Large Cell Lymphoma of the Oral Cavity
AJMS Al Ameen J Med Sci (2 0 1 2 )5 (1 ):9 8-1 0 2 (A US National Library of Medicine enlisted journal) I S S N 0 9 7 4-1 1 4 3 C O D E N : A A J M B G CASE REPORT A Report of a Rare Case of Anaplastic
More informationMany of the hematolymphoid disorders are derived
REVIEW ARTICLE Practical Immunohistochemistry in Hematopathology: A Review of Useful Antibodies for Diagnosis Ji Lu, MD and Karen L. Chang, MD Abstract: This review article offers some useful panels of
More informationFinancial disclosures
Cutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchc Geisel School of
More informationEDUCATIONAL COMMENTARY DIFFERENTIATING IMMATURE PERIPHERAL BLOOD CELLS
Educational commentary is provided through our affiliation with the American Society for Clinical Pathology (ASCP). To obtain FREE CME/CMLE credits click on Continuing Education on the left side of the
More informationLarge cell immunoblastic Diffuse histiocytic (DHL) Lymphoblastic lymphoma Diffuse lymphoblastic Small non cleaved cell Burkitt s Non- Burkitt s
Non Hodgkin s Lymphoma Introduction 6th most common cause of cancer death in United States. Increasing in incidence and mortality. Since 1970, the incidence of has almost doubled. Overview The types of
More informationMECHANISMS OF HUMAN DISEASE: LABORATORY SESSIONS LYMPHOMA. April 16, 2008
MECHANISMS OF HUMAN DISEASE: LABORATORY SESSIONS LYMPHOMA April 16, 2008 FACULTY COPY GOAL: Learn the appearance of normal peripheral blood elements and lymph nodes. Recognize abnormal peripheral blood
More information2012 by American Society of Hematology
2012 by American Society of Hematology Common Types of HIV-Associated Lymphomas DLBCL includes primary CNS lymphoma (PCNSL) Burkitt Lymphoma HIV-positive patients have a 60-200 fold increased incidence
More informationMimics of Lymphoma in Routine Biopsies. Mixed follicular and paracortical hyperplasia. Types of Lymphoid Hyperplasia
Mimics of Lymphoma in Routine Biopsies Patrick Treseler, MD, PhD Professor of Pathology University of California San Francisco Types of Lymphoid Hyperplasia Follicular hyperplasia (B-cells) Paracortical
More informationPrimary Spinal T-Cell Rich B-Cell Lymphoma: A Case Report
Primary Spinal T-Cell Rich B-Cell Lymphoma: A Case Report Pages with reference to book, From 148 To 149 Suhail Muzaffar,Irshad Nabi Soomro,Naila Kayani,Shahid Siddiqui ( Departments of Pathology, The Aga
More informationPlasma cell myeloma (multiple myeloma)
Plasma cell myeloma (multiple myeloma) Common lymphoid neoplasm, present at old age (70 years average) Remember: plasma cells are terminally differentiated B-lymphocytes that produces antibodies. B-cells
More informationJMSCR Vol. 03 Issue 06 Page June 2015
www.jmscr.igmpublication.org Impact Factor 3.79 ISSN (e)-2347-176x An Indolent Natural Killer Cell Leukemia Presenting with Bilateral Ankle Arthritis and Low Grade Fever Abstract Author Subhash Chandra
More informationPathology of the Lymphoid System
Pathology of the Lymphoid System Learning Objectives: Define lymphadenitis and enumerate its types. Briefly describe the morphological appearance of reactive lymph node. Describe the microscopic picture
More informationVETERINARY HEMATOLOGY ATLAS OF COMMON DOMESTIC AND NON-DOMESTIC SPECIES COPYRIGHTED MATERIAL SECOND EDITION
VETERINARY HEMATOLOGY ATLAS OF COMMON DOMESTIC AND NON-DOMESTIC SPECIES SECOND EDITION COPYRIGHTED MATERIAL CHAPTER ONE HEMATOPOIESIS GENERAL FEATURES All blood cells have a finite life span, but in normal
More informationAscitic Fluid and Use of Immunocytochemistry. Mercè Jordà, University of Miami
Ascitic Fluid and Use of Immunocytochemistry Mercè Jordà, University of Miami Is It Malignant? Yes? No Ascitic Fluid Cytomorphologic Useful Findings Tight clusters with smooth borders Cellular and nuclear
More informationPeripheral blood Pleural effusion in a cat
Tools for the Diagnosis of Lymphoproliferative Diseases When is it difficult to diagnose lymphoproliferative disease? Persistent lymphocytosis consisting of small Lymph node aspirates containing an excess
