Appendix E-1 (Figures and Tables) Fig. E-1

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Page 1 Appendix E-1 (Figures and Tables) Fig. E-1 Survival curves (Kaplan-Meier) for revised knees (failed primary TKAs revised to TKAs [TKA TKA] and failed primary UKAs revised to TKAs [UKA TKA]) according to year of operation: 1994 to 2002 (Fig. E-1A) and 2003 to 2011 (Fig. E-1B), with any reason for rerevision as the end point. RR = relative risk of re-revision in the Cox regression analysis, where UKA TKA was used as the reference group and adjusting for propensity-score covariates of sex, age at revision, duration of time since the revision operation, primary diagnosis, and type of fixation. CI = confidence interval, and time = duration of follow-up in years. The Kaplan-Meier survival curves were terminated when fewer than thirty knees remained at risk.

Page 2 Fig. E-2 Changes in the severity level of problems according to each of the five domains of the EQ-5D among patients with a failed primary TKA revised to TKA at a minimum postoperative followup of one year (Norwegian Arthroplasty Register, 1994 to 2005). * = preoperative level of problems. Up to eleven of the patients had not reported either the preoperative or postoperative status for each EQ-5D domain. Therefore, only the remaining patients who reported both preoperative and postoperative status were used in the assessment of the changes in severity level for each domain.

Page 3 Fig. E-3 Changes in severity level of problems according to each of the five domains of the EQ-5D among patients with a failed UKA revised to TKA at a minimum postoperative follow-up of one year (Norwegian Arthroplasty Register, 1994 to 2005) * = preoperative level of problems. Up to seven of the patients had not reported either the preoperative or postoperative status for each EQ-5D domain. Therefore, only the remaining patients who reported both preoperative and postoperative status were used in the assessment of the changes in severity level for each domain.

Page 4 Table E-1 Types of Prosthesis Brands Used 1994-2011* 1994-2005 Prosthesis (Manufacturer) N = 768 N = 578 N = 150 N = 127 Genesis I (Smith & 73 24 29 13 Nephew) AGC-Anatomic (Biomet) 15 12 7 1 AGC-Universal (Biomet) 10 20 5 9 LCS (DePuy Synthes) 103 41 51 26 Duracon (Stryker) 33 33 2 4 NexGen (Zimmer) 69 56 5 2 Profix (Smith & Nephew) 163 201 37 57 LCS Complete (DePuy 178 141 0 9 Synthes) e.motion (B. Braun) 4 12 0 1 Triathlon (Stryker) 13 5 0 0 Vanguard (Biomet) 28 13 0 0 Maxim (Biomet) 10 0 2 0 Scorpio (Stryker) 30 6 0 0 Others 39 14 12 5 *Refers to the whole study population (Fig. 1). Refers to the study population with patient-reported outcome measure (PROM) data in addition to the Norwegian Arthroplasty Register (NAR) data (Fig. 1). TKA TKA = failed primary total knee arthroplasty (TKA) revised to TKA, and UKA TKA = failed primary unicompartmental knee arthroplasty (UKA) revised to TKA.

A Comparative Study of 768 Revised TKAs and 578 UKAs Revised to TKAs from the Norwegian Page 5 TABLE E-2 Reasons for Re-Revision of TKA TKA Versus UKA TKA by Age at Revision (Norwegian Arthroplasty Register, 1994 to 2011) <60 Yr* 60-70 Yr* >70 Yr* Indication (Reason) N = 163 N = 193 P Value N = 222 N = 188 P Value N = 383 N = 197 P Value Loose femoral 2 1 0.47 3 2 0.79 4 1 0.51 component Loose tibial component 4 9 0.27 8 8 0.73 4 2 0.97 Loose patellar 0 0 1 0 0.36 0 0 component Dislocation of patella 1 0 0.28 1 0 0.36 2 0 0.31 Dislocation other than 0 0 0 0 1 0 0.47 patella Instability 8 12 0.59 3 1 0.40 7 0 0.06 Malalignment 2 6 0.23 1 2 0.47 3 1 0.70 Deep infection 11 4 0.03 5 2 0.36 14 5 0.47 Periprosthetic fracture 0 0 1 0 0.36 3 0 0.21 Defect or wear of 3 0 0.06 1 1 0.91 0 0 polyethylene inserts Pain alone 3 12 0.04 5 1 0.15 3 2 0.78 Progression of arthritis 0 0 0 0 1 0 0.47 Arthrofibrosis and stiff 4 0 0.03 0 1 0.36 1 0 0.47 knee Other reason 0 2 0.19 1 1 0.91 0 0 *More than one reason for revision and/or re-revision was reported for some patients. TKA TKA = failed primary total knee arthroplasty (TKA) revised to TKA, and UKA TKA = failed primary unicompartmental knee arthroplasty (UKA) revised to TKA. P value for chi-square test.