5 81 Larynx ICD-O-3 Topography Codes Delete C32.3 Laryngeal cartilage 5 81 Larynx ICD-O-3 Topography Codes Add an asterisk after C32.8 5 81 Larynx ICD-O-3 Topography Codes Add an asterisk after C32.9 5 81 Larynx ICD-O-3 Topography Codes Add below C32.9* Larynx, NOS *Stage by location of tumor bulk or epicenter 9 123 Mucosal Melanoma of the ICD-O-3 Histology Code Replace 8020-8090 with 8720-8790 Head and Neck 10 130 Esophagus and Esophagogastric Junction ICD-O-3 Histology Code Insert 8247-8248, after 8243-8245, 11 146 Stomach ICD-O-3 Histology Code Insert 8247-8248, after 8243-8245, 12 153 Small Intestine ICD-O-3 Histology Code Insert 8247-8248, after 8243-8245, 14 174 Colon and Rectum ICD-O-3 Histology Code Insert 8247-8248, after 8243-8245, 14 193 Colon and Rectum Figure 14.3 Change to image labels: T4b;R2 changed to T3;R2 15 207 Anus Regional Lymph Nodes In the description of the regional lymph nodes, Perirctal should read Perirectal 15 216 Anus Figure 15.10 New image 16 223 Gastrointestinal Stromal Regional Lymph Nodes (N) delete "NX Regional lymph nodes cannot be assessed" 16 223 Gastrointestinal Stromal Regional Lymph Nodes (N) Add an asterisk after "N0 No regional lymph node metastasis" 16 219 Gastrointestinal Stromal ICD-O-3 Topography Codes C17.4-C17.9 change to C17.8-C17.9 16 219 Gastrointestinal Stromal ICD-O-3 Topography Codes Delete C48.1 Specified part of peritoneum (mesentery and omentum) 8/10/10 Page 1 of 6
16 219 Gastrointestinal Stromal ICD-O-3 Topography Codes Insert after C20.9 Rectum C48.0-C48.8 Retroperitoneum and Peritoneum 16 223 Gastrointestinal Stromal Below Regional Lymph Nodes (N) box Add *If regional node status is unknown, use N0, not NX. beneath the Regional Lymph Nodes (N) box 19 247 Intrahepatic Bile Ducts Summary of Changes pretreatment serum CA199 to pretreatment serum CA19-9 20 257 Gallbladder Regional Lymph Nodes (delete, periduodenal, peripancreatic,) Should now read Celiac and superior mesenteric artery node involvement is now considered distant metastatic disease. 23 277 Ampulla of Vater Anatomic Stage/Prognostic Stage 1A should be Stage IA (Roman numeral vs. Arabic) 24 Exocrine and Endocrine 294 Pancreas Histopathologic Type Insert "tumors that" into the following sentence: The staging system applies to all tumors that arise in the pancreas. 25 317 Lung Distant Metastasis (M) M1b Distant metastasis should now read M1b Distant metastasis (in extrathoracic organs) 27 335 Bone Pathologic Staging (low vs. high grade) for recording stage. to (low vs. high grade) system for recording grade. 27 338 Bone Anatomic Stage/Prognostic G3, 4 to G3, 4 High grade 29 371 Cutaneous Squamous Cell Carcinoma Primary (T)* 2 asterisks added to the end of T2 note - any size with two or more high-risk features** 29 372 Cutaneous Squamous Cell Carcinoma Anatomic location The word "non" was deleted. Now reads."primary site hair-bearing lip" 30 383 Merkel Cell Carcinoma Regional Lymph Nodes (N) ** Micrometastases are diagnosed after sentinel or elective lymphadenectomy now reads **Isolated tumor cells in a lymph node are classified as micrometastases (N1a) and the presence of isolated tumor cells recorded using the prognostic factor. Micrometastases are diagnosed after sentinel or elective lymphadenectomy. 8/10/10 Page 2 of 6
30 378 Merkel Cell Carcinoma Anatomic Stage/Prognostic Stage IIIB changed to Any T cn1/n1b/n2 M0 The following note was inserted below Anatomic Stage/Prognostic table Note: Isolated tumor cells should be considered positive nodes, similar to melanoma (see Chapter 31). 30 384 Merkel Cell Carcinoma Insert below Anatomic Stage/Prognostics table Note: Isolated tumor cells should be considered positive nodes, similar to melanoma (see Chapter 31). 32 441 Breast Pathologic (pn)* All of Pathologic (pn)* should be yellow shaded 32 442 Breast Pathologic (pn)* pn3a through pn3c should be yellow shaded 33 462 Vulva Regional Lymph Nodes (N) N1a IIIA One lymph node metastasis each 5mm or less should now read N1a IIIA One or two lymph node metastases each 5mm or less 33 463 Vulva ICD-O-3 Histology Code 8248-8276, to 8248-8576, 36 487 Corpus Uteri Notes on Pathologic Grading Note 1 should read Notable nuclear atypia, which exceeds that which is routinely expected for the architectural grade, increases the tumor grade by 1. 