SUPPLEMENTAL MATERIAL. Table 1: International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9) codes identifying

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1 SUPPLEMENTAL MATERIAL Table 1: International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9) codes identifying variables used to calculate propensity scores Medical Conditions ICD-9 Codes Description History of intracerebral 431 Intracerebral hemorrhage hemorrhage 1 History of Major Bleeding Hemopericardium 430 Subarachnoid hemorrhage 431 Intracerebral hemorrhage 432 Other and unspecified intracranial hemorrhage Internal hemorrhoids with other complication External hemorrhoids with other complication Unspecified hemorrhoids with other complication Hemorrhage, unspecified Esophageal varices with bleeding Esophageal varices in diseases classified elsewhere Gastroesophageal laceration-hemorrhage syndrome Other specified disorders of esophagus Acute gastric ulcer with hemorrhage Acute gastric ulcer with hemorrhage and Chronic or unspecified gastric ulcer with hemorrhage Chronic or unspecified gastric ulcer with hemorrhage and Acute duodenal ulcer with hemorrhage Acute duodenal ulcer with hemorrhage and Chronic or unspecified duodenal ulcer with hemorrhage Chronic or unspecified duodenal ulcer with hemorrhage and

2 533.0 Acute peptic ulcer of unspecified site with hemorrhage Acute peptic ulcer of unspecified site with hemorrhage and Chronic or unspecified peptic ulcer of unspecified site with hemorrhage Chronic or unspecified peptic ulcer of unspecified site with hemorrhage and Acute gastrojejunal ulcer with hemorrhage Acute gastrojejunal ulcer with hemorrhage and Chronic or unspecified gastrojejunal ulcer with hemorrhage Chronic or unspecified gastrojejunal ulcer with hemorrhage and Acute gastritis Atrophic gastritis Gastric mucosal hypertrophy Alcoholic gastritis Other specified gastritis Unspecified gastritis and gastroduodenitis Duodenitis Other specified disorders of stomach and duodenum Diverticula of small intestine Diverticula of colon Other specified disorders of peritoneum Hemorrhage of rectum and anus Angiodysplasia of intestine with hemorrhage 578 Gastrointestinal hemorrhage Other specified disorders of kidney and ureter Hematuria

3 623.8 Other specified noninflammatory disorders of vagina Excessive or frequent menstruation Metrorrhagia Hemarthrosis, site unspecified Hemarthrosis, shoulder region Hemarthrosis, upper arm Hemarthrosis, forearm Hemarthrosis, hand Hemarthrosis, pelvic region and thigh Hemarthrosis, lower leg Hemarthrosis, ankle and foot Hemarthrosis, other specified sites Epistaxis Hemoptysis 852 Subarachnoid subdural and extradural hemorrhage following injury 853 Other and unspecified intracranial hemorrhage following injury Congestive heart failure used to calculate CHADS 2 score Rheumatic heart failure (congestive) Malignant hypertensive heart disease with heart failure Benign hypertensive heart disease with heart failure Unspecified hypertensive heart disease with heart failure 428.x Heart failure Acute edema of lung unspecified Stroke/TIA used to calculate CHADS 2 score Occlusion of cerebral arteries 435 Transient cerebral ischemia 436 Acute but ill-defined cerebrovascular disease Diabetes used to calculate 250.x Diabetes CHADS 2 score 2

4 Hypertension used to calculate CHADS 2 score x Essential hypertension 402.x Hypertensive heart disease 403.x Hypertensive chronic kidney disease 404.x Hypertensive heart and chronic kidney disease 405.x Secondary hypertension Rebleeding Risk - Prior bleed used to calculate HEMORR 2 HAGES score 430.xx 431.xx 432.xx Subarachnoid hemorrhage Intracerebral hemorrhage Other and unspecified intracranial hemorrhage 3, 4 E934.2 Anticoagulants causing adverse effects in therapeutic use Hemorrhage and infarction of thyroid Hemorrhagic disorder due to intrinsic circulating anticoagulants Hemorrhagic disorder due to intrinsic circulating anticoagulants Choroidal hemorrhage unspecified Expulsive choroidal hemorrhage Vitreous hemorrhage Other disorders of labyrinth Other otorrhea Other and unspecified capillary diseases Esophageal varices with bleeding Esophageal varices in disease classified elsewhere, with bleeding Other disorders of circulatory system Other specified periodontal diseases Other and unspecified diseases of the oral soft tissues Esophageal hemorrhage Acute gastric ulcer with hemorrhage Acute gastric ulcer with hemorrhage and Chronic or unspecified gastric ulcer with hemorrhage

