NICE TA Adherence Check list April 2014 Drug Indication NICE Approval Release Date Bortezomib Multiple myeloma (induction therapy) Afatinib Rituximab Pixantrone Aflibercept Teriflunomide Fluocinolone acetonide intravitreal implant Peginterferon alfa and ribavirin Lung cancer (non small cell, EGFR mutation positive) Vasculitis(anti-netrophil cytoplasmic antibodyassociated) monotherapy for treating multiply relapsed or refractory aggressive non- Hodgkin's B cell lymphoma macular oedema secondary to central retinal vein occlusion relapsing remitting multiple sclerosis TA311 TA310 TA308 TA306 TA305 TA303 23/4/2014 Yes 23/4/2014 Yes 26/3/2014 Yes 26/02/2014 Yes 26/02/2014 Yes 22/01/2014 Yes Diabetic macular oedema TA301 27/11/2013 yes chronic hepatitis C in children and young people TA300 27/11/2013 Yes Ranibizumab choroidal neovascularisation TA298 27/11/2013 Yes associated with pathological myopia Ocriplasmin Vitreomacular Traction TA297 23/10/2013 Yes for local use Aflibercept ( Eylea) Wet-age related Macular degeneration TA294 24/07/2013 Yes Eltrombopag Idiopathic thrombocytopenia purpura TA293 24/07/2013 Yes Aripiprazole (oral) Bipolar Disorder (children 13yrs & over) TA292 24/07/2013 Yes Mirabegron Overactive Bladder TA290 26/06/2013 Yes Dapagliflozin Combination thearpy Rivaroxaban Type2 diabetes TA288 26/06/2013 Yes Pulmonary embolism & preventing recurrent venous thromboembolism TA287 26/06/2013 Yes
Ranibizumab visual impairment caused by macular oedema secondary to retinal veil occlusion TA283 22/05/2013 Yes Kyphoplasty Vertebral Fractures TA279 25/04/2013 Yes Pirfenidone Idiopathic pulmonary fibrosis TA282 24/04/2013 Yes Abatacept RA (first TNF) TA280 24/04/2013 Yes Vertebroplasty Vertebral Fractures TA279 24/04/2013 Yes Omalizumab Asthma - over 12yo & adults TA278 24/04/2013 Yes Omalizumab Asthma - 6-11yo TA278 24/04/2013 Yes Colistimethate Cystic Fibrosis TA276 27/03/2013 Yes Sodium (pseudomonas lung infection) Tobramycin Cystic Fibrosis TA276 27/03/2013 Yes (pseudomonas lung infection) Ranibizumab Diabetic macular oedema TA274 27/02/2013 Yes Apixaban Stroke & Systemic embolism TA275 27/02/2013 Yes Verumafenib Locally Adv. Or metastatic TA269 12/12/2012 Yes BRAF V600 mutationpositive unresectable metastatic Ipilimumab Metastatic melanoma TA268 12/12/2012 Yes Ivabradine Heart Failure II - IV TA267 28/11/2012 Yes Mannitol Cystic Fibrosis TA266 28/11/2012 Yes Botulinum toxin A Chronic migraine TA260 27/11/2012 Yes Denosumab Bone Metastases for solid tumours TA265 24/10/2012 Yes
Alteplase Acute ischaemic stoke TA264 26/09/2012 Yes Rivaroxaban deep vein thrombosis and prevention of recurrent deep vein thrombosis and pulmonary embolism TA261 25/07/2012 Yes Abiraterone (Zytiga) Metastatic Castration resistant Prostate Ca TA259 27/06/2012 Yes Erlotinib NSCLC with EGFR activating mutations TA258 27/06/2012 Yes Rivaroxaban Stroke prevention in AF TA256 23/05/2012 Yes Bocepravir Telaprevir Genotype 1 chronic Hepatitis C Genotype 1 chronic Hepatitis C TA253 TA252 25/04/2012 Yes 25/04/2012 Yes Fingolimod highly active relapsing remitting multiple sclerosis (In Adults) TA254 25/04/2012 Yes Dabigatran Stroke prevention in AF TA249 15/03/2012 Yes etexilate Exenatide LAR Type 2 diabetes TA248 22/02/2012 Yes Pharmalgen Hypersensitivity to bee & TA246 22/02/2012 Yes wasp venom Tocilizumab Rheumatoid arthritis TA247 22/02/2012 Yes Apixaban Rituximab Prevention of VT after total Hip or Knee replacement in Adults 1st line Treatment of Follicular Lymphoma stages III - IV TA245 TA243 25/01/2012 Yes 25/01/2012 Yes Roflumilast COPD TA244 25/01/2012 Yes
