Appendix 2. Detailed information about herbal prescriptions used in the included trials First author (Year) Herbal Medicinal Preparation Name Chen Tongqiao (2013) 22 huoxue Guo Biyan (2004) 23 Qingdu Granule He Tongqiao (2013) 24 huoxue Pharmaceutical Active Ingredients Unit Dose Prescription Method Paeoniae Radix Rubra Persicae Semen Jujubae Fructus Herbal preparation extracted with 250 ml yellow rice wine Carthami Flos Allii Radix Zingiberis Rhizoma Recens 9 g Moschi Moschiferus 0. 6 g 9 g Chrysanthemi lndici Flos Not mentioned Xanthii Fructus Paridis Rhizoma Rubus parvifolius Zanthoxylum nitidum Prunellae Spica Gentianae Radix Codonopsis Pilosulae Radix Manufactured by pharmaceutical co Paeoniae Radix Rubra Persicae Semen Carthami Flos Herbal preparation extracted with water Allii Radix Zingiberis Rhizoma Recens Moschi Moschiferus 0. Pharmaceutical formulation granule Administration Method once a day at bedtime each time, Dissolve granule in water, 2 500ml divided into 3, 3
Jujubae Fructus Hu (2000) 25 - Cyperi Rhizoma Water extracted Pattern/Syndrome of qi stagnation and blood stasis Paeoniae Radix Rubra spleen qi deficiency pattern/syndrome Codonopsis Pilosulae Radix liver-kidney yin deficiency pattern/syndrome Rehmanniae Radix Preparata Crataegii Fructus Schizandrae Fructus kidney yang deficiency pattern/syndrome Aconiti Lateralis Radix Praeparata Crataegii Fructus Jiang Shenling Dolichoris Semen Not Manufactured by (2013) 26 baizhu mentioned pharmaceutical co powder Nelumbinis Semen Ginseng Radix Amomi Fructus Dioscoreae Rhizoma Li - Dioscoreae Rhizoma Herbal preparation (2014) 27 extracted with 500ml water 2 granule Each time 3 Taking 100ml herbal, 2
Pheretimae Corpus Xanthii Fructus Salviae Miltiorrhizae Radix Liao (1998) 28 Tongqiao tablet Radix Ilicis Pubescentis Pheretimae Corpus 30g Produced by preparation department in hospital. Each tablet weighing 0. containing 2.24g of crude drugs Liu - Astragali Radix 30g Herbal preparation (2005) 29 Saposhnikoviae Radix extracted with water Armeniacae Semen Salviae Miltiorrhizae Radix 30g Cyperi Rhizoma Aurantii Fructus Pericarpium Liu - Duration of illness 15day Herbal preparation (2014) 30 Pinelliae Rhizoma extracted with 500ml water Lonicerae Flos Forsythiae Fructus Tablet 4 tablets (2.0g) each time, 3 2, 2
Taraxaci Herbai Fritillariae Bulbus Duration of illness>15day, 25d Agastachis Herba Aucklandiae Radix Duration of illness>25day Mori Radicis Cortex Persicae Semen Carthami Flos Citri Pericarpium Lu (2013) 31 - Ginseng Radix Dolichoris Semen Herbal preparation extracted with 500ml water Cinnamomi Ramulus Liquidambar formosana Hance Astragali Radix Qu - Astragali Radix 18g Herbal preparation (2013) 32 Gardeniae Fructus 18g extracted Codonopsis Pilosulae Radix 18g with water Rehmanniae Radix 300ml divided into 2, 2 after the meal Taking 150ml herbal, 3
Sato Tsumura- (1988) 38 Saireito Shi Huanglong (2005) 33 tonger pill Sun Qingqiao (2005) 34 Capsule Puerariae Radix 30g Phellodendri Cortex Paeoniae Radix Alba Viticis Fructus Gentianae Radix Not Manufactured by mentioned pharmaceutical co Cinnamomi Cortex Spissus Zingiberis Rhizoma Recens Ginseng Radix Zizyphi Fructus Pinelliae Rhizoma Polyporus Gentianae Radix 2 mm diameter pills with Powdered herbal preparation Magnoliae Cortex and water Gardeniae Fructus Akebiae Caulis Polyporus Coptidis Rhizoma Scrophulariae Radix Not Produced by Rehmanniae Radix mentioned preparation granule pill capsule 1. each time, 2 time a day each time with warm water, 2 times a day 5 capsules each time, 3 times a
Tian Shenling (2014) 35 baizhu powder Zhang Erzhang (2013) 36 Zhao Huanglong (2012) 37 tonger pill Salviae Miltiorrhizae Radix Achyranthis Radix Bombycis Corpus cum Batryticatus Angelicae Sinensis Radix Amomi Rotundus Fructus department in hospital. Each capsule weighing 0.4 containing 2.2 of crude drugs 3 more unknown herbal preparation Dolichoris Semen Not Manufactured by mentioned pharmaceutical co Nelumbinis Semen Ginseng Radix Amomi Fructus Dioscoreae Rhizoma Lonicerae Flos Herbal preparation Forsythiae Fructus extracted with water Citri Pericarpium Sojae Semen Praeparatum Mentha arvensis var. piperascens Makinv. Schizonepetae Herba Praeparata Polyporus 2 mm diameter pills with Powdered herbal preparation day granule Each time, 3 pill Taking 150ml herbal, 3 after the meal each time with warm water, 2 times a
Gentianae Radix and water day Akebiae Caulis Gardeniae Fructus Magnoliae Cortex Coptidis Rhizoma