5 531.6 Chronic or unspecified gastric ulcer with hemorrhage and Acute duodenal ulcer with hemorrhage Acute duodenal ulcer with hemorrhage and Chronic or unspecified duodenal ulcer with hemorrhage Chronic or unspecified duodenal ulcer with hemorrhage and Peptic ulcer site unspecified Acute peptic ulcer of unspecified site with hemorrhage and Chronic or unspecified peptic ulcer of unspecified site with hemorrhage Chronic or unspecified peptic ulcer of unspecified site with hemorrhage and Acute gastrojejunal ulcer with hemorrhage Acute gastrojejunal ulcer with hemorrhage and Chronic or unspecified gastrojejunal ulcer with hemorrhage Chronic or unspecified gastrojejunal ulcer with hemorrhage and Angiodysplasia of stomach and duodenum with hemorrhage Diverticulitis of small intestine with hemorrhage Diverticulitis of colon with hemorrhage Hemoperitoneum (nontraumatic) Hemorrhage of rectum and anus Perforation of intestine 578.xx Gastrointestinal hemorrhage Other specified disorders of bladder Hematuria

6 626.6 Metrorrhagia Postmenopausal bleeding 719.1x Hemarthrosis Other disorders of synovium tendon and bursa Epistaxis Hemorrhage from throat Hemoptysis Secondary and recurrent hemorrhage as an early complication of trauma Hepatic or renal disease used to calculate HEMORR 2 HAGES score 3 identified using codes coinciding with end stage renal disease, cirrhosis, and high creatinine 570 Acute and subacute necrosis of liver 571.4x Chronic hepatitis Cirrhosis of liver without mention of alcohol Biliary cirrhosis Other chronic nonalcoholic liver disease Unspecified chronic liver disease without mention of alcohol 572 Liver abscess and sequelae of chronic liver disease 573 Other disorders of liver 585 Chronic kidney disease (ckd) Chronic kidney disease, stage iii (moderate) Chronic kidney disease, stage iv (severe) Chronic kidney disease, stage v End stage renal disease Chronic kidney disease, unspecified Nonspecific abnormal results of function study of kidney Ethanol (Alcohol) abuse used to calculate HEMORR 2 HAGES score Alcohol withdrawal delirium Alcohol-induced persisting amnestic disorder Alcohol-induced persisting dementia 303.x Alcohol dependence syndrome

7 305.0x Nondependent abuse of drugs Alcoholic gastritis Alcoholic fatty liver Acute alcoholic hepatitis Alcoholic cirrhosis of liver Alcoholic liver damage unspecified V11.3 Personal history of alcoholism Malignancy 141 Malignant neoplasm of tongue 142 Malignant neoplasm of major salivary glands 143 Malignant neoplasm of gum 144 Malignant neoplasm of floor of mouth 145 Malignant neoplasm of other and unspecified parts of mouth 146 Malignant neoplasm of oropharynx 147 Malignant neoplasm of nasopharynx 148 Malignant neoplasm of hypopharynx 149 Malignant neoplasm of other and ill-defined sites within the lip oral cavity and pharynx 150 Malignant neoplasm of esophagus 151 Malignant neoplasm of stomach 152 Malignant neoplasm of small intestine including duodenum 153 Malignant neoplasm of colon 154 Malignant neoplasm of rectum rectosigmoid junction and anus 155 Malignant neoplasm of liver and intrahepatic bile ducts 156 Malignant neoplasm of gallbladder and extrahepatic bile ducts 157 Malignant neoplasm of pancreas 158 Malignant neoplasm of retroperitoneum and peritoneum 159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum

8 160 Malignant neoplasm of nasal cavities middle ear and accessory sinuses 161 Malignant neoplasm of larynx 162 Malignant neoplasm of trachea bronchus and lung 163 Malignant neoplasm of pleura 164 Malignant neoplasm of thymus heart and mediastinum 165 Malignant neoplasm of other and ill-defined sites within the respiratory system and intrathoracic organs 166 No match 167 No match 168 No match 169 No match 170 Malignant neoplasm of bone and articular cartilage 171 Malignant neoplasm of connective and other soft tissue 172 Malignant melanoma of skin 174 Malignant neoplasm of female breast 175 Malignant neoplasm of female breast 176 Kaposi's sarcoma 177 No match 178 No match 179 Malignant neoplasm of uterus-part unspecified 180 Malignant neoplasm of cervix uteri 181 Malignant neoplasm of placenta 182 Malignant neoplasm of body of uterus 183 Malignant neoplasm of ovary and other uterine adnexa 184 Malignant neoplasm of other and unspecified female genital organs 185 Malignant neoplasm of prostate

9 186 Malignant neoplasm of testis 187 Malignant neoplasm of penis and other male genital organs 188 Malignant neoplasm of bladder 189 Malignant neoplasm of kidney and other and unspecified urinary organs 190 Malignant neoplasm of eye 191 Malignant neoplasm of brain 192 Malignant neoplasm of other and unspecified parts of nervous system 193 Malignant neoplasm of thyroid gland 194 Malignant neoplasm of other endocrine glands and related structures 195 Malignant neoplasm of other and ill-defined sites 196 Secondary and unspecified malignant neoplasm of lymph nodes 197 Secondary malignant neoplasm of respiratory and digestive systems 198 Secondary malignant neoplasm of other specified sites 199 Malignant neoplasm without specification of site 200 Lymphosarcoma and reticulosarcoma and other specified malignant tumors of lymphatic tissue 201 Hodgkin's disease 202 Other malignant neoplasms of lymphoid and histiocytic tissue 203 Multiple myeloma and immunoproliferative neoplasms 204 Lymphoid leukemia 205 Myeloid leukemia 206 Monocytic leukemia 207 Other specified leukemia 208 Leukemia of unspecified cell type

10 Reduced platelet count or 287.x Purpura and other hemorrhagic conditions function used to calculate HEMORR 2 HAGES score 3 identified using codes coinciding with reduced platelet count or function Hypertension used to calculate HEMORR 2 HAGES score x Essential hypertension 402.x Hypertensive heart disease 403.x Hypertensive chronic kidney disease 404.x Hypertensive heart and chronic kidney disease 405.x Secondary hypertension Anemia used to calculate HEMORR 2 HAGES score x Iron deficiency anemias 281.x Other deficiency anemias Hereditary spherocytosis Hereditary elliptocytosis Anemias due to disorders of glutathione metabolism Other hemolytic anemias due to enzyme deficiency Thalassemias Sickle-cell disease unspecified Other sickle-cell disease with crisis 283.x Acquired hemolytic anemias 284.x Aplastic anemia and other bone marrow failure syndromes 285.x Other and unspecified anemias Excessive fall risk or neuropsychiatric disease E880 E888 Accidental fall on or from stairs or steps Other and unspecified fall used to calculate HEMORR 2 HAGES score 3 identified using codes 332 Parkinson's disease 334 Spinocerebellar disease Abnormality of gait

11 coinciding with falling, dementia, Parkinson diesease, or psychiatric disease Senile dementia uncomplicated Amnestic disorder in conditions classified elsewhere Orthostatic hypotension Dizziness and giddiness Polyneuropathy in diabetes Alcoholic polyneuropathy Bipolar i disorder, single manic episode Bipolar i disorder, most recent episode (or current) manic Bipolar disorder, other Major depressive disorder single episode Major depressive disorder recurrent episode 311 Depressive disorder not elsewhere classified 295 Schizophrenic disorders Simple type schizophrenia Disorganized type schizophrenia Catatonic type schizophrenia Paranoid type schizophrenia Schizophreniform disorder Latent schizophrenia Schizophrenic disorder, residual type Schizoaffective disorder Other specified types of schizophrenia Unspecified schizophrenia 297 Delusional disorders Paranoid state simple Delusional disorder Paraphrenia Shared psychotic disorder