Cyclophosphamide Follicular lymphoma TA243 25/01/2012 Yes Nilotinib Tocilizumab CML dasatinib, nilotinib, imatinib (intolerant, resistant) Juvenile Idiopathic systemic arthritis TA241 TA238 13/01/2012 Yes 14/12/2011 Yes Ticagrelor ACS TA236 26/10/2011 Yes Mifamurtide Osteosarcoma TA235 26/10/2011 Yes Golimumab Ankylosing spondylitis TA233 24/08/2011 Yes Retigabine Partial onset seizures TA232 27/07/2011 Yes Bivalirudin STEMI undergoing primary TA230 27/07/2011 Yes PCI Dexamethasone implant (Ozurdex) Macular oedema associated with retinal vein occlusion TA229 27/07/2011 Yes Bortezomib Multiple Myeloma (1st line) TA228 27/07/2011 Yes Thalidomide Mulitple myeloma (1st line) TA228 27/07/2011 Yes Rituximab Follicular NHL (maintenance) TA226 22/06/2011 Yes Golimumab Naftidrofuryl oxalate Romiplostim Rheumatoid arthritis (2nd line ) Intermiittent claudication associated with peripheral vasular disease Idiopathic thrombocytopenia purpura TA225 22/06/2011 Yes TA223 25/05/2011 Yes TA221 27/04/2011 Yes
Golimumab Psoriatic arthritis TA220 27/04/2011 Yes Rivastigmine Alzheimer's disease TA217 23/03/2011 Yes Rivastigmine (patch) Alzheimer's disease TA217 23/03/2011 Yes Donepezil Alzheimer's disease TA217 23/03/2011 Yes Galantamine Alzheimer's disease TA217 23/03/2011 Yes Azacitidine Myelodysplastic syndrome TA218 23/03/2011 Yes Memantine Alzheimer's disease TA217 23/03/2011 Yes Bendamustine CLL (1st line) TA216 23/02/2011 Yes Pazopanib Metastatic renal cell Ca (1st line) TA215 23/02/2011 Yes Aripiprazole (oral) Schizophrenia (15-17yo) TA213 26/01/2011 Yes Raloxifene Secondary prevention of TA161 26/01/2011 Yes osteoporosis Teriparatide Osteoporosis TA161 26/01/2011 Yes Alendronate Secondary prevention TA161 26/01/2011 Yes Etidronate Secondary prevention TA161 26/01/2011 Yes Risedronate Secondary prevention TA161 26/01/2011 Yes Strontium ranelate Secondary prevention TA161 26/01/2011 Yes Alendronate Primary prevention TA160 26/01/2011 Yes Etidronate Primary prevention TA160 26/01/2011 Yes Risedronate Primary prevention TA160 26/01/2011 Yes Strontium ranelate Primary prevention TA160 26/01/2011 Yes Prucalopride Refractory constipation in TA211 15/12/2010 Yes women Clopidogrel Occlusive vascular events TA210 15/12/2010 Yes Dipyridamole (MR) Occlusive vascular events TA210 15/12/2010 Yes
Imatinib Unresectable/metastatic TA86 24/11/2010 Yes GIST Imatinib Unresectable/metastatic GIST TA209 24/11/2010 Yes Denosumab Post-menopausal TA204 27/10/2010 Yes osteoporosis Liraglutide Type 2 diabetes TA203 27/10/2010 Yes Adalimumab Psoriatic arthritis TA199 25/08/2010 Yes Etanercept Psoriatic arthritis TA199 25/08/2010 Yes Infliximab Psoriatic arthritis TA199 25/08/2010 Yes Dronedarone AF TA197 25/08/2010 Yes Abatacept RA (after failure of TNF) TA195 25/08/2010 Yes Adalimumab RA (after failure of TNF) TA195 25/08/2010 Yes Etanercept RA (after failure of TNF) TA195 25/08/2010 Yes Infliximab RA (after failure of TNF) TA195 25/08/2010 Yes Rituximab RA (after failure of TNF) TA195 25/08/2010 Yes Capecitabine Advanced gastric Ca TA191 28/07/2010 Yes Gefitinib Gefitinib Rituximab in combination with fludarabine & cyclophosphamide Locally-advanced or TA192 28/07/2010 Yes metastatic NSCLC (1st line) Locally-advanced or TA192 28/07/2010 Yes metastatic NSCLC (1st line) CLL (relapsed or refractory) TA193 28/07/2010 Yes Pemetrexed NSCLC (maintenance) TA190 23/06/2010 Yes Somatropin Growth failure in children TA188 26/05/2010 Yes Adalimumab Crohn's disease TA187 19/05/2010 Yes Infliximab Crohn's disease TA187 19/05/2010 Yes Certolizumab pegol Rheumatoid arthritis TA186 24/02/2010 Yes Trabectedin Advanced soft tissue sarcoma TA185 24/02/2010 Yes
