They are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
|
|
- Gerard Henry Murphy
- 5 years ago
- Views:
Transcription
1 bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see: NICE Pathway last updated: 20 March 2018 This document contains a single flowchart and uses numbering to link the boxes to the associated recommendations. Page 1 of 10
2 Page 2 of 10
3 1 Person aged 16 or over with diffuse large B-cell lymphoma No additional information 2 Central nervous system prophylaxis Explain to people with diffuse large B-cell lymphoma that they have an increased risk of central nervous system lymphoma if the testis, breast, adrenal gland or kidney is affected. Explain to people with diffuse large B-cell lymphoma that they may have an increased risk of central nervous system lymphoma if they have 2 or more of the following factors: elevated lactate dehydrogenase age over 60 years poor performance status (ECOG score of 2 or more) more than one extranodal site involved stage III or IV disease. Explain that the level of risk increases with the number of factors involved. Offer central nervous system-directed prophylactic therapy to people with diffuse large B-cell lymphoma: that affects the testis, breast, adrenal gland or kidney or who have 4 or 5 of the factors associated with increased risk of central nervous system relapse listed above. Consider central nervous system-directed prophylactic therapy for people with diffuse large B- cell lymphoma who have 2 or 3 of the factors associated with increased risk of central nervous system relapse listed above. 3 Radiotherapy after first-line immunochemotherapy Consider consolidation radiotherapy delivering 30 Gy to sites involved with bulk disease at diagnosis for people with advanced-stage diffuse large B-cell lymphoma that has responded to first-line immunochemotherapy. For each person, balance the possible late effects of radiotherapy with the possible increased need for salvage therapy if it is omitted, and discuss the options with them. Page 3 of 10
4 4 When to offer fluorodeoxyglucose-positron emission tomography-ct imaging Do not routinely offer FDG-PET-CT imaging for interim assessment during treatment for diffuse large B-cell lymphoma. Offer FDG-PET-CT imaging to assess response at completion of planned treatment for people with diffuse large B-cell lymphoma. Consider FDG-PET-CT imaging to assess response to treatment before autologous stem cell transplantation for people with high-grade non-hodgkin's lymphoma. 5 Salvage therapy Multi-agent immunochemotherapy Offer salvage therapy with multi-agent immunochemotherapy to people with relapsed or refractory diffuse large B-cell lymphoma who are fit enough to tolerate intensive therapy: explain that this is primarily to obtain sufficient response to allow consolidation with autologous or allogeneic stem cell transplantation, but is also beneficial even if not followed by transplantation consider R-GDP immunochemotherapy, which is as effective as other commonly used salvage regimens and less toxic. Stem cell transplantation Offer consolidation with autologous stem cell transplantation to people with chemosensitive diffuse large B-cell lymphoma (that is, there has been at least a partial response to chemotherapy) who are fit enough for transplantation. Consider consolidation with allogeneic stem cell transplantation for people with chemosensitive diffuse large B-cell lymphoma (that is, there has been at least a partial response to chemotherapy): that relapses after autologous stem cell transplantation or in whom stem cell harvesting is not possible. Page 4 of 10
5 Pixantrone monotherapy The following recommendations are from NICE technology appraisal guidance on pixantrone monotherapy for treating multiply relapsed or refractory aggressive non-hodgkin's B-cell lymphoma. Pixantrone monotherapy is recommended as an option for treating adults with multiply relapsed or refractory aggressive non-hodgkin's B-cell lymphoma only if: the person has previously been treated with rituximab and the person is receiving third- or fourth-line treatment and the manufacturer provides pixantrone with the discount agreed in the patient access scheme. People currently receiving treatment initiated within the NHS with pixantrone monotherapy that is not recommended for them by NICE in this guidance should be able to continue treatment until they and their NHS clinician consider it appropriate to stop. NICE has written information for the public on pixantrone. 6 Follow-up For people in complete remission after first-line treatment with curative intent for diffuse large B- cell lymphoma: offer regular clinical assessment consider stopping regular clinical assessment aimed at detecting relapse 3 years after completing treatment for people in ongoing complete remission offer urgent appointments to people who experience a recurrence of lymphoma symptoms or new symptoms that suggest disease relapse do not offer lactate dehydrogenase surveillance for detecting relapse do not offer routine surveillance imaging (including chest X-ray, CT and PET-CT) for detecting relapse in people who are asymptomatic. Quality standards The following quality statement is relevant to this part of the interactive flowchart. 4. End-of-treatment summary plan Page 5 of 10
6 7 Monitoring after treatment See Non-Hodgkin's lymphoma/non-hodgkin's lymphoma overview /Monitoring after treatment Page 6 of 10
