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Fall 2012 innovations in Orthopaedics The New Center for Joint Replacement & Preservation: State-of-the-Art, Patient-Focused pg 4 Grants are boosting researcher training and clinician development pg 3 A look at the joint replacement and preservation surgical team pg 6 Orthopaedic surgeons and engineers collaborate to innovate pg 7 University Hospitals Case Medical Center and Case Western Reserve University School of Medicine are consistently recognized as two of the premier institutions in the nation, according to U.S.News & World Report s annual rankings.

Chairman s Message New Center for Joint Replacement & Preservation Offers Expert, Patient-Centered Care In June 2012, we opened the Center for Joint Replacement & Preservation at University Hospitals Case Medical Center, bringing together a 105-yearlegacy of surgical expertise and a patient care unit tailor-made to the needs of joint replacement and joint preservation patients. The nine highvolume orthopaedic surgeons who make up the joint replacement and joint preservation team handle both complex and simple joint problems Celebrating the opening of the new Center for Joint Replacement & Preservation with a ceremonial ribbon cutting on May 31, 2012. and have completed fellowships at some of the world s top medical centers. While joint replacements are the most common procedures performed, the center also offers expertise in joint preservation, including hip arthroscopy for impingement and acetabular osteotomies. The Center for Joint Replacement & Preservation provides a comfortable, healing environment for patients, and simulates a high-end hotel experience. Equipped to handle up to 30 patients at a time, the center also has nurses and physical therapists who specialize in the care of joint replacement and preservation patients, and on-site physical therapy. Orthopaedic surgeons and engineers at Case Western Reserve University and UH Case Medical Center are also studying joint replacement surgery through the UH Case Medical Center/Case Western Reserve University Center for Evaluation of Implant Performance. Backed by more than $10 million in funding from the National Institutes of Health to Case Western Reserve University School of Medicine, the center has one of the largest implant retrieval programs in the U.S. It also features a computerized registry of the hospital s hip and knee replacement patients going back to 1985. In this issue, we also highlight recent grants to Case Western Reserve University School of Medicine from NIH and the Orthopaedic Research & Education Foundation supporting clinician development, researcher training and a fellowship in joint replacement surgery. You ll also read about recent awards and honors to the Department of Orthopaedic Surgery at Case Western Reserve University School of Medicine and the Department of Orthopaedics at University Hospitals Case Medical Center. We are proud that our specialty has once again been recognized this year by U.S.News & World Report s annual Best Hospitals rankings with UH Case Medical Center ranked in all 12 methodology-ranked specialties. The hospital joins a prestigious group of only 13 hospitals in the country ranked in all specialties. UH Case Medical Center also has been recognized as a national model for quality care as the recipient of the 2012 American Hospital Association-McKesson Quest for Quality Prize. The prestigious award named UH Case Medical Center the top hospital in the nation for its leadership and innovation in quality improvement and safety. We welcome your comments, questions and suggestions. Feel free to contact us via email or phone, or through our professional referral service. Randall E. Marcus, MD Charles H. Herndon Professor and Chairman Department of Orthopaedic Surgery University Hospitals Case Medical Center Case Western Reserve University School of Medicine Innovations in Orthopaedics Fall 2012, Volume 4, Issue 1 Contributors: Randall E. Marcus, MD; Matthew J. Kraay, MS, MD; Michael J. Salata, MD Publication Coordinator: Rich Riley Director of System Marketing: Donna Casey, RN, MBA Innovations in Orthopaedics is published biannually by University Hospitals for physicians and should be relied upon for medical education purposes only. It does not provide a complete overview of the topics covered and should not replace the independent judgment of a physician about the appropriateness or risks of a procedure for a given patient. UHhospitals.org. 2012 University Hospitals in Cleveland, Ohio. All rights reserved. Produced by McMurry. Contents of this publication may not be reproduced without the express written consent of University Hospitals. The commitment to exceptional patient care begins with revolutionary discovery. University Hospitals Case Medical Center is the primary affiliate of Case Western Reserve University School of Medicine, a national leader in medical research and education and consistently ranked among the top research medical schools in the country by U.S.News & World Report. Through their faculty appointments at Case Western Reserve University School of Medicine, physicians at UH Case Medical Center are advancing medical care through innovative research and discovery that bring the latest treatment options to patients. 2 UNIVERSITY HOSPITALS CASE MEDICAL CENTER Fall 2012 1-866-UH4-CARE (1-866-844-2273)

