2017BREAST SEMINAR SERIES

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Hands-on Breast Screening and Diagnosis Course * Screening of 510 full field digital mammography cases. * Reading a mixture of normals and proven abnormals at high resolution viewing stations. * Immediate feedback and discussion of every case by the Faculty. Mammography Education, Inc. 2017BREAST SEMINAR SERIES May 1-5, 2017 Combined Multimodality Diagnosis of Breast Diseases and Screening Scottsdale, Arizona Scottsdale Plaza Hotel 7200 N. Scottsdale Road * Learn how to minimize call-back rates without missing cancers. * Discussion of further workup of all abnormals - guidance to reach the correct diagnosis. NEW RE-DESIGNED COURSE FACULTY LÁSZLÓ TABÁR, MD,FACR (Hon) and GILLIAN NEWSTEAD, MD, FACR Professor of Radiology Designed for: Radiologists Surgeons Pathologists Implications of mammography, MRI, breast ultrasound and interventional methods in your practice This course teaches how to find breast cancer in its early stages and differential diagnosis of breast diseases using the multimodality approach 34 Category I CME credit hours. Fulfills MQSA interpretation requirement

FACULTY László Tabár, M.D., F.A.C.R. (Hon)., Department of Mammography, Falun, Sweden Gillian Newstead, MD, FACR Professor of Radiology University of Chicago Medical Center, Diagnostic Radiology Chicago, USA Images from the non-profit Tabar Foundation for Research and Education for Breast Cancer www.tabarfoundation.org II

Mammography Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians. Mammography Education, Inc. designed these medical education activities for a maximum of 34 credit hours in Category I of the Physicians' Recognition Award of the American Medical Association. Each physician should claim only those hours of credit that he / she actually spent in the educational activity. CREDITS We would like to thank Carestream Health and EIZO for providing the viewing stations and the engineering expertise at this teaching seminar. III

Course Overview: * This Hand-on Breast Imaging course, led by László Tabár, MD, FACR (Hon), will offer radiologists 510 full field digital mammography cases for screening (315 obligatory, the rest by popular demand). * Normals will be mixed with proven abnormal cases. * Reading will take place at high resolution work stations. * During the course the attendees will progressively improve their interpretive expertise, as they learn the full spectrum of normal breast images, with all findings explained with the help of 3-dimensional histology images. * These skills will lead to fewer call-backs and greater confidence in reading large number of mammograms. * Feedback and discussion of every case by the Faculty after every reading session. * Special emphasis will be placed on finding early phase breast cancers. * All abnormal cases are fully worked up and the complete imaging workup will be presented in detail, including ultrasound, MRI and large section histopathology. * Attendees will receive a unique present, a pdf copy of Dr. Tabar's PowerPoint presentation of each positive case, including full explanation, mammographic workup/hand-held US, 3D automated US images and breast MRI with large section histologic confirmation. IV

15 obligatory, the 2017 This course fulfills the following MQSA and ACR accreditation requirements: Interpretation/multireading of at least 315 (obligatory) cases, with the possibility of reading 510 cases mammograms under direct supervision of a qualified interpreting physician. Initial qualifications for Full Field Digital mammography (FFDM) under MQSA Instruction in the interpretation of mammograms and education in basic breast anatomy, pathology, physiology. Program Objectives: 1. Learn the full spectrum of normal mammograms through detailed explanation of the mammographic images. 2. Progressive improvement of the attendees' interpretive expertise. 3. Increase confidence in reading large numbers of full field digital mammograms at lower call-back rates. 4. Improve skills in detecting early phase breast cancer at digital mammography screening. 5. Greater proficiency in working up screen-detected findings. 6. Appreciate the clinical relevance of unifocal/multifocal/diffusely infiltrating breast cancers. 7. Emphasize the importance of multimodality approach to workup cases in a multidisciplinary environment. Attendees interpreting minimum 315 digital mammography examinations will receive a Certificate confirming the actual number of mammographic examinations read under the direct supervision of an interpreting physician, which will count towards meeting the physician interpretive requirements for MQSA qualification and certification maintenance. V

