Adrenal exhaustion and immunoglobulin suppression: common findings in 54 dogs with Sudden Acquired Retinal Degeneration (SARD)
|
|
- Julian Watts
- 5 years ago
- Views:
Transcription
1 Adrenal exhaustion and immunoglobulin suppression: common findings in 54 dogs with Sudden Acquired Retinal Degeneration (SARD) Caroline D. Levin RN Copyright July 8, 008. March, 009, The author reviewed the charts of 54 SARD-affected dogs between Dogs were tested/treated by their general practice veterinarian. Results were fairly consistent despite slight variations in hormone replacement therapy and lab facilities (see below). Follow-up lab results represent only a brief window in time; treatment is life-long. Two laboratories revised their reference ranges during this time period and those revisions are reflected below. Note to practioners: reference ranges at are extremely narrow and slight elevations are significant, correlating closely with clinical signs of PU/PP/ lethargy/confusion, etc. Initial evaluation ranged from years post-sard onset (mean =.6 ). 5 of 54 dogs (98%) demonstrated elevations in one or more adrenal sex-hormones (progesterones, androgen, and/or estrogens). Inadequate cortisol production is a common cause of elevated sex-hormones in both dogs and humans. -7 When production of active cortisol fails during adulthood the condition is described as adrenal exhaustion. 8,9 4 dogs had assayed as well. 40 of 4 (9%) demonstrated low levels of IgM, IgG and/or IgA. However, this trend was not consistent between lab facilities. One explanation may involve sample collection or handling technique. If serum samples are permitted to warm, aggregate, yielding high false-positive levels. 0, Sample age, evaporation, and reagent shelf life are also reported to erroneously affect outcomes. Rising estrogen levels are reported to suppress both immunoglobulin production in humans and bone marrow activity in dogs. -5 of the 54 dogs received low-dose cortisol and thyroid hormone replacement therapy. Duration of treatment prior to retest = (mean =.6 ). Of the dogs treated, 95% demonstrated improved sex-hormone levels and 00% demonstrated improved immunoglobulin levels. % of dogs (#0,, 5, 50, 5) demonstrated some degree of functional vision confirmed by GP veterinarian or veterinary ophthalmologist. Recommendations: SARD-affected dogs should be promptly tested and treated for adrenal exhaustion, as hormone replacement therapy improves sex-hormone levels and immunoglobulin production in nearly all dogs and may restore functional vision in some dogs.. Levin C. Sudden Acquired Retinal Degeneration, associated pattern of adrenal activity, and hormone replacement in three dogs a retrospective study. Proceedings of the 8 th Annual Meeting of the College of Veterinary Ophthalmologists 007; 8:.. Guthrie GP, Wilson EA, Quillen DL, Jawad MJ. Adrenal androgen excess and defective -beta-hydroxylation in women with idiopathic hirsutism (abstract). Archives of Internal Medicine 98; 4: Deaton M, Glorioso JE, Mclean, DB. Congenital Adrenal Hyperplasia Not really a zebra. American Family Physician 999; 59: Naessen S, Carlstrom K, Garoff L, Glant R, Hirschberg AL. Polycystic ovary syndrome in bulimic women an evaluation based on new diagnostic criteria (abstract). Gynecological Endocrinology 00; : Derman RJ. Effects of sex steroids on women s health: implications for practitioners (abstract). American Journal of Medicine 995; A: 7S-4S. 6. Plechner AJ. Cortisol abnormality as a cause of elevated estrogen and immune destabilization: Insights for human medicine from a veterinary perspective. Medical Hypothesis 004; 6: Jeffries MK. Safe Uses of Cortisol third edition. Charles C. Thomas Publisher, Ltd, Springfield, Marik PE. Adrenal-exhaustion syndrome in patients with liver disease (abstract). Intensive Care Medicine 006; : Selye H. The Stress of Life revised edition. McGraw-Hill, Incorporated: New York, Yoshida H, Ishikawa H, Honda S, Miura Y, Ogata M. False positive reaction of heat-inactivated sera in enzyme-linked immunosorbent assay for antibody to hepatitis C virus (abstract). Fukushima Journal of Medical Science 99; 8; Luginbühl A, Nikolic M, Beck H. Complement Factor D, Albumin and Immunoglobulin G Anti-Band Protein Antibodies Mimic Serum in Promoting Rosetting of Malaria-Infected Red Blood Cells. Infection and Immunity 007; 75: Key M. Pathology: Immunohistochemical Staining Methods fourth edition. Dako Laboratories, Carpinteria, California, Hart JE. Endocrine pathology of estrogens: species differences (abstract). Pharmacology Therapeutics 990; 47: Zayed I, van Esch E, McConnell R. Systemic and histopathologic changes in beagle dogs after chronic daily oral administration of synthetic or natural estrogens with special reference to the kidney & thyroid. Toxicologic Pathology 998; 6: Blum M, Zacharovich D, Pery J, Kitai E. Lowering effect of estrogen treatment on in menopausal women (abstract). Revue française degynecologie et d obstetrique 990; 4:
