Mayo Clinic Pancreatic and Hepato-Biliary Cancer Symposium 2018

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Mayo Clinic Pancreatic and Hepato-Biliary Cancer Symposium 2018 October 26-27, 2018 Program Schedule Friday, October 26, 2018 7:30 a.m. Registration & Continental Breakfast 8:00 Welcome Announcements GLOBAL BURDEN OF HEPATO-BILIARY CA, IMAGING AND DIAGNOSTIC CHALLENGES Moderator: Marcela A. Salomao, M.D. 8:15 Gallbladder Cancer in Chile: Perspectives from a High Incidence Region Jorge Gallardo, M.D. 8:35 HCC in Sub-Saharan Africa: Challenges in Diagnosis and Management TBD 9:00 Diagnosis and Assessment of Treatment of Response in Hepato-Biliary Cancers Alvin C. Silva, M.D. 9:20 Pathological Challenges in Hepato-Biliary Cancers Marcela A. Salomao, M.D. 9:40 Rare Cancers of the Hepato-Biliary System Michael S. Torbenson, M.D. 10:00 Panel and Q&A 10:20 Break THERAPEUTIC INNOVATIONS IN THE MANAGEMENT OF HEPATO-BILIARY CANCERS Moderator: Amit Mathur, M.D. 10:45 Transplant Beyond Milan Criteria in HCC Linda L. Wong, M.D. 11:05 Surgical Management of HCC Adyr A. Moss, M.D.

Friday, October 26, 2018 (continued) 11:25 Protons vs. Photons for HCC Chris L. Hallemeier, M.D. 11:45 Sequencing of Anti-angiogenics in HCC Mitesh J. Borad, M.D. 12:05 p.m. Precision Medicine in the Management of Biliary Cancers Daniel H. Ahn, D.O. 12:25 Panel and Q&A 12:45 Lunch CONTROVERSIES AND CONUNDRUMS IN HEPATO-BILIARY CANCER MANAGEMENT Moderator: TBD 1:30 The Case for Radio-Embolization in Management of HCC TBD 1:45 Radio-Embolization is Not Indicated in Management of HCC Steven R. Alberts, M.D. 2:00 There is a Role for Adjuvant Therapy in Biliary Cancers FOR Rachna T. Shroff, M.D, M.S. 2:15 There is Not a Role for Adjuvant Therapy in Biliary Cancers AGAINST Kabir Mody, M.D. 2:30 Panel and Q&A 2:45 Break

Friday, October 26, 2018 (continued) Pancreatic Sessions Select One (Concurrent Breakouts in separate rooms) BREAKOUT A: PANCREATIC CANCER: ACCELERATING PROGRESS FROM BENCH TO BEDSIDE MEETING ROOM: GREENWAY Moderator: Martin E. Fernandez-Zapico, M.D. 3:00 Microbiome: Not Just Gut Bacteria, but Affects Treatment Response Christian Jobin, Ph.D. 3:30 Exploiting the Immune System to Target Pancreatic Cancer Daniel D. Billadeau, Ph.D. 4:00 Stroma and Stem Cells: Are they Relevant? Michael T. Barrett, Ph.D. 4:30 Panel and Q&A 4:45 Break Moderator: TBD BREAKOUT B: HEPATO-BILARY CANCER: ACCERLERATING PROGESS FROM BENCH TO BEDSIDE MEETING ROOM: HERBERGER 4/5 A/B 3:00 Cellular Origins of Hepato-Biliary Cancers Hao Zhu, M.D. 3:20 Genomic Profiling of Hepato-Biliary Cancers Lewis R. Roberts, M.B., Ch.B., Ph.D. 3:40 Animal Models in HCC Research Dan G. Duda, Ph.D., DMD 4:00 Animal Models in Cholangiocarcinoma Research Supriya K. Saha M.D., Ph.D. 4:30 Panel and Q&A 4:45 Break

Friday, October 26, 2018 (continued) 5:00 Keynote Speaker: Introduction Daniel D. Von Hoff M.D., F.A.C.P. 5:15 Pancreatic Cancer Biology and Medicine David A. Tuveson M.D., Ph.D. 6:00 Adjourn 6:00 Welcome Reception

Saturday, October 27, 2018 7:45 a.m. Breakfast 8:15 Welcome Announcements MANAGEMENT OF THE EARLY STAGE PATIENT Moderator: Adyr A. Moss, M.D. 8:30 Case History Kumar Sandrasegaran, M.D. 8:45 Interventional and Diagnostic Endoscopy Douglas O. Faigel, M.D. 9:05 When Should the Surgeon Operate? Eric Nakakura, M.D., Ph.D. 9:35 Adjuvant Therapy after Resection Margaret A. Tempero, M.D. 10:05 Q&A 10:20 Break MANAGEMENT OF THE NON-METASTATIC ADVANCED PATIENT Moderator: Jonathan B. Ashman, M.D., Ph.D. 10:40 Chemotherapy: Which Regimen and How Long? Jordan D. Berlin, M.D. 11:10 Why Delay Surgery if Clearly Resectable? Mark J. Truty, M.D., M.S. 11:40 View Point: Radiation Therapy Facilitates Margin Negative Surgery Theodore S. Hong, M.D. 12:10 p.m. Q&A 12:30 Lunch MANAGEMENT OF THE PATIENT WITH ADVANCED DISEASE Moderator: Robert R. McWilliams, M.D. 1:30 Case History Robert McWilliams ( may change later) 1:45 Chemotherapy Regimens: Is More and Longer Better? Zev Wainberg, M.D.

Saturday, October 27, 2018 (continued) 2:15 Use of Molecular Profiling to Guide Therapy Diane M. Simeone, M.D. 2:45 Q&A 3:00 Break PNET AND NEW APPROACHES Moderator: Daniel H. Ahn, D.O. 3:30 How Do I Manage Pancreatic Neuroendocrine Cancers Thorvardur R. Halfdanarson, M.D. 4:00 New Agents and Combinations in Late Stage Trials Colin D. Weekes, M.D., Ph.D. 4:30 Conclusion and Adjourn Ramesh K. Ramanathan, M.D. and Daniel D. Von Hoff M.D., F.A.C.P.