More informationGastric Carcinoma with Lymphoid Stroma: Association with Epstein Virus Genome demonstrated by PCR
Gastric Carcinoma with Lymphoid Stroma: Association with Epstein Virus Genome demonstrated by PCR Pages with reference to book, From 305 To 307 Irshad N. Soomro,Samina Noorali,Syed Abdul Aziz,Suhail Muzaffar,Shahid
More informationFOLLICULARITY in LYMPHOMA
FOLLICULARITY in LYMPHOMA Reactive Follicular Hyperplasia Follicular Hyperplasia irregular follicles Follicular Hyperplasia dark and light zones Light Zone Dark Zone Follicular hyperplasia MIB1 Follicular
More informationPart 1. Slides 1-38, Rita Alaggio Soft tissue tumors Trondheim 14. mars 2013
Part 1 Slides 1-38, Rita Alaggio Soft tissue tumors Trondheim 14. mars 2013 Pediatric Pathology Soft Tissue Tumors AN UPDATE Rita Alaggio Azienda Ospedaliera Università di Padova Soft Tissue Tumors More
More informationDiagnostic Cytology of Cancer Cases
Diagnostic Cytology of Cancer Cases Somporn Techangamsuwan Companion Animal Cancer Research Unit (CAC-RU) Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University 1 Tumor or Non-tumor
More informationMedullary Thyroid Carcinoma. This case was provided by Treant Hospital, Bethesda, Hoogeveen, The Netherlands
Medullary Thyroid Carcinoma This case was provided by Treant Hospital, Bethesda, Hoogeveen, The Netherlands ADS-01504 Rev. 001 2016 Hologic, Inc. All rights reserved. Overview Medullary Thyroid Carcinoma
More informationSmall B-cell (Histologically Low Grade) Lymphoma
Frequency of Lymphoid Neoplasms Small B-cell (Histologically Low Grade) Lymphoma Stephen Hamilton-Dutoit Institute of Pathology Aarhus University Hospital B-cell neoplasms 88% Diffuse large B-cell lymphoma
More informationLymphoma/CLL 101: Know your Subtype. Dr. David Macdonald Hematologist, The Ottawa Hospital
Lymphoma/CLL 101: Know your Subtype Dr. David Macdonald Hematologist, The Ottawa Hospital Function of the Lymph System Lymph Node Lymphocytes B-cells develop in the bone marrow and influence the immune
More informationClassifications of lymphomas
Classifications of lymphomas Lukes and Collins Kiel classification Working formulation REAL classification (1994) WHO classification (2000) WHO CLASSIFICATIONF OF NEOPLASMS HAEMATOPETIC AND LYMPHOID TISSUES
More informationFine-Needle Aspiration Cytology in the Diagnosis of Lymphoma The Next Step
Fine-Needle Aspiration Cytology in the Diagnosis of Lymphoma The Next Step Linda M. Sandhaus, MD Since 985, almost 2 articles have been published in the medical literature on the subject of fine-needle
More informationThomas Hodgkin and Hodgkin lymphoma
J Hematopathol (2014) 7:123 138 DOI 10.1007/s12308-014-0214-3 REVIEW ARTICLE Thomas Hodgkin and Hodgkin lymphoma Judith A. Ferry Received: 26 June 2014 /Accepted: 31 July 2014 /Published online: 12 August
More informationQUALITY ASSURANCE PROGRAM CYTOLOGY CYCLE 01/2018 (TRIAL)
[Pick the Date] FINAL REPORT QUALITY ASSURANCE PROGRAM CYTOLOGY CYCLE 01/2018 (TRIAL) NOTES FROM THE COORDINATOR 1. For this cycle 01/2018, a total of 32 pen drives had been circulated. Twenty-eight institutions
More informationBone Marrow. Procedures Blood Film Aspirate, Cell Block Trephine Biopsy, Touch Imprint
Bone Marrow Protocol applies to acute leukemias, myelodysplastic syndromes, myeloproliferative disorders, chronic lymphoproliferative disorders, malignant lymphomas, plasma cell dyscrasias, histiocytic
More informationPathology of Hematopoietic and Lymphoid tissue
Pathology of Hematopoietic and Lymphoid tissue Peerayut Sitthichaiyakul, M.D. Department of Pathology and Forensic Medicine Faculty of Medicine, Naresuan University CONTENTS White blood cells and lymph
More informationCase year female. Routine Pap smear
Case 1 57 year female Routine Pap smear Diagnosis? 1. Atypical glandular cells of unknown significance (AGUS) 2. Endocervical AIS 3. Endocervical adenocarcinoma 4. Endometrial adenocarcinoma 5. Adenocarcinoma
More informationCase Presentation. Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD. Department of Pathology Jordan University Hospital Amman, Jordan
