NIHR Supporting collaboration in life sciences research Dr Matt Hallsworth - Head of External Relations, NIHR Office for Clinical Research Infrastructure (NOCRI)
Research funders build capabilities and directly support academic research and collaboration with partners including industry Expert UK researchers are supported by expert research funders and charities: Medical Research Council (MRC) Strong basic / discovery science portfolio Innovate UK - Supports the Cell Therapy Catapult - Developing the Precision Medicine Catapult - Funds promising SME-led translational projects via the Biomedical Catalyst Wellcome Trust and medical research charities Rich and diverse disease focused research programmes www.nihr.ac.uk
Early translation into clinical development underpinned by a dedicated, expert national infrastructure The NIHR is making clinical translation more efficient by: Investing in health research infrastructure to support experimental medicine and clinical trials Working with the Health Research Authority to streamline approvals for clinical research Encouraging patient participation in research studies Introducing performance metrics for patient recruitment and study start-up Unlocking data and bioresources to enable rapid recruitment, patient and disease stratification, and real world studies Simplifying access for industry via the National Institute for Health Research (NIHR) Office for Clinical Research Infrastructure (NOCRI) www.nihr.ac.uk
NIHR clinical research infrastructure Invention Evaluation Adoption Early-phase clinical research NIHR Biomedical Research s NIHR Biomedical Research Units NIHR Clinical Research Facilities Late-phase clinical research > 0.5 billion p.a. investment in relevant infrastructure to support clinical research at all points in the development pipeline Experimental Cancer Medicine s NIHR Health Technology Cooperatives NIHR Diagnostic Evidence Cooperatives NIHR Clinical Research Network NIHR CLAHRCs www.nihr.ac.uk
Enabling translation into the clinic: NIHR Biomedical Research s and Units www.nihr.ac.uk 5
Structured models for collaboration: NIHR Translational Research Partnerships (TRPs) Discovery Delivery Data Respiratory Inflammatory Diseases 36 NHS Trusts and University partners Translationa l Research Partnership Joint & Related Inflammatory Disease Belfast Manchester Newcastle Leicester Nottingham Single Point of contact for industry Operational Management Birmingham Cambridge NOCRI Quality Oxford University College London Imperial Speed Southampton Barts & London Kings College www.nihr.ac.uk 6
Structured models for collaboration: NIHR Translational Research Collaborations (TRCs) Dementia TRC Formed of NIHR Dementia BRUs and BRCs with Dementia theme - Cambridge, Imperial, King s, Newcastle, Oxford and UCL Industry Collaborations: Identification of new Biomarkers for Parkinson s Disease All D-TRC centres plus industry partner Deep and Frequent Phenotyping project: early biomarkers in AD Pre-competitive industry consortium, broad industry interest; co-funded by NIHR and MRC Rare Diseases TRC 13 disease themes plus cross-cutting paediatric theme; deep phenotyping projects of rare diseases Complements and links with other national and international initiatives. www.nihr.ac.uk 7
Experimental Cancer Medicine s (ECMCs) ECMCs are jointly funded by Cancer Research UK, the NIHR in England and the Departments of Health for Scotland, Wales and Northern Ireland. ECMC Network is made of up 18 s across the UK. Support pioneering, early-stage clinical trials and translation of scientific discoveries into new cancer treatments for patients. Both adult and paediatric centres. www.nihr.ac.uk 8
Enabling translation into the clinic: Diagnostic Evidence Co-operatives (DECs) Discovery Delivery Data Diagnostic Evidence Co-operatives act as a catalyst for the generation of high-quality evidence of clinical validity, clinical utility, cost effectiveness and care pathway benefits of commercially-supplied IVDs. Diagnostic Evidence Co-operatives are focused on: Enabling collaboration between clinicians and other healthcare professionals, patients, the IVD industry, providers of pathology services, NHS commissioners, academic researchers including health economists, and patient groups. Creating new, world-class methodologies for IVD assessment, where required www.nihr.ac.uk
Enabling translation into the clinic: Diagnostic Evidence Co-operatives (DECs) Leeds Teaching Hospitals NHS Trust Liver diseases, Musculoskeletal diseases, Renal diseases. Oxford Health NHS Foundation Trust Primary care IVDs: Horizon scanning and rapid reviews to identify new and emerging IVDs, Identifying unmet needs for IVDs, Integrating primary care with laboratory services, Patient, carer and clinician factors in implementing IVDs, improving evidence for primary care IVDs. Newcastle upon Tyne NHS Foundation Trust Cancer, Cardiovascular disease and stroke, Genetics, Infection, Liver disease, Musculoskeletal disease, Respiratory, Transplantation. Imperial College Healthcare NHS Trust Cancer, Cardiovascular diseases, Gut health, Infectious diseases, Metabolic medicine, Primary Care, Respiratory diseases. www.nihr.ac.uk
Delivering clinical trials at pace and at scale: NIHR Clinical Research Network 15 Local Clinical Research Networks (LCRNs) Research active clinicians across 30 therapy areas Detailed understanding of care pathways Flexible deployment of resources Links with rest of UK. www.nihr.ac.uk 11
Unlocking data to drive innovation The NIHR supports access to unrivalled, clinically-coded health data and biorepositories, to better understand disease and care pathways. More than 60 million people are served by a National Health System Example data resources: UK Biobank is a unique resource of data and samples linked to medical histories and health records from 500,000 adult participants. Clinical Practice Research Datalink (CPRD) enables observational studies, clinical trial feasibility and protocol optimisation, post-market surveillance, and the collection of patient-reported outcomes and samples. NIHR BioResource enables recall to clinical studies by genotype and phenotype and helps stratify and select patients for trials UK data can support ambitious population and research studies, innovative and adaptive clinical trial design, and even real world studies and better clinical decision making 12
Accessing expertise and capabilities Discovery Delivery Data To work with the NIHR infrastructure contact the team at: nocri@nihr.ac.uk Signposting Finding the right experts Introduction Advice and tools to establish collaborations www.nihr.ac.uk 13