Department News Grant Funding Supports Orthopaedic Training and Research Significant grants recently have been given to support researcher training and clinician development in the Department of Orthopaedic Surgery at University Hospitals Case Medical Center and Case Western Reserve University schools of medicine and engineering. Awarded to Case Western Reserve University School of Medicine, the funding is from the National Institutes of Health and the Orthopaedic Research & Education Foundation. NIH-Funded Training Program in Musculoskeletal Research Training future musculoskeletal researchers is crucial because musculoskeletal diseases are major causes of morbidity, mortality and impaired quality of life for millions of people in the U.S. Case Western Reserve University has received an NIH grant of nearly $1.9 million for its Training Program in Musculoskeletal Research. Established in 1986, the program is one of the oldest training programs in musculoskeletal medicine in the country. It trains three postdoctoral and four predoctoral individuals in musculoskeletal research, and develops these individuals toward careers in musculoskeletal research. Edward M. Greenfield, PhD, Harry E. Figgie III Professor of Orthopaedic Surgery, Case Western Reserve University School of Medicine, manages the program, whose faculty includes 34 trainers from 12 departments in the schools of medicine, engineering, and arts and sciences. The faculty provides a rigorous curriculum of courses, seminars and conferences and collaborates with trainees on intensive research projects. Honors and Awards New Endowed Professorships Two members of the orthopaedics faculty were named the inaugural holders of endowed professorships at Case Western Reserve University School of Medicine: n Patrick J. Getty, MD, is the Barbara H. Ruhlman Professor in Orthopaedic Surgery. n Edward Greenfield, PhD, is the Harry E. Figgie III Professor of Orthopaedic Surgery. NIH Supports Research on Implant Retrieval The UH Case Medical Center/Case Western Reserve University Center for Evaluation of Implant Performance is the beneficiary of an approximately $2 million NIH grant awarded to Case Western Reserve University School of Medicine. The center comprises one of the largest implant retrieval programs in the U.S. and has a computerized registry of UH Case Medical Center s hip and knee replacement patients. Through grants to Case Western Reserve University School of Medicine, the NIH has supported the implant retrieval program with more than $10 million in funding over the past decade. For more information about the UH Case Medical Center/ Case Western Reserve University Center for Evaluation of Implant Performance, please see Research Corner on page 7. Orthopaedic Research & Education Foundation Supports Residents and Fellows The Department of Orthopaedic Surgery has received two grants from the Orthopaedic Research & Education Foundation: n A $50,000 grant to fund clinician development n A $20,000 Omega grant for the fellowship in joint replacement surgery The clinician development grant funds continuing medical education programs, graduate medical education fellowships, research projects, and residency enhancement programs to promote high-caliber education and skill development throughout the careers of orthopaedic surgeons. The Omega grant funds one fellow in joint replacement surgery in the Department of Orthopaedic Surgery. Resident Award Orthopaedic resident Jonathan Streit, MD, won second place in the annual Mount Sinai Barry Freedman Award for residency programs in northeast Ohio for his research project on acetabular wear patterns in individuals with different types of cam deformity of the proximal femur. Patrick J. Getty, MD, second from right, receiving his endowed chair award; pictured with, from left, Randall E. Marcus, MD, Fred Rothstein, MD, President, University Hospitals Case Medical Center, and Barbara H. Ruhlman. UHhospitals.org/ortho UNIVERSITY HOSPITALS CASE MEDICAL CENTER 1-866-UH4-CARE 3