Topotecan (oral) Relapsed SCLC TA184 25/11/2009 Yes Cisplatin (in Cervical Ca TA183 28/10/2009 Yes combination) Topotecan Cervical Ca TA183 28/10/2009 Yes Prasugrel ACS TA182 28/10/2009 Yes Pemetrexed NSCLC (1st line) TA181 23/09/2009 Yes Ustekinumab Psoriasis TA180 23/09/2009 Yes Sunitinib GIST TA179 23/09/2009 Yes Alitretinoin Chronic hand eczema TA177 26/08/2009 Yes Cetuximab Metastatic colorectal Ca (1st line) TA176 26/08/2009 Yes Fluorouracil Colorectal Ca (first line) TA176 26/08/2009 Yes Tenofovir disoproxil Hepatitis B TA173 22/07/2009 Yes Cyclophosphamide CLL TA174 22/07/2009 Yes Fludarabine CLL TA174 22/07/2009 Yes phosphate Rituximab CLL TA174 22/07/2009 Yes Lenalidomide Mulitple myeloma TA171 18/06/2009 Yes Rivaroxaban VTE prophylaxis (post hip or knee replacement) TA170 22/04/2009 Yes Sunitinib Renal cell Ca (1st line) TA169 25/03/2009 Yes Oseltamivir Treatment of influenza TA168 25/02/2009 Yes Zanamivir Treatment of influenza TA168 25/02/2009 Yes Infliximab UC (acute exacerbations) TA163 17/12/2008 Yes Febuxostat Hyperuricaemia TA164 17/12/2008 Yes Strontium ranelate Secondary prevention TA162 26/11/2008 Yes Erlotinib NSCLC - treatment TA162 26/11/2008 Yes Oseltamivir Prevention of influenza TA158 24/09/2008 Yes
Zanamivir Prevention of influenza TA158 24/09/2008 Yes Dabigatran VTE prophylaxis (post hip or TA157 24/09/2008 Yes etexilate knee replacement) Ranibizumab AMD TA155 27/08/2008 Yes Entecavir Hepatitis B TA153 27/08/2008 Yes CSII (adults& Type 1 diabetes TA151 23/07/2008 Yes Children over 12 years & over) Adalimumab Psoriasis TA146 25/06/2008 Yes Cetuximab Head & neck Ca (locally TA145 25/06/2008 Yes advanced) Adalimumab Ankylosing spondylitis TA143 28/05/2008 Yes Etanercept Ankylosing spondylitis TA143 28/05/2008 Yes Darbopoetin Ca treatment-induced anaemia TA142 28/05/2008 Yes Epoetin alfa, beta & Ca treatment-induced TA142 28/05/2008 Yes delta anaemia Rituximab Follicular non-hodgkin's TA137 27/02/2008 Yes lymphoma Infliximab Psoriasis TA134 23/01/2008 Yes Pemetrexed Mesothelioma TA135 23/01/2008 Yes Ezetimibe Hypercholesterolaemia TA132 28/11/2007 Yes Adalimumab RA (first TNF) TA130 24/10/2007 Yes Etanercept RA (first TNF) TA130 24/10/2007 Yes Infliximab RA (first TNF) TA130 24/10/2007 Yes Bortezomib Relapsed Multiple myeloma TA129 24/10/2007 Yes
Natalizumab Multiple sclerosis TA127 22/08/2007 Yes Varenicline Smoking Cessation TA123 25/07/2007 Yes Carmustine Glioma TA121 27/06/2007 Yes (implant) Temozolomide Glioma TA121 27/06/2007 Yes Gemcitabine Metastatic breast Ca TA116 24/01/2007 Yes Paclitaxel Metastatic breast Ca TA116 24/01/2007 Yes Cinacalcet Secondary hyperparathyroidism TA117 24/01/2007 Yes Buprenorphine Managing Opiod Dependancy TA114 01/01/2007 Yes Methadone Managing Opiod Dependancy TA114 01/01/2007 Yes Naltrexone Managing Opiod Dependancy TA114 01/01/2007 Yes Anastrozole Breast Ca TA112 22/11/2006 Yes Exemestane Breast Ca TA112 22/11/2006 Yes Letrozole Breast Ca TA112 22/11/2006 Yes Doxorubicin hydrochloride Breast Ca TA109 21/09/2006 Yes Cyclophosphamide Early breast Ca TA109 21/09/2006 Yes Docetaxel Early breast Ca TA109 21/09/2006 Yes Ribavirin Hepatitis C (mild) TA106 26/08/2006 Yes Peginterferon alfa Hepatitis C (mild) TA106 26/08/2006 Yes