Case Presentation Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD Department of Pathology Jordan University Hospital Amman, Jordan The 25th Annual Congress of the ADIAP The 8/11/2013 1 5th International
More informationPathology of Hematopoietic and Lymphoid tissue
CONTENTS Pathology of Hematopoietic and Lymphoid tissue White blood cells and lymph nodes Quantitative disorder of white blood cells Reactive lymphadenopathies Infectious lymphadenitis Tumor metastasis
More informationSalivary Gland Cytology
Salivary Gland Cytology Diagnostic challenges and potential pitfalls Tarik M. Elsheikh, MD Professor and Medical Director Anatomic Pathology Cleveland Clinic FNA Salivary Gland Lesions Indications Distinguish
More informationRespiratory Tract Cytology
Respiratory Tract Cytology 40 th European Congress of Cytology Liverpool, UK Momin T. Siddiqui M.D. Professor of Pathology and Laboratory Medicine Director of Cytopathology Emory University Hospital, Atlanta,
More informationNodular lymphocyte predominant Hodgkin lymphoma. Lymphoma Tumor Board. January 5, 2018
Nodular lymphocyte predominant Hodgkin lymphoma Lymphoma Tumor Board January 5, 2018 Etiology Subtypes of Classical Hodgkin Lymphoma (chl)* Nodular sclerosing HL Most common subtype Composed of large tumor
More informationADx Bone Marrow Report. Patient Information Referring Physician Specimen Information
ADx Bone Marrow Report Patient Information Referring Physician Specimen Information Patient Name: Specimen: Bone Marrow Site: Left iliac Physician: Accession #: ID#: Reported: 08/19/2014 - CHRONIC MYELOGENOUS
More informationABERRANT EXPRESSION OF CD19 AND CD43
ABERRANT EXPRESSION OF CD19 AND CD43 IN A PATIENT WITH THERAPY-RELATED ACUTE MYELOID LEUKEMIA AND A HISTORY OF MANTLE CELL LYMPHOMA Yen-Chuan Hsieh, 1 Chien-Liang Lin, 2 Chao-Jung Tsao, 2 Pin-Pen Hsieh,
More informationDOWNLOAD ENTIRE DOCUMENT FROM
PREVIEW ONLY 1 Atlas on Bethesda system for reporting Thyroid Cytology PREVIEW ONLY 2 OVERVIEW 1. Indications and goal of thyroid FNA 2. Contraindications 3. Procurement of cell sample 4. Staining methods
More informationÓ Journal of Krishna Institute of Medical Sciences University 104
ISSN 2231-4261 CASE REPORT Unusual Alveolar Pattern in Node Based Diffuse Large B-cell Lymphoma 1* 1 1 1 Archana C. Buch, Jay Y. Sheth, Sunita A Bamanikar, Aditi A. Pandey 1 Department of Pathology, Padmashri
More informationNEW IHC A n t i b o d i e s
NEW IHC Antibodies TABLE OF CONTENTS NEW IHC ANTIBODIES from Cell Marque CITED1 (5H6).... 1 Claudin 7 (5D10F3).... 1 GATA1 (4F5).... 1 Transgelin (2A10C2).... 1 NEW IHC ANTIBODIES using RabMAb Technology
More informationEDUCATIONAL COMMENTARY DISTINGUISHING MORPHOLOGIC LOOK-ALIKES
EDUCATIONAL COMMENTARY DISTINGUISHING MORPHOLOGIC LOOK-ALIKES Educational commentary is provided through our affiliation with the American Society for Clinical Pathology (ASCP). To obtain FREE CME/CMLE
More informationAggressive B-cell Lymphomas
Neoplastic Hematopathology Update 2018 Aggressive B-cell Lymphomas Raju K. Pillai City of Hope National Medical Center I do not have any disclosures Disclosures Outline New entities and changes in WHO
More information88-year-old Female with Lymphadenopathy. Faizi Ali, MD
88-year-old Female with Lymphadenopathy Faizi Ali, MD Clinical History A 88-year-old caucasian female presented to our hospital with the complaints of nausea, vomiting,diarrhea, shortness of breath and
More informationPathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON
Pathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON Presentation outline Background and epidemiology of sarcomas Sarcoma classification Sarcoma
More informationCase Report PAX5-Negative Classical Hodgkin Lymphoma: A Case Report of a Rare Entity and Review of the Literature
Hindawi Case Reports in Hematology Volume 2017, Article ID 7531729, 4 pages https://doi.org/10.1155/2017/7531729 Case Report PAX5-Negative Classical Hodgkin Lymphoma: A Case Report of a Rare Entity and
More informationHEMATOPATHOLOGY (SHANDS HOSPITAL AT THE UNIVERSITY OF FLORIDA): Rotation Director: Ying Li, M.D., Ph.D., Assistant Professor
HEMATOPATHOLOGY (SHANDS HOSPITAL AT THE UNIVERSITY OF FLORIDA): Rotation Director: Ying Li, M.D., Ph.D., Assistant Professor I. Description of the rotation: During this rotation, the resident will gain
