MALT LYMPHOMA. Silvia Montoto, St Bartholomew s Hospital, London, UK ESMO Preceptorship on Lymphoma

Size: px
Start display at page:

Download "MALT LYMPHOMA. Silvia Montoto, St Bartholomew s Hospital, London, UK ESMO Preceptorship on Lymphoma"

Transcription

1 MALT LYMPHOMA Silvia Montoto, St Bartholomew s Hospital, London, UK ESMO Preceptorship on Lymphoma Madrid, November 2016

2 Disclosuresof commercial support Roche Gilead

3 Marginal zone B-cell lymphomas SMZL, NMZL, MALT The NHL Classification Project, Blood 1997

4 The Mucosa Associated Lymphoid Tissue concept Native MALT normally present in certain extra-nodal sites (e.g., Peyer s patches) Acquired MALT where lymphoid tissue is not a natural component (e.g.,sjögren, Hashimoto, H. pylori-gastritis) MALT Lymphoma first described in the stomach by Isaacson and Wright in 1983, but can arise from a wide variety of extra-nodal tissues (usually at acquired MALT sites)

5 MALT lymphoma: clinicalcharacteristics Median age: 60 years BM involvement: 15-20% Most common: gastric(1/3) Other sites of involvement: Small bowel/colon Lung Ocular Skin Thyroid Salivary glands

6 Gastric MALT 50% of primary gastric lymphoma Associated with HP infection(2/3) Molecular characteristics: t(11;18)(q21;q21) Potential histological transformation to a highgrade lymphoma

7 H. pylori and MALT lymphoma B B B B B B B B B H. pylori-dependent MALT lymphoma neutrophilsactivation with release of genotoxic free radicals H. pylori-independent MALT lymphoma genetic alterations B B B B B B additional genetic damages B B-cell proliferation H. pylori chronic gastritis contact-dependent B-cell stimulation antigen selection autoimmunity T T T T T mucosal T-cell proliferation diffuse large B-cell lymphoma

8 Diagnosis and staging of gastric MALT OGD nonspecific gastritis peptic ulcer rarely mass lesions often multifocal (even if macroscopically normal) FISH Echo-endoscopy H pylori detection CAP CT BM aspirate and biopsy

9 Detection of Helicobacter pylori Test Sensitivity Specificity Advantages Disadvantages Histology: H/E, IHC Histology: urease test (Clo-test) Histology: culture 95% 99% Information re gastric histo Interobserver variability; affected by PPI/ATB use 90% 93% Rapidresults Affected by PPI/ATB use 58% 100% ATBsensitivity Trained staff; expensive Serology 76-84% 79-90% Widely available; inexpensive Urea breath test >95% >95% Useful before/after treatment Stool Ag test 96% 97% Useful before/after treatment +vemight reflect past infection; not useful after treatment False veif PPI/ATB; personnel/resources Stool collection; false veif PPI/ATB;

10 Gastric MALT-Staging Zuccaet al, Annals of Oncol, 2013

11 Gastric MALT lymphoma: OS according to treatment Treatment n CR rate 5-year OS Antibiotics 45 67% 94% Local treatment a % 91% Chemotherapy 8 50% 75% Combined modality b 5 100% 80% Total 72 74% 89% a surgery ± RT, b surgery + adjuvant chemotherapy Pinotti et al, 1997

12 Surgery for gastric MALT Surgery +/- additional treatment (chemo, RT): 5-year OS: 85%-95% Total gastrectomy should be considered since MALT lymphoma is often multifocal

13 Radiotherapy for gastric MALT Author n RT dose (Gy) FFP Schechter, % at 2 yr Tsang, % at 5 yr Yahalom, median 89% at 4 yr Hitchcock, median 78% (100% local)

14 Chemotherapy for MALT Single Agent ORR CR Reference alkylating 100% 75% Hummel, JCO 1995 cladribine 100% 84% Jager, JCO 2002 oxalyplatin 93% 56% Raderer, JCO 2005 Combination CVP 100% 100% Zinzani, Cancer 2004 FM 100% 100% Zinzani, Cancer 2004 MCP 100% 53% Wohrer, Ann Oncol 2003

15 Response to antibiotics Reference n staging CR rate time to CR relapses procedure (%) (mos.) (n) Savio, CT Pinotti, CT Neubauer, CT±EUS Nobre Leitao, CT+EUS Steinbach, CT±EUS Montalban, CT±EUS Ruskone-Formestraux, CT+EUS LY03 interim analysis, CT

16 Predictive factors for lack of response to antibiotics Deep infiltration of gastric wall Lymph node involvement Increased number of large cells t(11;18)

17 ESMO guidelines: localised stage

18 ESMO guidelines: advanced stage

19 IELSG 19 study

20 IELSG 19 study Zuccaet al, J ClinOncol, 2013

21 Assessment of response Histology& assessment of HP eradication Persistence of residual lymphoma on Bx can last 12 months PCR for B-cell clonality remains +ve in 50% of histological CR

22 Follow-up EGILS 2011 guidelines follow-up gastroscopies with biopsies seem advisable ESMO 2013 guidelines a long-term careful endoscopic and systemic follow-up is recommended for all patients

23 Histological transformation in MZL 340 patients with MZL 46% MALT 25% SMZL 11% NMZL 18% CBL-MZL HT Bx-proven Median follow-up: 5 yrs Conconi et al, Annals Oncol, 2015

24 Non-gastric MALT

25 Non-gastric MALT Chlamydia psittaci v Sjögren syndrome Borrelia burgdorferi Hashimoto thyroiditis

26 Non-gastric MALT: outcome according to primary site Zucca et al, Blood, 2003

27 MALT of the salivary glands: IELSG patients with MALT Median follow-up: 55 months Jackson et al, The Oncol, 2015

28 OAL and Chlamydia: IELSG 27 48% eradication RR: 65% Ferreri et al, J Clin Oncol, 2012

29 Summary Antigen-driven processes treatment of initiating event Disseminated disease, limited to mucosal sites, not associated with poor outcome Excellent prognosis (OS) regardless of treatment

30 Thank you!

31 Pathogenesis rare, 2% t(1;14) BCL10 deregulation common, 35% t(11;18) API2/MALT1 fusion at non-gi sites, 20% t(14;18) MALT 1 deregulation NF-kB activation Antibiotic-resistant gastric MALT lymphoma

