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1 Impact factor: /ICV: Pharma Science Monitor 6(1), Jan-Mar 2015 PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES Journal home page: A CLINICAL STUDY ON THE EFFECT OF MADHWASHWAYOGA (KALPIT YOGA) ON BALASHOSHA W. R. F. MALNUTRITION Rai Dinesh K.* 1, Sharma Ramveer 2, Sharma Rajendra K. 3, Sharma Shiva K. 4 1 Associate Professor & H.O.D. Kaumarbhritya Deptt. Madan Mohan Malviya Government Ayurveda College Udaipur Rajasthan. 2 Associate Professor & H.O.D. Prasuti & Stree roga Deptt. Madan Mohan Malviya Government Ayurveda College Udaipur Rajasthan. 3 Lecturer, Anatomy Deptt. Madan Mohan Malviya Government Ayurveda College Udaipur Rajasthan. 4 Lecturer, Agad tantra Deptt. Madan Mohan Malviya Government Ayurveda College Udaipur Rajasthan. ABSTRACT The clinical study of this research is conducted in 12 patients. Madhwashwa yoga (Hypothetical) is a combination of three drugs Ashwagandha, Sunthi and Yastimadhu. According to Aetiopathogenesis and symptomatology, the Balashosha is a disorder of malnutrition. Growth and development is the main mile stone of childhood. The medicine was given to growing children, selected from OPD of Ayurveda College Udaipur (raj). After completion of the course it is find out that. The Madhwashwa yoga accelerates the growth, development and immunity of growing child. The results of this yoga in development and nutrition in children are very significant. KEYWORDS: childhood, growth, development, immunity, well nutrition, Balashosha, Madhwashwa yoga. INTRODUCTION As we know the child is future of a nation. The stage of growth and development is called childhood. Proper nutrition is the main effective cause of growth and development of a child. The childhood stage is more prompt to growth and development than the other stage of age. In developing countries, the proper nutrition is a great problem because of poorness, Illiteracy, and lack of awareness of the society. The malnutrition develops because the poor parents could not provide proper and balanced nutritional diet to their child. The essential ingredient of the diet i.e. Carbohydrate, Proteins, Fats, Vitamins, and Minerals must be component of a child diet. The presence of proper ratio of these substances in the body is called well nutrition. According to nutritional science, the milk is a complete diet for the feeding child, but after one year of age, only milk couldn t provide the essential elements for the growth of a child. The composition of milk varies according to mother s age and quality of diet. According to Ayurveda, three chief cause of the disease are-

2 Impact factor: /ICV: Asatmendriyarth samyoga, Pragyaparadha and Parinam (1). in other words, main cause of diseases are Aahar (Ingestion),Vihar (Behavior) and Kala (Environment or Time). The Aahar (Proper Improper diet) is may be a cause of growth and development of body or disease. So the growth / development and health of a child is totally depends on the diet. Ashtaksheeradoshs described in Ayurveda are (2) Vaivarna (Discoloured), Vairashya (Differ taste), Vaigandha (Odour deformed), Paichilya (Excessive viscid), Fenasanghat (Frouthy), Ruksha (Lack of fat), Gaurava (heavy for digestion), and Atisneha (Unctuous). According to Doshavaishamya, the kseer dosha again divided in four groups Vataj ksheeradosh, Pittaj ksheeradosh, Kaphaj ksheeradosh andtrtidoshaj ksheeradosh.the chief character of Balshosha disease is Shosha (Loss of muscle mass) and according to Samprapti (Pathogenesis) this originated by Kaphaj ksheeradoshaj. Causes:- According to Vagabhata- the causes of Balashosha are - Day sleeping, High quantity of drinking, and feeding of shleshmic dusht ksheer. and arise the symptoms of Balashosha. The symptom of is disease are Arochak (Anorexia ), Pratishyay (Rhinitis), Jwara (Mild pyrexia), Kasa (Cough), Sushyata (loss of muscle mass), Pale colouration on mouth and conjunctiva (Anaemia). (3) The purpose of selection the topic for research is raised ratio of Bala shosha (Malnutrition disorder) in Bala roga clinic of MMM govt. Ayueveda College Udaipur. It is a fact, that a lot of clinical and conceptual work has been done on this topic, but relatively simple / easy / low coast formulated preparation is the need of the day. The duration of consumption, Palatable dose form ensures the compliances of the patients. MATERIAL AND METHODS A hypothetical combination of three Dravyas (Herbal drugs) are selected in powder form named as Madhvashva yoga for correction of dosh gati and roga marga i. e. to break down pathogenesis. In Balshosh due to above discuss various types of causes, the diminished Agni generate the Aama. This Aama mixed with Rasa dhatu and vitiate the Rasa called as Aam Rasa. This Aam rasa circulate through various Srotasa in all over the body and creates a stage of Srotas vaigunya by which it decrease the function of Rasa vaha srotasa. Due to decreased circulation of rasa or Aam rasa the conversion of rasa in other Dhatu is diminished and the Shosha of the body is developed.