2 Adrenal exhaustion and immunoglobulin suppression: common findings in 54 dogs with Sudden Acquired Retinal Degeneration (SARD) Caroline D. Levin RN Dog Breed, Age & Gender Interval from SARD onset Lab results : initial Testing facility & normal range Hormone replacement treatment Lab results : post-treatment Interval between tests 0 y/o, M/n estradiol.40 Cornell University estradiol: males < 0 pg/ml triamcinolone acetonide mg IM methylprednisolone mg PO SID levothyroxine 0.mg PO BID estradiol Maltesemix, 9.5 y/o, F/s Newfoundland 6 y/o, M/n Brittany 9 y/o, M/n estradiol 7. IgA 0 IgG 500 IgM 400 estradiol. IgA 5 IgG >5000 IgM 400 estradiol 4.0 IgA 5 IgG 000 IgM 50 Antech Diagnostics estradiol: spayed females and neutered males <5-0 pg/ml (in conjunction with Cornell) IgA: 0-50 mg/dl IgG: mg/dl IgM: mg/dl JRT, 7 y/o, F/s PVGB, y/o, F/s Labradormix, 8 y/o, M/n androstene..6/ 6.4 estradiol 45.7/ 46.4 progesterone 0.5/ OH prog. 0.65/.9 androstene..5/0. estradiol 6.5/ 70.7 progesterone 0.8/ OH prog. 0.04/ 0.6 androstene../7.8 estradiol 49./ 44.4 progesterone 0./.57 7-OH prog. 0.47/. Univ. of Tennessee CVM prior to 5/008 Baseline androstenedione ng/ml estradiol pg/ml progesterone pg/ml 7-OH prog pg/ml Post-ACTH androstene ng/ml estradiol pg/ml progesterone pg/ml 7-OH prog pg/ml triamcinolone acetonide.8mg IM dexamethasone sod phos mg IM methylprednisolone mg PO levothyroxine 0.5mg PO BID androstendione.9/7.4 estradiol 44./ 6.4 progesterone 0./.07 7-OH prog 0.09/.6 4
3 8 Eng. Pointer, 8.5 y/o, F/s androstene..8/ 8.5 estradiol.4/ 6. progesterone 0.6/. 7-OH prog. 0.05/.96 Univ. of Tennessee CVM prior to 5/ Cairn Terrier, Chow-mix, Golden Retr-mix, year 6 baseline only androstene..6 estradiol 8. progesterone OH prog. 0.6 androstene..0/ 0.9 estradiol 45.8/ 59.7 progesterone 0.0/ OH prog. 0.07/ 0.9 androstene..4/ 0. estradiol 84.0/ 77.0 progesterone 0.45/ 4 7-OH prog. 0.4/.68 Baseline androstenedione ng/ml estradiol pg/ml progesterone pg/ml 7-OH prog pg/ml Post-ACTH androstene ng/ml estradiol pg/ml progesterone pg/ml 7-OH prog pg/ml Change in reference range Brittany 6 y/o, F/s androstene. 6.9/.0 estradiol 55.6/ 5.9 progesterone 0./.4 7-OH prog. 0./.98 Univ. of Tennessee CVM after 5/008 prednisone.mg PO SID androstene..8/.4 estradiol 49.0/ 5.7 progesterone 0.5/ OH prog 0.06/ 0.57 Shnauzerpoodle mix, androstene. 7.6/ 45. estradiol 9.9/ 84.5 progesterone 0./.65 7-OH prog. 0.9/.5 Baseline androstenedione ng/ml estradiol pg/ml progesterone pg/ml 7-OH prog pg/ml Post-ACTH androstene ng/ml estradiol pg/ml progesterone pg/ml 7-OH prog pg/ml
4 4 GSD, 4.5 total estrogen 5.9 IgA 49 IgG 989 IgM 96 methylprednisolone 4mg PO SID Total estrogen 5. IgA 56 IgG 049 IgM 0 month 5 Boxer, 9 y/o, M/n 4 total estrogen 5.5 no assayed prednisone 5mg PO SID total estrogen 5. no assayed month 6 Labradormix, total estrogen 5. IgA 4 IgG 98 IgM 88 triamcinolone acetonide mg IM methylpredniolone 4mg PO SID total estrogen 5.09 IgA 58 IgG 077 IgM y/o, F/s total estrogen 5.9 IgA 7 IgG 96 IgM 0 triamcinolone acetonide.5mg IM dexamethasone sod phos.4mg IM methylprednisolone 4mg PO SID total estrogen 5.6 IgA 89 IgG 4 IgM Springer y/o, M/n Pomeranian, 7 y/o, M/n y/o, M/n total estrogen 5. IgA 4 IgG 78 IgM 80 total estrogen 5.7 IgA 6 IgG 80 IgM 77 total estrogen 5.40 IgA 4 IgG 87 I gm 84 females pg/ml IgA: mg/dl IgG: mg/dl IgM: mg/dl triamcinolone acetonide 0.mg IM methylprednisolone 4mg PO SID levothyroxine 0.5mg PO BID triamcinolone acetonide 0.5mg IM dexamethasone sod phos. 0.5mg IM methylprednisolone 0.5mg PO SID levothyroxine 0.mg PO BID triamcinolone acetonide.5mg IM methylprednisolone mg PO SID levothyroxine 0.mg PO BID total estrogen 5. IgA 6 IgG 06 IgM 4 total estrogen 5.4 IgA 48 IgG 96 IgM 95 total estrogen 4.88 IgA 78 IgG 5 IgM Australian Cattle Dog, total estrogen 5.7 IgA 5 IgG 46 IgM 5 Cocker 6 y/o, M/n total estrogen 5.08 IgA 57 IgG 989 IgM 00