32 Alkylating agents for MALT 24 patients, 17 stage I, 7 stage IV Cyclophosphamide or Chlorambucil for 8-24 mos. 100%ORR (75%CR) 5-year EFS: 50% 5-year OS: 75% 5 relapses at initial sites (1with transformation) Hammel et al. JCO, 1995

33 C psittaci in Ocular Adnexae Lymphoma (OAL) Orbital Lymph Chlamydia OAL biopsies node P-value (n= 40) (n= 20) (n= 26) psittaci 32 (80%) 0 3 (12%) trachomatis ns pneumoniae ns Objective response following doxycycline: 48% (6/27: CR, 7/27: PR) Ferreri et al, JNCI, 2006

34 Non-gastric MALT Zucca et al. Blood, 2003

35 IELSG study of non-gastric MALT lymphoma N: 180 (68M/ 112F, median age: 59 yrs) PS>2: 4% B-symptoms: 3% Bone marrow involvement: 14% Nodal involvement: 21% More than 1 extra-nodal: 23% Stage IV: 27%

36 OAL and Chlamydia: IELSG 27 Reference Country No. of Assessed Cases Frequency of Positive Cases Ferreri 2004 Italy 40 80% You 2005 Korea 33 79% Gracia 2006 Cuba 20 5% Vargas 2005 USA 7 0% Daibata 2006 Japan 18 0% Rosado 2005 USA 49 0% Mulder 2006 Nederlands 20 0% Zhang 2005 USA 15 0% Zucca and Bertoni, JNCI, 2006

MALT LYMPHOMA. Silvia Montoto, St Bartholomew s Hospital, London, UK ESMO Preceptorship on Lymphoma

MALT LYMPHOMA. Silvia Montoto, St Bartholomew s Hospital, London, UK ESMO Preceptorship on Lymphoma MALT LYMPHOMA Silvia Montoto, St Bartholomew s Hospital, London, UK ESMO Preceptorship on Lymphoma Lugano, 3-4 November 2017 Disclosures: Roche: honoraria Gilead: travel grant ESMO Preceptorship on Lymphoma

More information

Primary non-hodgkin Lymphomas of the Gastrointestinal Tract (GI-NHL)

Primary non-hodgkin Lymphomas of the Gastrointestinal Tract (GI-NHL) Portorož, Slovenia, June 15-16, 2007 Falk Symposium 160 Pathogenesis and Clinical Practice in Gastroenterology Primary non-hodgkin Lymphomas of the Gastrointestinal Tract (GI-NHL) Emanuele Zucca, M.D.

More information

Treatment: Gastric MALT lymphoma Anastasios Stathis, M.D.

Treatment: Gastric MALT lymphoma Anastasios Stathis, M.D. Treatment: Gastric MALT lymphoma Anastasios Stathis, M.D. Phase I and Lymphoma Unit Oncology Ins6tute of Southern Switzerland Bellinzona, Switzerland Gastric MALT lymphoma MALT lymphomas: approximately

More information

Limited Role of Bone Marrow Aspiration and Biopsy in the Initial Staging Work-up of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma in Korea

Limited Role of Bone Marrow Aspiration and Biopsy in the Initial Staging Work-up of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma in Korea Gut and Liver, Vol. 8, No. 6, November 2014, pp. 637-642 ORiginal Article Limited Role of Bone Marrow Aspiration and Biopsy in the Initial Staging Work-up of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

More information

Marginal zone lymphoma: Associated autoimmunity & auto-immune disorders

Marginal zone lymphoma: Associated autoimmunity & auto-immune disorders Marginal zone lymphoma: Associated autoimmunity & auto-immune disorders Dr Andrew Wotherspoon Histopathology department Royal Marsden Hospital London, UK AI disorders affect 5-9% of the world populagon

More information

FOLLICULARITY in LYMPHOMA

FOLLICULARITY in LYMPHOMA FOLLICULARITY in LYMPHOMA Reactive Follicular Hyperplasia Follicular Hyperplasia irregular follicles Follicular Hyperplasia dark and light zones Light Zone Dark Zone Follicular hyperplasia MIB1 Follicular

More information

Regression of Advanced Gastric MALT Lymphoma after the Eradication of Helicobacter pylori

Regression of Advanced Gastric MALT Lymphoma after the Eradication of Helicobacter pylori Gut and Liver, Vol. 6, No. 2, April 2012, pp. 270-274 CASE REPORT Regression of Advanced Gastric MALT Lymphoma after the Eradication of Helicobacter pylori Soo-Kyung Park, Hwoon-Yong Jung, Do Hoon Kim,

More information

Case Report Mucosa-Associated Lymphoid Tissue Lymphoma of the Lacrimal Gland: Sustained Remission after Eradication of Helicobacter Pylori Infection

Case Report Mucosa-Associated Lymphoid Tissue Lymphoma of the Lacrimal Gland: Sustained Remission after Eradication of Helicobacter Pylori Infection Case Reports in Gastrointestinal Medicine Volume 2011, Article ID 945752, 4 pages doi:10.1155/2011/945752 Case Report Mucosa-Associated Lymphoid Tissue Lymphoma of the Lacrimal Gland: Sustained Remission

More information

CASE REPORTS INTRODUCTION

CASE REPORTS INTRODUCTION CASE REPORT Clin Endosc 2013;46:288-292 Print ISSN 2234-2400 / On-line ISSN 2234-2443 http://dx.doi.org/10.5946/ce.2013.46.3.288 Open Access Two Cases of Diffuse Large B-Cell Lymphomas in the Cervical

More information

Helicobacter and gastritis

Helicobacter and gastritis 1 Helicobacter and gastritis Dr. Hala Al Daghistani Helicobacter pylori is a spiral-shaped gram-negative rod. H. pylori is associated with antral gastritis, duodenal (peptic) ulcer disease, gastric ulcers,

More information

INTRODUCTION. See editorial on page 659. Background/Aims: We investigated the effectiveness of

INTRODUCTION. See editorial on page 659. Background/Aims: We investigated the effectiveness of Gut and Liver, Vol. 10, No. 5, September 2016, pp. 706-713 ORiginal Article Helicobacter pylori Eradication Therapy Is Effective as the Initial Treatment for Patients with H. pylori-negative and Disseminated

More information

Pathology of the indolent B-cell lymphomas Elias Campo

Pathology of the indolent B-cell lymphomas Elias Campo Pathology of the indolent B-cell lymphomas Elias Campo Hospital Clinic, University of Barcelona Small B-cell lymphomas Antigen selection NAIVE -B LYMPHOCYTE MEMORY B-CELL MCL FL LPL MZL CLL Small cell

