Index Note: Page numbers of article titles are in boldface type. A Alginate, tooth-shaped, for constructs, encapsulated pulp cells in, 589 590 Antibiotic paste, triple, change in root length and width in use of, 631 Antibiotic pills and pastes, 615 617 Apical bone, failure to heal, 635 Apical papilla, stem cells from, 555 Autologous fibrin matrix, in regenerative endodontic procedures, 619, 620, 621 B Bacteria, pulpal regeneration and, 591 Bioactive materials, in pulp capping, 528 529 Bioceramics, as implant materials, 505 Blood clot revascularization, 617 within root canal, 579, 580 Bone grafts, in regenerative therapy, 539 Bone morphogenetic protein, 567 C Calcium hydroxide, as antimicrobial agent, 615, 616 in pulp capping, 527 Cardiac muscle, mesenchymal stem cells for therapy of, 661 Caries, pulp response to, 522 523, 524 pulpal and periradicular response to, 521 536 Cell homing, dental pulp-dentin regeneration by, 569 570 Cell-reprogramming techniques, 501 502 Chitosan, 645 Computed tomography, cone beam, in assessment of regenerative endodontic procedures, 634 635 Construct(s), and scaffolds, used to regenerate dental tissue, 577 588 dental tissue, 581, 583 generation of, 579 steps in use of, 578 in tissue regeneration, steps in use of, 578 periodontal, scaffolds to create, stem cell survival in, 581, 584 periodontal ligament, 582 tissue engineered, in dental treatment in future, 585 survival of stem cells in, 584 tooth-shaped alginate, encapsulated pulp cells in, 589 590 Dent Clin N Am 56 (2012) 691 697 doi:10.1016/s0011-8532(12)00053-5 0011-8532/12/$ see front matter ª 2012 Elsevier Inc. All rights reserved. dental.theclinics.com
692 Index D Deciduous teeth, human exfoliated, stem cells from, 554 555 Dental follicle precursor cells, 555 556 Dental pulp. See Pulp. Dental pulp-dentin regeneration, by cell homing, 569 570 Dental tissue, and supporting structures, regeneration of, 497 498 constructs and scaffolds employed to regenerate, 577 588 regeneration of, 578 definition of, 579 history of, 579 580 steps to use constructs in, 578 tissue injury and, 592 Dental treatment, in future, tissue engineered constructs in, 585 Dentin-pulp regeneration, cellular events in, 594 596 in young permanent tooth, 656 molecular events in, 596 597 translational opportunities for, 597 598 Dentinogenesis, reparative, importance of, 595 Discoloration, caused by minocycline, 634 E Endodontic procedures, regenerative, 639 649 access and disinfection for, 615 617 American Association of Endodontists protocol considerations for, 613 621 and tissue engineering, 609, 677 689 bone healing and tooth retention following, 633 case selection for, 615 clinical concerns in, 628 632 clinical considerations for, 603 626 clinically successful, case studies of, 604 608, 613 commitment to, 609 cone beam computed tomography in assessment of, 629 632, 633 early case study protocols in, 610 613 early outcomes of, 628 follow-up of, 619 621 future protocols in, 621 623 goals of, 610 histology from animal studies, 632 634 informed consent for, 615 major effort of, 678 outcomes of, 627 637 case reports of, 630 potential complications/undesired outcomes of, 634 635 pulp repair and regeneration and, 678 679 recent outcomes of, 628 632 signaling molecules for, effects and interactions of, 564 stimulating, scaffolds, and seals in, 617 619, 620, 621 terminology in, 610 trauma literature on, 609 623