More informationThe patient had a mild splenomegaly but no obvious lymph node enlargement. The consensus phenotype obtained from part one of the exercise was:
Case History An 86 year old male was admitted to hospital with chest infection. Haematological examination subsequently revealed the following: Hb- 11.0 g/dl; WBC- 67.1 x 10^9/l; PLT- 99 x10^9/l; RBC-
More information155.2 Malignant neoplasm of liver not specified as primary or secondary. C22.9 Malignant neoplasm of liver, not specified as primary or secondary
ICD-9 TO ICD-10 Reference ICD-9 150.9 Malignant neoplasm of esophagus unspecified site C15.9 Malignant neoplasm of esophagus, unspecified 151.9 Malignant neoplasm of stomach unspecified site C16.9 Malignant
More informationLymphatic system component
Introduction Lymphatic system component Statistics Overview Lymphoma Non Hodgkin s Lymphoma Non- Hodgkin's is a type of cancer that originates in the lymphatic system. It is estimated to be the sixth most
More informationMolecular Pathology of Lymphoma (Part 1) Rex K.H. Au-Yeung Department of Pathology, HKU
Molecular Pathology of Lymphoma (Part 1) Rex K.H. Au-Yeung Department of Pathology, HKU Lecture outline Time 10:00 11:00 11:15 12:10 12:20 13:15 Content Introduction to lymphoma Review of lymphocyte biology
More informationACCME/Disclosures ALK FUSION-POSITIVE MESENCHYMAL TUMORS. Tumor types with ALK rearrangements. Anaplastic Lymphoma Kinase. Jason L.
Companion Meeting of the International Society of Bone and Soft Tissue Pathology The Evolving Concept of Mesenchymal Tumors ALK FUSION-POSITIVE MESENCHYMAL TUMORS Jason L. Hornick, MD, PhD March 13, 2016
More informationLYMPHOMAS an overview of some subtypes of NHLs
One of the confusing aspects of the lymphoid neoplasms concerns the use of the descriptive terms "leukemia" and "lymphoma." LYMPHOMAS an overview of some subtypes of NHLs Leukemia is used for lymphoid
More informationSuccessful flow cytometric immunophenotyping of body fluid specimens
Successful flow cytometric immunophenotyping of body fluid specimens Fiona E. Craig, MD Division of Hematopathology Mayo Clinic Arizona 2017 MFMER slide-1 Financial disclosure No conflicts 2017 MFMER slide-2
More informationThe spectrum of flow cytometry of the bone marrow
The spectrum of flow cytometry of the bone marrow Anna Porwit Lund University Faculty of Medicine Dept. of Clinical Sciences Div. Oncology and Pathology anna.porwit@med.lu.se Disclosure of speaker s interests
More informationCase Report Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell Pattern
Case Reports in Hematology Volume 23, Article ID 84253, 6 pages http://dx.doi.org/.55/23/84253 Case Report Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell Pattern Rowan L.
More informationEvening specialty conference: Liver
Evening specialty conference: Liver Joseph Misdraji, M.D. Disclosure of Relevant Financial Relationships Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee)
More informationInternational Journal of Pharma and Bio Sciences CHROMOPHOBE VARIANT OF RENAL CELL CARCINOMA MASQUARDING AS RENAL ONCOCYTOMA ON CYTOLOGY.
Case Report Pathology International Journal of Pharma and Bio Sciences ISSN 0975-6299 CHROMOPHOBE VARIANT OF RENAL CELL CARCINOMA MASQUARDING AS RENAL ONCOCYTOMA ON CYTOLOGY. DR.MAMATHA K*, DR. ARAKERI
More informationParticipants Identification No. % Evaluation
BMD-02 Cell Identification Participants Identification No. % Evaluation Erythrocyte precursor, normal 228 95.8 Educational Erythrocyte, normal 7 3.0 Educational Erythrocyte precursor with megaloblastic
More informationSelf assessment case. Dr Saleem Taibjee Dorset County Hospital, Dorchester
Self assessment case Dr Saleem Taibjee saleemtaibjee@gmail.com Dorset County Hospital, Dorchester Clinical details 34-year-old man: Shave excision Skin tag / papilloma left thigh The best diagnosis is:
More informationFinancial disclosures
Mesenchymal Neoplasms with Melanocytic Differentiation By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchcock Medical Center Geisel
More information