BIOMAT-ENDO: preliminary results on 1100 thyroid carcinoma cases

Transcription

1 See discussions, stats, and author profiles for this publication at: BIOMAT-ENDO: preliminary results on 1100 thyroid carcinoma cases Conference Paper June 2016 READS 22 9 authors, including: Mariana Purice National Institute of Endocrinology CI Parhon 84 PUBLICATIONS 124 CITATIONS Sorin Mircea Rusu 6 PUBLICATIONS 4 CITATIONS SEE PROFILE SEE PROFILE Available from: Mariana Purice Retrieved on: 11 August 2016

2 BIOMAT-ENDO: preliminary results on 1100 thyroid carcinoma cases Mariana Purice 1, A. Goldstein 1, Iulia Chiriac 1, Alexandra-Cristina Mihai 1, Andreea Giurgi 2,Sorin Rusu 3, Monica Radulescu 3, Adina Ghemigian 1,4, Catalina Poiana 1,4 1 C.I.Parhon National Institute of Endocrinology, Bucharest, 2 Faculty of Biology, University of Bucharest 3 SOFTWIN ROMANIA, 4 Carol Davila University of Medicine and Pharmacy, Bucharest

3 Estimated incidence, mortality & prevalence in European countries EUCAN DATA (2012) EUROPEAN CANCER OBSERVATORY Incidence 2012 Mortality 2012 Prevalence 2012 Number Rate Number Rate 1-year 3-years 5-years EUROPE EU Thyroid cancer a relatively rare neoplasm worldwide, 1-5% of all cancers in females and around 2% in males The most common endocrine malignancy worlwide During the past several decades, an increasing incidence has been reported in some European countries, the United States and some parts of the China 2

4 National Institute of Endocrinology C.I.Parhon Bucharest Department of Nuclear Medicine (DNM) years of management of TC over patients evidenced in classic file format (FISE) 1966 patient 1980 patient 2015 patient

5 : 2335 new cases have been discovered (25% of the total cases). ACTIVES (86%) NEW ( ) 20% (25%) 1452 (14%) 2000 * September TOTAL PATIENTS TC ACTIVES NEW ( ) ARCHIVED ( > 10 years absence/dead)

6 National Institute of Endocrinology C.I.Parhon Bucharest Department of Nuclear Medicine (DNM) 9274 active patients with diagnostic of thyroid cancer (TC) evidenced in classic file format (FISE ) active files = Biblioteca din Alexandria

7 Dramatic Chernobyl moment: April years!!!! Chernobyl Reactor No way No way Gomel town

8 Spatial distribution in Europe of average country/region-specific cumulative whole-body radiation doses (msv) from Chernobyl (26 April 1986) Belarus: bb-brest; bg-gomel;br-grodno; bi-minsk; bm-mogilev; bv-vitebsk Ukraine: uc-chernigov; uk-kiev; ur-rivno; uz-zhytomir; uo-rest of Ukraine Russia: rb-bryansk; rk-kaluga; ro-orel; rt-tula Cardis E et al, Int J Cancer

9 National Institute of Endocrinology C.I.Parhon Department of Nuclear Medicine (DNM) 50 years management of TC : radio iodine 131 I therapy (RIT) investigations: in Vivo and in Vitro, specific to TC follow up of treated patients During 50 years the MANAGEMENT of TC has changed substantially as a result of our expanding knowledge and the availability of newer diagnostic and therapeutic modalities. thyroidectomy modified philosophy/variability performances in histopathogy diagnostic lower ablation 131 I dose high specific TC tumor markers high resolution gamma camera r htsh alternative to thyroxin withdrawal before RIT molecular genetics of TC others 8

10 BIOMAT-ENDO software was born (Cex Research Contract BIOMAT: ) MODERN DATA BASE FOR: 1.1 Patient Follow up from the first hospitalization and during all periods of radioiodine therapy or follow up (years) 1.2 screening of thyroid nodule (retrospective) Mathematic applications using these DATA 2.1 Correlations & statistic 2.2 Dynamic studies 2.3 Modeling the trends for different population groups Open DB for any new input parameter in Patient monitoring module (ex: Medular carcinoma/men)

11 Developed as a Windows Forms application, in client-server architecture The back-end of the application is a data base (DB) that can store all data regarding the patient hospitalized in the DNM starting with the first hospitalization, continuing with all the periods of RIT and with the follow up. 10

12 Insert clinical data BIOMAT- ENDO Patient monitoring module Insert in Vivo & in Vitro data Insert surgery & RIT or other therapy

13 BIOMAT-ENDO data base private grant : October 2015-September 2016 Thanks to all of you that gave us your VOTE in September 2015!!!!! TARGETS over 2000 digitalized data* Applying various machine-learning techniques to explore and understand the information contained in data base Descriptive study: will allow to reveal the main patients typologies. Modelling data: with the perspective of discriminating several situations and predicting them. algorithms: decision trees, random forests, support vector machines and logistic regression

14 RESULTS SQL( Structure Query Language)

15 Correlations: Can be done between input parameters, can be printed and exported on a host PC). Statistic: At the level of Data base we can imagine and construct a huge number of queries. From them, we obtain different statistic results. 14

16 New cases n= Chernobil

17 Distribution new cases* on decades n= Introduction criteria : -archive ( non active): alphabetic order all A-H new pts( before first RIT) --other

18 Age and gender distribution n=1110 4% 18% 53% 43% 82% < >45 F M

19 Risk factors Antecedents 0% 1% 1% 17% 31% 37% 69% 44% ZONA ENDEMICA ZONA NON ENDEMICA MEN B BASEDOW Gusa nodulara Gusa polinodulara Hashimoto X GN+ GPN= 81% B Basedow : 1% Hashimoto : 1% X= fara antecedente : 17 % MEN: 1 caz

20 Distribution by histopathology * the higher heterogeneity of the data : laboratory results

21 Distribution by histopathology * Fara AP existent in FO

22 Final remarks The Department of Nuclear Medicine has an evidence that represents more than 80% of the total thyroid cancer cases in Romania and BIOMAT-ENDO data base is a very useful tool to keep them in an uniform digitalized format. 2. Careful studies of selected populations and health outcomes could be possible using BIOMAT-ENDO data base in order to study the effects of Chernobyl accident in Romania and compare them to other nuclear disaster predictions. 3. Our target is to arrive to >2000 cases in BIOMAT-ENDO data base, so that we could apply for statistical mathematic descriptive & modeling studies query results SAMM (Statistique, Analyse, Modélisation Multidisciplinaire) Universite Paris I Panthéon Sorbonne

23 The Team Dr. Lucian Beznea Eusebie Marcu Dr. Andrei Goldstein Prof. Dr.Catalina Poiana Dr. Radu Purice Stefan Diaconescu Dr. Maria Belgun Dr. Alexandra Mihai Sorin Rusu Monica Radulescu Mst.Andreea Giurgi Dr. Iulia Chiriac Cooperation bilateral francophone Dr. Adina Ghemigian George Butoi IT As.Nicoleta Craciun