Trastuzumab Early breast Ca TA107 23/08/2006 Yes Etanercept Psoriasis TA103 26/07/2006 Yes Docetaxel Prostate Ca TA101 28/06/2006 Yes Basiliximab Renal transplantation TA99 26/04/2006 Yes (adults) Capecitabine Colon Ca TA100 26/04/2006 Yes Fluorouracil Colon Ca TA100 26/04/2006 Yes Oxaliplatin Colon Ca TA100 26/04/2006 Yes Peginterferon alfa Hepatitis B TA96 22/02/2006 Yes Adefovir dipivoxil Hepatitis B TA96 22/02/2006 Yes Carboplatin Ovarian Ca (advanced) TA91 01/05/2005 Yes Cisplatin Ovarian Ca (advanced) TA91 01/05/2005 Yes Doxorubicin Ovarian Ca TA91 01/05/2005 Yes hydrochloride (peg.lipsomal) Paclitaxel Ovarian Ca (advanced) TA91 01/05/2005 Yes Topotecan Ovarian Ca TA91 01/05/2005 Yes Basiliximab Renal transplantation (adolescents & children) TA85 22/09/2004 Yes Pimecrolimus Eczema TA82 01/08/2004 Yes Tacrolimus Eczema TA82 01/08/2004 Yes Clopidogrel ACS TA80 01/07/2004 Yes Zaleplon Insomnia TA77 01/04/2004 Yes Interferon alfa Hepatitis C (moderate-severe) TA75 01/01/2004 Yes
Peginterferon alfa Hepatitis C (moderate-severe) TA75 01/01/2004 Yes Ribavirin Hepatitis C (moderate-severe) TA75 01/01/2004 Yes Imatinib CML TA70 01/10/2003 Yes Cyclophosphamide Aggressive non-hodgkin's lymphoma TA65 01/09/2003 Yes Doxorubicin Non-Hodgkin's lymphoma TA65 01/09/2003 Yes hydrochloride Verteprofin PDT of AMD TA68 01/09/2003 Yes Rituximab Somatropin Aggressive non-hodgkin's lymphoma Growth hormone deficiency in adults TA65 TA64 01/09/2003 Yes 01/08/2003 Yes Capecitabine Metastatic colorectal Ca TA61 01/05/2003 Yes Tegafur with uracil Metastatic colorectal Ca TA61 01/05/2003 Yes Paclitaxel Ovarian Ca TA55 01/01/2003 Yes Insulin glargine Type 1&2 diabetes TA53 01/12/2002 Yes Alteplase Acute MI TA52 01/10/2002 Yes Reteplase Acute MI TA52 01/10/2002 Yes Streptokinase Acute MI TA52 01/10/2002 Yes Tenecteplase Acute MI TA52 01/10/2002 Yes Etanercept Juvenile arthritis TA35 01/03/2002 Yes Gemcitabine Pancreatic Ca TA25 01/05/2001 Yes Temozolomide Brain cancer TA23 01/04/2001 Yes Riluzole MND TA20 01/01/2001 Yes
Drug Indication NICE Approval Release Date Pemetrexed Aflibercept Lung cancer (non small cell, non squamous) Colorectal cancer(metastatic) TA 309 TA307 23/4/2014 No 23/3/14 No for Local Use Canakinumab Juvenile idiopathic arthritis (systemic) TA302 Terminated Appraisal 27/11/2013 No Bosutinib Leukaemia (chronic myeloid) TA299 27/11/2013 No Crizotinib Lung CA TA296 25/09/2013 No Everolimus Advanced breast Ca TA295 not 28/08/2013 No Pegloticase Servere debilitating chronic tophaceous gout TA291 26/06/2013 No
Ruxolitinib Bevacizumab in combo with Gemcitabine & Carboplatin Disease-related splenomegaly or symptoms in adults with myelofibrosis 1st recurrence of platinum-sensitive advanced ovarian cancer TA289 TA285 26/06/2013 No 22/05/2013 No Bevacizumab in combo with Paclitaxel & Carboplatin 1st line treatment of advanced ovarian cancer TA284 22/05/2013 No Loxapine inhalation Acute agitation & disturbed behaviours associated with schizophrenia & bipolar disorder TA286 Terminated Appraisal Canakinumab CAPS TA281 Terminated Appraisal Methylnalrexone opioid-induced bowel TA277 Terminated dysfunction in people Appraisal with advanced illness