12 297.8 Other specified paranoid states Unspecified paranoid state Prior stroke used to calculate Charlson Myocardial infarction used to calculate Charlson 434 Occlusion of cerebral arteries 435 Transient cerebral ischemia 436 Acute but ill-defined cerebrovascular disease 410 Acute myocardial infarction 412 Old myocardial infarction Congestive heart failure 428 Heart failure used to calculate Charlson Peripheral vascular disease used to calculate Charlson Comorbidity 441 Aortic aneurysm and dissection Peripheral vascular disease, unspecified Gangrene Index 5 V434 Occlusion of cerebral arteries NOT PVD Resection and replacement of lower limb arteries Cerebrovascular disease used to calculate Charlson 430 Subarachnoid hemorrhage If traumatic the vessels may be normal 431 Intracerebral hemorrhage ditto 432 Other and unspecified intracranial hemorrhage ditto 433 Occlusion and stenosis of precerebral arteries 434 Occlusion of cerebral arteries 435 Transient cerebral ischemia 436 Acute but ill-defined cerebrovascular disease 437 Other and ill-defined cerebrovascular disease 438 Late effects of cerebrovascular disease Dementia used to 290 Dementias calculate Charlson

13 Chronic pulmonary disease used to calculate Charlson Comorbidity Index Bronchitis not specified as acute or chronic 491 Chronic bronchitis 492 Emphysema 493 Asthma 494 Bronchiectasis 495 Extrinsic allergic alveolitis 496 Chronic airway obstruction not elsewhere classified 500 Coal workers' pneumoconiosis 501 Asbestosis 502 Pneumoconiosis due to other silica or silicates 503 Pneumoconiosis due to other inorganic dust 504 Pneumonopathy due to inhalation of other dust 505 Pneumoconiosis unspecified Chronic respiratory conditions due to fumes and vapors Rheumatologic disease used to calculate Charlson Systemic lupus erythematosus Systemic sclerosis Polymyositis Rheumatoid arthritis Felty's syndrome Other rheumatoid arthritis with visceral or systemic involvement 725 Polymyalgia rheumatica Rheumatoid lung Peptic ulcer disease used to calculate Charlson Acute gastric ulcer with hemorrhage Acute gastric ulcer with hemorrhage without obstruction Acute gastric ulcer with hemorrhage with obstruction Acute gastric ulcer with without obstruction Acute gastric ulcer with with obstruction

14 531.2 Acute gastric ulcer with hemorrhage and Acute gastric ulcer with hemorrhage and without obstruction Acute gastric ulcer with hemorrhage and with obstruction Acute gastric ulcer without mention of hemorrhage or Acute gastric ulcer without hemorrhage or without obstruction Acute gastric ulcer without hemorrhage or with obstruction Gastric ulcer unspecified as acute or chronic without mention of hemorrhage or Gastric ulcer unspecified as acute or chronic without hemorrhage or without obstruction Gastric ulcer unspecified as acute or chronic without hemorrhage or with obstruction Acute duodenal ulcer with hemorrhage Acute duodenal ulcer with hemorrhage without obstruction Acute duodenal ulcer with hemorrhage with obstruction Acute duodenal ulcer with Acute duodenal ulcer with without obstruction Acute duodenal ulcer with with obstruction Acute duodenal ulcer with hemorrhage and Acute duodenal ulcer with hemorrhage and without obstruction Acute duodenal ulcer with hemorrhage and with obstruction

15 532.3 Acute duodenal ulcer without mention of hemorrhage or Acute duodenal ulcer without hemorrhage or without obstruction Acute duodenal ulcer without hemorrhage or with obstruction Acute peptic ulcer of unspecified site with hemorrhage Acute peptic ulcer of unspecified site with hemorrhage without obstruction Acute peptic ulcer of unspecified site with hemorrhage with obstruction Chronic or unspecified peptic ulcer of unspecified site with hemorrhage Acute gastrojejunal ulcer with hemorrhage Acute gastrojejunal ulcer with Acute gastrojejunal ulcer with hemorrhage and Acute gastrojejunal ulcer without mention of hemorrhage or Chronic or unspecified gastrojejunal ulcer with hemorrhage Chronic or unspecified gastrojejunal ulcer with Chronic or unspecified gastrojejunal ulcer with hemorrhage and Chronic gastrojejunal ulcer without mention of hemorrhage or No match Gastrojejunal ulcer unspecified as acute or chronic without mention of hemorrhage or Mild liver disease used to Alcoholic cirrhosis of liver