Index 693 Endodontics, definition of, 640 inflammation-regeneration in, 684 nonsurgical, causes and incidences of failure of, 640 pulp tissue engineering in, 595 596 Epithelial-mesenchymal transition, induced stemness by, 666 667 Ethylenediamine tetraacetic acid, 593, 597 598, 617 F Fibroblast growth factor, 568 G Glass ionomer and adhesives, in pulp capping, 528 Growth factor(s), and signaling pathways, 683 effects of, on dental stem/progenitor cells, 563 575 fibroblast, 568 insulin-like, 568 569 nerve, 569 platelet-derived, 566 vascular endothelial growth factor, 568 H Hyaluronic acid, 645 I Immunomodulatory therapies, using mesenchymal stem cells, for systemic diseases, 662 664 Induced pluripotent stem cells, and dental pluripotentlike stem cells, 556 Inflammation-regeneration, in endodontics, 684 Insulin-like growth factor, 568 569 L Liver, mesenchymal stem cell-mediated generation therapy for, 662 M Mesenchymal stem cells, 551 allogeneic versus autologous, 665 666 dental, dental tissue engineering using, 655 direct pulp capping using, 655 656 in periodontal ligament regeneration, 658 pulp revitalization using, 656 657 pulp tissue engineering using, 657 658 tissue engineering of dental structures and periodontium using, 654 658 derivation from many tissues, 652 for oral and systemic diseases, therapeutic potential of, 651 675 for therapy of cardiac muscle, 661 function of, effects on aging, 665 immunomodulatory therapies using, for systemic diseases, 662 664
694 Index Mesenchymal (continued) in bone marrow tissues, 652 in skin wound closure, 659 661 in vitro induction of, toward different cell lineages, 653, 654 in vitro transdifferentiation potential of, in different cell types, 659, 660 induced stemness by epithelial transition with, 666 667 isolation, identification, and differentiation of, 551 553 life span of, 652 653 morphology of, 652 regenerative therapies using, for systemic diseases, 658 662 therapies using, challenges and future directions in, 664 666 to mediate generation therapy of liver, 662 to mediate therapy of pancreatic b-cells, 661 662 types of, phenotypic comparison of, 653 Mineral trioxide aggregate, 591, 593, 641 in pulp capping, 527 528 Minocycline, discoloration caused by, 634 Molar development, schematic of, 500, 501 Multiple sclerosis, immunomodulatory therapy using mesenchymal stem cells in, 664 N Nanofiber scaffolds, 646 Nanostructured films, and self-assembled peptides, 508 Nerve growth factor, 569 Niches, stem cells and, 682 Nondental tissues, regeneration of, 496 4977 NOTCH signaling proteins, 682 683 O Odontoblast cell secretion, during reparative dentinogenesis, 597 3D Organ printing, 505 Organ/tissue engineering, key components of, 508 P Pancreatic b-cells, mesenchymal stem cell-mediated therapy of, 661 662 Peptides, self-assembled, 507 508 nanostructured films and, 508 Periodontal defect, bone graft for treatment of, 539 Periodontal disease, 529 530, 537 538 Periodontal ligament, regeneration of, mesenchymal stem cells in, 658 stem cells from, 679 Periodontal ligament constructs, 582 Periodontitis, apical, 529 530 treatment with bone allograft material and resorbable membrane, 541 Periodontium, and dental structures, tissue engineering of, mesenchymal stem cells in, 654 658 Periradicular disease, 529 531 guided tissue regeneration in, 530 531 management and treatment options in, 530, 531
Index 695 Platelet-derived growth factor, 566 Platelet-rich plasma, in regenerative endodontic procedures, 619, 620, 621 Polyglycolic acid, 645 Protein(s), bone morphogenetic, 567 NOTCH signaling, 682 683 Pulp, natural regenerative potential of, harvesting of, 589 601 regeneration of, bacteria and, 591 creation of conducive environment for, 592 594 inflammatory and immune challenges to, 593 594 microbial challenges to, 592 593 response to caries, 522 523, 524 stem cells from, 553 554 in regenerative engineering, 585 vascularization of, 683 Pulp capping, direct, mesenchymal stem cells in, 655 656 materials of, 526 529 newer materials for, 591 Pulp capping procedure, direct, 527, 528 indirect, 525 Pulp constructs, 583 585 