7 Why we made the recommendations on obinutuzumab Current first-line treatment for symptomatic advanced follicular lymphoma is induction therapy with rituximab plus chemotherapy, followed by maintenance treatment with rituximab when there has been a response to induction therapy. The main evidence on the effectiveness and safety of obinutuzumab is from an ongoing clinical trial. It shows that obinutuzumab plus chemotherapy followed by obinutuzumab maintenance treatment delays disease progression more than current treatment. However, it also shows that undesirable side effects are more common with obinutuzumab than with rituximab. There are not enough data to know with certainty whether obinutuzumab increases life expectancy. The company's revised economic analyses focuses on higher-risk subgroups. Obinutuzumab costs more than branded rituximab and even more than the biosimilar versions of rituximab. However, using the preferred assumptions and the discounted prices for obinutuzumab and rituximab, the cost-effectiveness estimate for obinutuzumab plus chemotherapy followed by obinutuzumab maintenance treatment, compared with rituximab plus chemotherapy followed by rituximab maintenance treatment, is lower than 30,000 per quality-adjusted life year gained. Therefore, obinutuzumab is recommended as an option for untreated advanced follicular lymphoma in patients at higher risk. For more information see the committee discussion in the NICE technology appraisal on obinutuzumab for untreated advanced follicular lymphoma. Glossary CHOP cyclophosphamide, doxorubicin, vincristine and prednisolone CVP cyclophosphamide, vincristine and prednisolone FISH fluorescence in situ hybridisation Page 7 of 10
8 FDG-PET-CT fluorodeoxyglucose-positron emission tomography-ct H. pylori Helicobacter pylori MALT mucosa-associated lymphoid tissue PET-CT positron emission tomography-ct Sources Non-Hodgkin's lymphoma: diagnosis and management (2016) NICE guideline NG52 Pixantrone monotherapy for treating multiply relapsed or refractory aggressive non-hodgkin's B- cell lymphoma (2014) NICE technology appraisal guidance 306 Your responsibility Guidelines The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals and practitioners are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or the people using their service. It is not mandatory to apply the recommendations, and the guideline does not override the responsibility to make decisions appropriate to the circumstances of the individual, in consultation with them and their families and carers or guardian. Local commissioners and providers of healthcare have a responsibility to enable the guideline to be applied when individual professionals and people using services wish to use it. They Page 8 of 10
9 should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with complying with those duties. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Technology appraisals The recommendations in this interactive flowchart represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected to take these recommendations fully into account, alongside the individual needs, preferences and values of their patients. The application of the recommendations in this interactive flowchart is at the discretion of health professionals and their individual patients and do not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian. Commissioners and/or providers have a responsibility to provide the funding required to enable the recommendations to be applied when individual health professionals and their patients wish to use it, in accordance with the NHS Constitution. They should do so in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Medical technologies guidance, diagnostics guidance and interventional procedures guidance The recommendations in this interactive flowchart represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, healthcare professionals are expected to take these recommendations fully into account. However, the Page 9 of 10
10 interactive flowchart does not override the individual responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or guardian or carer. Commissioners and/or providers have a responsibility to implement the recommendations, in their local context, in light of their duties to have due regard to the need to eliminate unlawful discrimination, advance equality of opportunity, and foster good relations. Nothing in this interactive flowchart should be interpreted in a way that would be inconsistent with compliance with those duties. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Page 10 of 10
They are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationNICE guideline Published: 20 July 2016 nice.org.uk/guidance/ng52
Non-Hodgkin s lymphoma: diagnosis and management NICE guideline Published: 20 July 2016 nice.org.uk/guidance/ng52 NICE 2017. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
Ongoing care for adults with psychosis or schizophrenia bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
Gestational diabetes: risk assessment, testing, diagnosis and management bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
Step 3: GAD with marked functional impairment or that has not improved after step 2 interventionsentions bring together everything NICE says on a topic in an interactive flowchart. are interactive and
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
: assessing the risk of fragility fracture bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
Strategy,, policy and commissioning on hepatitis B and C testing NICE Pathways bring together everything NICE says on a topic in an interactive flowchart. NICE Pathways are interactive and designed to
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
diagnosis and assessment bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published.