5 Dachshound 9 total estrogen 5.9 IgA 57 IgG 96 IgM 9 4 Labrador Retriever, total estrogen 5.0 IgA 49 IgG 98 IgM 89 5 GSD-mix,.5 y/o, F/s.5 total estrogen 5. IgA 49 IgG 98 IgM 89 6 Australian Shepherd, 0 y/o, F/s 5 total estrogen 5.0 IgA 5 IgG 947 IgM 96 females pg/ml 7 Pug, 5 total estrogen 5.6 IgA 49 IgG 968 IgM 97 IgA: mg/dl IgG: mg/dl IgM: mg/dl 8 Akita-mix, 7 y/o, M/n total estrogen 5. IgA 47 IgG 6 IgM 74 9 Mini Dachshund, y/o, F/s 6 total estrogen 5.68 IgA 5 IgG 97 IgM 9 0 Lhasa- Apso mix, y/o, F/s total estrogen 5.7 IgA 57 IgG 898 IgM 86 triamcinolone acetonide 0.06mg mg IM dexamethasone sod phos 0.8g mg IM levothyroxine 0.mg PO BID total estrogen 5.09 IgA 88 IgG 6 IgM 95
6 Change in reference range Husky-mix, total estrogen 5.7 IgA 58 IgG 77 IgM 96 prednisone 5 mg PO SID Total estrogen 5. IgA 66 IgG 5 IgM 98 Brittany 9 y/o, M/n years total estrogen 5.5 IgA 5 IgG 97 IgM 9 triamcinolone acetonide 0.mg IM dexamethasone sod phos.6mg IM methylprednisolone mg PO SID levothyroxine 0.mg PO BID total estrogen 5.0 IgA 68 IgG 09 IgM 0 6 Springer y/o, M/n weeks total estrogen 5.04 IgA 6 IgG 05 IgM 99 triamcinolone acetonide 0.5mg IM dexamethasone sod phos.mg IM methylprednisolone mg PO SID levothyroxine 0.5mg PO BID total estrogen 4.89 IgA 74 IgG 05 IgM total estrogen 5.9 IgA 5 IgG 0 IgM 05 triamcinolone acetonide 0.4mg IM dexamethasone sod phos.06mg IM methylprednisolone mg PO SID levothyroxine 0.mg PO BID total estrogen 5.7 IgA 58 IgG 5 IgM 08 month 5 Scottish Terrier, 0 y/o, F/s 8 total estrogen 5.7 IgA 50 IgG 089 IgM 8 females pg/ml triamcinolone acetonide mg IM, weekly for 4 weeks levothyroxine mg PO BID total estrogen 5. IgA 58 IgG 5 IgM 87 month 6 Mini Dachshund, tota l estrogen 5.9 IgA 49 IgG 998 IgM 0 IgA: mg/dl IgG: mg/dl IgM: mg/dl triamcinolone acetonide 0.4mg IM dexamethasone sod phos. 0.5mg IM levothyroxine 0.05mg PO BID tota l estrogen 5. IgA 8 IgG 69 IgM 07 7 Shih-tzu, 8.5 y/o, M/n total estrogen 5.9 IgA 47 IgG 98 IgM 9 triamcinolone acetonide.5mg IM, weekly x wks;.mg IM, weekly x wk; then levothyroxine 0.5mg PO BID total estrogen 5.0 IgA 9 IgG 6 IgM 0 8 Mini Dachshund, 7 y/o, F/s 5.5 total estrogen 5.4 IgA 5 IgG 08 IgM 9 9 GSD, y/o, M/n total estrogen 5.6 IgA 5 IgG 08 IgM 94
7 40 Brittany 4 total estrogen 5.4 IgA 9 IgG 8 IgM 6 4 Pug, 7 y/o, F/s 7 total estrogen 5. IgA 58 IgG 0 IgM Staffordshire Terrier, 4y/o, F/s Sheltland Sheepdog, 8.5 y/o, M/n Chow-mix, 0.5 y/o, M/n Mini- Shnauzer, 9 y/o, M/n 7 weeks total estrogen 5.05 IgA 68 IgG 858 IgM total estrogen 5. IgA 58 IgG 09 IgM 04 total estrogen 5.4 IgA 4 IgG 89 IgM 58 total estrogen 5. IgA 57 IgG 6 IgM 97 females pg/ml IgA: mg/dl IgG: mg/dl IgM: mg/dl
8 Return to original reference range 46 Pug, 6 y/o, F/s total estrogen 5.07 IgA 5 IgG 978 IgM 9 Depo medrol 5mg IM dexamethasone sod phos 0.5mg IM levothyroxine 0.mg PO BID total estrogen 5.04 IgA 65 IgG 08 IgM Miniature Poodle, 0 y/o, F/s total estrogen 5. IgA 57 IgG 6 IgM Mini- Dachshund, 9y/o, F/s 7 total estrogen 5. IgA 5 IgG 080 IgM 94 females pg/ml triamcinolone acetonide 0.08mg IM dexamethasone sod phos 0.7mg IM levothyroxine 0.05mg PO BID total estrogen 5.06 IgA 59 IgG IgM Wheaton Terrier, 9 y/o, M/i 7 total estrogen 5.09 IgA 5 IgG 6 IgM 9 IgA: mg/dl IgG: mg/dl IgM: mg/dl triamcinolone acetonide 0.mg IM dexamethasone sod phos.6mg IM methylprednisolone mg PO SID levothyroxine 0.5mg PO BID total estrogen 5.07 IgA 59 IgG 68 IgM Spaniel-mix, 7 y/o, M/n total estrogen 5.9 IgA 57 IgG 84 IgM 96 triamcinolone acetonide 0.57 mg IM dexamethasone sod phos.57 mg IM methylprednisolone mg PO SID levothyroxine 0.mg PO BID total estrogen 5.06 IgA 66 IgG 05 IgM 0 5 Mini- Dachsund mix 6 y/o, M/n total estrogen 5.09 IgA 57 IgG 99 IgM 98 triamcinolone acetonide 0.05 mg IM dexamethasone sod phos 0.8 mg IM methylprednisolone.5mg PO SID levothyroxine 0.mg PO BID retest pending 5 Australian Shepherdmix y/o, M/n total estrogen 5. IgA 48 IgG 9 IgM 90 Course of antiinflammatory-level prednisone: 0mg PO qod tapered to: prednisone 5g PO SID levothyroxine 0.6mg PO BID total estrogen 5.09 IgA 57 IgG 984 IgM weeks total estrogen 5.9 IgA 5 IgG 9 IgM 9 54 Mini- Dachsund 0 y/o, F/s.5 total estrogen 5.07 IgA 6 IgG 05 IgM 00 triamcinolone acetonide 0.07 mg IM dexamethasone sod phos 0.6 mg IM levothyroxine 0.mg PO BID retest pending
In the past few years, a new disease has been identified called Sudden Acquired Retinal Degeneration Syndrome (SARDS).
