HEMATOLOGY & ONCOLOGY REVIEWS 19th Annual Fellows Research Presentations

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Mayo Clinic School of Continuous Professional Development 28th Annual Mayo Clinic HEMATOLOGY & ONCOLOGY REVIEWS 19th Annual Fellows Research Presentations Course Directors Gerardo Colon-Otero, M.D. Rami Manochakian, M.D. Steven R. Alberts, M.D. Pashtoon Kasi, M.D., M.B.B.S. Mark R. Litzow, M.D. 17.0 AMA PRA CATEGORY 1 CREDITS THE RITZ-CARLTON AMELIA ISLAND, FLORIDA AUGUST 1 4, 2018

COURSE HIGHLIGHTS Comprehensive review of hematology/oncology that focuses on the application of new clinical and research advancements over the preceding year Attendees will leave with up-to-date, practical information with immediate clinical application The most important clinical management questions will be addressed in highly interactive sessions INTENDED AUDIENCE Practicing hematologists, medical oncologists, scientists, researchers, nurses, physician assistants, pharmacists and clinical research associates and trainees. LEARNING OBJECTIVES Upon conclusion of this program, participants should be able to: List new practice-changing developments in hematology and oncology in 2017-2018 Select the appropriate clinical conditions in hematology and oncology where new treatments were developed in 2017 and 2018 Identify risks and benefits of new treatments approved by the FDA Describe the most important management issues in hematology and oncology and select the best treatments based on current evidence COURSE DIRECTORS Steven Alberts, M.D. Gerardo Colon-Otero, M.D. Pashtoon Kasi, M.D., M.B.B.S. Mark Litzow, M.D. Rami Manochakian, M.D. ONLINE REGISTRATION CE.MAYO.EDU/HO2018 REGISTRATION FEE(S): On or Before 7/1/18 After 7/1/2018 M.D., D.O., Scientist $675.00 $750.00 Resident, Fellow, NP, PA, Allied Health Professional, Retiree $500.00 $575.00 Simulation Center Education Session $50.00 $50.00 SIMULATION CENTER EDUCATIONAL SESSION (Additional Fee) 2.0 AMA PRA Category 1 Credit Wednesday, August 1, 2018, 2:30-5:30 pm This optional hands-on workshop in the Mayo Clinic Simulation Center will engage participants in interactive education sessions covering marrow procedures, Ommaya reservoir and LP chemotherapy procedures and simulation scenarios of diagnostic dilemmas. LODGING & ACCOMMODATIONS The Ritz-Carlton Amelia Island Call 866-763- 2960 or book online at https://aws.passkey. com/go/28thhemandoncreviews. Reserve your room before Tuesday, July 10, 2018 in order to receive a discounted rate starting at $269 per night plus applicable taxes. Please identify yourself as a participant of the Mayo Clinic Hematology/Oncology Reviews when making your reservation. CANCELLATION POLICY Please visit ce.mayo.edu/cancellation for more information.