Cover Story Grand Opening of the Center for Joint Replacement & Preservation Improving outcomes and satisfaction through expert, patient-centered care Randall E. Marcus, MD, Charles H. Herndon Professor and Chairman, Department of Orthopaedics, UH Case Medical Center/Case Western Reserve University School of Medicine Matthew J. Kraay, MS, MD, Director, Division of Joint Reconstruction and Arthritis Surgery, UH Case Medical Center; and the Kingsbury G. Heiple and Fred A. Lennon Professor of Orthopaedics, Case Western Reserve University School of Medicine A forty-year legacy of surgical expertise in joint replacement surgery, a new state-of-the-art dedicated patient care unit and leading-edge research are the hallmarks of the $3 million Center for Joint Replacement & Preservation at University Hospitals Case Medical Center, which opened in June 2012. Several years ago, the members of the Division of Joint Reconstruction and Arthritis Surgery at UH Case Medical Center developed a shared vision to establish a specialty center of excellence for joint replacement surgery to address the unique needs of patients undergoing these procedures. To accomplish this goal, they sought out the advice of previous patients, nurses, therapists and other caregivers to redesign the patient care environment, and refine the process of how patient care is delivered. The best outcomes for patients undergoing joint replacement or preservation are provided when you have surgeons, nurses and physical therapists who all specialize in joint replacement and preservation procedures working in a state-of-the-art facility that is attractive and comfortable for our patients, says Randall E. Marcus, MD, Charles H. Herndon Professor and Chairman, Department of Orthopaedics, UH Case Medical Center/ Case Western Reserve University School of Medicine. A Soothing Setting The Center for Joint Replacement & Preservation combines existing expertise with a space tailor-made to the unique needs of 30 joint replacement patients. It is built to simulate a high-end hotel experience since most of these patients are healthy and simply here to improve their quality of life, says Dr. Marcus. Floor and wall coverings, paint colors and tile schemes create a soothing environment. Special features, like noise-reducing panels around nursing workstations and a silent paging system, provide a quiet, healing atmosphere. The patient rooms have no transoms or steps and higher toilets to facilitate safe movement. The center s nurses and physical therapists also specialize, and have had additional training, in working with joint replacement and preservation patients. To accelerate rehabilitation and make it more convenient for patients, the center has its own physical therapy center. We can put the joints in perfectly, but we can t make them work, says Dr. Marcus. Patient participation in the rehabilitation process is vital. Since more knowledgeable joint replacement patients have better outcomes, fewer complications and higher satisfaction, the center offers 1 a preoperative class to teach them what to expect and about their role in the joint replacement process. High-Volume, Low-Complication Research shows that hospitals with high-volume joint replacement programs consistently have better outcomes with fewer complications than other hospitals. The nine surgeons in the Center for Joint Replacement & Preservation perform nearly 2,000 joint replacement and preservation procedures each year, one of the highest volumes in Ohio and the U.S. UH Case Medical Center has been recognized as a HealthGrades Specialty Center of Excellence (2007) for Joint Replacement and has one of the lowest complication rates in the country. The six joint replacement specialists and three joint preservation specialists all completed fellowships in joint replacement and joint preservation surgery at some of the top centers in the world. For more information about the surgical team, please see Physician Highlight on page 6. My joint replacement colleagues Drs. Petersilge, Marcus, Fitzgerald, Wilber and Wera all bring an incredible degree of expertise and experience to our program, says Matthew J. Kraay, MS, MD, Director, Division of Joint Reconstruction and Arthritis Surgery, UH Case Medical Center; and the Kingsbury G. Heiple and Fred A. Lennon Professor of Orthopaedics, Case Western Reserve University School of Medicine. While some of our patients present with routine problems, many others come to UH Case Medical Center for complex primary or revision surgical procedures or with complicated medical problems and co-morbidities that are difficult to manage in the community hospital setting. The UH Case 4 UNIVERSITY HOSPITALS CASE MEDICAL CENTER Fall 2012 1-866-UH4-CARE (1-866-844-2273)

2 3 Medical Center joint replacement surgery staff, with subspecialty training in joint replacement surgery, and the comprehensive tertiary medical care resources available at UH Case Medical Center make these complex procedures in these challenging patients a possibility. Although joint replacement surgery has historically been the focus of our adult joint reconstruction program, we are seeing a growing number of adolescent and young adult patients with joint problems that if undiagnosed and untreated will frequently end up with joint replacements. Within the last several years, advances in our understanding of arthritis and the development of innovative biologic techniques have caused us to expand the scope of what we initially envisioned as a Joint Replacement Center, to include joint preserving surgical treatment options for our patients. These include pelvic osteotomies, arthroscopic hip impingement