More information

Patient underwent hemicolectomy: 7 x 4.5 cm intusscepted segment of ileum in colon - mucosal

Patient underwent hemicolectomy: 7 x 4.5 cm intusscepted segment of ileum in colon - mucosal Extranodal Lymphomas Rena Buckstein Odette Cancer Center Case: JT 69 yo male COO software company PMHx: basal cell back, cholesterol Presents to ER with severe abdominal pain, bloody diarrhea x 2d In ER

More information

GENETIC MARKERS IN LYMPHOMA a practical overview. P. Heimann Dpt of Medical Genetics Erasme Hospital - Bordet Institute

GENETIC MARKERS IN LYMPHOMA a practical overview. P. Heimann Dpt of Medical Genetics Erasme Hospital - Bordet Institute GENETIC MARKERS IN LYMPHOMA a practical overview P. Heimann Dpt of Medical Genetics Erasme Hospital - Bordet Institute B and T cell monoclonalities Rearrangement of immunoglobin and TCR genes may help

More information

Recurrence after Radiotherapy for Gastric Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Trisomy 18

Recurrence after Radiotherapy for Gastric Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Trisomy 18 CASE REPORT Recurrence after Radiotherapy for Gastric Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Trisomy 18 Hisashi Ishikawa 1, Masaya Iwamuro 1,2, Hiroyuki Okada 3,KeisukeHori 1, Masahide

More information

Splenic marginal zone NHL: Update on biology and therapy. Jonathan W. Friedberg M.D., M.M.Sc.

Splenic marginal zone NHL: Update on biology and therapy. Jonathan W. Friedberg M.D., M.M.Sc. Splenic marginal zone NHL: Update on biology and therapy Jonathan W. Friedberg M.D., M.M.Sc. Marginal zone NHL: A Neglected Lymphoma? Marginal zone NHL/MALT; 3 rd most common B-cell NHL Al-Hamadani et

More information

Key words : low-grade MALT lymphoma, epithelial change, empty lamina propria, B-cell clonality, H. pylori, eradication, long-term follow-up

Key words : low-grade MALT lymphoma, epithelial change, empty lamina propria, B-cell clonality, H. pylori, eradication, long-term follow-up Department of Pathology, The University of Tokushima School of Medicine, Tokushima, Japan ; Department of Oral and Maxillofacial Surgery, The University of Tokushima School of Dentistry, Tokushima, Japan

More information

A RETROSPECTIVE INTERNATIONAL STUDY OF PRIMARY EXTRANODAL MARGINAL ZONE LYMPHOMA OF THE LUNG (BALT-LYMPHOMA)

A RETROSPECTIVE INTERNATIONAL STUDY OF PRIMARY EXTRANODAL MARGINAL ZONE LYMPHOMA OF THE LUNG (BALT-LYMPHOMA) 28 A RETROSPECTIVE INTERNATIONAL STUDY OF PRIMARY EXTRANODAL MARGINAL ZONE LYMPHOMA OF THE LUNG (BALT-LYMPHOMA) Principal investigators Giovanni Martinelli European Institute of Oncology Milan, Italy Pier

More information

Index. Note: Page numbers of article titles are in boldface type.

Index. Note: Page numbers of article titles are in boldface type. Note: Page numbers of article titles are in boldface type. A Adherence, to bismuth quadruple therapy, 543 546 Adjuvant therapy, probiotics as, 567 569 Age factors, in gastric cancer, 611 612, 616 AID protein,

More information

PRIMARY GASTRIC LYMPHOMA: CASE REPORT WITH REVIEW OF LITERATURE

PRIMARY GASTRIC LYMPHOMA: CASE REPORT WITH REVIEW OF LITERATURE PRIMARY GASTRIC LYMPHOMA: CASE REPORT WITH REVIEW OF LITERATURE Rana K. Sherwani, *Kafil Akhtar, Noorin Zaidi, Anjum Ara Department of Pathology, J.N. Medical College, Aligarh Muslim University, Aligarh,

More information

Histopathology: gastritis and peptic ulceration

Histopathology: gastritis and peptic ulceration Histopathology: gastritis and peptic ulceration These presentations are to help you identify, and to test yourself on identifying, basic histopathological features. They do not contain the additional factual

More information

NON HODGKINS LYMPHOMA: INDOLENT Updated June 2015 by Dr. Manna (PGY-5 Medical Oncology Resident, University of Calgary)

NON HODGKINS LYMPHOMA: INDOLENT Updated June 2015 by Dr. Manna (PGY-5 Medical Oncology Resident, University of Calgary) NON HODGKINS LYMPHOMA: INDOLENT Updated June 2015 by Dr. Manna (PGY-5 Medical Oncology Resident, University of Calgary) Reviewed by Dr. Michelle Geddes (Staff Hematologist, University of Calgary) and Dr.

More information

Non-Hodgkin s Lymphomas Version

Non-Hodgkin s Lymphomas Version NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) Non-Hodgkin s Lymphomas Version 2.2015 NCCN.org Continue Principles of Radiation Therapy PRINCIPLES OF RADIATION THERAPY a Treatment with

More information

What is the status of Sequential Therapy Versus Standard Triple- Drug Therapy in peptic ulcer disease in eradicating H pylori?

What is the status of Sequential Therapy Versus Standard Triple- Drug Therapy in peptic ulcer disease in eradicating H pylori? What is the status of Sequential Therapy Versus Standard Triple- Drug Therapy in peptic ulcer disease in eradicating H pylori? Sequential Therapy Versus Standard Triple- Drug Therapy for Helicobacter pylori

More information

EGILS consensus report. Gastric extranodal marginal zone B-cell lymphoma of MALT

EGILS consensus report. Gastric extranodal marginal zone B-cell lymphoma of MALT Gut Online First, published on February 11, 2011 as 10.1136/gut.2010.224949 Guidelines For numbered affiliations and full list of contributors see end of article. Correspondence to Agnès Ruskoné-Fourmestraux,

More information

J Clin Oncol 23: by American Society of Clinical Oncology INTRODUCTION

J Clin Oncol 23: by American Society of Clinical Oncology INTRODUCTION VOLUME 23 NUMBER 31 NOVEMBER 1 2005 JOURNAL OF CLINICAL ONCOLOGY O R I G I N A L R E P O R T Long-Term Follow-Up of Gastric MALT Lymphoma After Helicobacter Pylori Eradication Thomas Wündisch, Christian