FACULTY Mayo Clinic Faculty Daniel Ahn, DO Sikander Ailawadhi, MD Steven Alberts, MD Steven Attia, DO Tanios Bekaii-Saab, MD Asher Chanan-Khan, MD Gerardo Colon-Otero, MD Roxana Dronca, MD Deborah Fischer, PA-C James Foran, MD Thomas Habermann, MD Tufia Haddad, MD Julie Hammack, MD Kathy Hebenstreit, RN Richard Joseph, MD Pashtoon Kasi, MD, MBBS Mohamed Kharfan Dabaja, MD, MBA Stephen Ko, MD Roberto Leon Ferre, MD Mark Litzow, MD Yanyan Lou, MD Amit Mahipal, MBBS Rami Manochakian, MD Kabir Mody, MD Jeanne Palmer, MD Allison Rosenthal, MD Taimur Sher, MD Winston Tan, MD Stephan Thome, MD Daniel Trifiletti, MD Joon Uhm, MD Prakash Vishnu, MBBS Harry Yoon, MD Guest Faculty David Adelstein, MD Cleveland Clinic Carey Anders, MD University of North Carolina, Chapel Hill Maria Cabanillas, MD MD Anderson Fred Hirsch, MD, PhD University of Colorado, Denver Selina Luger, MD University of Pennsylvania Anita Rajaskhar, MD UF Health Richard Riedel, MD Duke University Neil Shah, MD, PhD University of California, San Francisco Guru Sonpavde, MD Dana-Farber Cancer Institute David Steensma, MD Dana-Farber Cancer Institute CREDIT In support of improving patient care, Mayo Clinic College of Medicine and Science is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team. Mayo Clinic College of Medicine and Science designates this live activity for a maximum of 17.0 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. AOA This program has been accredited by the American Osteopathic Association for 17 credits of AOA Category 2-A. Other Healthcare Professionals A certificate of attendance will be provided to other healthcare professionals for requesting credits in accordance with state nursing boards, specialty societies, or other professional associations. PROGRAM AGENDA Optional Simulation Center Educational Session: Wednesday, August 1, 2018 1:00p.m. Transportation Departs The Ritz-Carlton 2:30 Simulation Center Educational Session (Additional Fee) Session 1: Marrow Procedures: Posterior Iliac Crest Electric Drill and Chemotherapy Administration via a Lumbar Puncture and Ommaya Session 2: Diagnosis and Treatment Dilemmas in Hematology/Oncology 5:30p.m. Transportation Departs Mayo Clinic

Thursday, August 2, 2018 7:00 a.m. Registration and Continental Breakfast Consultative Hematology: Benign Hematology and Hematologic Malignancies Moderator: Prakash Vishnu, MBBS 8:00 Welcome Gerardo Colon-Otero, MD 8:20 What is New on the Management of Thrombosis? Anita Rajaskhar, MD 8:40 Advances in the Management of Hemophilia Prakash Vishnu, MBBS 9:00 Case Presentations, Q&A 9:20 Break Chronic Myeloid Disorders (CMPN and MDS) Moderator: Gerardo Colon-Otero, MD 9:40 An Update in the Management of Chronic Myeloproliferative Neoplasias (CMPN) Jeanne Palmer, MD 10:00 What is New on the Management of Chronic Myelogenous Leukemia (CML) Neil Shah, MD, PhD 10:20 Management of Myelodysplastic Syndromes (MDS) David Steensma, MD 10:40 Case Presentation, Q&A 11:00 Break Acute Leukemias Moderator: James Foran, MD 11:20 An Update on the Management of Acute Myelogenous Leukemia (AML) Selina Luger, MD 11:40 What is New on the Management of Acute Lymphoblastic Leukemia (ALL)? Mark Litzow, MD 12:00 p.m. Case Presentations, Q&A 12:20 Lunch CLL Myeloma Moderator: Asher Chanan-Khan, MD 1:20 State of the Art Management of Chronic Lymphocytic Leukemia (CLL) Asher Chanan-Khan, MD 1:40 Management of Multiple Myeloma in 2017 Sikander Ailawadhi, MD 2:00 Case Presentations, Q&A Lymphomas Moderator: Thomas Habermann, MD 2:20 An Update on the Treatment of Hodgkin Disease Taimur Sher, MD 2:40 Low-grade Non-Hodgkin Lymphoma: State-of-the-Art Treatment Allison Rosenthal, MD 3:00 Break 3:20 Aggressive Lymphomas: What is New? Thomas Habermann, MD 3:40 Update on cellular therapies (CAR-T cells and stem cell transplant) for hematological malignancies Mohamed Kharfan Dabaja, MD, MBA 4:00 Case Presentations, Q&A, Post-Test 4:20 Adjourn 5:00 Fellows Research Posters Discussions 6:30 p.m. Dinner with Career Adviser Panel for Fellows and Faculty and Interested Participants Friday, August 3, 2018 7:30 a.m. Continental Breakfast GU and GYN Oncology Moderator: Winston Tan, MD 8:00 What is New on the Management of Bladder Cancer? Guru Sonpavde, MD 8:20 What is New on the Management of Renal Cell Cancer? Richard Joseph, MD 8:40 Case Presentations, Q&A 9:00 New Developments in the Management of Metastatic Prostate Cancer Winston Tan, MD 9:20 An Update on the Management of Gynecologic Oncology Patients Gerardo Colon-Otero, MD