Pulp-dentin complex, main roles of, 680 stem cells to repair, 681 Pulp/dentin regeneration, cells to be used for, 642 644 scaffolding material for, 644 646 Pulp repair and regeneration, regenerative endodontics and, 678 679 Pulp revascularization, clinical studies of, 640 642 Pulp revitalization, mesenchymal stem cells in, 656 657 Pulp tissue engineering, in endodontics, 595 596 Pulpal injury, endodontic repair versus regeneration in, 538 periodontal repair versus regeneration in, 538 539 R Regenerative endodontics. See Endodontic procedures, regenerative. Regenerative therapy, 537 547 bone grafts in, 539 growth and differentiation factors in, 543 guided tissue regeneration for, 540 541 stem cells in, 543 544 Restorative materials, in regenerative dentistry, 598 Rheumatoid arthritis, immunomodulatory therapy using mesenchymal stem cells in, 663 664 Root canal, blood clot revascularization within, 579, 580 treatment of, 640 S Scaffold(s), and constructs, used to regenerate dental tissue, 577 588 choice of, 681 composed of extracellular matrix proteins, 580, 581 for dental regeneration, types of, 580, 581 in new tissue-engineering approaches, 591, 618
696 Index Scaffold(s) (continued) materials for, 503 nanofiber, 646 naturally derived, 505 physical properties of, 581 stem cells for, 681 structure of, 581, 582 synthetic, 503 505, 506 507 to create periodontal constructs, stem cell survival in, 581, 584 Signaling molecules, for regenerative endodontics, effects and interactions of, 564 mechanism of action and pulp-dentin complex regeneration, 565 Signaling pathways, growth factors and, 683 Skin wound closure, mesenchymal stem cells in, 659 661 Sodium hypochlorite, 593, 597 Stem cell and biomaterials research, in dental tissue engineering and regeneration, 495 520 Stem cells, and niches, 682 dental, 552, 553 and their sources, 549 561 dental follicle, 679 dental pluripotentlike, and induced pluripotent stem cells, 556 dental/progenitor, effects of growth factors on, 563 575 dental pulp, 553 554 embryonic, 498 499 for scaffolds, 681 from apical papilla, 555, 679, 680 from human exfoliated deciduous teeth, 554 555 general characterisitcs of, 550 in pulp, in regenerative medicine, 585 in regenerative therapy, 539 in tissue regeneration, 498 induced pluripotent, 502 and dental pluripotentlike stem cells, 556 mesenchymal. See Mesenchymal stem cells. origin of, 679 periodontal ligament, 679 somatic or adult, 499, 500 storage of, 553 survival in tissue engineered constructs, 584 to repair pulp-dentin complex, 681 undifferentiated, selective removal of, 502 Stromal cell-derived factor 1, 569 Systemic diseases, mesenchymal stem cells for immunomodulatory therapies using, 662 664 mesenchymal stem cells in regenerative therapy for, 658 662 Systemic lupus erythematosus, immunomodulatory therapy using mesenchymal stem cells in, 663 T Tissue engineering, and regeneration, stem cell and biomaterials research in, 495 520 approaches in, past and present, 496
Index 697 goal of, 496 in regenerative endodontics, 609 key element of, 577 mesenchymal stem cells in, 655, 657 658 regenerative endodontics and, 677 689 scaffolds in, 502 505 Tissue injury, and regeneration of dental tissue, 592 Tissue regeneration, guided, regenerative therapy in, 540 541 stem cells in, 498 Tooth injury, mild versus intense, cellular sequences of events in, 594 595 Transdifferentiation, 501 502 Transforming growth factor ß, 566 567 Trioxide aggregate, mineral, 591, 593, 641 in pulp capping, 527 528 V Vascular endothelial growth factor, 568 Vascularization of dental pulp, 683 Vital pulp therapy, 523 529 indirect, 525 526 pulp exposure in, 526 W Wound closure, skin, mesenchymal stem cells in, 659 661 Wound healing, natural, and tissue environment, 591