More information

Radiotherapy in DLCL is often worthwhile. Dr. Joachim Yahalom Memorial Sloan-Kettering, New York

Radiotherapy in DLCL is often worthwhile. Dr. Joachim Yahalom Memorial Sloan-Kettering, New York Radiotherapy in DLCL is often worthwhile Dr. Joachim Yahalom Memorial Sloan-Kettering, New York The case for radiotherapy Past: Pre-Rituximab randomized trials Present: R-CHOP as backbone, retrospective

More information

Stage IV marginal zone B-cell lymphoma prognostic factors and the role of rituximab: Consortium for Improving Survival of Lymphoma (CISL) study

Stage IV marginal zone B-cell lymphoma prognostic factors and the role of rituximab: Consortium for Improving Survival of Lymphoma (CISL) study Stage IV marginal zone B-cell lymphoma prognostic factors and the role of rituximab: Consortium for Improving Survival of Lymphoma (CISL) study Sung Yong Oh, 1,2 Won Seog Kim, 3 Jin Seok Kim, 4 Seok Jin

More information

Large cell immunoblastic Diffuse histiocytic (DHL) Lymphoblastic lymphoma Diffuse lymphoblastic Small non cleaved cell Burkitt s Non- Burkitt s

Large cell immunoblastic Diffuse histiocytic (DHL) Lymphoblastic lymphoma Diffuse lymphoblastic Small non cleaved cell Burkitt s Non- Burkitt s Non Hodgkin s Lymphoma Introduction 6th most common cause of cancer death in United States. Increasing in incidence and mortality. Since 1970, the incidence of has almost doubled. Overview The types of

More information

Non-Hodgkin lymphoma

Non-Hodgkin lymphoma Non-Hodgkin lymphoma Non-Hodgkin s lymphoma Definition: - clonal tumours of mature and immature B cells, T cells or NK cells - highly heterogeneous, both histologically and clinically Non-Hodgkin lymphoma

More information

Mucosa-associated lymphoid tissue lymphoma of the urinary bladder

Mucosa-associated lymphoid tissue lymphoma of the urinary bladder DOI 10.1007/s13691-012-0041-2 CASE REPORT Mucosa-associated lymphoid tissue lymphoma of the urinary bladder Taeko Matsuoka Takayuki Yoshino Yoshiharu Fukuhara Naoto Miyanaga Kuniyuki Oka Reizo Nagayama

More information

Chlamydia psittaci Infection in Nongastrointestinal Extranodal MALT Lymphomas and Their Precursor Lesions

Chlamydia psittaci Infection in Nongastrointestinal Extranodal MALT Lymphomas and Their Precursor Lesions Hematopathology / CHLAMYDIA PSITTACI in MALT lymphomas Chlamydia psittaci Infection in Nongastrointestinal Extranodal MALT Lymphomas and Their Precursor Lesions Ariane Aigelsreiter, MD, 1 Tanja Gerlza,

More information

Transformed lymphoma: biology and treatment

Transformed lymphoma: biology and treatment Transformed lymphoma: biology and treatment Silvia Montoto Centre for Haemato-Oncology Barts Cancer Institute 1.00 0.75 0.50 0.25 0.00 N =330 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 Years %Viability

More information

Predictive factors for regression of gastric MALT lymphoma after anti-helicobacter pylori treatment

Predictive factors for regression of gastric MALT lymphoma after anti-helicobacter pylori treatment Gut 2001;48:297 303 297 PAPERS Predictive factors for regression of gastric MALT lymphoma after anti-helicobacter pylori treatment A Ruskoné-Fourmestraux, A Lavergne, P H Aegerter, F Megraud, L Palazzo,

More information

Helicobacter pylori 幽門螺旋桿菌 馬偕紀念醫院新竹分院一般內科, 肝膽腸胃科陳重助醫師

Helicobacter pylori 幽門螺旋桿菌 馬偕紀念醫院新竹分院一般內科, 肝膽腸胃科陳重助醫師 Helicobacter pylori 幽門螺旋桿菌 馬偕紀念醫院新竹分院一般內科, 肝膽腸胃科陳重助醫師 Hp : Helicobacter pylori Part 1. Pathophysiology and immune response Pathogenesis of Hp infection Part 2. Clinical manifestation Part 3. Dx tests for

More information

Small B-cell (Histologically Low Grade) Lymphoma

Small B-cell (Histologically Low Grade) Lymphoma Frequency of Lymphoid Neoplasms Small B-cell (Histologically Low Grade) Lymphoma Stephen Hamilton-Dutoit Institute of Pathology Aarhus University Hospital B-cell neoplasms 88% Diffuse large B-cell lymphoma

More information

Helicobacter 2008;13:1-6. Am J Gastroent 2007;102: Am J of Med 2004;117:31-35.

Helicobacter 2008;13:1-6. Am J Gastroent 2007;102: Am J of Med 2004;117:31-35. An Update on Helicobacter pylori and Its Treatment Trenika Mitchell, PharmD, BCPS Clinical Assistant Professor University of Kentucky College of Pharmacy October 18, 2008 Objectives Review the epidemiology

More information

LYMPHOMA in HIV PATIENTS. Silvia Montoto, St Bartholomew s Hospital, London, UK ESMO Preceptorship on Lymphoma

LYMPHOMA in HIV PATIENTS. Silvia Montoto, St Bartholomew s Hospital, London, UK ESMO Preceptorship on Lymphoma LYMPHOMA in HIV PATIENTS Silvia Montoto, St Bartholomew s Hospital, London, UK ESMO Preceptorship on Lymphoma Lugano, 3-4 November 2017 Disclosures: Roche: honoraria Gilead: travel grant ESMO Preceptorship

More information

FOLLICULAR LYMPHOMA: US vs. Europe: different approach on first relapse setting?

