INSTITUTE OF MOLECULAR MEDICINE DRAFT Programme. T rinity C entre St James s Hospital

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17 t h IMM Annual Meeting Cancer F r i d a y N o v e m b e r 7 t h 2 0 1 4 T h e Durkan Lecture Theatre T rinity C entre St James s Hospital

8.15 am REGISTRATION SESSION 01 CANCER Chairs: Professor John O Leary, Professor of Histopathology, Trinity College Dublin; Professor John Kennedy, Clinical Professor of Medicine, Trinity College Dublin, Consultant Oncologist, St. James s Hospital Dublin 9.00 am OPENING of MEETING Professor Padraic Fallon Stokes Professor of Translational Immunology, Interim Director, Institute of Molecular Medicine, Trinity College Dublin 9.15 am 11 th INSTITUTE of MOLECULAR MEDICINE LECTURE Professor John Reynolds Professor John Reynolds, Professor of Surgery, Trinity College Dublin and St James s Hospital, Principal Investigator, Institute of Molecular Medicine, Trinity College Dublin Tending the Bridges between Surgery and Science 10.00 am the Donal Hollywood Memorial Lecture Professor Michael Baumann Professor of Radiation Oncology, Director University Cancer Centre and Chairman OncoRay-Centre for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, University of Technology Dresden Perspectives of biological individualized high precision radiation oncology 11.00 am COFFEE

SESSION 02 INFECTION and CANCER Chairs: Professor Orla Sheils, Professor in Molecular Pathology and Director of Medical Ethics, Dept. Histopathology, Director of Postgraduate Research, Trinity College Dublin; Professor Deirdre McNamara, Associate Professor and interim Head, Dept. Clinical Medicine, AMNCH, Consultant Gastroenterologist, AMNCH, Trinity College Dublin 11.30am Professor Colm Bergin Clinical Professor of Medicine, Trinity College Dublin, Consultant Physician in Infectious Diseases, St. James s Hospital Dublin, Associate Director of Clinical Research, Wellcome/HRB Research Facility (SJH and TCD) Infection, Immunology and Cancer: Investigating the interface 12.00 pm Dr Cara Martin Associate Professor in Molecular Pathology and Tumour Biology, Molecular Pathology research Group, Dept. Pathology, The Coombe Women and Infants University Hospital and Trinity College Dublin Cervix and head & neck HPV associated cancers - comparative insights Oral Presentations - Ph.D Catrgory 12.30 pm 1. Jamie O Sullivan, Haemostasis Research Group N-Linked Glycans within Von Willebrand Factor A1A2A3 domains play a critical role in modulating VWF clearance via macrophages 2. Andrea Petrasca, Immunology Group Human V δ2+ ϒδ T cells promote differentiation of B cells into effector cells that release antibody and IL-4 and stimulate alloreactive T cell proliferation 3. James Phelan, Dept. Surgery Elucidating the link between metabolism, hypoxia, inflammation, p53 and obesity in Barrett s Oesophagus 4. Kieran Crosbie-Staunton, Nanomedicine Group Screening of Multifunctional Magnetic Iron Oxide Nanoparticles for Theranostic Applications 13.00 hrs LUNCH Poster Session

SESSION 03 INNOVATIONS and TECHNOLOGIES Chairs: Dr Jacintha O Sullivan, Associate Professor, Dept. Surgery, Principal Investigator, Surgery Research Group, Trinity College Dublin; Dr Adriele Prina-Mello, Senior Research Fellow, School of Medicine, Principal Investigator, AMBER/CRANN, Trinity College Dublin 14.00 hrs Professor Ian Cree Yvonne Carter Professor of Pathology, Warwick Medical School, Hon. Consultant Pathologist, University Hospital, Coventry and Warwickshire NHS Trust Progress in early cancer detection 14.30 hrs Professor Stephen Finn Associate Professor and Consultant Pathologist, Dept. Histopathology, Trinity College Dublin, and St James s Hospital Dublin Next generation sequencing for clinical applications: Hopes and Hurdles Oral Presentations - Research Fellow Catrgory 15.00 pm 1. Melissa J Conroy, Dept. Surgery Specific recruitment of Th1 and Th17 cells to the liver and viscera ladipose tissue of obesity associated cancer patients 2. Frederick Sheedy, TB Immunology Group The Mal/TRAP S180L polymorphism affects susceptibility to tuberculosis through regulation of host IFNy-dependent responses 3. Alice M Coughlan, renal Inflammation Group Comparison of human myeloid engraftment in three immunodeficient strains of mice SESSION 04 TUMOUR INFLAMMATION and IMMUNOLOGY Chairs: Dr Derek Doherty, Associate Professor of Immunology, Head, Dept. Immunology, Trinity College Dublin; Dr Joanne Lysaght, Ussher Lecturer, Assistant Professor, Dept. Surgery, Trinity College Dublin

15.30 hrs Professor Paul Browne Professor Paul Browne, Head, School of Medicine, Professor of Haematology, Trinity College Dublin, Consultant Physician, St. James s Hospital Dublin Therapeutic innovation in myeloma: a model for the cancer-immunology interface 16.00 hrs Dr Claire Gardiner Associate Professor of Biochemistry, Trinity College Metabolic reprogramming of Natural Killer immune cells how can we exploit this 16.30 hrs COFFEE (Poster Viewing) SESSION 05 State-of-the-art Lecture Chairs: Professor Shaun McCann, Professor Emeritus of Haematology and Academic Medicine, St James s Hospital and Trinity College Dublin; Professor Aideen Long, Principal Investigator, Institute of Molecular Medicine, Dean of Graduate Studies, Trinity College Dublin. 17.00pm Speaker Professor Richard Kennedy Centre for Cancer Research and Cell Biology Queen s University Belfast Development of gene expression based biomarkers for cancer patient care 18.00 hrs POSTER COMPETITION Prizes and Photographs

19.00 hrs RECEPTION Stone Building