1st day of the 5-day course Morning lectures between 8:30 AM and 12:00 PM 8:30 INTRODUCTION 8:45 BASIC TECHNIQUES of IMAGE ACQUISITION. REVIEW of BASIC IMAGING REQUISITES and TIPS TO RECOGNIZE and AVOID ACQUISITION ERRORS - Newstead G Breaks at 10:00 and at 11:00 AM 10:15 BASICS of IMAGE INTERPRETATION. REVIEW of the MRI PRESENTATION of BENIGN and MALIGNANT DISEASE with LEXICON DESCRIPTORS - Newstead G 11:15 BREAST MRI READING TECHNIQUE with CASE REVIEW - Newstead G 12:00 PM - 1:00 PM L u n c h VI

1st day Afternoon program between 1:00 PM and 5:00 PM Breaks at 2:30 and at 3:30 PM 1:00 PM INTRODUCTION FOLLOWED BY DIDACTIC LECTURES COVERING: THE BASIS FOR EFFICIENT INTERPRETATION OF THE MAMMOGRAPHIC IMAGE Correlative 3-dimensional, subgross anatomy and mammography of the normal breast The problem: The variable appearance of the normal mammogram. The solution: classification into structural subtypes, mammographic parenchymal patterns, based on 3D/subgross histologic-mammographic correlation. Result: Increased confidence in reading a mammogram and finding subtle perceptual abnormalities The dynamic change of mammographic patterns and its application in clinical practice THE HETEROGENEITY OF THE NORMAL MAMMOGRAMS Practical implication, problems and solutions. Mammographic patterns and the risk of developing breast cancer. The problem of reading the mammograms of dense breasts. HANDS ON SCREENING. SESSION 1. PRACTICE OF READING NORMAL MAMMOGRAMS AT HIGH RESOLUTION VIEWING STATIONS. Learning a proven successful method to view digital mammograms Mixture of the variable appearance of normal mammograms. Learn how to minimize call-back rates without missing a cancer. Immediate feedback of each case. Faculty-audience interaction. EVALUATION OF SCREENING SESSION 1. 5:00 PM End of Day 1 VII

2nd day Morning lectures between 8:30 AM and 12:00 PM Breaks at 10:00 and at 11:00 AM 8:30 DIDACTIC LECTURE SERIES COVERING THE FOLLOWING TOPICS: The site of origin of the breast cancer influences diagnosis, choice of treatment and patient outcome. NON-CALCIFIED ASYMMETRIC DENSITIES WITH architectural distortion on the mammogram. ANALYSIS of BENIGN RADIATING STRUCTURES on the mammogram, originating in the ducts: Radial scar Radial scar Neoductgenesis ANALYSIS of MALIGNANT LESIONS PRESENTING as RADIATING STRUCTUREs on the mammogram. Clinical presentation, mammographic appearance and outcome 1) Duct forming invasive carcinoma / Neoductgenesis cases presenting on the mammogram as architectural distortion. The role of MRI in diagnosing diffuse breast carcinoma Non-calcified architectural distortion: extensive duct forming invasive cancer HANDS ON SCREENING. SESSION 2: a) Normal cases mixed with cases b) having architectural distortion. EVALUATION OF SCREENING. SESSION 2. 12:00 PM Lunch VIII