FOLLICULAR LYMPHOMA: US vs. Europe: different approach on first relapse setting? Indolent Lymphoma Workshop Bologna, Royal Hotel Carlton May 2017 FOLLICULAR LYMPHOMA: US vs. Europe: different approach on first relapse setting? Armando López-Guillermo Department of Hematology, Hospital

More information

Lymphoma- Med A-new drugs and treatments

Lymphoma- Med A-new drugs and treatments Lymphoma- Med A-new drugs and treatments Silvia Montoto Lisbon, 19/03/2018 #EBMT18 www.ebmt.or Disclosures: Roche, Gilead Silvia Montoto Lisbon, 19/03/2018 #EBMT18 www.ebmt.or Outline Lymphoma- what is

More information

Treatment Nodal Marginal Zone Lymphoma

Treatment Nodal Marginal Zone Lymphoma Workshop : Indolent lymphomas Treatment Nodal Marginal Zone Lymphoma Catherine Thieblemont Hôpital Saint-Louis, Paris - France Bologna 16th, 2017 Ø No standardized treatment Ø Similarly treated as FL Treatment

More information

Open questions in the treatment of Follicular Lymphoma. Prof. Michele Ghielmini Head Medical Oncology Dept Oncology Institute of Southern Switzerland

Open questions in the treatment of Follicular Lymphoma. Prof. Michele Ghielmini Head Medical Oncology Dept Oncology Institute of Southern Switzerland Open questions in the treatment of Follicular Lymphoma Prof. Michele Ghielmini Head Medical Oncology Dept Oncology Institute of Southern Switzerland Survival of major lymphoma subtypes at IOSI 1.00 cause-specific

More information

A CASE OF PRIMARY THYROID LYMPHOMA. Prof Dr.Dilek Gogas Yavuz Marmara University School of Medicine Endocrinology and Metabolism Istanbul, Turkey

A CASE OF PRIMARY THYROID LYMPHOMA. Prof Dr.Dilek Gogas Yavuz Marmara University School of Medicine Endocrinology and Metabolism Istanbul, Turkey A CASE OF PRIMARY THYROID LYMPHOMA Prof Dr.Dilek Gogas Yavuz Marmara University School of Medicine Endocrinology and Metabolism Istanbul, Turkey 38 year old female She recognized a mass in her right neck

More information

Understanding your diagnosis. Dr Graham Collins Consultant Haemtologist Oxford University Hospitals

Understanding your diagnosis. Dr Graham Collins Consultant Haemtologist Oxford University Hospitals Understanding your diagnosis Dr Graham Collins Consultant Haemtologist Oxford University Hospitals Common questions I get asked What is lymphoma? What subtype do I have and what does that mean? What are

More information

CASE DISCUSSION ON GASTRIC CANCER BASED ON ESMO GUIDELINES

CASE DISCUSSION ON GASTRIC CANCER BASED ON ESMO GUIDELINES ESMO Preceptorship GI Tumours Singapore 20-22 nd October CASE DISCUSSION ON GASTRIC CANCER BASED ON ESMO GUIDELINES Professor. J-Y. Douillard MD PhD ESMO Chief Medical Officer CLINICAL PRACTICE GUIDELINES

More information

1. Please review the following table, make any changes you think are necessary and highlight those changes. Feel free to put notes on the next page

1. Please review the following table, make any changes you think are necessary and highlight those changes. Feel free to put notes on the next page COME HOME Non-Hodgkin pathway development worksheet, v6 September 2014 1. Please review the following table, make any changes you think are necessary and highlight those changes. Feel free to put notes

More information

Indolent Lymphomas: Current. Dr. Laurie Sehn

Indolent Lymphomas: Current. Dr. Laurie Sehn Indolent Lymphomas: Current Dr. Laurie Sehn Why does indolent mean? Slow growth Often asymptomatic Chronic disease with periods of relapse (long natural history possible) Incurable with current standard

More information

Peptic ulcer disease. Nomin-Erdene. D SOM-531

Peptic ulcer disease. Nomin-Erdene. D SOM-531 Peptic ulcer disease Nomin-Erdene. D SOM-531 Learning objectives Stomach gross anatomy PUD Epidemiology Pathogenesis Clinical manifestation Diagnosing Treatment Complicated ulcer disease Surgical procedures

More information

original article S. Luminari 1 *, M. Cesaretti 1, L. Marcheselli 1, I. Rashid 2, S. Madrigali 1, A. Maiorana 3 & M. Federico 1 introduction

original article S. Luminari 1 *, M. Cesaretti 1, L. Marcheselli 1, I. Rashid 2, S. Madrigali 1, A. Maiorana 3 & M. Federico 1 introduction 21: 855 859, 2010 doi:10.1093/annonc/mdp402 Published online 22 October 2009 Decreasing incidence of gastric MALT lymphomas in the era of anti-helicobacter pylori interventions: results from a population-based

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: helicobacter_pylori_testing 01/01/2019 N/A 01/01/2020 01/01/2019 Policy Effective April 1, 2019 Description

More information

We are IntechOpen, the first native scientific publisher of Open Access books. International authors and editors. Our authors are among the TOP 1%

We are IntechOpen, the first native scientific publisher of Open Access books. International authors and editors. Our authors are among the TOP 1% We are IntechOpen, the first native scientific publisher of Open Access books 3,350 108,000 1.7 M Open access books available International authors and editors Downloads Our authors are among the 151 Countries

More information

PET-imaging: when can it be used to direct lymphoma treatment?

PET-imaging: when can it be used to direct lymphoma treatment? PET-imaging: when can it be used to direct lymphoma treatment? Luca Ceriani Nuclear Medicine and PET-CT centre Oncology Institute of Southern Switzerland Bellinzona Disclosure slide I declare no conflict

More information

Lancashire and South Cumbria Haematology NSSG Guidelines for Follicular Lymphoma:

Lancashire and South Cumbria Haematology NSSG Guidelines for Follicular Lymphoma: 1 Lancashire and South Cumbria Haematology NSSG Guidelines for Follicular Lymphoma: 2018-19 1.1 Pretreatment evaluation The following tests should be performed: FBC, U&Es, creat, LFTs, calcium, LDH, Igs/serum

More information

Treatment of Helicobacter pylori Infection

Treatment of Helicobacter pylori Infection Treatment of Helicobacter pylori Infection Epidemiology of H. pylori infection (North America) Which are the high risk groups? Epidemiology of H. pylori infection (North America) Which are the high risk

More information

Lymphocyte Predominant Hodgkin s Lymphoma. Case Presentation. How would you treat the patient?