16 calculate Charlson Chronic hepatitis Cirrhosis of liver without alcohol Biliary cirrhosis Diabetes (mild to moderate) used to calculate Charlson Diabetes mellitus without mention of complication Diabetes with ketoacidosis Diabetes with hyperosmolarity Diabetes with other coma Diabetes with peripheral circulatory disorders Diabetes with chronic complications used to calculate Charlson Diabetes with renal manifestations Diabetes with ophthalmic manifestations Diabetes with neurological manifestations Hemiplegia or paraplegia used to calculate Charlson 342 Hemiplegia and hemiparesis Paraplegi Renal disease used to calculate Charlson 582 Chronic glomerulonephritis 585 Chronic kidney disease (ckd) 586 Renal failure unspecified 588 Disorders resulting from impaired renal function Nephritis and nephropathy not specified as acute or chronic with lesion of proliferative glomerulonephritis Nephritis and nephropathy, not specified as acute or chronic, with lesion of membranous glomerulonephritis Nephritis and nephropathy, not specified as acute or chronic, with lesion of membranoproliferative glomerulonephritis Nephritis and nephropathy, not specified as acute or chronic, with lesion of rapidly progressive glomerulonephritis Nephritis and nephropathy, not specified as acute or chronic,

17 with lesion of renal cortical necrosis Nephritis and nephropathy not specified as acute or chronic with lesion of renal medullary necrosis Any malignancy, including lymphoma and leukemia used to calculate Charlson Comorbidity Index Malignant neoplasm of lip 141 Malignant neoplasm of tongue 142 Malignant neoplasm of major salivary glands 143 Malignant neoplasm of gum 144 Malignant neoplasm of floor of mouth 145 Malignant neoplasm of other and unspecified parts of mouth 146 Malignant neoplasm of oropharynx 147 Malignant neoplasm of nasopharynx 148 Malignant neoplasm of hypopharynx 149 Malignant neoplasm of other and ill-defined sites within the lip oral cavity and pharynx 150 Malignant neoplasm of esophagus 151 Malignant neoplasm of stomach 152 Malignant neoplasm of small intestine including duodenum 153 Malignant neoplasm of colon 154 Malignant neoplasm of rectum rectosigmoid junction and anus 155 Malignant neoplasm of liver and intrahepatic bile ducts 156 Malignant neoplasm of gallbladder and extrahepatic bile ducts 157 Malignant neoplasm of pancreas 158 Malignant neoplasm of retroperitoneum and peritoneum 159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum 160 Malignant neoplasm of nasal cavities middle ear and accessory sinuses 161 Malignant neoplasm of larynx

18 162 Malignant neoplasm of trachea bronchus and lung 163 Malignant neoplasm of pleura 164 Malignant neoplasm of thymus heart and mediastinum 165 Malignant neoplasm of other and ill-defined sites within the respiratory system and intrathoracic organs 166 No match 167 No match 168 No match 169 No match 170 Malignant neoplasm of bone and articular cartilage 171 Malignant neoplasm of connective and other soft tissue Malignant melanoma of skin Malignant melanoma of skin of eyelid including canthus Malignant melanoma of skin of ear and external auditory canal Malignant melanoma of skin of other and unspecified parts of face Malignant melanoma of skin of scalp and neck Malignant melanoma of skin of trunk except scrotum Malignant melanoma of skin of upper limb including shoulder Malignant melanoma of skin of lower limb including hip Malignant melanoma of other specified sites of skin Melanoma of skin site unspecified 174 Malignant neoplasm of female breast 175 Malignant neoplasm of male breast 176 Kaposi's sarcoma 177 No match 178 No match 179 Malignant neoplasm of uterus-part unspecified

