Diagnosis and Management of Advanced Heart Failure

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Presented by the Department of Medicine, Division Of Cardiology University of California, San Francisco SATURDAY: OCTOBER 28, 2006 www.cme.ucsf.edu UCSF SYMPOSIUM: Diagnosis and Management of Advanced Heart Failure The Meritage Resort Napa, California

faculty COURSE CHAIRS Teresa De Marco, MD, FACC Professor of Clinical Medicine Director, Heart Failure and Pulmonary Hypertension Medical Director, Heart Transplantation, UCSF Kanu Chatterjee, MB, FRCP, FACC, FCCP, MACP Ernest Gallo Distinguished Professor of Medicine Chatterjee Center for Cardiac Research, UCSF UCSF FACULTY Amanda Browne, RN,CNS Heart Failure Nurse Coordinator Donald Hill, MD Clinical Professor of Surgery Director, Surgical Heart Failure Byron K. Lee, MD Assistant Professor of Medicine, Cardiac Electrophysiology Charles W. Hoopes, MD Assistant Professor of Surgery Director, Heart and Lung Transplantation Dana P. McGlothlin, MD Assistant Clinical Professor of Medicine Director of Coronary Care Unit Associate Director, Pulmonary Hypertension J. Eduardo Rame, MD Assistant Clinical Professor of Medicine, Heart Failure and Transplant Cardiology Thomas A. Ports, MD, FACC, FAHA, FSCAI, FACP, FCCP Professor of Medicine Director, Interventional Cardiology Zian H. Tseng, MD Assistant Professor of Medicine, Cardiac Electrophysiology Yerem Yeghiazarians, MD, FACC, FAHA, FSCAI Assistant Professor of Medicine Director, Cardiac Stem Cell Translation Development Program

agenda SATURDAY - OCTOBER 28, 2006 7:00 am Registration and Breakfast 7:50 am WELCOME REMARKS Teresa De Marco Moderator: Teresa De Marco 8:00 8:30 am Diastolic and Systolic Heart Failure: Differences and Similarities Kanu Chatterjee 8:30 9:00 am Neurohormonal Modulation in Advanced Systolic Heart Failure Kanu Chatterjee 9:00 9:30 am The Role of Heart Failure Clinics in Advanced Heart Failure Amanda Browne 9:30 10:10 am Acute Decompensated Heart Failure: Diagnosis and Management Teresa De Marco 10:10 10:30 am BREAK 10:30 11:00 am Moderator: Dana P. McGlothlin Cardiorenal Syndrome in Heart Failure: Prognostic and Therapeutic Considerations J. Eduardo Rame 11:00 11:30 am Cardiac Resynchronization Therapy: Selection and Optimization Byron K. Lee 11:30 12:00 noon Sudden Cardiac Death: Role of ICDs in Heart Failure Zian H. Tseng Moderator: Kanu Chatterjee 12:00 12:30 pm Panel COURSE OVERVIEW Over the past decade, great strides have been made in the understanding of heart failure with reduced as well as preserved ejection fraction. New diagnostic and therapeutic modalities have entered the stage. Electrophysiologic devices have become standard of care for the management of advanced heart failure patients. Patient selection and optimization of these devices remain challenges to the practitioner managing the advanced heart failure population. Mechanical ventricular assist devices are emerging not only as bridging therapy but also as long-term destination therapy for the subset of patients who are not candidates for transplantation. Heart transplantation remains the most effective surgical approach of last resort to improve quality of life as well as longevity. This symposium on advanced left and right heart failure will address the most current diagnostic and therapeutic advances in the field. We have chosen topics directly relevant to patient care and assembled a nationally and internationally recognized faculty for their expertise in each area. Additionally, we will provide a glimpse into the future utilizing stem cell therapies for advanced heart failure. We cordially invite practicing cardiovascular specialists, primary care physicians, cardiac nurse practitioners and nurse specialists to join us for this symposium.

12:30 1:30 pm HOSTED BUFFET LUNCHEON Moderator: J. Eduardo Rame 1:30 2:00 pm Revascularization for Ischemic Cardiomyopathy: Diagnostic and Therapeutic Considerations J. Eduardo Rame 2:00 2:30 pm Hypertrophic Obstructive Cardiomyopathy: Role of Alcohol Septal Ablation Thomas A. Ports 2:30 3:00 pm Ventricular Assist Devices As Bridging Or Destination Therapy Donald Hill 3:00 3:30 pm Heart Transplantation Update Teresa De Marco 3:30 3:50 pm BREAK Moderator: Charles W. Hoopes 3:50 4:30 pm Right Heart Failure and Pulmonary Arterial Hypertension: A Therapeutic Approach Dana P. McGlothlin 4:30 5:00 pm Surgical Therapies for Right Heart Failure Charles W. Hoopes 5:00 5:30 pm Stem Cell Therapies: Current Status and Future Promise Yerem Yeghiazarians Moderator: Kanu Chatterjee 5:30 pm Panel 6:00 pm RECEPTION AND HOSTED DINNER EDUCATIONAL OBJECTIVES Upon completion of this symposium participants should be able to # Discuss the pathophysiologic process leading to the development of heart failure due to systolic dysfunction as well as heart failure with preserved ejection fraction. # Describe the contemporary pharmacologic approaches to the management of chronic heart failure and the latest treatment strategies for acute decompensated heart failure. # Understand the contribution of the cardiorenal syndrome to the prognosis of heart failure as well as the opportunities for future therapeutic approaches. # Describe the novel diagnostic tools such as B-type natriuretic peptides and the current status of implantable hemodynamic monitors. # Apply current concepts for indications, patient selection, and optimization of cardiac resynchronization devices and the role of implantable cardioverter defibrillators in patients with heart failure at risk for sudden death.