SARDS CLINCAL CASE STUDIES In the past few years, a new disease has been identified called Sudden Acquired Retinal Degeneration Syndrome (SARDS). The disease manifests itself as a loss of vision which
More informationSudden Acquired Retinal Degeneration, associated pattern of adrenal activity, and hormone replacement therapy in a Brittany Spaniel
Sudden Acquired Retinal Degeneration, associated pattern of adrenal activity, and hormone replacement therapy in a Brittany Spaniel Caroline D. Levin RN 18709 S. Grasle Road Oregon City, OR 97045 cdlevin@comcast.net
More informationSARDS case report #8. Melatonin vs. cortisol replacement Comparison of two therapies utilized in a case of canine Sudden Acquired Retinal Degeneration
SARDS case report #8 Melatonin vs. cortisol replacement Comparison of two therapies utilized in a case of canine Sudden Acquired Retinal Degeneration Caroline D. Levin RN 18709 S. Grasle Road Oregon City,
More informationOriginally trained to find live game, their temperament makes them an ideal family dog
Originally trained to find live game, their temperament makes them an ideal family dog Labrador Retriever Lifetime costs: 20,648 Annual costs: 2,332.85 Purchase price: 681 Feeding costs: 537.37 Insurance:
More informationbeen given to the current obesity epidemic
Ban_01_07_016-021 1/30/07 9:31 AM Page 16 Overweight Pets: What s the big deal? By Elizabeth Lund, DVM, MPH, PhD Contributing Author Much attention has been given to the current obesity epidemic that is
More informationDevelopmental Kidney Diseases
Customer Name, Street Address, City, State, Zip code Phone number, Alt. phone number, Fax number, e-mail address, web site Developmental Kidney Diseases (Diseases That Are Inherited or Occur during Development
More informationCoagulation factor VII deficiency. Hemophilia A (German Shepherd Dog, type 1) Pyruvate kinase deficiency (Labrador Retriever type)
Blood and Clotting Coagulation factor VII deficiency Elliptocytosis Hemophilia A (German Shepherd Dog, type 2) Pyruvate kinase deficiency (Labrador Retriever type) Thrombopathia (American Eskimo Dog type)
More informationRetinal Detachment. Basics OVERVIEW GENETICS SIGNALMENT/DESCRIPTION OF PET
Customer Name, Street Address, City, State, Zip code Phone number, Alt. phone number, Fax number, e-mail address, web site Retinal Detachment Basics OVERVIEW Retinal refers to the retina; the retina is
More informationResults for Trendy. Explanation of Results
Canine HealthCheck Results for Trendy Trendy's genetic health profile: Trendy's appearance profile: Trendy is not at-risk for any of the diseases tested Trendy is a Female Trendy is not a carrier for any
More informationResults for Ceaser. Em Locus (Melanistic Mask) Explanation of Results
Results for Ceaser Ceaser's demographic profile:!"## $"%&'!&"(&) *&+,(-&)&. $"%&' /000000 1)&&.' 12##.3+ /&0' 4"#& 566)307 891' :;;?!"#$%&'''''''!"#$%&'(&$)* +, -./4567 0$1')12$345(&&)),!"# $% &'&((((
More informationResults for Farrah. These tests were developled and performed by Paw Print Genetics, Spokane WA. Explanation of Results
Canine HealthCheck Results for Farrah Farrah's demographic profile: Call Name: Farrah Registered Name: Amber Bear's She's All That Breed: Collie Sex: Female Age: 1 Owner: Registration #: DN44645703 Microchip/Tattoo:
More informationResults for Diva. These tests were developled and performed by Paw Print Genetics, Spokane WA. Explanation of Results
Canine HealthCheck Results for Diva Diva's demographic profile: Call Name: Diva Registered Name: Rus Pekos Diva Chudo Prirody Breed: Golden Retriever Sex: Female Approx. DOB: 2016-07 Owner: Registration
More informationUncomplicated Diabetes Mellitus in Dogs Basics
Glendale Animal Hospital 623-934-7243 www.familyvet.com Uncomplicated Diabetes Mellitus in Dogs Basics OVERVIEW Increased levels of glucose (sugar) in the blood (known as hyperglycemia ) when the dog has
More informationSARDS CASE REPORT #3. Short-term hormone replacement in a Springer Spaniel affected with Sudden Acquired Retinal Degeneration Syndrome (SARDS)
SARDS CASE REPORT #3 Short-term hormone replacement in a Springer Spaniel affected with Sudden Acquired Retinal Degeneration Syndrome (SARDS) Caroline D. Levin RN 18709 S. Grasle Road Oregon City, OR 97045
More informationSeizures in Dogs & Cats What You Need to Know!
Seizures in Dogs & Cats What You Need to Know! One of the scariest events in pet parents lives is seeing their fur baby have a seizure. They re downright frightening even when you know what seizures look
More informationResults for Dar. These tests were developled and performed by Paw Print Genetics, Spokane WA. Explanation of Results
Canine HealthCheck Results for Dar Dar's demographic profile: Call Name: Dar Registered Name: Newman's Allendar of Lost Acres Breed: Collie Sex: Male Age: 0 Owner: Registration #: DN47650805 Microchip/Tattoo:
More informationGlomerulonephritis (Kidney Inflammation Involving the Glomerulus, the Blood Filter ) Basics
Glomerulonephritis (Kidney Inflammation Involving the Glomerulus, the Blood Filter ) Basics OVERVIEW The kidney filters the blood and removes various waste products from the body as it produces urine;
More informationDIAGNOSIS OF CANINE HYPERADRENOCORTICISM: A CASE-BASED APPROACH Ellen N. Behrend, VMD, PhD, DACVIM
DIAGNOSIS OF CANINE HYPERADRENOCORTICISM: A CASE-BASED APPROACH Ellen N. Behrend, VMD, PhD, DACVIM Case 1: Signalment: 10 yr old, CM, Miniature poodle; History: Presented for teeth cleaning; PE: Severe
More informationIn thousands of cases spanning three decades, I have
Adrenal-Immune Disturbance in Animals Offers Therapeutic Insights for Multiple Human Disorders Alfred J. Plechner, D.V.M. Originally published in Townsend Letter for Doctors & Patients, as Chaos in the
More informationCushing's disease, Cushing's syndrome
Greenville Veterinary Clinic LLC 409 E. Jamestown Rd. Greenville, PA 16125 (724) 588-5260 Canine hyperadrenocorticism Cushing's disease, Cushing's syndrome AffectedAnimals: Although dogs of almost every
More informationROLE OF HORMONAL ASSAY IN DIAGNOSING PCOD DR GAANA SREENIVAS (JSS,MYSURU)
ROLE OF HORMONAL ASSAY IN DIAGNOSING PCOD DR GAANA SREENIVAS (JSS,MYSURU) In 1935, Stein and Leventhal described 7 women with bilateral enlarged PCO, amenorrhea or irregular menses, infertility and masculinizing
More informationAssociated Terms: Bladder Stones, Ureteral Stones, Kidney Stones, Cystotomy, Urolithiasis, Cystic Calculi
Associated Terms: Bladder Stones, Ureteral Stones, Kidney Stones, Cystotomy, Urolithiasis, Cystic Calculi The term "ACVS Diplomate" refers to a veterinarian who has been board certified in veterinary surgery.