19 180 Malignant neoplasm of cervix uteri 181 Malignant neoplasm of placenta 182 Malignant neoplasm of body of uterus 183 Malignant neoplasm of ovary and other uterine adnexa 184 Malignant neoplasm of other and unspecified female genital organs 185 Malignant neoplasm of prostate 186 Malignant neoplasm of prostate 187 Malignant neoplasm of penis and other male genital organs 188 Malignant neoplasm of bladder 189 Malignant neoplasm of kidney and other and unspecified urinary organs 190 Malignant neoplasm of eye 191 Malignant neoplasm of brain 192 Malignant neoplasm of other and unspecified parts of nervous system 193 Malignant neoplasm of thyroid gland 194 Malignant neoplasm of other endocrine glands and related structures 195 Malignant neoplasm of other and ill-defined sites 200 Lymphosarcoma and reticulosarcoma and other specified malignant tumors of lymphatic tissue 201 Hodgkin's disease 202 Other malignant neoplasms of lymphoid and histiocytic tissue 203 Multiple myeloma and immunoproliferative neoplasms 204 Lymphoid leukemia 205 Myeloid leukemia 206 Monocytic leukemia

20 207 Other specified leukemia 208 Leukemia of unspecified cell type Moderate or severe liver disease used to calculate Charlson Comorbidity Index Hepatic encephalopathy ortal hypertension Hepatorenal syndrome Other sequelae of chronic liver disease Esophageal varices with bleeding Esophageal varices without mention of bleeding Esophageal varices in diseases classified elsewhere Metastatic solid tumor used to calculate Charlson Secondary and unspecified malignant neoplasm of lymph nodes of head face and neck Secondary and unspecified malignant neoplasm of intrathoracic lymph nodes Secondary and unspecified malignant neoplasm of intraabdominal lymph nodes Secondary and unspecified malignant neoplasm of lymph nodes of axilla and upper limb Secondary and unspecified malignant neoplasm of lymph nodes of inguinal region and lower limb Secondary and unspecified malignant neoplasm of intrapelvic lymph nodes Secondary and unspecified malignant neoplasm of lymph nodes of multiple sites Secondary and unspecified malignant neoplasm of lymph nodes site unspecified Secondary malignant neoplasm of lung Secondary malignant neoplasm of mediastinum Secondary malignant neoplasm of pleura

21 197.3 Secondary malignant neoplasm of other respiratory organs Secondary malignant neoplasm of small intestine including duodenum Secondary malignant neoplasm of large intestine and rectum Secondary malignant neoplasm of retroperitoneum and peritoneum Malignant neoplasm of liver secondary Secondary malignant neoplasm of other digestive organs and spleen Secondary malignant neoplasm of kidney Secondary malignant neoplasm of other urinary organs Secondary malignant neoplasm of skin Secondary malignant neoplasm of brain and spinal cord Secondary malignant neoplasm of other parts of nervous system Secondary malignant neoplasm of bone and bone marrow Secondary malignant neoplasm of ovary Secondary malignant neoplasm of adrenal gland Secondary malignant neoplasm of other specified sites Disseminated malignant neoplasm Other malignant neoplasm of unspecified site AIDS used to calculate Charlson Comorbidity Index 5 42 Human immunodeficiency virus (hiv) disease 43 No match 44 No match

22 Supplemental References 1. White RH, Beyth RJ, Zhou H, Romano PS. Major bleeding after hospitalization for deep-venous thrombosis. Am J Med. 1999;107: Gage BF, Waterman AD, Shannon W, Boechler M, Rich MW, Radford MJ. Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. JAMA. 2001;285: Gage BF, Yan Y, Milligan PE, Waterman AD, Culverhouse R, Rich MW, Radford MJ. Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF). Am Heart J. 2006;151: Harley CR, Riedel AA, Hauch O, Nelson M, Wygant G, Reynolds M. Anticoagulation therapy in patients with chronic atrial fibrillation: a retrospective claims data analysis. Curr Med Res Opin. 2005;21: Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992;45:

S2 File. Clinical Classifications Software (CCS). The CCS is a

S2 File. Clinical Classifications Software (CCS). The CCS is a diagnosis categorization scheme based on the ICD-9-CM that aggregates all diagnosis codes into 262 mutually exclusive, clinically homogeneous