黃偉謙 Wei-Chien Huang, Ph.D. 2009.May. 9 Office Address Center for Molecular Medicine China Medical University Hospital E-mail: d89443002@ntu.edu.tw; whuang@mail.cmu.edu.tw Tel: 04-22052121 ext.7931 Fax: 04-22079142 EDUCATIONS Ph.D. Department of Pharmacology, College of Medicine, National Taiwan University. PROFESSIONAL EXPERIENCE 2007.11-present Assistant Professor, Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan. Associate Research Fellow, Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan. 2006.03-2007.10 Postdoctoral fellow, Department of Molecular and Cellular Oncology, M.D. Anderson Cancer Center, University of Texas, Houston, TX 2004.04-2006.03 Postdoctoral Fellow, Department of Pharmacology, College of Medicine, National Taiwan University, Taiwan 2002.09-2003.01 Lecturer, Ching-Kuo Institute of Manager and Health, Keelung, Taiwan. 1999.09-2000.06 Teaching Assistant, Department of Pharmacology, College of Medicine, National Cheng-Kung University. AWARDS AND HONORS 2007 Medical Young Investigator Award, Prof. Chen-Yuan Lee Foundation 2006 Taiwan Merit Scholarship, Ministry of Education, Taiwan. 2006 Outstanding Research Award, College of Medicine, National Taiwan University. 2006 Young Investigator Award, Taiwan Pharmacological Society 2005 Postdoctoral Fellowship Award, National Health Research Institute, Taiwan. 2004 Outstanding Research Award, Taiwan Pharmacological Society
2004 American Society for Biochemistry and Molecular Biology (ASBMB) Graduate Travel Award. 2004 The 14 th Annual Wang Ming-Ning Award. 2003 Outstanding Research Award, College of Medicine, National Taiwan University. Grants 1. NSC (5,910,000 NTD/3 year) Role of nuclear HER-2 in acquired resistance to EGFR inhibitors. (PI) CoPI: Dr. Mien-Chien Hung 2. NHRI (1999000 NTD/year) Novel roles of nuclear IKKalpha in tumor progression and metastasis. (PI) CoPI: Dr. Mien-Chien Hung 3. NRPGM (Approved) The role of sodium/glucose transporter1 in EGFR-targeted therapy of lung cancers. (PI) CoPI: Dr. Mien-Chien Hung 4. CMU (800,000NTD) Loss of IKKβ activity enhances cell cycle arrest through p53-dependent pathway (co-pi)
黃偉謙 Wei-Chien Huang, Ph.D. PEER-REVIEWED PUBLICATIONS (*equal contribution, # Correspendence) 1. Pei-Ming Yang*, Wei-Chien Huang*, Yi-Chu Lin*, Wen-Yu Huang, Hui-Amm Wu, Wei-Lun Chen, Yu-Fan Chang, Chia-Wei Chou, Cherng-Chyi Tezng, Yeh-Long Chen, Ching-Chow Chen. (2009). Loss of IKKb activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis. J. Cell. Mol. Med. In press. 2. Wei-Chien Huang # and Mien Chie Hung #. (2009) Induction of Akt activity by chemotherapy confers acquired resistance. Journal of Formos. Med. Assoc. 108(3): 180-194. 3. Weihua Zhang, Rachel Tsan, Wei-Chien Huang, Qiuyu Wu, Chao-Hwa Chiu, Isaiah J. Fidler, Mien-Chie Hung #. (2008) Survival of Cancer Cells is Maintained by EGFR. Cancer Cell. 13: 385-393. IF: 24.077 Cited : 4. Jer-Yen Yang, Cong S. Zong, Weiya Xia, Hirohito Yamaguchi, Qingqing Ding, Xiaoming Xie, Jing-Yu Lang, Chien-Chen Lai, Chun-Ju Chang, Wei-Chien Huang, Hsin Huang, Hsu-Ping Kuo, Dung-Fang Lee, Long-Yuan Li, Huang-Chun Lien, Xiaoyun Cheng, King-Jen Chang, Chwan-Deng Hsiao, Fuu-Jen Tsai, Chang-Hai Tsai, Aysegul A. Sahin, William J. Muller, Gordon B. Mil1ls, Dihua Yu, Gabriel N. Hortobagyi and Mien-Chie Hung #. (2008) ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat. Cell Biol. 10: 138-148 IF: 18.485 Cited 5. Dung-Fang Lee, Hsu-Ping Kuo, Chun-Te Chen, Jung-Mao Hsu, Chao-Kai Chou, Yongkun Wei, Hui-Lung Sun, Long-Yuan Li, Bo Ping, Wei-Chien Huang, Xianghuo He, Jen-Yu Hung, Chien-Chen Lai, Qingqing Ding, Jen-Liang Su, Jer-Yen Yang, Aysegul A. Sahin, Gabriel N. Hortobagyi, Fuu-Jen Tsai, Chang-Hai Tsai and Mien-Chie Hung # (2007) IKKbeta Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mtor Pathway. Cell. 130: 440-455. IF: 29.194 Cited :0 6. Wei-Chien Huang, Tsia-Kai Ju, Mien-Chie Hung #, Ching-Chow Chen #. (2007) Phosphorylation of CBP by IKK Promotes Cell Growth by Switching the Binding Preference of CBP from p53 to NF-κB. Mol Cell. 26:75-87 IF:14.033 Cited :7 7. Jun-Jie Chen*, Wei-Chien Huang*, and Cheng-Chow Chen #. (2005) Transcriptional regulation of cyclooxygenase-2 by proteasome inhibitor MG132 involves CRE element binding CCAAT/enhancer binding protein delta and recruitment of CBP. Mol. Biol. Cell. 16: 5579-5591. IF: 6.562