Lymphocyte Predominant Hodgkin s Lymphoma. Case Presentation. How would you treat the patient? Lymphocyte Predominant Hodgkin s Lymphoma Wei Ai, MD, PhD Assistant Clinical Professor University of California, San Francisco January 2010 Case Presentation 32 yo male, diagnosed with stage IIIA lymphocyte

More information

Diagnosis of lymphoid neoplasms has been

Diagnosis of lymphoid neoplasms has been Iranian Journal of Pathology (2007)2 (1), 1-61 Review Article Mehdi Nassiri Dep. of Pathology, University of Miami Miller School of Medicine, Miami, USA Abstract Correct diagnosis and classification of

More information

Head and Neck: DLBCL

Head and Neck: DLBCL Head and Neck: DLBCL Nikhil G. Thaker Chelsea C. Pinnix Valerie K. Reed Bouthaina S. Dabaja Department of Radiation Oncology MD Anderson Cancer Center Case 60 yo male Presented with right cervical LAD

More information

Two Cases of Primary Gastric Lymphoma, Mucosa-Associated Lymphoid Tissue (MALT)-type

Two Cases of Primary Gastric Lymphoma, Mucosa-Associated Lymphoid Tissue (MALT)-type Med. J. Kagoshima Univ., Vol. 47, Suppl. 2. 93-96, November, 1995 Case Report Two Cases of Primary Gastric Lymphoma, Mucosa-Associated Lymphoid Tissue (MALT)-type Mitsuharu NOMOTO1, Hiroshi SHIRAHAMA1,

More information

PET-adapted therapies in the management of younger patients (age 60) with classical Hodgkin lymphoma

PET-adapted therapies in the management of younger patients (age 60) with classical Hodgkin lymphoma PET-adapted therapies in the management of younger patients (age 60) with classical Hodgkin lymphoma Ryan Lynch MD Assistant Professor, University of Washington Assistant Member, Fred Hutchinson Cancer

More information

Indolent Lymphomas. Dr. Melissa Toupin The Ottawa Hospital

Indolent Lymphomas. Dr. Melissa Toupin The Ottawa Hospital Indolent Lymphomas Dr. Melissa Toupin The Ottawa Hospital What does indolent mean? Slow growth Often asymptomatic Chronic disease with periods of relapse (long natural history possible) Incurable with

More information

2012 by American Society of Hematology

2012 by American Society of Hematology 2012 by American Society of Hematology Common Types of HIV-Associated Lymphomas DLBCL includes primary CNS lymphoma (PCNSL) Burkitt Lymphoma HIV-positive patients have a 60-200 fold increased incidence

More information

Ocular Adnexal MALTomas: Case Series of Patients Treated With Primary Radiation

Ocular Adnexal MALTomas: Case Series of Patients Treated With Primary Radiation Ocular Adnexal MALTomas: Case Series of Patients Treated With Primary Radiation Wesley Russell, MD, Arnold Herskovic, MD, David Gessert, Jack A. Cohen, MD, Jonathan B. Rubenstein, MD, and Stephanie A.

More information

ASTRO Refresher Course Lymphoma. Chris Kelsey, M.D. Duke University Medical Center

ASTRO Refresher Course Lymphoma. Chris Kelsey, M.D. Duke University Medical Center ASTRO Refresher Course 2015 Lymphoma Chris Kelsey, M.D. Duke University Medical Center Disclosure Varian Medical Systems Research funding for lung cancer trial Learning Objectives Awareness of Deauville

More information

Helicobacter Pylori Testing HELICOBACTER PYLORI TESTING HS-131. Policy Number: HS-131. Original Effective Date: 9/17/2009

Helicobacter Pylori Testing HELICOBACTER PYLORI TESTING HS-131. Policy Number: HS-131. Original Effective Date: 9/17/2009 Easy Choice Health Plan, Inc. Harmony Health Plan of Illinois, Inc. Missouri Care, Inc. Ohana Health Plan, a plan offered by WellCare Health Insurance of Arizona, Inc. WellCare Health Insurance of Illinois,

More information

LYMPHOMA IN OLDER PEOPLE. Ama Rohatiner, St. Bartholomew s Hospital, Londonj

LYMPHOMA IN OLDER PEOPLE. Ama Rohatiner, St. Bartholomew s Hospital, Londonj LYMPHOMA IN OLDER PEOPLE Ama Rohatiner, St. Bartholomew s Hospital, Londonj LYMPHOMA IN OLDER PEOPLE PERSPECTIVES HALF OF ALL NEWLY-DIAGNOSED PTS. WITH LYMPHOMA ARE >60 MAY REQUIRE DIFFERENT MANAGEMENT

More information

Hodgkin. The PET World. Sally Barrington

Hodgkin. The PET World. Sally Barrington Hodgkin The PET World Sally Barrington PET-CT Staging in HL PET-CT changes stage 15-30% RATHL - Advanced HL 1171 pts Stage by PET-CT compared with cect and BMB 20% stage change; upstaging 14% Most upstaging

More information

Extranodal Marginal Zone Lymphoma From Ocular Adnexae With Subcutaneous Involvement

Extranodal Marginal Zone Lymphoma From Ocular Adnexae With Subcutaneous Involvement EXTRAORDINARY CASE REPORT Extranodal Marginal Zone Lymphoma From Ocular Adnexae With Subcutaneous Involvement Brady E. Beltrán, MD,* Jorge J. Castillo, MD, Pilar Quiñones, MD, Domingo Morales, MD, Antonio

More information

Marginal Zone Lymphoma

Marginal Zone Lymphoma Marginal Zone Lymphoma Subtype Report February 2017 Marginal Zone Lymphoma Overview The focus of this report is on Marginal Zone lymphoma (MZL). This report will provide a brief explanation of the biology

More information

HAEMATOLOGICAL MALIGNANCY

HAEMATOLOGICAL MALIGNANCY HAEMATOLOGICAL MALIGNANCY Reference Compulsory reading Haematology at Glance 2 nd ed. Atul Mehta & Victor Hoffbrand Chapters: 20 to 31 Pages: 46 to 69 Pathogenesis of Haematological Malignancy Figure (a)

More information

Implications of ACOSOG Z11 for Clinical Practice: Surgical Perspective

Implications of ACOSOG Z11 for Clinical Practice: Surgical Perspective :$;7)#*8'-87*4BCD'E7)F'31$4.$&'G$H'E7)F&'GE'>??ID >?,"'@4,$)4*,#74*8'!74/)$++'74',"$'A.,.)$'7%'()$*+,'!*42$)!7)74*67&'!3 6 August 2011 Implications of ACOSOG Z11 for Clinical

More information

REGISTRATION FORM 1 / 2

REGISTRATION FORM 1 / 2 IDENTIFICATION AND BASELINE DATA REGISTRATION FORM 1 / 2 M Patient s initials: Sequential case N : SEX : F Date of birth: Place of birth I I Centre I I Address I I Telephone number I I Actual profession

More information

Conjunctival CD5+ MALT lymphoma and review of literatures

Conjunctival CD5+ MALT lymphoma and review of literatures ISPUB.COM The Internet Journal of Pathology Volume 8 Number 2 Conjunctival CD5+ MALT lymphoma and review of literatures M Fard Citation M Fard. Conjunctival CD5+ MALT lymphoma and review of literatures.