receiving palliative care Vinflunine TCCU TA272 Fluocinolone implant Tadalafil Diabetic macular oedema Benign Prostatic Hyperplasia TA271 Decitabine AML TA270 Bevacizumab Adalimumab Lapatinib Trastuzumab Adv/Metastatic breast Ca 1st line Moderate-severe UC (2nd line) HER2 +ve metastatic breast Ca HER2 +ve metastatic breast Ca 22/05/2013 No 24/04/2013 No 27/03/2013 No 23/01/2013 No 23/01/2013 No TA273 Terminated 23/01/2013 No TA263 TA262 TA257 TA257 12/12/2012 No 22/08/2012 No 27/06/2012 No 27/06/2012 No 27/06/2012 No
Cabazitaxel Metastatic prostate Ca TA255 11/05/2012 No Dasatinib CML 1st line TA251 25/04/2012 No Eribulin Locally advanced or metastatic breast cancer TA250 03/04/2012 No Bevacizumab Metastatic colorectal Ca 2nd Line TA242 25/01/2012 No Cetuximab Metastatic colorectal Ca (2nd line) TA242 25/01/2012 No Panitumumab Metastatic colorectal TA242 25/01/2012 No Ca (2nd line) Dasatinib CML dasatinib, nilotinib, imatinib (intolerant, resistant) TA241 not 13/01/2012 No Imatinib CML dasatinib, TA241 13/01/2012 No nilotinib, imatinib (intolerant, resistant) Fulvestrant Breast Ca TA239 14/12/2011 No Panitumumab Metastatic colorectal TA240 Terminated Ca (2nd line) Bendamustine Indolent NHL TA206 Agomelatine Depression TA231 Erlotinib NSCLC - maintenance TA227 Golimumab Cilostazol Inositol nicotinate RA (methotrexatenaïve) Intermiittent claudication associated with peripheral vasular disease Intermiittent claudication associated with TA224 Terminated TA223 TA223 14/12/2011 No 27/10/2011 No 27/07/2011 No 29/06/2011 No 22/06/2011 No 25/05/2011 No 25/05/2011 No
peripheral vasular disease Pentoxifylline Intermiittent claudication associated with peripheral vasular disease TA223 Trabectedin Relapsed ovarian Ca TA222 Everolimus Advanced RCC (2nd TA219 line) 25/05/2011 No 27/04/2011 No 19/04/2011 No Bevacizumab Metastatic breast Ca TA214 Raloxifene Primary prevention TA160 of osteoporosis 23/02/2011 No 26/01/2011 No Bevacizumab Trastuzumab Metastatic colorectal Ca HER2 +ve metastatic gastric Ca TA212 TA208 Ofatumumab CLL TA202 Fesoterodine Non-Hodgkin's lymphoma TA206 Imatinib GIST (adjuvant) TA196 Sorafenib Hepatocellular Ca TA189 Sorafenib Renal cell Ca TA178 Sunitinib Renal cell Ca (2nd TA178 line) Temsirolimus Renal cell Ca TA178 15/12/2010 No 24/11/2010 No 27/10/2010 No 27/10/2010 No 25/08/2010 No 26/05/2010 No 29/08/2009 No 29/08/2009 No 29/08/2009 No Bevacizumab Cetuximab Amantadine Renal cell Ca Head & neck Ca (recurrent or metastatic) Treatment of influenza TA178 TA172 TA168 29/08/2009 No 24/06/2009 No 25/02/2009 No
Amantadine Prevention of influenza TA158 24/09/2008 No Pegaptanib sodium AMD TA155 27/08/2008 No Telbivudine Hepatitis B TA154 27/08/2008 No Carmustine (implant) Glioblastoma multiforme TA149 25/06/2008 No Bevacizumab NSCLC TA148 Infliximab Ankylosing spondylitis TA143 Infliximab UC (sub-acute manifestations) TA140 Pemetrexed NSCLC (2nd line) TA124 25/06/2008 No 28/05/2008 No 23/04/2008 No 22/08/2007 No Fludarabine phosphate CLL TA119 28/02/2007 No Bevacizumab Cetuximab Fluorouracil Adv./metastatic colorectal Ca Metastatic colorectal Ca (2nd line) Colorectal Ca (metastatic) TA118 TA118 TA118 Paclitaxel Early breast Ca TA108 24/01/2007 No 24/01/2007 No 24/01/2007 No 27/09/2006 No Efalizumab Psoriasis TA103 Market Authorisation withdrawn 26/07/2006 No Drotrecogin alfa Sepsis TA84 terminated No Temsirolimus Mantle cell lymphoma TA207 Terminated No