3 Impact factor: /ICV: The Madhvashva Yoga hypothetical combination is formed by three drugs i.e. Ashvagandha,Yastimadhu and Shunthi and is selected due to its properties and action for Samprapti vighatana (Breacking of Pathogenesis). The combination has the properity of (1) Deepan (2) Amapachan (3) Kaphavishodhan (4) Srotomukhavishodhan (5) Balya (6) Brihan. Method of Madhvashva Yoga preparation - The drug was prepared by three drugs as a combination of (i) Ashwa gandha 1 part, (ii) Shunthi one half part (iii) Yasthimadhu one part and formed in granulation form. (4) Sr.No. Name of drug Latin Name Useful part Quantity 1 Ashwagandha Withania somnifra (linn) Dunal Roots 1 kg 2 Sunthi Zingiber officinale Rose Rhizome 500 gms. 3 Yastimadhu Glycyrrhiza glabra Roots 335 gms. For the present study the patients were selected and screened from the O.P.D. of M.M.M. Govt. Ayurveda college Hospital Udaipur..For research following criteria for selection of the patient and methods of assessment has been adopted - (1) Selection of the patients (2) Laboratory investigations (3) Grouping of the selected patients (4) Drugs, Dose, Anupan & duration (5) Observation of the patients (6) Assessment criteria Inclusive criteria:- The patients were selected irrespective of their sex,religion, economic status and educational status of their parents. (1) Sex Male /female (b) Age In this study 5 to 10 years children are included. (c) The patients are selected in the urban area because hospital is established in Udaipur city. Exclusive criteria:- Patients who are suffering from following symptoms they are selected in this clinical study other are excluded. (i) Arochak (Anorexia), (ii) Pratishyaya (Rhinitis), (iii) Jwara (Pyrexia), (iv) Kasa (Cough), (v) Shosha (Loss of muscle mass), (vi) Snigdh & Shukla mukh (Pale mouth). (vii) Snigdh &Shukla Ekshan (Pale conjunctiva). Initially and at the end of the study the number of cases were as follow -

4 Impact factor: /ICV: Table No ---1 Final numbers of the cases Sr. No Initial selected cases Finally trilled cases Percentage % Observations:- Parameter and Gradation Score - For the assessment of total effect of therapy following categories were taken into consideration --- Sr. No. Relief Percentage Gradation 1. Complete Relief 100% Marked Relief 75 99% Moderate Relief 50 74% Mild Relief % + 5. No Relief <25% - The percentage of relief was calculated as per scores with average scores of the symptomatology and local finding. Drug Administration:- The drug Madhwashwa Yoga granules was administered in dose of 1-2 gram b. d. With milk for three months, the children and guardian were instructed to follow Aachar Rasayan (Make a pleasant and lovely environment) and vegetarian diet. All other medicines are stopped. Laboratory Investigations:- In this study the cases were selected and evaluated by following investigations - (i) Complete Haemogram - Blood counting (C.B.C.), Hemoglobin percentage (Hb%) (iii) Erythrocyte Sedimentation Rate (E. S. R.) (iv) X- rays chest (v) Sonography of abdomen for diagnosis of Hepatomegaly (vi) B. M. I.(Body Mass Index) Table - 2. Age wise classification of the cases Sr. No. Age group No. of the cases Percentage yrs % yrs % yrs % Table - 3. Diet wise classification of cases Sr. No. Diet type No. of cases Percentage 1. Vegetarian % 2. Non vegetarian %