37 493 Ovary and Primary ICD-O-3 Histology Code Histology code ranges should read: Peritoneal Carcinoma 8000-8576, 8590-8671, 8930-9110 (C56.9 only) 8000-8576, 8590-8671, 8930-8934, 8940-9110 (C48.1-C48.8 only) 39 509 Gestational Trophoblastic Prognostic Index Scores a score of or less, and high risk is a score of 8 or greater. to a score s of 6 or less, and high risk is a score of 7 or greater. 40 518 Penis Figure 40.1 Insert Ta in upper left-hand corner of figure, similar to other figures on page 519 41 532 Prostate Pathologic (pt)* pt2 to pt4 should have blue shading 8/10/10 Page 3 of 6
41 525 Prostate Anatomic Stage/Prognostic * T2a should read N0 M0 PSA <20 Gleason 7 41 525 Prostate Anatomic Stage/Prognostic * Insert above T2a N0 M0 PSA 20 Gleason 7 T2a N0 M0 PSA 10<20 Gleason 6 41 534 Prostate Anatomic Stage/Prognostic * T2a N0 M0 PSA<20 Gleason 7 should read T2a N0 M0 PSA <20 Gleason 7 41 534 Prostate Anatomic Stage/Prognostic * Insert after T1a-c N0 M0 PSA 10<20 Gleason 6 T2a N0 M0 PSA 10<20 Gleason 6 41 531 Prostate 2nd paragraph, last sentence change National Cancer Database Registry to National Cancer Data Base 41 531 Prostate 2nd paragraph, 2nd sentence change compared to the previous Stage groups to compared to the previous stage groups 41 530 Prostate 1st paragraph, 6th line change vesicle to vesical 42 545 Testis Prognostic Factors (Site- 42 545 Testis Prognostic Factors (Site- 42 545 Testis Prognostic Factors (Site- Serum tumor marker..paragraph should now read Serum tumor marker levels should be measured prior to orchiectomy, but levels after orchiectomy are used for assignment of S category, taking into account the half life of AFP and hcg. Stage grouping of classification of Stage IS requires persistent elevation of serum tumor markers following orchiectomy. Insert after Alpha fetoprotein (AFP) - half life 5-7 days Insert after Huma chorionic gonadotropin (hcg) - half life 1-3 days 8/10/10 Page 4 of 6
42 541 Testis Clinical Staging. 42 539 Testis Anatomic Stage/Prognostic 42 544 Testis Anatomic Stage/Prognostic 43 556 Kidney Prognostic Factors (Site- 4th & 5th sentence should read: Serum tumor markers, including AFP, hcg, and LDH, should be obtained prior to orchiectomy, but levels after orchiectomy are used to complete the status of the serum tumor markers (S), taking into account the half life of AFP and hcg. Stage grouping classification of Stage IS requires persistent elevation of serum tumor markers following orchiectomy. After S1-3 delete (measured post orchiectomy) After S1-3 delete (measured post orchiectomy) Under Clinically significant: delete Presence or absence of extranodal extension and Size of the largest tumor deposit in the lymph nodes 43 554 Kidney Anatomic Stage/Prognostic Stage IIII should read: Stage II 51 619 Malignant Melanoma of the Uvea Distant Metastasis (M) M1c Largest diameter of the largest metastasis 8 cm or more - should be - M1c Largest diameter of the largest metastasis 8.1 cm or more 53 634 Histopathologic Type Low Grade <1.5 mm beyond the capsule should now read 1.5 mm beyond the capsule 53 631 Carcinoma of the ICD-O-3 Histology Code 8980-8982 to 8980-8981 Lacrimal Gland 54 637 Sarcoma of the Orbit ICD-O-3 Histology Code Delete 8800-9136, 9142, 9582 Delete 9751-9758 Insert 8800-8936, 8940-9136, 9141-9508, 9520-9582 57 680 Lymphoid Neoplasms Definitions of TNM Should be yellow shading from Node to Nx Clinically abnormal peripheral lymph nodes; no histologic confirmation 57 681 Lymphoid Neoplasms Definitions of TNM Should be green shading from Visceral through M1 8/10/10 Page 5 of 6
57 681 Lymphoid Neoplasms Definitions of TNM Front Matter Shoud be no shading from Peripheral Blood Involvement through B2 Remove 6th Edition language from cover (please visit ww.cancerstaging.net for related product information..) 709 7th Edition Task Forces The Statistical Task Force member listing inserted before OTHER CONTRIBUTORS 8/10/10 Page 6 of 6