surgery, biologic joint resurfacing and cartilage transplantation. This new collaboration with our colleagues specializing in joint preservation surgery Drs. Goodfellow, Victoroff and Salata gives us a unique ability to provide the full spectrum of joint preservation and joint replacement surgical treatment options for our patients, regardless of age, states Dr. Kraay. A Focus on Quality and Research Continually improving joint replacement outcomes and patient satisfaction is one of the center s goals. As part of the Joint Commission for Accreditation of Hospital Organizations certification process to become a designated Center of Excellence, a multidisciplinary performance improvement committee is tracking and analyzing complications, quality metrics and outcomes, and establishing targets for improvement. The committee is comprised of surgeons, nurses, administrators, physical therapists, anesthesiologists, infectious diseases specialists and members of the hospital s Quality Committee. Through the UH Case Medical Center/Case Western Reserve University Center for Evaluation of Implant Performance, orthopaedic surgeons and engineers at Case Western Reserve University and UH Case Medical Center are studying failed and successful joint replacements. The center has one of the largest implant retrieval programs in the U.S., which has received more than $10 million in funding from the National Institutes of Health, and a computerized registry of the hospital s hip and knee replacement patients going back to 1985. For more information about the UH Case Medical Center/Case Western Reserve University Center for Evaluation of Implant Performance, please see Research Corner on page 7. Contact the Center for Joint Replacement & Preservation For more information about the Center for Joint Replacement & Preservation at University Hospitals Case Medical Center, please call 216-844-7200. 1. Joint replacement procedures are performed in ORs equipped with high exchange laminar air flow technology. Surgical team members wear body exhaust spacesuits, all in order to minimize infection risk of airborne bacteria. As a result, the infection rate is less than one percent. 2. All of the UH Case Medical Center joint replacement surgeons are fellowship-trained in adult reconstructive or joint replacement surgery and are board-certified. Shown here (clockwise from top) are Drs. Glenn Wera, Randall E. Marcus, Steven Fitzgerald and William Petersilge. 3. An on-site physical therapy center, located on the same floor as the Center for Joint Replacement & Preservation, helps foster patient compliance with the rehabilitation process. UHhospitals.org/ortho UNIVERSITY HOSPITALS CASE MEDICAL CENTER 1-866-UH4-CARE 5

Physician Highlight Replacing and Preserving Joints A group of highly skilled, fellowship-trained orthopaedic surgeons is producing superior outcomes at UH Case Medical Center The nine orthopaedic surgeons who make up the joint replacement and joint preservation team at the Center for Joint Replacement & Preservation at University Hospitals Case Medical Center combine training at some of the world s top medical centers and their extensive experience to produce superior outcomes for patients with both complex and simple joint problems. All of our surgeons have had fellowship training beyond their orthopaedics residency training at the top centers in the world in joint replacement and preservation surgery, including Mayo Clinic, the Hospital for Special Surgery, Rush University Medical Center, Scripps Medical Center and Oxford University, says Randall E. Marcus, MD, Charles H. Herndon Professor and Chairman, Department of Orthopaedics, UH Case Medical Center/Case Western Reserve University School of Medicine. Dr. Marcus completed his residency at Case Western Reserve University. Then he completed fellowships in orthopaedic surgery at Oxford University (England), the University of Basel (Switzerland) and the University of Washington. Dr. Marcus is one of six joint replacement specialists and three joint preservation specialists in the Center for Joint Replacement & Preservation. All are on the faculty at Case Western Reserve University School of Medicine. We re very skilled at what we do, and we are all high-volume surgeons, says joint replacement specialist Matthew J. Kraay, MS, MD, Director, Division of Joint Reconstruction and Arthritis Surgery, UH Case Medical Center; and the Kingsbury G. Heiple and Fred A. Lennon Professor of Orthopaedics, Case Western Reserve University School of Medicine. In all, the nine surgeons in the Center for Joint Replacement & Preservation perform nearly 2,000 joint replacement and preservation procedures per year. Dr. Kraay completed his residency and a fellowship in total joint replacement and adult reconstructive surgery at Case Western Reserve University. He also completed a fellowship in arthritis surgery at the Hospital for Special Surgery in New York. Michael J. Salata, MD, Attending Surgeon, Department of Orthopaedic Surgery, UH Case Medical