5 Impact factor: /ICV: Table - 4. Prikriti wise (Constitutional) classification Sr.No. Prakriti No. of the cases Percentages 1. Kaphaj Pittaj % 2. Vata Kaphaj % 3 Vata Pittaj % Table 5 Effect of Therapy n =12 Sr. No. Clinical features Mean % tage S.D. +- S.E. +- T. Value P. Value B.T. A.T. 1. Anorexia < Rhinitis < Mild pyrexia < 0,05 4. Cough < Wasting of <0.001 muscle mass 6. Paleness of oral mucosa < 0,02 7. Paleness of < 0.05 conjunctiva 8. Laziness < Digestion < Fatigue < Memory < Adjustment with < Climate 13. Concentration < 0.02 loss 14. Palpitation < Breath holding < time 16. Chest expansion < B.M.I < Height ,26 < Body weight < H.B.% <0.001 Table Results after completion of therapy Sr. No. Results No. of the cases Percentages 1. Complete relief Marked Relief Moderate Relief % 4. Mild Relief % 5. No Response Total

6 Impact factor: /ICV: OBSERVATIONS AND RESULTS In this clinical study of cases shown marked response and 16.67% of cases showed mild response. There was maximum cases shown improvement in Hemoglobin percentage. In the Hb % it was shown significant (P<0.001) results in Iron deficiency. In this study moderate relief (50-74%) was observed in 50% of cases. Marked relief (75-99%) was observed in 33.33%, and mild relief (25-49%) was observed in % of cases. DISCUSSION AND CONCLUSION The clinical study suggest that the internal use of Madhwashwa yoga improve the power of digestion and reduce the symptoms of malnourishment like Laziness, Weakness, Lack of concentration and increases the Body weight, Height, Memory, Hemoglobin Percentage, Body mass index and Immunity.The clinical symptom of Bal shosh Anorexia, Rhinitis Mild Pyrexia, Cough, loss of Muscles mass and Paleness of oral mucosa and conjunctiva (Anaemia) were removed after the therapy. The Anupan Milk also has a nutritional value so called Jiwaniya (Improving the life slandered). It improves the potency of drugs as well as growth and development of child. The specification of the drug, it can say that the drug balances the vitiated doshas, and break down the Aetiopathology of Balashosha and results in good Health of a child. The properties of the yoga mainly corrective with parameter of Laboratory investigations are correlating with the drug gradation shows scientific study which also shows new path for researchers. At last observations and results are significant with optimistic achievement. The sample of the study (12 cases) was too small, it may be advocated that the subject is open for further study in large numbers of cases for future researchers. REFERENCES 1. Charak / Sutra Pt.Kashi Nath Shastri & Gorakh Nath Shastri. 2. Charak / Sutra Pt.Kashi Nath Shastri & Gorakh Nath Shastri, Chaukhamba Chaukhamba samskrita Samsthan Varanasi IVth edition, Smavat 2033.samskrita Samsthan Varanasi, IVth edition, Smavat Atyah: Swapna Sheetambu shleshmik stanya sevinah I, Shishoh Kaphena ruddheshu srotahsu rasavahishu II, Arochakah Pratishyayo jwarah kasashcha jayate I, Kumarh Shushyati tatah snigdha shuklamukhekshanah II Ashtanga Samgriha / Utt. 2/ Dr. Brhma Nand Tripathi, Chaukhamba samskrita Samsthan, Varanasi, Edition Dravyaguna Vignyan Vol. IInd, Edition 2009, Prof. P.V. Sharma, Chaukhamba Bharati Academy Varanasi (India). For Correspondence Dr. Rai Dinesh K. raidinesh3007@gmail.com