2nd day Afternoon program between 1:00 PM and 5:00 PM. Breaks at 2:30 and at 3:30 PM 1:00 PM ANALYSIS of MALIGNANT LESIONS PRESENTING as RADIATING STRUCTUREs on the mammogram. Clinical presentation, mammographic appearance and outcome, cont. 2) Diffuse forms of invasive breast cancer: the most deceptive and frequently missed cancer of the breast. The value of ultrasound and MRI in finding and diagnosis invasive lobular cancer subtypes. Case demonstrations, histologic-imaging correlation. Long-term outcome - Tabar L, Newstead G Example 1. Multimodality workup of a huge diffuse invasive lobular carcinoma. Example 2. Diffuse and solid invasive lobular carcinoma. HANDS ON SCREENING. SESSION 3: a) Normal cases mixed with cases b) having architectural distortion, (both duct forming invasive carcinoma and diffusely infiltrating breast cancers). EVALUATION OF SCREENING. SESSION 3. 5:00 PM End of Day 2 IX

3rd day Morning program between 8:30 AM and 12:00 PM Breaks at 10:00 and at 11:00 AM 8:30 DIDACTIC LECTURE SERIES COVERING THE FOLLOWING TOPICS: ANALYSIS of CALCIFIED MALIGNANT BREAST LESIONS ORIGINATING in the MAJOR DUCTS. Clinical presentation, mammographic appearance and patient outcome. Diffuse duct forming invasive carcinoma / neoductgenesis cases presenting on the mammogram as any of the four malignant type of calcifications within the major ducts (DAB). The role of MRI in diagnosing diffuse breast carcinoma - Tabar L, Newstead G. BREAST DISEASES ORIGINATING IN THE MAJOR DUCTS Benign type calcifications originating in the major ducts a) Secretory disease type calcifications Malignant type calcifications originating in the major ducts: Four different types of calcifications: a) fragmented casting type, b) dotted, snake skin-like, c) skipping stone-like and d) pearl necklace-like a) Fragmented casting type calcifications. Example 1. Example 2. Fragmented casting type calcifications (breast cancer of ductal origin DAB). X HANDS ON SCREENING. SESSION 4: a) Normal cases mixed with b) cases having non-calcified architectural distortion, (both duct forming invasive carcinoma and diffuse ininfiltrating breast cancers) and c) calcifications localized within the major ducts. 12:00 PM Lunch EVALUATION OF SCREENING. SESSION 4.

3rd day Afternoon program between 1:00 PM and 5:00 PM Breaks at 2:30 and at 3:30 PM 1:00 PM ANALYSIS of CALCIFIED MALIGNANT BREAST LESIONS ORIGINATING in the MAJOR DUCTS, cont. Clinical presentation, mammographic appearance and patient outcome.the role of MRI in diagnosing b) Dotted casting type calcifications snake skin-like * The concept of neoductgenesis. Long-term follow-up results. New aspects, correct terminology. * The role of breast MRI examination in demonstrating the extent of Gr 3 in situ carcinoma - Newstead G * Mammographic /3D histologic correlation helping to explain the underlying pathophysiology and outcome. c) Skipping stone-like calcifications d) Pearl necklace-like calcifications Practice of calcification analysis. Faculty-audience interaction. HANDS ON SCREENING. SESSION 5: a) Normal cases mixed with b) cases having non-calcified architectural distortion, (both duct forming invasive carcinoma and diffusely infiltrating breast cancers) and c) calcifications localized within the major ducts. 5:00 End of Day 3 EVALUATION OF SCREENING. SESSION 5. XI

4th day Morning program between 8:30 AM and 12:00 PM Breaks at 10:00 and at 10:00 AM 8:30 ALGORITHM FOR CLASSIFYING BREAST DISEASES ACCORDING TO THEIR SITE OF ORIGIN Benign breast diseases originating in the TDLU and associated with calcifications on the mammogram - Fibrocystic change. Fibroadenoma. Different types of adenosis. Understanding pathophysiology leading to calcified and non-calcified hyperplastic breast changes. - Conventional and 3D histology images of small breast cysts containing sediment of psammoma body-like calcifications, seen as "teacup-like calcifications on the mammogram. - Detailed analysis of calcifications associated with hyperplastic breast changes Weddellites (A), powdery calcifications (B), pleomorphic calcifications on the mammogram. A B HANDS ON SCREENING. SESSION 6: a) Normal cases mixed with b) cases having non-calcified architectural distortion, (both duct forming invasive carcinoma and diffusely infiltrating breast caancers) c) calcifications localized within the major ducts and TDLUS. d) 1-14 mm unifocal and multifocal stellate and circular tumors. EVALUATION OF SCREENING. SESSION 6. 12:00 Lunch XII