9:40 Case Discussion 10:00 Break Sarcomas and Melanomas Moderator: Steven Attia, MD 10:20 An Update on the Management of Sarcomas Richard Riedel, MD 10:40 Update on the Management of Malignant Melanoma Roxana Dronca, MD 11:00 Case Presentations, Q&A Head and Neck Cancer and Thyroid Cancer Moderator: Stephen Ko, MD 11:20 An Update on the Treatment of Head and Neck Cancer David Adelstein, MD 11:40 What is New on the Management of Metastatic Thyroid Cancer? Maria Cabanillas, MD 12: 00 p.m. Case Presentations, Q&A 12:20 Lunch GI Oncology Moderators: Steven Alberts, MD and Pashtoon Kasi, MD, MBBS 1:20 Management of Metastatic Hepatocellular Carcinoma Kabir Mody, MD 1:40 Management of Metastatic Biliary Tract Cancers Amit Mahipal, MBBS 2:00 Treatment Options for Resectable, Borderline, and Locally Advanced Pancreatic Cancer Daniel Ahn, DO 2:20 Case Discussions, Q&A 2:40 Break 3:00 Management of Metastatic Gastric and Esophageal Cancers Harry Yoon, MD 3:20 Adjuvant Therapy for Colon Cancer Tanios Bekaii-Saab, MD 3:40 Treatment Options for Metastatic Colorectal Cancer Pashtoon Kasi, MD, MBBS 4:00 Case Discussion, Q&A 4:40 p.m. Adjourn Saturday, August 4, 2018 7:30 a.m. Continental Breakfast Lung Cancer Moderator: Rami Manochakian, MD 8:00 Update on the Management of Non-Small Cell Lung Cancer without Targetable Mutations Fred Hirsch, MD, PhD 8:20 Update on Targeted Therapy in Non-Small Cell Lung Cancer Rami Manochakian, MD 8:40 What is New on the Treatment of Small Cell Lung Cancer? Yanyan Lou, MD 9:00 Case Discussion, Q&A 9:20 Break Primary and Secondary Brain Tumors Moderator: Joon Uhm, MD 9:40 Update on the Management of Primary Brain Tumors Joon Uhm, MD 10:00 Management of Metastatic Brain Tumors in 2017 Daniel Trifiletti, MD 10:20 Approach to Spinal Metastases Julie Hammack, MD 10:40 Case Discussions, Q&A Breast Cancers Moderators: Alvaro Moreno-Aspitia, MD 11:00 Update on the Management of HER2-Positive Disease Roberto Leon Ferre, MD 11:20 What is New on the Treatment of Hormone Receptor-Positive Disease Tufia Haddad, MD 11:40 What is New on the Treatment of Triple-Negative Breast Cancer Carey Anders, MD 12:00 Case Discussion, Q&A 12:20 p.m. Lunch

28th Annual Mayo Clinic HEMATOLOGY & ONCOLOGY REVIEWS Save the Date 29th Annual Hematology/Oncology Reviews 20th Annual Fellows' Research Presentation The Ritz-Carlton Amelia Island, Florida July 31-August 3, 2019 MC8100-05rev0318 MAYO CLINIC 4500 San Pablo Road Jacksonville, Florida 32224 NON-PROFIT ORG. U.S. POSTAGE PAID MAYO CLINIC