Center; and Assistant Professor, Orthopaedics, Case Western Reserve University School of Medicine, leads the joint preservation team. He completed his residency at University of Michigan Hospitals, followed by two fellowships at Rush University Medical Center: (1) sports medicine and shoulder surgery and (2) hip arthroscopy and joint preservation surgery. Randall E. Marcus, MD Michael J. Salata, MD William Petersilge, MD Roger G. Wilber, MD Brian Victoroff, MD Matthew J. Kraay, MS, MD Steven Fitzgerald, MD Glenn Wera, MD Donald Goodfellow, MD Contact Our Experts Professional Highlights: Other Joint Replacement Surgeons Steven Fitzgerald, MD Fellowship: Mayo Clinic Residency: Case Western Reserve University William Petersilge, MD Fellowship: Scripps Clinic Residency: Case Western Reserve University Glenn Wera, MD Fellowship: Rush-Presbyterian St. Luke s Medical Center Residency: Case Western Reserve University Roger G. Wilber, MD Fellowship: Wayne State University School of Medicine Residency: State University of New York Medical School Professional Highlights: Other Joint Preservation Surgeons Donald Goodfellow, MD Fellowship: University of California Los Angeles Medical Center Residency: Case Western Reserve University Brian Victoroff, MD Fellowship: The Orthopedic Specialty Hospital, Salt Lake City Residency: George Washington University Hospital For more information about the joint replacement and preservation specialists, and to refer your patients, please call 216-844-7200. 6 UNIVERSITY HOSPITALS CASE MEDICAL CENTER Fall 2012 1-866-UH4-CARE (1-866-844-2273)

Research Corner Improving Orthopaedic Implants and Outcomes Collaboration between orthopaedic surgeons and engineers contributes to better joint replacement components and patient outcomes Orthopaedic surgeons and engineers are working together to improve the performance of joint replacement components and the outcomes of joint replacement procedures through the University Hospitals Case Medical Center/Case Western Reserve University Center for Evaluation of Implant Performance. A partnership between the Department of Orthopaedics (at the medical school and the hospital) and the university s Department of Mechanical and Aerospace Engineering, the center has one of the largest implant retrieval programs in the U.S. and a computerized registry of the hospital s hip and knee replacement patients. This is a truly unique scientific collaboration between our Department of Orthopaedic Surgery and our colleagues in the College of Engineering at Case Western Reserve University, says Matthew J. Kraay, MS, MD, Co-Director, UH Case Medical Center/Case Western Reserve University Center for Evaluation of Implant Performance. We capitalize on our individual areas of expertise to do a detailed analysis of why the implants failed and what we can do to improve them and to improve surgical outcomes. Dr. Kraay is also Director, Division of Joint Reconstruction and Arthritis Surgery, UH Case Medical Center; and the Kingsbury G. Heiple and Fred A. Lennon Professor of Orthopaedics, Case Western Reserve University School of Medicine. Clare M. Rimnac, PhD, co-directs the center. At Case Western Reserve University School of Engineering, she is Associate Dean for Research, Wilbert J. Austin Professor of Engineering in the Department of Mechanical and Aerospace Engineering, and a Professor of Biomedical Engineering. Dr. Rimnac is also a Professor of Orthopaedics at Case Western Reserve University School of Medicine. Multicenter Implant Retrieval Program Almost 10 years ago, our implant retrieval program started a collaboration with researchers at Drexel and Thomas Jefferson Universities, who had similar interests in analysis of retrieved joint replacement devices. This partnership has received nearly $10 million of funding for implant retrieval research from the National Institutes of Health over the past decade. This program has subsequently grown to include nearly a dozen other leading academic medical centers and universities in the U.S. The UH Case Medical Center implant retrieval program has established an international reputation for scientific Clare M. Rimnac, PhD, and Matthew Kraay, MS, MD, Co-Directors of the University Hospitals Case Medical Center/Case Western Reserve University Center for Evaluation of Implant Performance contributions leading to improvements in implant design and materials used for joint replacement devices. These include identifying the mechanisms of oxidation of polyethylene in vivo, and the effects of manufacturing technique and resin type on wear of polyethylene components. Drs. Kraay and Rimnac and their colleagues received the Otto Aufranc Award from the Hip Society in 2006 for their implant retrieval research. Measurement of wear in hip replacement has been another area of interest for the retrieval program. Researchers from the UH Case Medical Center/Case Western Reserve University Center for Evaluation of Implant Performance have worked closely with the developers of the most widely used