2017 4th day Afternoon program between 1:00 PM and 5:00 PM Breaks at 2:30 and at 3:30 PM 1:00 PM THE DIDACTIC LECTURE SERIES WILL COVER THE FOLLOWING TOPICS: Grade 2 cancer in situ: Mammographic / 3-D histologic / MRI correlation of cases with crushed stone-like/pleomorphic calcifications on the mammogram - Tabar L Mammographic / histologic correlation of pleomorphic calcifications The morphologic analysis of calcifications representing a less aggressive carcinoma: Grade 1 / well differentiated CIS Grade 1 in situ carcinoma: Mammographic / 3D histologic / MRI correlation of cases with powdery calcifications on the mammogram. HANDS ON SCREENING. SESSION 7: a) Normal cases mixed with b) cases having non-calcified architectural distortion, (both duct forming invasive carcinoma and diffusely infiltrating breast cancers) and c) calcifications localized within the major ducts. EVALUATION OF SCREENING. SESSION 7. 5:00 PM End of Day 4 XIII

5th day Morning program between 8:30 AM and 12:00 PM Breaks at 10:00 and at 11:00 AM 8:00 HOW TO FIND THE INVASIVE BREAST CANCER WHEN IT IS STILL SMALL. SCREENING COMBINED WITH AN ANALYTICAL APPROACH FOR THE DIFFERENTIAL DIAGNOSIS OF STELLATE / SPICULATED LESIONS. A systematic method for viewing mammograms. Areas on the mammogram where most breast cancers will be found. Viewing dense breasts. Potential solution. 3D automated US using CAD. Viewing relatively easy-to-read breasts HANDS ON SCREENING. SESSION 8 a) Normal cases mixed with b) cases having non-calcified architectural distortion, (both duct forming invasive carcinoma and diffusely infiltrating breast cancers) c) calcifications localized within the major ducts and TDLUS. d) 1-14 mm unifocal and multifocal stellate and circular tumors. EVALUATION OF SCREENING. SESSION 8. EVALUATION OF SCREENING. SESSION 9 12:00 Lunch XIV HANDS ON SCREENING. SESSION 9: a) Normal cases mixed with b) cases having non-calcified architectural distortion, (both duct forming invasive carcinoma and diffusely infiltrating breast cancers) c) calcifications localized within the major ducts and TDLUS. d) 1-14 mm unifocal and multifocal stellate and circular tumors.

5th day Afternoon program between 1:00 PM and 4:30 PM Breaks at 2:30 and at 3:30 PM Practicing the detection of non-calcified breast cancer. Subtle mammography finding / MRI shows that the entire lobe is filled with a diffuse breast cancer, confirmed at histology Multifocal invasive and in situ carcinoma on an area measuring 180X60 mm pn 4/9 4:30 PM Closing remarks. End of course. XV

For more information and registration please contact: Mammography Education, Inc. 4429 E. Spur Drive CAVE CREEK, AZ 85331, USA Phone: (480) 419 0227 Fax: (480) 419 0219 e-mail: info@mammographyed.com Internet: www.mammographyed.com Hotel room booking directly with the hotel The schedule is subject to change without notice and does not represent a commitment on the part of the organizers All rights reserved including the right of reproduction in whole or in part of any form. Copyright Computer simulation images of the development of Grade 2 in situ carcinoma within the TDLU. The lobule becomes gradually distended and deformed. Calcifications are formed within the necrotic debris and are seen on the mammogram as crushed stone-like calcifications. XVI

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