Cited :16 8. Wei-Chien Huang and Ching-Chow Chen #. (2005) Akt Phosphorylation of p300 at Ser-1834 Is Essential for Its Histone Acetyltransferase and Transcriptional Activity. Mol. Cell. Biol. 25: 6592-6602. IF: 6.773 Cited :32 9. Chin-Chuan Tsai, Tung-Tuan Lai, Wei-Chien, Huang, I-Min Liu, Shorong-Shii Liou. (2005) Role of cgmp signals in tetramethylpyrazine-induced relaxation of the isolated rat aortic strip. Life Sci. 77: 1416-1424. 10. Wei-Chien Huang, Su-Tin Chan, Tzu-Lin Yang, Chern-Chy Tzeng, and Ching-Chow Chen. (2004) Inhibition of ICAM-1 gene expression, monocyte adhesion, and cancer cell invasion by targeting IKK complex: molecular and functional study of novel α-methylene-γ-butyrolactone derivatives. Carcinogenesis 25: 1925-1934. IF: 5.366. cited 18 11. Ching-Chow Chen, Man-Ping Chow, Wei-Chien Huang, Yi-Chu Lin, and Ya-Jen Chang. (2004) Flavonoids Inhibit TNF-α-induced Up-regulation of ICAM-1 in Respiratory Epithelial Cells through AP-1 and NF-kB: Structure-activity Relationships. Mol. Pharmacol. 66:683-693. IF: 4.469 Cited 41 12. Wei-Chien Huang, Jun-Jie Chen, and Ching-Chow Chen (2003) c-src-dependent tyrosine phosphorylation of IKKβ is involved in TNF-α-induced ICAM-1 expression. J. Biol. Chem. 278: 9944-9952. IF: 5.808 cited : 48 13. Wei-Chien Huang, Jun-Jie Chen, Hiroyasu Inoue, and Ching-Chow Chen (2003) Tyrosine phosphorylation of IKKα/β by PKC-dependent c-src activation is involved in TNF-α-induced COX-2 expression. J. Immunol. 170: 4767-4775. IF: 6.293 Cited 50 14. Wong KL, Chan P, Huang WC, Yang TL, Liu IM, Lai TY, Tsai CC, Cheng JT. (2003) Effect of tetramethylpyrazine on potassium channels to lower calcium concentration in cultured aortic smooth muscle cells. Clin Exp Pharmacol Physiol. 30: 793-8. IF: 1.746 Cited :5 15. Tsai CC, Lai TY, Huang WC, Yang T, Liu IM, Wong KL, Chan P, Cheng JT. (2003) Tetramethylpyrazine as potassium channel opener to lower calcium influx into cultured aortic smooth muscle cells. Planta Med. 69:557-8. IF:1.78 Cited 2. 16. Tsai CC, Lai TY, Huang WC, Liu IM, Cheng JT. (2002) Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro. Life Sci. 71: 1321-30. 17. Ching-Chow Chen, Chian-Yin Chow, Yi-Tao Sun, and Wei-Chien Huang
(2001) TNF-α-induced activation of downstream NF-κB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion: Involvement of PKCα, tyrosine kinase, and IKKα, but not MAPK, pathway. Cell. Signal. 13:543-553. 18. Huang WC, Chen PC, Jou SB, Cheng JT. (2001) Protein kinase C and changes in manganese superoxide dismutase gene expression in cultured glial cells. Clin Exp Pharmacol Physiol. 28: 822-5. 19. Cheng JT, Liu IM, Huang WC, Kou DH. (2000) Stimulatory effect of trans-cinnamaldehyde on noradrenaline secretion in guinea-pig ileum myenteric nerve terminals. Life Sci. 66:981-90. 20. Huang WC, Juang SW, Liu IM, Chi TC, Cheng JT. (1999) Changes of superoxide dismutase gene expression and activity in the brain of streptozotocin-induced diabetic rats. Neurosci Lett. 275:25-8. SYMPOSIUM PRESENTATIONS. 1. Inhibition of IKK activity enhances cell cycle arrest through p53-dependent p21cip/waf1 activation. (2008) Wei-Chien Huang, Yi-Chu Lin, Wen-Yu Huang, Hui-Ann Wu, Wei-Lun Chen, Yu-Fan Chang, Chia-Wei Chou, Cherng-Chyi Tzeng, Yeh-Long Chen, Ching-Chow Chen. 2008 Annual meeting of America Association for Cancer Research. San Diego, CA, USA 2. Phosphorylation of CBP by IKKα Promotes Cell Growth by Switching the Binding Preference of CBP from p53 to NF-κB. (2007) Wei-Chien Huang, Tsia-Kai Ju, Mien-Chie Hung, Ching-Chow Chen. American association of Cancer Research (AACR) Annual Meeting, Los Angeles, CA, USA. 3. Role of nuclear IκB kinase (IKK) in tumorigenesis: phosphorylation and functional regulation of CREB-binding protein (CBP). Wei-Chien Huang, and Ching-Chow Chen. (2005) 30 th FEBS Congress & 9 th IUBMB Conference, Budapest, Hungary 4. PI3K/Akt stimulates HAT activity of p300 and enhances its recruitment to ICAM-1 promoter. Wei-Chien Huang and Ching-Chow Chen (2004) American Society for Biochemistry and Molecular Biology 2004 Annual Meeting, Boston, MA, USA. 5. Tyrosine Phosphorylation of IKKα/β by PKC-dependent c-src Activation Is Involved in TNF-α-induced Cyclooxygenase-2 Expression. Wei-Chien Huang and Ching-Chow Chen (2003) Experimental Biology 2003 Annual Meeting,San Diego, CA, USA
第一作者或通訊作者非第一作者總計 五年內著作 5 4 9 歷年著作 10 10 20