University of Groningen ADHD & Addiction van Emmerik-van Oortmerssen, Katelijne IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2018 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): van Emmerik-van Oortmerssen, K. (2018). ADHD & Addiction: Prevalence, diagnostic assessment and treatment of ADHD in substance use disorder patients [Groningen]: Rijksuniversiteit Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 05-12-2018
ADHD & ADDICTION prevalence, diagnostic assessment and treatment of ADHD in substance use disorder patients Katelijne van Emmerik-van Oortmerssen
The research described in this thesis was financially supported by Fonds NutsOhra (project number 1001-036). ISBN: 978-94-034-0662-6 ISBN: 978-94-034-0661-9 (Electronic version) Cover design and lay-out: Debbie Hesseling The Fat Moose. Printed by: ProefschriftMaken. Copyright 2018: K. van Emmerik-van Oortmerssen, Amsterdam, the Netherlands. All rights reserved. No part of this thesis may be reproduced, distributed, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author.
ADHD & Addiction Prevalence, diagnostic assessment and treatment of ADHD in substance use disorder patients Proefschrift ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 20 juni 2018 om 14.30 uur door Katelijne van Oortmerssen geboren op 26 oktober 1978 te Ede
Promotores Prof. dr. R.A. Schoevers Prof. dr. W. van den Brink Copromotor Dr. E. Vedel Beoordelingscommissie Prof. dr. P.J. Hoekstra Prof. dr. O.M. Tucha Prof. dr. V.M. Hendriks
TABLE OF CONTENTS Prologue Part I: General introduction Chapter 1: Chapter 2: General Introduction to this thesis An introduction to ADHD and addiction In: Dom G, Moggi F, eds. Co-occurring addictive and psychiatric disorders: a practicebased handbook from a European perspective. Berlin: Springer-Verlag; 2015: 179-191. 11 17 Part II: Prevalence of ADHD and additional comorbidities in SUD patients Chapter 3: Chapter 4: Chapter 5: Chapter 6: Prevalence of attention-deficit hyperactivity disorder in substance In: Dom G, Moggi F, eds. Co-occurring addictive and psychiatric disorders: a practicebased handbook from a European perspective. Berlin: Springer-Verlag; 2015: 179-191. The International ADHD in Substance use disorders Prevalence study: background, methods and study population Int J Methods Psychiatr Res. 2013;22(3):232-244. Variability in the prevalence of adult ADHD in treatment seeking substance use disorder patients: results from an international multi-center study exploring DSM-IV and DSM-5 criteria. Drug Alcohol Depend. 2014;134:158-166. Psychiatric comorbidity in treatment-seeking substance use disorder patients with and without attention deficit hyperactivity disorder: results of the IASP study Addiction. 2014;109(2):262-272. 33 53 73 91 Part III: Diagnostic assessment and Integrated treatment of ADHD in SUD patients Chapter 7: Chapter 8: Investigating the efficacy of integrated cognitive behavioral therapy for adult treatment seeking substance use disorder patients with comorbid ADHD: study protocol of a randomized controlled trial BMC Psychiatry. 2013;13:132. Diagnosing ADHD during active substance use: feasible or flawed? Drug Alcohol Depend. 2017;180:371-375. 113 135
Chapter 9: Chapter 10: Chapter 11: Integrated cognitive behavioral therapy for ADHD in adult substance use disorder patients: results of a randomized clinical trial. Submitted for publication Integrated cognitive behavioral therapy for patients with Substance Use Disorder and comorbid ADHD: two case presentations Addict Behav. 2015;45:214-217. Prediction of drop-out and outcome in integrated cognitive behavioral therapy for ADHD and SUD: Results from a randomized clinical trial. In preparation for submission. 149 169 179 Part IV: Summary and Discussion Chapter 12: Epilogue Summary and General Discussion 199 225 Part V: Appendix Samenvatting [Summary in Dutch] Dankwoord [Acknowledgements in Dutch] List of publications About the author 229 237 243 249
PROLOGUE At the Jellinek Addiction Treatment Centre, we meet John for an intake. He has been drinking too much alcohol for a long time, and since he has less and less control of his drinking behavior, he is seeking help. John is a 34-year old single man; he finished higher education although it took considerable effort, and has had many short jobs since then. He is very talkative, restless and inpatient during intake, and confirms that he has been like this all his life. He is also suffering from concentration problems since childhood. These symptoms lead us to suspect the presence of a comorbid diagnosis of ADHD, and raise a couple of questions: What is the chance that John has a comorbid diagnosis of ADHD? If John has comorbid ADHD, does that mean that he differs from patients without ADHD in terms of complexity? What is the optimal timing for administering a diagnostic assessment of ADHD? If John has a comorbid diagnosis of ADHD, what treatment can we offer him? Do we know anything about the odds that John successfully completes treatment?
PART I: GENERAL INTRODUCTION