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
overview bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
Managing comorbid health problems in people with eating disorders bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated
More informationTechnology appraisal guidance Published: 30 August 2017 nice.org.uk/guidance/ta472
Obinutuzumab with bendamustine for treating follicular lymphoma refractory to rituximab Technology appraisal guidance Published: 30 August 2017 nice.org.uk/guidance/ta472 NICE 2018. All rights reserved.
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
Assessment and immediate management of suspected acute coronary syndrome bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
Recognising and managing bipolar disorder in adults in primary care bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
Cryopreservation to preserve e fertility in people diagnosed with cancer bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
: treatment bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationChoosing and delivering ering interventions entions for
Choosing and delivering ering interventions entions for psychosis and schizophrenia in adults bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
in children and young people: recognition, detection, risk profiling and NICE Pathways bring together everything NICE says on a topic in an interactive flowchart. NICE Pathways are interactive and designed
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
Assessment and investigation of urinary incontinence in women bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
Chronic fatigue syndrome myalgic encephalomyelitis elitis overview bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationTechnology appraisal guidance Published: 31 January 2018 nice.org.uk/guidance/ta502
Ibrutinib for treating relapsed or refractory mantle cell lymphoma Technology appraisal guidance Published: 31 January 2018 nice.org.uk/guidance/ta502 NICE 2018. All rights reserved. Subject to Notice
More informationTechnology appraisal guidance Published: 25 January 2012 nice.org.uk/guidance/ta243
Rituximab for the first-line treatment of stage III-IV follicular lymphoma Technology appraisal guidance Published: 25 January 2012 nice.org.uk/guidance/ta243 NICE 2017. All rights reserved. Subject to
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
Coexisting mental disorders in adults with autism spectrum disorder bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published. To view the latest
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
Strategy,, policy and commissioning to delay or prevent ent of dementia, bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They
More informationNICE guideline Published: 10 February 2016 nice.org.uk/guidance/ng36
Cancer of the upper aerodigestive e tract: assessment and management in people aged 16 and over NICE guideline Published: 10 February 2016 nice.org.uk/guidance/ng36 NICE 2018. All rights reserved. Subject
More informationUpdate: Non-Hodgkin s Lymphoma
2008 Update: Non-Hodgkin s Lymphoma ICML 2008: Update on non-hodgkin s lymphoma Diffuse Large B-cell Lymphoma Improved outcome of elderly patients with poor-prognosis diffuse large B-cell lymphoma (DLBCL)
More informationTechnology appraisal guidance Published: 26 February 2014 nice.org.uk/guidance/ta306
Pixantrone monotherapy for treating multiply relapsed or refractory aggressive e non-hodgkin's B-cell lymphoma Technology appraisal guidance Published: 26 February 2014 nice.org.uk/guidance/ta306 NICE
More informationScottish Medicines Consortium
Scottish Medicines Consortium rituximab 10mg/ml concentrate for infusion (MabThera ) Roche (No.330/06) 10 November 2006 The Scottish Medicines Consortium (SMC) has completed its assessment of the above
More informationClinical guideline Published: 23 February 2009 nice.org.uk/guidance/cg81
Advanced breast cancer: diagnosis and treatment Clinical guideline Published: 23 February 2009 nice.org.uk/guidance/cg81 NICE 20. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationTechnology appraisal guidance Published: 28 June 2017 nice.org.uk/guidance/ta446
Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma Technology appraisal guidance Published: 28 June 2017 nice.org.uk/guidance/ta446 NICE 2017. All rights reserved. Subject to Notice of rights
More informationTechnology appraisal guidance Published: 28 September 2016 nice.org.uk/guidance/ta411
Necitumumab for untreated advanced or metastatic squamous non-small-cell lung cancer Technology appraisal guidance Published: 28 September 2016 nice.org.uk/guidance/ta411 NICE 2017. All rights reserved.
