Key words : herpes zoster, skin reaction, systemic lunus erythematosus (SLE)

Key words : herpes zoster, skin reaction, systemic lunus erythematosus (SLE)

Fig. 1 Cumulative percent of cases with herpes zoster in relation to systemic lupus eryth- (SLE). Patients with SLE who had ematosus herpes zoster (9 cases) before diaymosis of SLE were omitted. Fig. 2 Dose of prednisolone (mg/day) when a patient with systemic lupus erythematosus had herpes zoster. Horizontal bars represent means Table 1 Crude incidence of herpes zoster in patients with systemic lupus erythematosus (SLE) No. of patients 119 No. of patients with zoster 56(47%) twice or more 11 before diagnosis of SLE 9 after diagnosis of SLE 50(42%) Person-Years observed* 918 Rate per 100 Person-Years 5.45 * The number of years observed is after diagnosis of SLE. (SD).

Table 2 Renal disorder and herpes zoster in patients with systemic lupus erythematosus Table 3 Complement fixation (CF) antibodies to varicella zoster virus in patients with systemic lupus erythematosus subjects (SLE) and in normal *not significant. * *Persistent proteinuria greater than 0.5g/day or cellular cast positive. *Antibody determined by complement fixation was considered positive when the titer was 1/4 or higher Fig. 3 Antibody titers to varicella zoster virus (VZV) determined by the neutralization test in patients with systemic lupus erythematosus (SLE) and in normal subjects. Horizontal bars represent means (SD). The titers in patients with SLE and a history of herpes zoster are significantly higher (p < 0. 01) than those in another groups. Table 4 Skin test reactions to varicella zoster virus (VZV) antigen in patients with systemic lupus erythematosus (SLE) and in normal subjects *Skin reactions to VZV antigen was considered positive when a diameter of erythema was 5mm or more

Table 5 Comparison of the characteristics of SLE patients based on the skin reactions *Skin reactions to varicella zoster virus antigen **Cumn1Pment fiyatinn greater than 0.5g/day or cellular cast positive. Table 6 Effect of prednisolone on skin reactions to varicella zoster virus *Patients with systemic lupus erythematosus who had not received steroid therapy

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