More information6 yr old MC labrador retriever. Peripheral Neutropenia and Occult Lymphoproliferative Disorders. 6 yr old MC labrador retriever.
Peripheral Neutropenia and Occult Lymphoproliferative Disorders Paul R. Avery VMD, PhD, DACVP Melanie S. Spoor Laurie Bohannon-Worsley Lauren C. Taraba Matthew D. Jones Anne C. Avery VMD, PhD Colorado
More informationThe occurrence of multiple endocrine disorders in veterinary
SMALL ANIMALS Multiple endocrine diseases in dogs: 35 cases (1996 2009) Shauna L. Blois, dvm, dvsc, dacvim; Erica Dickie, bsc; Stephen A. Kruth, dvm, dacvim; Dana G. Allen, dvm, msc, dacvim Objective To
More informationKeratoconjunctivitis Sicca (KCS) Dry Eye in Dogs
Keratoconjunctivitis Sicca (KCS) Dry Eye in Dogs The eyes of dogs are beautiful orbs with intricate parts functioning together to enable each of us to see the incredible world surrounding us. Their eyes,
More informationSAMPLE REPORT. Order Number: PATIENT. Age: 40 Sex: F MRN:
Patient: Age: 40 Sex: F MRN: SAMPLE PATIENT Order Number: Completed: Received: Collected: SAMPLE REPORT Progesterone ng/ml 0.34 0.95 21.00 DHEA-S mcg/dl Testosterone ng/ml 48 35 0.10 0.54 0.80 430 Sex
More informationAddison s Disease. Disclosures. Ringo 9/8/2016. Consulting, AVL Laboratories, St. Louis, MO. Signalment: 2 ½ year old, MC, Gt Dane History:
Addison s Disease Stanley I. Rubin, DVM, MS Diplomate ACVIM Clinical Professor Department of Veterinary Clinical Medicine Disclosures Consulting, AVL Laboratories, St. Louis, MO Ringo Signalment: 2 ½ year
More informationOvarian Remnant Syndrome
Ovarian Remnant Syndrome Dawna L. Voelkl, DVM, Dipl ACT University of Missouri College of Veterinary Medicine Ovarian Remnant Syndrome Definition Incidence Clinically applicable anatomy and etiology Clinical
More informationGlaucoma Basics OVERVIEW GENETICS SIGNALMENT/DESCRIPTION OF PET
Glaucoma Basics OVERVIEW Glaucoma is a disease of the eye, in which the pressure within the eye is increased (pressure within the eye is known as intraocular pressure or IOP) High intraocular pressure
More informationCalcium Oxalate Urolithiasis
Customer Name, Street Address, City, State, Zip code Phone number, Alt. phone number, Fax number, e-mail address, web site Calcium Oxalate Urolithiasis (Calcium Oxalate Stones in the Urinary Tract) Basics
More informationHypothyroidism (Low Levels of Thyroid Hormone) Basics
Glendale Animal Hospital 623-934-7243 www.familyvet.com Hypothyroidism (Low Levels of Thyroid Hormone) Basics OVERVIEW Clinical condition that results from inadequate production and release of thyroid
More informationAdrenal Insufficiency During Pregnancy
Disclosures Adrenal Insufficiency During Pregnancy Research funding from Diurnal Limited via NIH CRADA mechanism Deborah P. Merke, M.D., M.S. Bethesda, MD Outline Primary Adrenal Insufficiency Physiological
More informationFactors influencing the antibody response of dogs vaccinated against rabies
Available online at www.sciencedirect.com Vaccine 25 (2007) 8500 8507 Factors influencing the antibody response of dogs vaccinated against rabies Lorna J. Kennedy a,, Mark Lunt b, Annette Barnes c, Lorraine
More informationNonulcerative Keratitis (Type of Inflammation of the Cornea) Basics
Nonulcerative Keratitis (Type of Inflammation of the Cornea) Basics OVERVIEW Keratitis is inflammation of the cornea; the cornea is the clear outer layer of the front of the eye The corneal epithelium
More informationAdrenal Stress Profile (Saliva)
Adrenal Stress Profile (Saliva) Ireland Cortisol Levels Sample 1 Post Awakening Sample 2 (+ 4-5 Hours) Sample 3 (+ 4-5 Hours) Sample 4 (Prior to Sleep) 11.42 2.10 1.60 0.47 Sum of Cortisol 15.590 DHEA
More informationSCHOOL OF MEDICINE AND HEALTH SCIENCES DIVISION OF BASIC MEDICAL SCIENCES DISCIPLINE OF BIOCHEMISTRY & MOLECULAR BIOLOGY
1 SCHOOL OF MEDICINE AND HEALTH SCIENCES DIVISION OF BASIC MEDICAL SCIENCES DISCIPLINE OF BIOCHEMISTRY & MOLECULAR BIOLOGY PBL SEMINAR: SEX HORMONES PART 1 An Overview What are steroid hormones? Steroid
More informationASY-857.1: Synacthen Stimulated 17OH-progesterone Test
ASY-857.1: Synacthen Stimulated 17OH-progesterone ASY-857.2: Associated Documents a Synacthen Standing Order form (ref 0827/2) G:\Division\NDO\common\ETCProtocols\0827 Standing Order Synacthen 2016.pdf
More informationNonulcerative Keratitis (Type of Inflammation of the Cornea) Basics
Nonulcerative Keratitis (Type of Inflammation of the Cornea) Basics OVERVIEW Keratitis is inflammation of the cornea; the cornea is the clear outer layer of the front of the eye The corneal epithelium
More informationHormone. Free Androgen Index. 2-Hydroxyestrone. Reference Range. Hormone. Estrone Ratio. Free Androgen Index
Hormonal Health PATIENT: Sample Report TEST REF: TST-12345 Hormonal Health 0.61 0.30-1.13 ng/ml DHEA-S 91 35-430 mcg/dl tient: SAMPLE TIENT e: x: N: Sex Binding Globulin 80 18-114 nmol/l Testosterone 0.34
More informationLab Guide Endocrine Section Lab Guide
Lab Guide - 2019 Endocrine Section Lab Guide Estradiol Estradiol, Cerner Name: Estradiol Competitive test principle using a polyclonal antibody specifically directed against 17βestradiol in Roche Cobas
More informationVAFO PRAHA s.r.o. Chrášťany 94, Rudná u Prahy Czech Republic Tel.: Fax: brit-petfood.