More information

Gastric MALT-lymphoma and Helicobacter pylori infection

Gastric MALT-lymphoma and Helicobacter pylori infection Aliment Pharmacol Ther 1997; 11 (Suppl. 1): 89 94. Gastric MALT-lymphoma and Helicobacter pylori infection E. BAYERDO RFFER, S. MIEHLKE, A. NEUBAUER & M. STOLTE* Department of Gastroenterology, Hepatology

More information

Acid-Peptic Diseases of the Stomach and Duodenum Including Helicobacter pylori and NSAIDs Prof. Sheila Crowe

Acid-Peptic Diseases of the Stomach and Duodenum Including Helicobacter pylori and NSAIDs Prof. Sheila Crowe Acid-Peptic Diseases of the Stomach and Duodenum Including Helicobacter pylori and NSAIDs 1 Division of Gastroenterology UC San Diego School of Medicine Clinical presentations of Helicobacter pylori infection

More information

doi: 10.1054/ bjoc.2001.2070, available online at http://www.idealibrary.com on http://www.bjcancer.com Somatostatin-receptor scintigraphy for staging and follow-up of patients with extraintestinal marginal

More information

Type of intervention Diagnosis. Economic study type Cost-effectiveness analysis.

Type of intervention Diagnosis. Economic study type Cost-effectiveness analysis. Noninvasive tests as a substitute for histology in the diagnosis of Helicobacter pylori infection Hahn M, Fennerty M B, Corless C L, Magaret N, Lieberman D A, Faigel D O Record Status This is a critical

More information

Clinicopathologic Study of Chromosomal Aberrations in Gastric Lymphomas of Korean Patients

Clinicopathologic Study of Chromosomal Aberrations in Gastric Lymphomas of Korean Patients The Korean Journal of Pathology 2009; 43: 5-12 DOI: 10.4132/KoreanJPathol.2009.43.1.5 Clinicopathologic Study of Chromosomal Aberrations in Gastric Lymphomas of Korean Patients Wook Youn Kim 1 Jung-Ho

More information

ÐÑÏÓÊÅÊËÇÌÅÍÅÓ ÎÅÍÏÃËÙÓÓÅÓ ÁÍÁÊÏÉÍÙÓÅÉÓ ÅËËÇÍÙÍ ÅÑÅÕÍÇÔÙÍ

ÐÑÏÓÊÅÊËÇÌÅÍÅÓ ÎÅÍÏÃËÙÓÓÅÓ ÁÍÁÊÏÉÍÙÓÅÉÓ ÅËËÇÍÙÍ ÅÑÅÕÍÇÔÙÍ ÐÑÏÓÊÅÊËÇÌÅÍÅÓ ÎÅÍÏÃËÙÓÓÅÓ ÁÍÁÊÏÉÍÙÓÅÉÓ ÅËËÇÍÙÍ ÅÑÅÕÍÇÔÙÍ 205 206 ÐÑÏÓÊÅÊËÇÌÅÍÅÓ ÎÅÍÏÃËÙÓÓÅÓ ÁÍÁÊÏÉÍÙÓÅÉÓ ÅËËÇÍÙÍ ÅÑÅÕÍÇÔÙÍ EPITHELIAL CELL TURNOVER IN NON-DYSPLASTIC GASTRIC MUCOSA ADJACENT TO EARLY AND

More information

RADIOIMMUNOTHERAPY FOR TREATMENT OF NON- HODGKIN S LYMPHOMA

RADIOIMMUNOTHERAPY FOR TREATMENT OF NON- HODGKIN S LYMPHOMA RADIOIMMUNOTHERAPY FOR TREATMENT OF NON- HODGKIN S LYMPHOMA Pier Luigi Zinzani Institute of Hematology and Medical Oncology L. e A. Seràgnoli University of Bologna, Italy Slovenia, October 5 2007 Zevalin

More information

B Breast cancer, managing risk of lobular, in hereditary diffuse gastric cancer, 51

B Breast cancer, managing risk of lobular, in hereditary diffuse gastric cancer, 51 Index Note: Page numbers of article titles are in boldface type. A Adenocarcinoma, gastric. See also Gastric cancer. D2 nodal dissection for 57 70 Adjuvant therapy, for gastric cancer, impact of D2 dissection

More information

The Nobel Prize in Physiology or Medicine for 2005

The Nobel Prize in Physiology or Medicine for 2005 The Nobel Prize in Physiology or Medicine for 2005 jointly to Barry J. Marshall and J. Robin Warren for their discovery of "the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer

More information

DERBYSHIRE JOINT AREA PRESCRIBING COMMITTEE (JAPC) MANAGEMENT OF DYSPEPSIA

DERBYSHIRE JOINT AREA PRESCRIBING COMMITTEE (JAPC) MANAGEMENT OF DYSPEPSIA DERBYSHIRE JOINT AREA PRESCRIBING COMMITTEE (JAPC) MANAGEMENT OF DYSPEPSIA o Patients of any age with ALARM signs should be referred through the 2-week referral system o Routine endoscopic investigation

More information

7 Omar Abu Reesh. Dr. Ahmad Mansour Dr. Ahmad Mansour

7 Omar Abu Reesh. Dr. Ahmad Mansour Dr. Ahmad Mansour 7 Omar Abu Reesh Dr. Ahmad Mansour Dr. Ahmad Mansour -Leukemia: neoplastic leukocytes circulating in the peripheral bloodstream. -Lymphoma: a neoplastic process in the lymph nodes, spleen or other lymphatic

More information

Sally Barrington Martin Hutchings

Sally Barrington Martin Hutchings Sally Barrington Martin Hutchings Therapeutic implications of BMI Bone marrow involvement means extranodal disease and by definition stage IV BMI detected by BMB is a poor prognostic feature in most lymphomas

More information

NON HODGKINS LYMPHOMA: AGGRESSIVE Updated June 2015 by Dr. Manna (PGY-5 Medical Oncology Resident, University of Calgary)

NON HODGKINS LYMPHOMA: AGGRESSIVE Updated June 2015 by Dr. Manna (PGY-5 Medical Oncology Resident, University of Calgary) NON HODGKINS LYMPHOMA: AGGRESSIVE Updated June 2015 by Dr. Manna (PGY-5 Medical Oncology Resident, University of Calgary) Reviewed by Dr. Michelle Geddes (Staff Hematologist, University of Calgary) and

More information

Lymphoma: The Basics. Dr. Douglas Stewart

Lymphoma: The Basics. Dr. Douglas Stewart Lymphoma: The Basics Dr. Douglas Stewart Objectives What is lymphoma? How common is it? Why does it occur? How do you diagnose it? How do you manage it? How do you follow patients after treatment? What

More information

Korean gastric cancer screening program, algorithms and experience.