More informationTechnology appraisal guidance Published: 18 July 2018 nice.org.uk/guidance/ta531
Pembrolizumab for untreated PD- L1-positive metastatic non-small-cell lung cancer Technology appraisal guidance Published: 18 July 2018 nice.org.uk/guidance/ta531 NICE 2018. All rights reserved. Subject
More informationTechnology appraisal guidance Published: 29 June 2011 nice.org.uk/guidance/ta227
Erlotinib monotherapy for maintenance treatment of non-small-cell lung cancer Technology appraisal guidance Published: 29 June 2011 nice.org.uk/guidance/ta227 NICE 2018. All rights reserved. Subject to
More informationTechnology appraisal guidance Published: 18 April 2018 nice.org.uk/guidance/ta518
Tocilizumab for treating giant cell arteritis Technology appraisal guidance Published: 18 April 2018 nice.org.uk/guidance/ta518 NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationTechnology appraisal guidance Published: 28 March 2018 nice.org.uk/guidance/ta516
Cabozantinib for treating medullary thyroid cancer Technology appraisal guidance Published: 28 March 2018 nice.org.uk/guidance/ta516 NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationPolicy for Central Nervous System [CNS] Prophylaxis in Lymphoid Malignancies
Policy for Central Nervous System [CNS] Prophylaxis in Lymphoid Malignancies UNCONTROLLED WHEN PRINTED Note: NOSCAN Haematology MCN has approved the information contained within this document to guide
More informationTechnology appraisal guidance Published: 8 November 2017 nice.org.uk/guidance/ta487
Venetoclax for treating chronic lymphocytic leukaemia Technology appraisal guidance Published: 8 November 2017 nice.org.uk/guidance/ta487 NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationTechnology appraisal guidance Published: 7 February 2018 nice.org.uk/guidance/ta505
Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma Technology appraisal guidance Published: 7 February 2018 nice.org.uk/guidance/ta505 NICE 2018. All rights
More informationTechnology appraisal guidance Published: 6 September 2017 nice.org.uk/guidance/ta476
Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancer Technology appraisal guidance Published: 6 September 2017 nice.org.uk/guidance/ta476 NICE 2018. All
More informationObinutuzumab in combination with bendamustine for treating rituximab-refractory follicular lymphoma
Obinutuzumab in combination with bendamustine for treating rituximab-refractory follicular lymphoma 1 st Appraisal Committee meeting Background and Clinical Effectiveness Committee A Lead team John Watkins
More informationTechnology appraisal guidance Published: 9 August 2017 nice.org.uk/guidance/ta465
Olaratumab atumab in combination with doxorubicin orubicin for treating advanced soft tissue sarcoma Technology appraisal guidance Published: 9 August 17 nice.org.uk/guidance/ta465 NICE 17. All rights
More informationTechnology appraisal guidance Published: 21 November 2018 nice.org.uk/guidance/ta546
Padeliporfin for untreated localised prostate cancer Technology appraisal guidance Published: 21 November 2018 nice.org.uk/guidance/ta546 NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationPutting NICE guidance into practice
Putting NICE guidance into practice Resource impact report: Olaparib for maintenance treatment of relapsed, platinum-sensitive, BRCA mutation-positive ovarian, fallopian tube and peritoneal cancer after
More informationTechnology appraisal guidance Published: 16 May 2018 nice.org.uk/guidance/ta520
Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapy Technology appraisal guidance Published: 16 May 2018 nice.org.uk/guidance/ta520 NICE 2018. All rights
More informationTechnology appraisal guidance Published: 20 December 2017 nice.org.uk/guidance/ta496
Ribociclib with an aromatase inhibitor for previously untreated, hormone receptor- positive, HER2-negative, e, locally advanced or metastatic breast cancer Technology appraisal guidance Published: 20 December
More informationTechnology appraisal guidance Published: 24 January 2018 nice.org.uk/guidance/ta500
Ceritinib for untreated ALK-positive non- small-cell lung cancer Technology appraisal guidance Published: 24 January 2018 nice.org.uk/guidance/ta500 NICE 2018. All rights reserved. Subject to Notice of
More informationTechnology appraisal guidance Published: 27 January 2016 nice.org.uk/guidance/ta380