S M L XL VAFO PRAHA s.r.o. Chrášťany 94, Rudná u Prahy Czech Republic Tel.: +420 257 952 141 Fax: +420 257 952 141 brit@brit-petfood.com brit-petfood.com S L M XL HERBAL & FRUIT EXTRACT ROSEMARY, GRAPE
More informationUrinary Hormone Metabolites Adrenal
Test Name Result Range Urinary Androgens (μg/g Cr) DHEA (Urine) 503.87 H 9.01-93.80 Urinary Glucocorticoids (μg/g Cr) Total Cortisol (Urine) 18.50 8.73-28.52 Total Cortisone (Urine) 35.72 14.12-42.84 Cortisol/Cortisone
More informationProceedings of the World Small Animal Veterinary Association Sydney, Australia 2007
Proceedings of the World Small Animal Veterinary Association Sydney, Australia 2007 Hosted by: Australian Small Animal Veterinary Association (ASAVA) Australian Small Animal Veterinary Association (ASAVA)
More informationCase Questions. Polycystic Ovarian Syndrome: Treatment Goals and Options. Differential Diagnosis of Hyperandrogenic Anovulation
Polycystic Ovarian Syndrome: Treatment Goals and Options Marc Cornier, MD Division of Endocrinology, Metabolism and Diabetes Colorado Center for Health and Wellness University of Colorado School of Medicine
More informationBIOSYNTHESIS OF STEROID HORMONES
BIOSYNTHESIS OF STEROID HORMONES Sri Widia A Jusman Department of Biochemistry & Molecular Biology FMUI sw/steroidrepro/inter/08 1 STEROID HORMONES Progestins (21 C) Glucocorticoids (21 C) Mineralocorticoids
More information3 SAMPL E REPORT S. This Assessment features three reporting options: Rhythm Adrenocortex Stress Profile Comprehensive Melatonin Profile GDX-4-225
3 SAMPL E REPORT S This Assessment features three reporting options: Rhythm Adrenocortex Stress Profile Comprehensive Melatonin Profile GDX-4-225 SAMPLE REPORT Rhythm Patient: SAMPLE PATIENT ID: Page 2
More informationS M L XL. brit-petfood.com facebook.com/britcare
S M L XL VAFO PRAHA s.r.o. Chrášťany 94, Rudná u Prahy Česká republika Tel.: +420 257 952 141 Fax: +420 257 952 141 brit@brit-petfood.com brit-petfood.com facebook.com/britcare PY J S L M XL SIZE MATTERS
More informationOne Day Hormone Check
One Day Hormone Check DOB: Sex: F MRN: Order Number: Completed: Received: Collected: Salivary Hormone Results Estradiol pmol/l >3330.0 Testosterone pmol/l
More informationSEX STERIOD HORMONES I: An Overview. University of PNG School of Medicine & Health Sciences Division of Basic Medical Sciences PBL MBBS III VJ Temple
SEX STERIOD HORMONES I: An Overview University of PNG School of Medicine & Health Sciences Division of Basic Medical Sciences PBL MBBS III VJ Temple 1 What are the Steroid hormones? Hormones synthesized
More informationHyperadrenocorticism or Cushing's Syndrome in Dogs
Customer Name, Street Address, City, State, Zip code Phone number, Alt. phone number, Fax number, e-mail address, web site Hyperadrenocorticism or Cushing's Syndrome in Dogs (Excessive Levels of Steroids
More informationQ & A O M E GA-3 FI SH OILS F OR DOGS AND CAT S
Q & A O M E GA-3 FI SH OILS F OR DOGS AND CAT S About the Author Sally Perea, DVM, MS, DACVN Dr. Sally Perea holds a Bachelor s degree in Animal Science, a Master s degree in Nutrition, and a Doctorate
More informationKerato-Conjunctivitis Sicca or Dry Eye
Kerato-Conjunctivitis Sicca or Dry Eye Keratoconjunctivitis sicca, usually abbreviated to KCS, is a condition of the eye, where insufficient tears are produced. The result is an eye that is dry, hence
More informationBleeding from the Nose (Epistaxis) Basics
Bleeding from the Nose (Epistaxis) Basics OVERVIEW Bleeding from the nose SIGNALMENT/DESCRIPTION OF PET Species Dogs Cats Breed Predilections Mean Age and Range Predominant Sex SIGNS/OBSERVED CHANGES IN
More informationThe Adrenals Are a key factor in all hormonal issues Because the adrenals can convert one hormone to another they play a role like no other in the bod
The Players Part II The Adrenals Are a key factor in all hormonal issues Because the adrenals can convert one hormone to another they play a role like no other in the body Can affect all hormone systems
More informationMy dog is suffering from atopy... what do I do now?
Dietary food for the targeted tackling of canine atopy My dog is suffering from atopy... what do I do now? reliable and affordable dietary food The veterinarian has identified skin problems in your dog.
