26 YEAR-OLD FEMALE WITH HEADACHES AND OLIGOMENORRHEA
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1 26 YEAR-OLD FEMALE WITH HEADACHES AND OLIGOMENORRHEA Katie O Sullivan, M.D. Adult/Pediatric Endocrinology Fellow University of Chicago Combined Pituitary Conference Thursday, September 11 th, 2014
2 History of Present Illness 26 yo female with no significant PMH Presented to medical care at OSH in 2004 with: Headaches x 4 years Whole head vs L-sided shooting pain q 3-4 months Not relieved with Ibuprofen Oligomenorrhea Fatigue No galactorrhea, no vision changes.
3 Diagnosis: Prolactinemia Prolactin levels elevated in 100 s MRI Brain 4/2004: 6.5 x 7.4 x 6.6 mm L-sided pituitary lesion. Treatment: Bromocriptine from : Did not tolerate Bromocriptine 2/2 HA, fatigue, nausea. Treatment change: Cabergoline 1 mg twice/week. 2007: Side effects on Cabergoline: headache and fatigue Cabergoline decreased to 0.5 mg twice/week.
4 Patient Treatment Course prior to UCMC: Treatment: Cabergoline (or Dostinex) 0.5 mg twice/week - 75% compliant. Regular menses on Cabergoline, not interested in fertility No vision changes Side effects: nausea, fatigue, dizziness/lh 2013: started intravaginal administration of Cabergoline Normal Range Prolactin ng/ml 6/2005 9/ /2009 9/2010 8/
5 Brain MRI Course: Brain MRI 4/2005: 6.5 x 7.4 x 6.6 mm lesion in L pit gland not significantly changed from Brain MRI 12/2005: 6 x 5 x 4.8 mm pituitary microadenoma Brain MRI 3/2009: 4.9 mm low-contrast nodule in L pit gland. No mass effect on optic chiasm or intracavernous extension. Brain MRI 12/2010: slight increase in size but less than 10 mm Brain MRI 9/2013: 6 x 7 x 7 mm pituitary microadenoma. Pituitary stalk is midline. No impingement on optic chiasm.
6 Establishes care at UCMC 3/2014: Neurology clinic for c/o chronic headache HA q 3-10 days, 10/10 intensity, esp early in AM or late at night. Does not wake her up from sleep. Triggers: stress, lights, noise Assc (+) Sxms: +LH, +dizziness, +blurry vision, +nausea. Assessment: HA likely secondary to pituitary adenoma Plan: Gabapentin 100 mg qhs, Riboflavin -> Provided great relief in headaches 6/2014: Endocrinology evaluation
7 Review of Systems General: +fatigue, +10 lb wt gain in prev 6 mos, +decreased appetite. No fever, night sweats. Neuro: +LH,+ chronic HA, +decreased concentration. Denies seizures, facial asymmetry, speech difficulty, weakness, numbness, confusion HEENT: +blurry vision. No conjunctival injection with HA or tearing. No hearing loss, hoarseness, dysphagia. CV: No chest pain, palpitations. Resp: No SOB, cough, wheezing. GI: +nausea. No vomiting, abdominal pain, constipation, diarrhea. GU: No UTI s, urinary frequency, urgency. +regular menses. Heme/Onc: No swollen glands. Skin: No easy bruising/bleeding, no dry skin, hair loss, rash. MSK: No joint swelling/pain, edema, muscle pain. +history of stress fractures at 21 yo when playing basketball. Psych: +depression sxms, +anxiety, +insomnia, +increased impulsivity.
8 Rest of History PMHx: Prolactin-secreting microadenoma Chronic headaches PSgHx: Appendectomy Medications: Cabergoline 0.5 mg 2x/wk Gabapentin 100 mg qhs Riboflavin Allergies: Penicillin Family Hx: Mother s/p thyroidectomy x 2 for goiter HTN (mother) Liver Disease (mother) 2 brothers, 1 sister healthy Social Hx: No tobacco or drug use. 2 EtOH drinks/month Single, lives alone Received training in community counseling but not currently practicing.
9 Physical Exam Vitals: BP 120/69, P 66, Wt 145 lb, Ht 5 6, BMI 23.4 General: Well-developed, no distress. HEET: Visual fields normal (per ophtho). PERRL, no scleral icterus. Oropharynx clear, mmm. Neck: No thyromegaly or thyroid nodules. Supple. Chest: Tanner V, +slight clear discharge with pressure on L breast. No discharge on R. CV: RRR, no murmur. Resp: Effort normal, breath sounds normal. Abdomen: No distension, soft, non-tender. Skin: Warm and dry. Neuro: Normal (per neurology). Psych: Behavior is normal.
10 General Labs CBC: Hgb 10.9 MCV 73 WBC 7.1 Plt Urine Pregnancy Test: negative
11 Pituitary Evaluation 9/2009 (OSH): Cortisol 12.4 ug/dl (11:13 AM) TFT s normal 8/2013 (OSH): Cortisol 12.8 ug/dl ACTH 21 BMP normal TFT s normal Normal Range Prolactin ng/ml 8/2013 6/ /2014 (UCMC): TSH 1.31 (0.3-4 mcu/ml) Free T ( ng/dl)
12 MRI Pituitary 7/2014: Coronal View
13 MRI Pituitary 7/2014: Sagittal View
14 7/2014 NSGY Evaluation Non-compliance with Cabergoline 2/2 to the following possible side effects: Nausea Impulsivity Difficulty concentrating Fatigue -> cannot take before an exam Depression started with cabergoline Assessment: Relative surgical indication if her Cabergoline really interferes massively with her quality of life and activities of daily living.
15 Transphenoidal Hypophysectomy 8/2014 Surgical procedure combined ENT/NSGY Used Medtronic VT fusion navigation system CSF leakage during procedure Blue-ish tumor easily identified, soft, separated, easily removed with curette. Pathology: Insufficient tissue for diagnosis
16 Post-Surgical Course POD #1: Dex 4 mg IV q6h, Vancomycin x 24h, Foley for strict is/o s. POD #3: Salty taste at back of throat, +serosanguinous drainage on mustache dressing. Plan: Clinda x 7 day. POD #4: Tm F LP performed: WBC 99 (65% PMN), RBC 562, Glucose 51, protein 51 Urine cx (+) Pseudomonas. Abx Aztreonam/Vanco/Flagyl. POD #5: Neck stiff, +photophobia. Blood Cx (+) E.coli CSF (-) cx.
17 Post-Surgical Course POD #6: WBC improved, neg bld cx, PICC placed POD #7-9: HA and nasal drainage improving. ID recc 3-wk course Cefepime through 9/23. POD #12: Patient threatens to leave AMA. POD #13: Patient leaves AMA. Presented to South Suburban Hospital for help with PICC line.
18 Post-Op Pituitary Assessment: Post-Op Day #0: Post-Op Day #9 (and 2 days s/p Dex) Prolactin ng/ml ACTH 1078 pg/ml GH 1.5 ng/ml LH 5.5 miu/ml FSH 7 miu/ml Estradiol 20 pg/ml TSH 2.68 Prolactin ng/ml ACTH 17.6 pg/ml Cortisol 23.5 mcg/dl TSH 0.92 mcu/ml Free T4 1.4 ng/dl T3 64 (normal ) No polyuria, no dilute UOP, sodium stable.
19 Thank You
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