Panobinostat for treating multiple myeloma after at least 2 previous treatments Technology appraisal guidance Published: 27 January 2016 nice.org.uk/guidance/ta380 NICE 2017. All rights reserved. Subject
More informationCPAG Summary Report for Clinical Panel Policy 1630 Bendamustine-based chemotherapy for first-line treatment of Mantle cell lymphoma (MCL) in adults
MANAGEMENT IN CONFIDENCE CPAG Summary Report for Clinical Panel Policy 1630 Bendamustine-based chemotherapy for first-line treatment of Mantle cell lymphoma (MCL) in adults The Benefits of the Proposition
More informationTechnology appraisal guidance Published: 26 April 2017 nice.org.uk/guidance/ta442
Ixekizumab for treating moderate to severe ere plaque psoriasis Technology appraisal guidance Published: 26 April 2017 nice.org.uk/guidance/ta442 NICE 2017. All rights reserved. Subject to Notice of rights
More informationClinical Commissioning Policy Proposition: Bendamustine with rituximab for relapsed indolent non-hodgkin s lymphoma (all ages)
Clinical Commissioning Policy Proposition: Bendamustine with rituximab for relapsed indolent non-hodgkin s lymphoma (all ages) Reference: NHS England 1607 1 First published: TBC Prepared by NHS England
More informationNICE guideline Published: 24 January 2018 nice.org.uk/guidance/ng83
Oesophago-gastric cancer: assessment and management in adults NICE guideline Published: 24 January 18 nice.org.uk/guidance/ng83 NICE 18. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationClinical guideline Published: 13 June 2012 nice.org.uk/guidance/cg141
Acute upper gastrointestinal bleeding in over 16s: management Clinical guideline Published: June 2012 nice.org.uk/guidance/cg141 NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationTechnology appraisal guidance Published: 28 June 2017 nice.org.uk/guidance/ta448
Etelcalcetide for treating secondary hyperparathyroidism Technology appraisal guidance Published: 28 June 2017 nice.org.uk/guidance/ta448 NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationTechnology appraisal guidance Published: 27 March 2019 nice.org.uk/guidance/ta572
Ertugliflozin as monotherapy or with metformin for treating type 2 diabetes Technology appraisal guidance Published: 27 March 2019 nice.org.uk/guidance/ta572 NICE 2019. All rights reserved. Subject to
More informationTechnology appraisal guidance Published: 24 January 2018 nice.org.uk/guidance/ta499
Glecaprevir pibrentasvir for treating chronic hepatitis C Technology appraisal guidance Published: 24 January 2018 nice.org.uk/guidance/ta499 NICE 2018. All rights reserved. Subject to Notice of rights
More informationTechnology appraisal guidance Published: 23 November 2016 nice.org.uk/guidance/ta418
Dapagliflozin in triple therapy for treating type 2 diabetes Technology appraisal guidance Published: 23 November 2016 nice.org.uk/guidance/ta418 NICE 2018. All rights reserved. Subject to Notice of rights
More informationRituximab for the first-line treatment of stage III-IV follicular lymphoma
Rituximab for the first-line treatment of stage III-IV (review of guidance 110) Issued: January 2012 guidance.nice.org.uk/ta243 NICE has accredited the process used by the Centre for Health Technology
More informationTechnology appraisal guidance Published: 11 April 2018 nice.org.uk/guidance/ta517
Avelumab for treating metastatic Merkelel cell carcinoma Technology appraisal guidance Published: 11 April 2018 nice.org.uk/guidance/ta517 NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationSmoking cessation interventions and services
National Institute for Health and Care Excellence Guideline version (Final) Smoking cessation interventions and services [E] Evidence reviews for advice NICE guideline NG92 Evidence reviews FINAL These
More informationTechnology appraisal guidance Published: 16 December 2015 nice.org.uk/guidance/ta370
Bortezomib for previously untreated mantle cell lymphoma Technology appraisal guidance Published: 16 December 2015 nice.org.uk/guidance/ta370 NICE 2018. All rights reserved. Subject to Notice of rights
More informationPancreatic Cancer in adults:
National Institute for Health and Care Excellence Version 1.0 Pancreatic Cancer in adults: diagnosis and management Appendix K 31 July 2017 Draft for Consultation Developed by the National Guideline Alliance,
More informationStrategies for the Treatment of Elderly DLBCL Patients, New Combination Therapy in NHL, and Maintenance Rituximab Therapy in FL