More informationAtrioventricular Valve Endocardiosis Basics
Atrioventricular Valve Endocardiosis Basics OVERVIEW Atrioventricular valve refers to the heart valves between the top chamber (known as the atrium ) and the bottom chamber (known as the ventricle ) of
More informationCorticosteroids. Veterinary Pharmacology Endocrine System. University of Tehran Faculty of Veterinary Medicine Academic Year
Veterinary Pharmacology Endocrine System Corticosteroids University of Tehran Faculty of Veterinary Medicine Academic Year 2008-9 Goudarz Sadeghi, DVM, PhD, DSc Associate Professor of Pharmacology Introduction
More informationOne Day Hormone Check
One Day Hormone Check Patient: EMILY TEST DOB: January 18, 1948 Sex: F MRN: 0000000004 Order Number: J5070009 Completed: March 07, 2014 Received: March 07, 2014 Collected: March 07, 2014 Alec Smart, ND
More information16 YEAR-OLD OBESE FEMALE WITH OLIGOMENORRHEA
16 YEAR-OLD OBESE FEMALE WITH OLIGOMENORRHEA Katie O Sullivan, MD Adult/Pediatric Endocrinology Fellow University of Chicago ENDORAMA Thursday, September 4th, 2014 Disclosures No financial interests. Will
More informationEndocrine Diseases Of The Dog
Peterson ME, Wheeler SH: Endocrine diseases of the dog. American Kennel Gazette 99:42-49, 1982 Endocrine Diseases Of The Dog Cushing's Syndrome, Hypothyroidism and Diabetes Mellitus are the three most
More informationAdrenal Insufficiency
Adrenal Insufficiency Normal adrenal physiology Clinical features, Laboratory findings Common causes of primary adrenal insufficiency Evaluation of suspected adrenal insufficiency Acute and chronic management
More informationMethylprednisolone iv to po dose
Methylprednisolone iv to po dose The Borg System i Methylprednisolone iv to po dose PRESTON T. PHILLIPS A R C H I T E C T ford residence southampton, ny Methylprednisolone iv to po dose Chemotherapy. Cytarabine
More informationPolycystic Ovary Syndrome HEATHER BURKS, MD OU PHYSICIANS REPRODUCTIVE MEDICINE SEPTEMBER 21, 2018
Polycystic Ovary Syndrome HEATHER BURKS, MD OU PHYSICIANS REPRODUCTIVE MEDICINE SEPTEMBER 21, 2018 Learning Objectives At the conclusion of this lecture, learners should: 1) Know the various diagnostic
More informationDiagnos-Techs, Inc. Clinical & Research Laboratory PO BOX , Tukwila, WA Tel: (425) CLIA License # 50D
Clinical & Research Laboratory PO BOX 389662, Tukwila, WA 98138-0662 Tel: (425) 251-0596 CLIA License # 50D0630141 Test Description Ref Values ASI TAP Adrenal Stress Index Free Cortisol Rhythm 07:00-08:00
More informationReproductive Health and Pituitary Disease
Reproductive Health and Pituitary Disease Janet F. McLaren, MD Assistant Professor Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology jmclaren@uabmc.edu Objectives
More informationStelios Mantis, MD DuPage Medical Group Pediatric Endocrinology
Stelios Mantis, MD DuPage Medical Group Pediatric Endocrinology 4 11 13 Initial Presentation Pt initially presented to pediatrician for school physical in fall 2012. Pt was found to be overweight (BMI:
More informationPulmonic Stenosis. How does the heart work?
Pulmonic Stenosis How does the heart work? The heart is the organ responsible for pumping blood to and from all tissues of the body. The heart is divided into right and left sides. The job of the right
More informationMineralocorticoids: aldosterone Angiotensin II/renin regulation by sympathetic tone; High potassium will stimulate and ACTH Increase in aldosterone
Disease of the Adrenals 1 Zona Glomerulosa Mineralocorticoids: aldosterone Angiotensin II/renin regulation by sympathetic tone; High potassium will stimulate and ACTH Increase in aldosterone leads to salt
More informationOsteochondritis Dissecans (OCD) Defective Cartilage in Young Dogs
Osteochondritis Dissecans (OCD) Defective Cartilage in Young Dogs This morning as I was driving home from my own acupuncture appointment for an orthopedic issue, I realized it s been some time since I
More informationTherapeutic Cohort Results
Patient: SAMPLE PATIENT DOB: Sex: MRN: Menopause Plus - Salivary Profile Therapeutic Cohort Results Hormone Average Result QUINTILE DISTRIBUTION 1st 2nd 3rd 4th 5th Therapeutic Range* Estradiol (E2) 8.7
More informationIDIOPATHIC EPILEPSY (SEIZURE DISORDER OF UNKNOWN CAUSE)
IDIOPATHIC EPILEPSY (SEIZURE DISORDER OF UNKNOWN CAUSE) BASICS OVERVIEW Idiopathic is the medical term for a disease or disorder of unknown cause; epilepsy is a brain disorder, in which the animal has
More informationHypoadrenocorticism or Addison's Disease (Inadequate Production of Hormones by the Adrenal Glands) Basics
Hypoadrenocorticism or Addison's Disease (Inadequate Production of Hormones by the Adrenal Glands) Basics OVERVIEW A hormonal disorder resulting from decreased production of hormones (glucocorticoids and/or
More informationTherapeutic Cohort Results
Patient: JANE DOE DOB: December 31, 1968 Sex: F MRN: Order Number: Completed: February 26, 2016 Received: February 26, 2016 Collected: February 26, 2016 One Day Hormone Check - Salivary Profile Therapeutic
More informationTherapeutic Cohort Results
Patient: PAGE LOVE DOB: January 11, 1983 Sex: F MRN: 1232704193 Order Number: J9020008 Completed: July 08, 2016 Received: July 02, 2016 Collected: July 01, 2016 Aum Healing Center Sarika Arora MD 332 Newbury
More informationComprehensivePLUS Hormone Profile with hgh
OLEBound400: 801 SW 16th St Suite 126 Renton WA 98057 425.271.8689 425.271.8674 (Fax) ComprehensivePLUS Hormone Profile with hgh Doctor ID Patient Name 6206 Doe, Jane Age Sex Date of Birth 44 F Date Collected
More informationTEST REPORT # SB. Patient Name: Comprehensive Male Profile I Patient Phone Number: TEST NAME RESULTS 08/12/18 RANGE
TEST REPORT Ordering Provider: David Getuwell, MD 8605 SW Creekside Place Beaverton, OR 97008 Phone: 503-466-2445 Fax: 503-466-1636 Samples Received 08/15/2018 Report Date 08/20/2018 Samples Collected
More informationChecking the Right Box at the Right Age: the Art of Pediatric Endocrine Testing
Checking the Right Box at the Right Age: the Art of Pediatric Endocrine Testing Jean-Pierre Chanoine, MD Endocrinology and Diabetes Unit British Columbia s Children s Hospital Objectives 1. Interpret the
More informationHYPOTHYROID DOGS Is Your Dog Overweight and Lazy with Thinning Hair? Your Dog May Need a Thyroid Screening.
HYPOTHYROID DOGS Is Your Dog Overweight and Lazy with Thinning Hair? Your Dog May Need a Thyroid Screening. The thyroid glands located in the neck produce hormones that affect the function of many parts
More informationCase. 24 year old female presented to your office complaining of excess hair growth on her face and abdomen. Questions?
