102 2004 35 2 3 : 1 2 2 ( 1 DK29220 ; 2 100083) ( Transcranial Magnetic Stimulation TMS) TMS TMS TMS TMS TMS TMS TMS ; ; ; Q189 Transcranial Magnetic Stimulation ( TMS) : Physiology Psychology Brain Mapping and Clinical Ap2 plications Andrew CN Chen 1 ZHANG Wei2Ting 2 HAN Ji2Sheng 2 ( 1 Human Brain Mapping and Cortical Imaging Laboratory Aalborg University Aalborg DK29220 Denmark ( ac @smi. auc. dk) ; 2 Neuroscience Research Institute Peking University Beijing 100083) Abstract Non2invasive Transcranial Magnetic Stimulation (TMS) can painlessly induce conductive current to excite cortex. This changes physiological processing in the brain. Varying the parameters of TMS differential physiologic effects psychological impacts can be examined. Modulation of sensory perception suppression or facilitation of cognitive capacity and behavioral performance depicts differential modulatory operation in the brain. TMS could be applied in the research of neurological disease psychiatric disorders and pharmacologi2 cal investigation. Stereotaxic and frameless TMS can improve the anatomy2guided TMS and use for navigation in brain surgery. Finally the principles derived from acupuncture mechanisms can be integrated into the fre2 quency modulation effects on the brain shared by TMS. Key words TMS physics ; Physiology ; Psychology ; Mechanisms and therapy 1771 ( Transcranial Magnetic Stimulation TMS) Bickford Fremming 1965 2002 30 TMS TMS TMS TMS TMS TMS : ; 8 0. 51. 0 [1 3 ] 3 (2003CB515400)
2004 35 2 103 TMS : TMS (stms) TMS (ptms) TMS (rtms) stms EEG/ ERP PET/ fmri ( 10 ) ptms TMS TMS PET TMS ( double2coil TMS dtms) rtms ( regional cerebral blood rtms(1 Hz flow rcbf) TMS ) rtms(525 Hz) rcbf stms TMS ;ptms TMS EEG ;rtms EEG TMS TMS ( In2 TMS ternational Society of Transcranial Magnetic Stimulation ISTS) BioMag TMS TMS [2 5 8 9 ] TMS 1000 TMS TMS ; TMS TMS GABA TMS TMS TMS (motor evoked potential TMS ; MEP) (compound muscle action potential CMAP) TMS TMS TMS ( stms ptms/ dtms rtms) TMS [2 ] [35 ] stms ( EEG) / ( ERP) (MEP) PET/ fmri TMS [6 ] [7 ] MEP/ CMAP stms TMS stms TMS ptms dtms [1 Terao Ugawa ] ( ) rtms TMS 1 Hz rtms ; 525 Hz rtms TMS ( )
104 2004 35 2 TMS () TMS TMS [1012 ] TMS [1 2 13 14 ] () TMS 100 ms TMS ( ) 60 ms 140 ms TMS () TMS TMS (dtms) 22 dtms 20 ms TMS TMS ; TMS TMS () TMS (MEP ; 22 ) ;stms 15 stms EEG TMS rtms TMS [3 8 ] () TMS TMS () TMS [9 ] 20200 ms 020 ms TMS 1. ( Parkinson s disease PD) : PD TMS TMS Brodmann 4 TMS PD GABA TMS PD 2 PD () TMS rtms TMS 2. ( ) : 10 Hz TMS TMS TMS TMS TMS MRI ptms 20 Anandan [2 ] Lisanby [5 ]
2004 35 2 105 () 1 Hz rtms TMS [3 ] 3. : rtms MEP TMS rtms rtms TMS 16 [16 () ] Beck Hamilton rtms TMS rtms rtms (SPECT) TMS [15 ] () ; TMS 20 Hz TMS 5 Hz TMS 5 1000 0. 3 Hz rtms () TMS ( ) [3 ] 2 () TMS TMS () 1T 1 Hz 60 TMS TMS TMS ; TMS TMS TMS [35 16 17 ] 2 80 % () stms TMS TMS 100 % 15 15 : (1) () ( Obsessive Compulsive Disor2 10 MEP 1 Hz rtms 60 %70 % TMS ders OCD) OCD ; (2) TMS 2 ; (3) 20 Hz TMS TMS 15 ; (4) 12 TMS OCD 2 OCD TMS OCD TMS (
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