New Evidence reports on presentations given at ASH 2009 Strategies for the Treatment of Elderly DLBCL Patients, New Combination Therapy in NHL, and Maintenance Rituximab Therapy in FL From ASH 2009: Non-Hodgkin
More informationAlcohol interventions in secondary and further education
National Institute for Health and Care Excellence Guideline version (Draft for Consultation) Alcohol interventions in secondary and further education NICE guideline: methods NICE guideline Methods
More informationTechnology appraisal guidance Published: 28 November 2018 nice.org.uk/guidance/ta547
Tofacitinib for moderately to severelyerely active ulcerative colitis Technology appraisal guidance Published: 28 November 2018 nice.org.uk/guidance/ta547 NICE 2019. All rights reserved. Subject to Notice
More informationClinical guideline Published: 17 March 2008 nice.org.uk/guidance/cg64
Prophylaxis against infective endocarditis: antimicrobial prophylaxis against infective e endocarditis in adults and children undergoing interventionalentional procedures Clinical guideline Published:
More informationTechnology appraisal guidance Published: 12 July 2017 nice.org.uk/guidance/ta456
Ustekinumab for moderately to severelyerely active Crohn s disease after previous treatment Technology appraisal guidance Published: 12 July 2017 nice.org.uk/guidance/ta456 NICE 2017. All rights reserved.
More informationClinical guideline Published: 27 June 2012 nice.org.uk/guidance/cg143
Sickle cell disease: managing acute painful episodes in hospital Clinical guideline Published: 27 June 2012 nice.org.uk/guidance/cg143 NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationRisk assessment for type 2 diabetes
Preventing type 2 diabetes NICE 2019. All rights reserved. Subject to Notice of rights. NICE Pathways NICE Pathways bring together everything NICE says on a topic in an interactive flowchart. NICE Pathways
More informationTechnology appraisal guidance Published: 31 August 2017 nice.org.uk/guidance/ta473
Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neck Technology appraisal guidance Published: 31 August 2017 nice.org.uk/guidance/ta473 NICE 2018. All rights reserved.
More informationTechnology appraisal guidance Published: 22 July 2009 nice.org.uk/guidance/ta174
Rituximab for the first-line treatment of chronic lymphocytic leukaemia Technology appraisal guidance Published: 22 July 2009 nice.org.uk/guidance/ta174 NICE 2018. All rights reserved. Subject to Notice
More informationNICE guideline Published: 10 February 2016 nice.org.uk/guidance/ng36
Cancer of the upper aerodigestive e tract: assessment and management in people aged 16 and over NICE guideline Published: 10 February 2016 nice.org.uk/guidance/ng36 NICE 2018. All rights reserved. Subject
More informationTechnology appraisal guidance Published: 9 August 2017 nice.org.uk/guidance/ta466
Baricitinib for moderate to severeere rheumatoid arthritis Technology appraisal guidance Published: 9 August 2017 nice.org.uk/guidance/ta466 NICE 2017. All rights reserved. Subject to Notice of rights
More informationLancashire and South Cumbria Haematology NSSG Guidelines for Follicular Lymphoma:
1 Lancashire and South Cumbria Haematology NSSG Guidelines for Follicular Lymphoma: 2018-19 1.1 Pretreatment evaluation The following tests should be performed: FBC, U&Es, creat, LFTs, calcium, LDH, Igs/serum
More informationTechnology appraisal guidance Published: 28 October 2015 nice.org.uk/guidance/ta359
Idelalisib for treating chronic lymphocytic leukaemia Technology appraisal guidance Published: 28 October 2015 nice.org.uk/guidance/ta359 NICE 2017. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
More informationSingle Technology Appraisal (STA) Midostaurin for untreated acute myeloid leukaemia
Single Technology Appraisal (STA) Midostaurin for untreated acute myeloid leukaemia Response to consultee and commentator comments on the draft remit and draft scope (pre-referral) Please note: Comments
More informationNational Horizon Scanning Centre. Temsirolimus (Torisel) for mantle cell lymphoma - relapsed and/or refractory. January 2008
Temsirolimus (Torisel) for mantle cell lymphoma - relapsed and/or refractory January 2008 This technology summary is based on information available at the time of research and a limited literature search.