computerized wear measurement software, to evaluate and refine this sophisticated research tool. This has resulted in a user friendly and accurate technique for clinical evaluation of the performance of hip replacement implants. Joint Replacement Registry Vital information on all patients who have had joint replacement surgery at UH Case Medical Center since 1985 is stored on a computerized registry database. Pre- and post-operative standardized outcome measures, detailed surgical procedure information, complications and patient self assessment evaluations are collected on our TJR patients. The merger of our implant retrieval program and our joint replacement registry into the UH Case Medical Center/Case Western Reserve University Center for Evaluation of Implant Performance allows us to study both successful and failed total joint replacement implants and advance the science of joint replacement surgery, states Dr. Kraay. Learn More For more information about the University Hospitals Case Medical Center/Case Western Reserve University Center for Evaluation of Implant Performance, please call 216-368-6442. UHhospitals.org/ortho UNIVERSITY HOSPITALS CASE MEDICAL CENTER 1-866-UH4-CARE 7

University Hospitals of Cleveland Marketing & Communications MSC 9160 11100 Euclid Avenue Cleveland, OH 44106 Printed on recycled paper! Nancy Kolaczko, RN, RNFA Orthopaedic Triage Service Clinical Nurse Nancy Kolaczko, RN, RNFA, answers physicians questions, triages patients and ensures that appointments are made within 48 hours when necessary. Call 216-983-0393 to access orthopaedic specialists and refer patients to University Hospitals Case Medical Center s Department of Orthopaedic Surgery. Arthroscopy Expertise Hip arthroscopy enables surgeons at the Joint Preservation and Cartilage Restoration Center at University Hospitals Case Medical Center to access the hip with minimal neurovascular risk and lower morbidity than open arthrotomy, and on an outpatient basis. Referral is appropriate for a number of conditions treatable by hip arthroscopy: n Mild hip dysplasia with labral tears n Femoroacetabular impingement (FAI) n Acetabular labral tears n Removal of loose bodies n Gluteus medius tears n Chronic trochanteric bursitis n Coxa saltans (snapping hip) n Iliopsoas tendonitis UH Case Medical Center is one of the only hospitals in the region offering hip arthroscopy for all these disorders. For intra-articular conditions the most common ailments treatable by hip arthroscopy patients between 15 and 55 years of age with pain localized to the hip joint and minimal evidence of osteoarthritis of the hip are candidates. Patients with extra-articular problems, particularly those who have failed conservative management, are generally candidates up to age 65, provided they have minimal evidence of osteoarthritis of the hip. These conditions can be difficult to diagnose, resulting in treatment delays of up to 21 months, according to Michael J. Salata, MD, Attending Surgeon, Department of Orthopaedic Surgery, UH Case Medical Center, with subspecialty training in hip arthroscopy, and Assistant Professor, Orthopaedics, Case Western Reserve University School of Medicine. Patients who fit the criteria for these conditions should be evaluated by a hip specialist, he says. That can save them a lot of time and discomfort. To refer a patient, please call 216-844-6094. Win an Apple ipad2! Your feedback is important to us. As a medical professional, your input is invaluable in helping us shape future issues of Innovations in Orthopaedics. We want to know what s important to you. Do you want to read about leading-edge research, learn about the latest technology, or hear firsthand case studies of how others in your specialty are improving and saving lives? Tell us what you want to read about and your name will be entered to win one of two Apple ipad 2s! Simply visit UHhospitals.org/innovations. A New Model for Drug Development The University Hospitals Case Medical Center Harrington Discovery Institute is a national model dedicated to physician-scientists, enabling them to transform their extensive, cross-cutting knowledge into therapies that improve patients lives. As part of its mission, University Hospitals Harrington Discovery Institute will enable physician-scientists to participate in and transform the drug development cycle within academia. UH Harrington Discovery Institute is part of the $250 million Harrington Project for Discovery & Development, which includes philanthropic and institutional (UH Case Medical Center) support as well as a mission-driven, for-profit bioaccelerator. To learn more about the UH Harrington Discovery Institute, please visit UHharringtondiscoveryinstitute.org. UH Transfer Referral Center Hotline Expedite adult and pediatric transfers with one call. Services include: n Basic or ALS transports n Ground and air medical evacuation n Critical care transports 216-844-1111 or 1-800-421-9199 8 UNIVERSITY HOSPITALS CASE MEDICAL CENTER Fall 2012 1-866-UH4-CARE (1-866-844-2273)