Hompes Method Prac00oner Training Level II Lesson Sixty Four GI Neurotransmitters + Case Study

Hompes Method Prac00oner Training Level II Lesson Sixty Four GI Neurotransmitters + Case Study Health for the People Ltd not for reuse without expressed permission Hompes Method is a trading name of Health For The People L< Registered in England & Wales Company # 6955670 VAT # 997294742

Gut-brain axis - intro The gut-brain axis is completely fascina8ng It s an interac8on between the CNS and ENS Of course, the ANS is inherently involved We know there is a bidirec8onal rela8onship It s said that approximately 80% of traffic travels from gut to brain

Gut-brain axis - intro The implica8ons are overwhelming Percep8ons, beliefs, thoughts, feelings DRASTICALLY affect the GI tract and thus The GI tract strongly affects the brain and mind Of course, research is young, the gut-brain axis has not been fully explained, and we re going to see fascina8ng stuff come out over the next decade

Gut brain axis - diagrams

Gut brain axis - diagrams Am J Physiol Gastrointest Liver Physiol 280: G173 G177, 2001.

Gut brain axis - diagrams

There are books on this topic

Psychoneuroimmunology Should really be called Psycho-neuro-immuno-gastro-endocrine-ology

GI neurotransmi\er produc8on Serotonin is produced in the enterocromaffin cells About 90-99% of the body s en8re serotonin pool About half of the body s dopamine is produced in the mesenteric organs Mesentery refers loosely to intes8ne GABA is produced in small/large intes8nal mucosa Acetylcholine can be synthesised in the intes8ne Adrenaline and noradrenaline can certainly produced in the GI tract

Burning ques8ons The ques8ons are: Do these NTs act mainly in the GI tract? Do they influence the CNS; if so, how much? Do they influence the ANS; if so, how much? Do they cross the blood brain barrier? Some say yes, some say no it needs further research It s not the 8me or place to answer these ques8ons in full, however

Mood modulates microbes

Don t forget non-microbial effects

Stress and the microbiome

Stress and the microbiome Stress reac8vity tends to be reduced when probio8cs are given Lower anger scores Reduc8on in urinary free cor8sol MRI s show changes in midbrain connec8vity

The gut talks back Routes of communicapon between the gut microbes and the brain include the vagus nerve, cytokines, short chain fa<y acids, and tryptophan. AcPng through some or all of these routes, psychobiopcs induce an anp-inflammatory response and alter behavioral responses to stress. h\ps://www.nature.com/ ar8cles/npp2016103

Microbes produce neurotransmi\ers There is evidence that the microbiota produce neurotransmi\ers: Lactobacilli acetylcholine & GABA Bifidobacteria acetylcholine & GABA Escherichia noradrenaline & serotonin Streptococcus noradrenaline, serotonin Enteroccocus serotonin Bacillus sp. dopamine & noradrenaline Histamine Not sure which bacterial types at this 8me

Microbes produce other chemicals SCFAs CLA (conjugated linoleic acid) BDNF Acetaldehyde (fungi) TMAO Cresol Ammonia LPS All the organic acids you see in an OAT (arabinose, etc.) Perhaps other unknown toxins h\ps://www.ncbi.nlm.nih.gov/pmc/ ar8cles/pmc4337795/figure/f3/

Case study 5-year old male: Started having neurological 8cs around 3-years Tics are more pronounced he s excited Lots of opinions from some of the world s leading neurology clinics If all you have is a hammer, everything looks like a nail Diagnosis: Toure\e s syndrome Prognosis: life8me of medica8ons Most frustra8ng finding for me? Nobody had bothered running any decent tests

Case study Addi8onal inves8ga8on: Diarrhoea each morning Certain food aversions Parents used online forums to realise that food can be important gluten, corn seemed to affect him Mum had autoimmune thyroidi8s Ate fish throughout pregnancy In her words, Ate tuna almost every day

Case study

Case Study So what evidence do we have on possible reasons for this Toure\e s syndrome? High HVA to VMA ra8o C. diff infec8on Inhibits HVA to VMA conversion (DBH enzyme) Clear GI inflamma8on (elevated lactoferrin) B6, B12, glutathione, Mg, Fe deficiencies Both the OAT and blood test confirmed B6 and glutathione Copper toxicity (high Cu/Zn ra8o) Heavy metals

Case Study Nutri8onal support protocol: B6 liquid 50mg Neurotransmi\er support Magnesium glycinate powder Relaxa8on of nervous system; glycine as inhibitory NT Sublingual glutathione An8oxidant, support liver and raise detoxifica8no Also supports neurotransmi\ers indirectly Vitamin C powder An8oxidant and to lower copper Zinc liquid To lower copper

Case Study GI Protocol (very hard to implement) Chewable colostrum for IgA support High dose probio8cs Primal Defense Garden of Life To crowd out C. diff S. boulardii Assists with C. diff (supported by the literature)

GI neurotransmi\ers - summary The GI tract/ent manufactures its own NTs The microbiota also manufacture NTs It s not known whether GI-derived NTs cross the BBB Mind and brain affect the composi8on and virulence of the microbiota via catecholamines GI microbiota affect brain and mind, and virtually all other 8ssues/organs Not only NTs, but also LPS, cresol, etc. Psycho-neuro-

Thanks Next up, we ll look at the associa8on between the GI tract, microbiome and neurotransmi\er produc8on, as well as a great case study.

h\p://www.wormbook.org/chapters/www_neuronalgenome/ neuronalgenome.html