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Updates In our continuing effort to provide you with the highest quality toxicology laboratory services available, we have compiled important changes regarding a number of tests we perform. Listed below are the types of changes that may be included in this notification, effective Changes - s that have had changes to the method/ CPT code, units of measurement, scope of analysis, reference comments, or specimen requirements. Discontinued s - s being discontinued with alternate testing suggestions. Please use this information to update your computer systems/records. These changes are important to ensure standardization of our mutual laboratory databases. If you have any questions about the information contained in this notification, please call our Client Support Department at (866) 522-2206. Thank you for your continued support of NMS Labs and your assistance in implementing these changes. The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. NMS Labs does not assume responsibility for billing errors due to reliance on the CPT Codes listed in this document. Page 1 of 6

Updates Code Name Name Method / CPT Code Specimen Req. Stability Scope Units Reference Comments Discontinue 7626SP 7620SP 7632SP 7642SP 7622SP 7631UH 7631U 7673P 7677P 7627SP 11-Deoxycortisol, 17-Hydroxyprogesterone, Aldosterone, Aldosteronism / Hypertension Panel, Androstenedione, Catecholamines Fractionated, 24 Hour Catecholamines Fractionated, Catecholamines, Fractionated and Free, Plasma Catecholamines, Fractionated and Free, Plasma Corticosterone, 7655UH Cortisol and Cortisone, 24 Hour 7659SP 7655U Cortisol and Cortisone, Cortisol and Cortisone, 7625UH Cortisol, 24 Hour 7625SP 7625U Cortisol, Cortisol, 7656UH Cortisone, 24 Hour 7658SP 7656U 7623SP 7679S 7674P Cortisone, Cortisone, DHEA (Dehydroepiandrosterone), Dihydrotestosterone (DHT), Serum Dopamine - Free, Plasma 7648UH Dopamine, 24 Hour 7648U 7675P Dopamine, Epinephrine - Free, Plasma 7646UH Epinephrine, 24 Hour 7646U 7634SP 7635SP 7640SP 7633SP Epinephrine, Estradiol (E2), Estriol (E3), Estrogens Fractionated, Estrone (E1), Page 2 of 6

Updates Code Name Name Method / CPT Code Specimen Req. Stability Scope Units Reference Comments Discontinue 7639UH 7639U HIAA (5-Hydroxyindoleacetic Acid), 24 Hour HIAA (5-Hydroxyindoleacetic Acid), 7638UH HVA (Homovanillic Acid), 24 Hour 7638U 7630SP 7645UH 7645U 7645SP 7676P HVA (Homovanillic Acid), Metanephrine, Metanephrines Fractionated, 24 Hour Metanephrines Fractionated, Random Metanephrines Fractionated, Norepinephrine - Free, Plasma 7647UH Norepinephrine, 24 Hour 7647U 7643SP 7621SP 7650SP 7667SP 7669SP 7612SP 7610SP 7601SP 7614SP 7602SP 7603SP 7600SP 7664SP 7637UH 7637U 7628SP 3135SP Norepinephrine, Normetanephrine, Progesterone, Sex Hormone Binding Globulin (SHBG), T3 - Total, T4 - Total, osterone, Free (CSA), osterone, Free and Total (CSA), osterone, Free and Total, osterone, Free, Total and Bioavailable (CSA), osterone, Free, Total and Bioavailable, osterone, Total and Bioavailable, osterone, Total, Thyroid Hormone Panel- Total, VMA (Vanillylmandelic Acid), 24 Hour VMA (Vanillylmandelic Acid), Vitamin D, 25-Hydroxy (D2 and D3), Vitamin K, 10008SP Vitamin K, (CSA) Page 3 of 6

Updates Code Name Name Method / CPT Code Specimen Req. Stability Scope Units Reference Comments Discontinue 7668SP rt3 - Total, Page 4 of 6

Updates Discontinued s Code Name Alternative 7626SP 11-Deoxycortisol, 7620SP 17-Hydroxyprogesterone, 7632SP Aldosterone, 7642SP Aldosteronism / Hypertension Panel, 7622SP Androstenedione, 7631UH Catecholamines Fractionated, 24 Hour 7631U Catecholamines Fractionated, 7673P Catecholamines, Fractionated and Free, Plasma 7677P Catecholamines, Fractionated and Free, Plasma 7627SP Corticosterone, 7655UH Cortisol and Cortisone, 24 Hour 7659SP Cortisol and Cortisone, 7655U Cortisol and Cortisone, 7625UH Cortisol, 24 Hour 7625SP Cortisol, 7625U Cortisol, 7656UH Cortisone, 24 Hour 7658SP Cortisone, 7656U Cortisone, 7623SP DHEA (Dehydroepiandrosterone), 7679S Dihydrotestosterone (DHT), Serum 7674P Dopamine - Free, Plasma 7648UH Dopamine, 24 Hour 7648U Dopamine, 7675P Epinephrine - Free, Plasma 7646UH Epinephrine, 24 Hour 7646U Epinephrine, 7634SP Estradiol (E2), 7635SP Estriol (E3), 7640SP Estrogens Fractionated, 7633SP Estrone (E1), 7639UH HIAA (5-Hydroxyindoleacetic Acid), 24 Hour 7639U HIAA (5-Hydroxyindoleacetic Acid), 7638UH HVA (Homovanillic Acid), 24 Hour 7638U HVA (Homovanillic Acid), 7630SP Metanephrine, 7645UH Metanephrines Fractionated, 24 Hour 7645U Metanephrines Fractionated, Random 7645SP Metanephrines Fractionated, 7676P Norepinephrine - Free, Plasma 7647UH Norepinephrine, 24 Hour 7647U Norepinephrine, 7643SP Normetanephrine, 7621SP Progesterone, 7650SP Sex Hormone Binding Globulin (SHBG), 7667SP T3 - Total, 7669SP T4 - Total, Page 5 of 6

Updates Discontinued s Code Name Alternative 7612SP osterone, Free (CSA), 7610SP osterone, Free and Total (CSA), 7601SP osterone, Free and Total, 7614SP osterone, Free, Total and Bioavailable (CSA), 7602SP osterone, Free, Total and Bioavailable, 7603SP osterone, Total and Bioavailable, 7600SP osterone, Total, 7664SP Thyroid Hormone Panel- Total, 7637UH VMA (Vanillylmandelic Acid), 24 Hour 7637U VMA (Vanillylmandelic Acid), 7628SP Vitamin D, 25-Hydroxy (D2 and D3), 3135SP Vitamin K, 10008SP Vitamin K, (CSA) 7668SP rt3 - Total, Page 6 of 6