Hirsutism Case 24 year old female presented to your office complaining of excess hair growth on her face and abdomen Questions? Started around puberty with gradual progression Irregular menstrual cycle
More informationTHE VALUE OF 24 HOUR PROFILES IN CONGENITAL ADRENAL HYPERPLASIA
THE VALUE OF 24 HOUR PROFILES IN CONGENITAL ADRENAL HYPERPLASIA This leaflet is a joint production between Professor Peter Hindmarsh and Kathy Geertsma The series editor is Professor Peter Hindmarsh Professor
More informationSTUDY ON CLINICAL AND THERAPEUTICAL APPROACHING PETS WITH DIABETES AND OBESITY
THE PUBLISHING HOUSE OF THE ROMANIAN ACADEMY MEDICINE Research article STUDY ON CLINICAL AND THERAPEUTICAL APPROACHING PETS WITH DIABETES AND OBESITY Cristina FERNOAGĂ, Mihai CORNILĂ, and Mario CODREANU
More informationSerum cortisol concentrations in dogs with pituitary-dependent hyperadrenocorticism and atypical hyperadrenocorticism
University of Tennessee, Knoxville From the SelectedWorks of Linda Frank MS, DVM, DACVD January, 2015 Serum cortisol concentrations in dogs with pituitary-dependent hyperadrenocorticism and atypical hyperadrenocorticism
More informationImmune-Mediated Anemia
Immune-Mediated Anemia (Destruction of Red Blood Cells Caused by an Immune Response) Basics OVERVIEW Accelerated destruction or removal of red blood cells related to an immune response, in which the body
More informationThe Case of the Limping Poodle
The Case of the Limping Poodle David C. Twedt DVM, Diplomate ACVIM Case Summary Signalment: Beau 6 yr N/M standard poodle History: Mild intermittent right front leg lameness No current medications Plan:
More informationFINALLY! A CURE FOR CATARACTS! or not...
FINALLY! A CURE FOR CATARACTS! or not.... Kerry Ketring, DVM Diplomate, ACVO All Animal Eye Clinic Cincinnati, Ohio www.allanimaleyeclinic.com A New Product? Homeopathic drops have been available over
More informationCanine Chronic Idiopathic Hepatitis
Canine Chronic Idiopathic Hepatitis David C. Twedt DVM, DACVIM Problem Acute Rt rear leg lameness History Probably stepped on by owner s horse Healthy otherwise No medications Physical exam Possible partial
More informationTHE ADRENAL (SUPRARENAL) GLANDS
THE ADRENAL (SUPRARENAL) GLANDS They are two glands, present above the kidneys. One adrenal gland is sufficient for human beings/mammals (example: we also have two kidneys but one is sufficient). The Adrenal
More informationFrequency of Endocrinopathies and Characteristics of Affected Dogs and Cats in Southern Brazil ( )
Acta Scientiae Veterinariae, 2016. 44: 1379. RESEARCH ARTICLE Pub. 1379 ISSN 1679-9216 Frequency of Endocrinopathies and Characteristics of Affected Dogs and Cats in Southern Brazil (2004-2014) Álan Gomes
More informationDiurnal Group plc. Analyst Day 11 December Date of Preparation: December 2018 Code: CORP-GB-0023
Diurnal Group plc Analyst Day 11 December 2018 Date of Preparation: December 2018 Code: CORP-GB-0023 1 Analyst Day: Challenges and Current Treatment Options for Congenital Adrenal Hyperplasia Prof John
More informationToxoplasma gondii IgM (Toxo IgM)
DIAGNOSTIC AUTOMATION, INC. 21250 Califa Street, Suite 102 and116, Woodland Hills, CA 91367 Tel: (818) 591-3030 Fax: (818) 591-8383 onestep@rapidtest.com technicalsupport@rapidtest.com www.rapidtest.com
More informationDisclosures. The Endocrine System. Objectives. Diabetes. The Endocrine System 4/5/17. Common Medications in Pediatric Endocrinology
Disclosures Common Medications in Pediatric Endocrinology I have nothing to disclose Carrie A. Tolman, CPNP Nationwide Children s Hospital Objectives The Endocrine System Review common endocrine disorders
More informationAssessment of the incidence of GDV following splenectomy in dogs
ttp://www.bsava.com/ PAPER Assessment of the incidence of GDV following splenectomy in dogs OBJECTIVE: To establish if splenectomy increases the incidence of gastric dilatation and volvulus (GDV) in dogs.
More informationPrednisone tapering schedule 60 mg
Buscar... Prednisone tapering schedule 60 mg I ve taken 60 mg. of prednisone for 5 days, no taper, as instructed by ER for breathing problems caused by interstitial pneumonitus. Absolutely no problems.
More informationTestosterone ELISA. Catalog No (96 Tests) For Research Use Only. Not for use in Diagnostic Procedures.
For Research Use Only. Not for use in Diagnostic Procedures. INTENDED USE The GenWay, Inc. Testosterone ELISA is for the quantitative determination of Testosterone concentration in human serum or plasma
More informationBalancing Hormone Function in Women By Meghna Thacker, NMD
Balancing Hormone Function in Women By Meghna Thacker, NMD Hormone function is central to health and well being in both men as well as women. A problem encountered with any one endocrine gland can lead
More informationThe most common clinical signs in dogs with
J Vet Intern Med 2007;21:1027 1033 Survival, Neurologic Response, and Prognostic Factors in Dogs with Pituitary Masses Treated with Radiation Therapy and Untreated Dogs Michael S. Kent, David Bommarito,
More informationThe most current assessment of this problem can be found in the Apex note dated
Him andpcos Smartphrase:.REFENDOPCOS NOTE: patients with suspected PCOS are welcomed to endocrine clinic. There is also a PCOS clinic is available in the Ob/Gyn Department. I am referring @name@, a @age@
More informationTreatment of hirsutism with a gonadotropin-releasing hormone agonist and estrogen replacement therapy*
Gynecology-endocrinology FERTILITY AND STERILITY Copyright 1994 The American Fertility Society Printed on acid-free paper in U S. A. Treatment of hirsutism with a gonadotropin-releasing hormone agonist
More information