More informationIndolent Lymphomas. Dr. Melissa Toupin The Ottawa Hospital
Indolent Lymphomas Dr. Melissa Toupin The Ottawa Hospital What does indolent mean? Slow growth Often asymptomatic Chronic disease with periods of relapse (long natural history possible) Incurable with
More informationTechnology appraisal guidance Published: 6 December 2017 nice.org.uk/guidance/ta493
Cladribine tablets for treating relapsing remitting multiple sclerosis Technology appraisal guidance Published: 6 December 2017 nice.org.uk/guidance/ta493 NICE 2018. All rights reserved. Subject to Notice
More informationTechnology appraisal guidance Published: 21 February 2018 nice.org.uk/guidance/ta507
Sofosbuvir velpatasvir voxilaprevir for treating chronic hepatitis C Technology appraisal guidance Published: 21 February 2018 nice.org.uk/guidance/ta507 NICE 2018. All rights reserved. Subject to Notice
More informationTechnology appraisal guidance Published: 11 October 2017 nice.org.uk/guidance/ta480
Tofacitinib for moderate to severeere rheumatoid arthritis Technology appraisal guidance Published: 11 October 2017 nice.org.uk/guidance/ta480 NICE 2018. All rights reserved. Subject to Notice of rights
More informationbrentuximab vedotin (Adcetris ) 50mg powder for concentrate for solution for infusion SMC No. (845/12) Takeda UK Ltd
brentuximab vedotin (Adcetris ) 50mg powder for concentrate for solution for infusion SMC No. (845/12) Takeda UK Ltd 05 September 2014 The Scottish Medicines Consortium (SMC) has completed its assessment
More informationLYMPHOMA Joginder Singh, MD Medical Oncologist, Mercy Cancer Center
LYMPHOMA Joginder Singh, MD Medical Oncologist, Mercy Cancer Center Lymphoma is cancer of the lymphatic system. The lymphatic system is made up of organs all over the body that make up and store cells
More informationTechnology appraisal guidance Published: 26 October 2016 nice.org.uk/guidance/ta416
Osimertinib for treating locally advanced or metastatic EGFR T790M mutation- positive non-small-cell lung cancer Technology appraisal guidance Published: 26 October 2016 nice.org.uk/guidance/ta416 NICE
More informationScottish Medicines Consortium
Scottish Medicines Consortium ibritumomab tiuxetan (Zevalin ) No. (171/05) Schering Health Care Ltd 8 April 2005 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product
More informationTechnology appraisal guidance Published: 24 August 2016 nice.org.uk/guidance/ta405
Trifluridine tipirracil for previously treated metastatic colorectal cancer Technology appraisal guidance Published: 24 August 2016 nice.org.uk/guidance/ta405 NICE 2018. All rights reserved. Subject to
More information12 th Annual Hematology & Breast Cancer Update Update in Lymphoma
12 th Annual Hematology & Breast Cancer Update Update in Lymphoma Craig Okada, MD, PhD Assistant Professor, Hematology January 14, 2010 Governors Hotel, Portland Oregon Initial Treatment of Indolent Lymphoma
More information