Korean gastric cancer screening program, algorithms and experience. Korean gastric cancer screening program, algorithms and experience. Jun Haeng Lee, MD. Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea Today s topics Korean cancer screening

More information

Role of 18 F-FDG PET Scans in Patients with Helicobacter pylori-infected Gastric Low-Grade MALT Lymphoma

Role of 18 F-FDG PET Scans in Patients with Helicobacter pylori-infected Gastric Low-Grade MALT Lymphoma Gut and Liver, Vol. 5, No. 3, September 2011, pp. 308-314 ORiginal Article Role of 18 F-FDG PET Scans in Patients with Helicobacter pylori-infected Gastric Low-Grade MALT Lymphoma Kyung Ho Song*, Mijin

More information

receive adjuvant chemotherapy

receive adjuvant chemotherapy Women with high h risk early stage endometrial cancer should receive adjuvant chemotherapy Michael Friedlander The Prince of Wales Cancer Centre and Royal Hospital for Women The Prince of Wales Cancer

More information

Gastrointestinal Tract Cancer

Gastrointestinal Tract Cancer Gastrointestinal Tract Cancer Tumors of the Stomach Gastric adenocarcinoma Incidence and Epidemiology Incidence mortality rates USA High incidence: Japan, China, Chile, Ireland risk lower socioeconomic

More information

Flow cytometric evaluation of endoscopic biopsy specimens from patients with gastrointestinal tract B-cell lymphoma: a preliminary report

Flow cytometric evaluation of endoscopic biopsy specimens from patients with gastrointestinal tract B-cell lymphoma: a preliminary report Jichi Medical University Journal Flow cytometric evaluation of endoscopic biopsy specimens from patients with gastrointestinal tract B-cell lymphoma: a preliminary report Satoko Oka,, Kazuo Muroi,, Kazuya

More information

PRIMARY MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA OF THE SALIVARY GLANDS: A MULTICENTER RARE CANCER NETWORK STUDY

PRIMARY MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA OF THE SALIVARY GLANDS: A MULTICENTER RARE CANCER NETWORK STUDY doi:10.1016/j.ijrobp.2010.09.046 Int. J. Radiation Oncology Biol. Phys., Vol. 82, No. 1, pp. 315 320, 2012 Copyright Ó 2012 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/$ - see front

More information

1 Department of Clinical Hematology, Institut Curie, Paris, France; 2 Laboratory

1 Department of Clinical Hematology, Institut Curie, Paris, France; 2 Laboratory Research Article Ocular adnexal lymphoma and Helicobacter pylori gastric infection Didier Decaudin, 1,2 * Agnès Ferroni, 3,4 Anne Vincent-Salomon, 5 Kheira Beldjord, 4,6 Pierre Validire, 7 Patricia de

More information

Correlation between Gastric Mucosal Morphologic Patterns and Histopathological Severity of

Correlation between Gastric Mucosal Morphologic Patterns and Histopathological Severity of Hindawi Publishing Corporation BioMed Research International Volume 2015, Article ID 808505, 7 pages http://dx.doi.org/10.1155/2015/808505 Research Article Correlation between Gastric Mucosal Morphologic

More information

PRIMARY GASTRIC LYMPHOMA: DISTRIBUTION AND CLINICAL RELE- VANCE OF DIFFERENT EPIDEMIOLOGICAL FACTORS

PRIMARY GASTRIC LYMPHOMA: DISTRIBUTION AND CLINICAL RELE- VANCE OF DIFFERENT EPIDEMIOLOGICAL FACTORS original paper Haematologica 1994; 79:213-217 PRIMARY GASTRIC LYMPHOMA: DISTRIBUTION AND CLINICAL RELE- VANCE OF DIFFERENT EPIDEMIOLOGICAL FACTORS Franca Fagioli, Gian Matteo Rigolin, Antonio Cuneo, Gianluigi

More information

Management of Suspicious Mucosa-Associated Lymphoid Tissue Lymphoma in Gastric Biopsy Specimens Obtained during Screening Endoscopy

Management of Suspicious Mucosa-Associated Lymphoid Tissue Lymphoma in Gastric Biopsy Specimens Obtained during Screening Endoscopy ORIGINAL ARTICLE Gastroenterology & Hepatology http://dx.doi.org/10.3346/jkms.2016.31.7.1075 J Korean Med Sci 2016; 31: 1075-1081 Management of Suspicious Mucosa-Associated Lymphoid Tissue Lymphoma in

More information

PhenoPath. Diagnoses you can count on B CELL NON-HODGKIN LYMPHOMA

PhenoPath. Diagnoses you can count on B CELL NON-HODGKIN LYMPHOMA PhenoPath Diagnoses you can count on B CELL NON-HODGKIN LYMPHOMA C urrent diagnosis of B cell non-hodgkin lymphoma (B-NHL) is based on the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid

More information

eastern cooperative oncology group Michael Williams, Fangxin Hong, Brad Kahl, Randy Gascoyne, Lynne Wagner, John Krauss, Sandra Horning

eastern cooperative oncology group Michael Williams, Fangxin Hong, Brad Kahl, Randy Gascoyne, Lynne Wagner, John Krauss, Sandra Horning Results of E4402 (RESORT): A Randomized Phase III Study Comparing Two Different Rituximab Dosing Strategies for Low Tumor Burden Indolent B-Cell Lymphoma Michael Williams, Fangxin Hong, Brad Kahl, Randy

More information

Why Do Axillary Dissection? Nodal Treatment and Survival NSABP B04. Revisiting Axillary Dissection for SN Positive Patients

Why Do Axillary Dissection? Nodal Treatment and Survival NSABP B04. Revisiting Axillary Dissection for SN Positive Patients Memorial Sloan-Kettering Cancer Center 1275 York Avenue, New York, NY 10065 10th International Congress on the Future of Breast Cancer Coronado, CA Why Do Axillary Dissection? 6 August 2011 Implications

More information

They are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:

They are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see: bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest

More information