New Directions in Tardive Dyskinesia Research

New Directions in Tardive Dyskinesia Research

Modern Problems of Pharmacopsychiatry Founded 1968 by F.A. Freyhant, N. Petrilowitscht, and F. Pichot Vol. 21 Series Editors T.A. Ban, Nashville, Tenn.; P. Pichot, Paris, and W. Pöldinger, Wil/St. Gallen ]1WΕRΞ S. Karger Basel München Paris. London NewΥοrk Tokyo Sydney

New Directions in Tardive Dyskinesia Research Volume Editors T. Bannet and R.H. Be/maker, Jerusalem 37 figures and 33 tables, 1983 S. Karger Basel München Paris London NewYork Tokyo Sydney

Modern Problems of Pharmacopsychíatry National Library of Medicine, Cataloging in Publication New directions in tardive dyskinesia research/ volume editors, J. Bannet and R.H. Belmaker. Basel; New York: Karger, 1983. (Modern problems of pharmacopsychiatry; v.21) 1. Dyskinesia, Drug-Induced I. Bannet, J. (Jacob) Π. Belmaker, R.H. III. Series Wl MO 168P v. 21 [WL 390 1532] ISBN 3-8055-3735-2 Drug Dosage The author and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each chug for any change in indications and dosage απd for added warnings απd precautions. This is particularly important when the recommended agent is a new απd/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage απd retrieval system, without permission in writing from the publisher. 0 Copyright 1983 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland) Printed in Switzerland by Tanner & Bosshard[ AG, Basel ISBN 3-8055-3735-2

Contents Barnet, J.; Be/maker, R.H. (Jerusalem): Introduction 1 Goetz, C.G.; Klawans, H.L.; Canvey, Ρ. (Chicago, Ill.): Animal Models of Tardive Dyskinesia: Their Use in the Search for New Treatment Methods 5 Domino, E.F.; Kovacic, B. (Ann Arbor, Mich.): Monkey Models of Tardive Dyskinesia 21 Jeste, D.V. (Washington, D.C.); Jeste, S.D. (Baltimore, Md.); Wyatt, R.J. (Washington, D.C.): Reversible Tardive Dyskinesia : Implications for Therapeutic Strategy and Prevention of Tardive Dyskinesia 34 Hyttel, J.; Christensen, A.V.; Arm, J. (Copenhagen-Valby): Neuroleptic Classification: Implications for Tardive Dyskinesia 49 Casey, D.E. (Portland, Oreg.); Toenniessen, L.M. (Pittsburgh, Pa.): Neuroleptic Treatment in Tardive Dyskinesía: Can It Be Developed Into a Clinical Strategy for Long-Term Treatment? 65 Pi, E.H. (Los Angeles, Calif.); Simpson, G.M. (Philadelphia, Pa.): Atypical Neuroleptics : Clozapine and the Benzamides in the Prevention and Treatment of Tardive Dyskinesia 80 Smith, R.C.; Misra, C.H.; Allen, R.; Gordon, J. (Houston, Tex.): Dosage and Blood Levels of Neuroleptics in Tardive Dyskinesia 87 Gerlach, J.; Casey, D.E. (Portland, Oreg.): Dopamine Agonists in Clinical Research for New Tardive Dyskinesia Treatments 97 Cools, A.R. (Nijmegen): Mesolimbic System and Tardive Dyskinesia: New Perspectives for Therapy 111 Offermeier, J.; Rooyen, J.M. van (Potchefstroom): Dopamine Inhibitory and Excitatory Systems in Tardive Dyskinesias 124 Bartholini, G. (Paris): GAGA System, GAGA Receptor Agonists and Dyskinesia 143 Thaker, G.K.; Hare, T.A.; Tamminga, C.A. (Baltimore, Md.): GAGA System: Clinical Research and Treatment of Tardive Dyskinesia 155 Alphs, L.D.; Davis, J.M. (Chicago, Ill.): Cholinergic Treatments for Tardive Dyskinesia 168 Blum, Ι.; Korczyn, A.D. (Ramat Aviv/Tel Aviv): Peptide Neurotransmitters and Their Implications for the Treatment of Tardive Dyskinesia 187 Bhargava, H.N. (Chicago, Ill.): Cyclo(Leu-Gly): A Possible Treatment for Tardive Dyskinesia? 196 Crow, T.J.; Owens, D.G.C.; Johnstone, E.C.; Cross, A.J.; Owen, F. (Harrow): Does Tardive Dyskinesia Exist? 206 Subject Index 220