www.cme.ucsf.edu COURSE REGISTRATION FORM UCSF SYMPOSIUM : Diagnosis and Management of Advanced Heart Failure The Meritage Resort, Napa, CA October 28, 2006 Dr. Mr. Mrs. Ms. Last Name First M.I. Degree Specialty Address City State Zip Daytime Phone Fax Email Would you like to be on our priority email list? Yes No Would you like to be on our priority fax list? Yes No Month/Date of birth to be used as OCME registrant number: / / X X Month Day Year Please indicate if you have any special needs: Registration Fee: $100 Physicians $50 Allied Health/Residents/Fellow/Nurse MDM07A16 Mail To: UCSF Office of CME P.O. Box 45368, San Francisco CA 94145-0368 Fax 415/ 502 1795 Registration Information 415/ 476 5808 Course Information 415/ 476 4251 Will you be attending our dinner reception? If so, # Adults # Children {under 12} Please charge my Visa MasterCard Amex for $ Checks payable to UC Regents Name on Card {Please Print} Card Number Authorized Signature Expiration Date Refund Policy: Cancellation requests received in writing before the first day of the conference will be refunded, less a $75 administrative fee. No refunds will be made on cancellation requests received after that date. GENERAL INFORMATION Pre-registration is preferred to ensure registrants receive a syllabus and CME Certificate at the course. HOW TO ENROLL Tuition $100 Practicing Physician $50 Allied Health Professional, Nurse, Resident, or Fellow Physicians in training must include a letter of verification from training program with registration to qualify for reduced tuition fee. Payment can be made by Visa, MasterCard, AmEx or check. Register via: Online Mail www.cme.ucsf.edu Complete course registration form and send with payment to: UCSF Office of CME P.O. Box 45368 San Francisco, CA 94145-0368 Fax Fax registration form to 415/ 502 1795 {please include your credit card number} Phone To register or to inquire about course status, please call the UCSF CME Registration Office at 415/ 476 5808. ON-SITE REGISTRATION {if space allows} Date Saturday, October 28, 2006 Time 7:00 8:00am Place The Meritage Resort 875 Bordeaux Way, Napa, CA 94559 866/ 370-NAPA REFUNDS Cancellation requests received in writing before the first day of the course will be refunded, less a $75 administrative fee. No refunds will be made on cancellations received after that date. ACCREDITATION The University of California, San Francisco School of Medicine (UCSF) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. UCSF designates this educational activity for a maximum of 8.5 AMA PRA Category 1 Credit(s).Physicians should only claim credit commensurate with the extent of their participation in the activity. This CME activity meets the requirements under California Assembly Bill 1195, continuing education and cultural and linguistic competency. Nursing For the purpose of recertification, the American Nurses Credentialing Center accepts AMA PRA Category 1 Credit issued by organizations accredited by the ACCME.

NON-PROFIT ORG U.S. POSTAGE Office of Continuing Medical Education UCSF Box 0742, LH-450 San Francisco, CA 94143-0742 P A I D AAPS REGISTER TODAY! { } For more information or to register online, visit our website at www.cme.ucsf.edu. You may also reach us by calling the Office of Continuing Medical Education at 415/ 476 4251 or email info@ocme.ucsf.edu UPCOMING CME COURSES @Adult Congenital Heart Association Nat i Conference September 15-17, South San Francisco, CA @Problem Solving in Adult Congenital Heart Disease September 16, South San Francisco, CA @23rd Annual Symposium Cardiology for the Practitioner October 23-25, Yosemite, CA @Advances in Heart Disease December 15-17, San Francisco, CA ACCOMMODATIONS Nestled in the heart of the Carneros Region amongst 8-acres of private vineyards, The Meritage Resort at Napa is the ideal destination for wine enthusiasts. Named for a distinct blend of American varietals that describe an exceptional class of wines, The Meritage Resort strikes the perfect blend of service, ambiance, amenities and experience. From the charming Tuscan décor and the very latest in high-tech amenities, to our gourmet restaurant, Siena, every need has been carefully considered and planned for. A block of guestrooms has been reserved a special UCSF discounted conference rate of $285. The contracted cut off date is September 28, 2006, or until the group room block is filled, whichever comes first. After this date, rooms will be provided on a space-available basis only. To make hotel reservations online, visit www.themeritageresort.com, use the booking code: UCSF Symposium/ NEGUC2. If you prefer to telephone in your reservation, call 1 866/ 370-NAPA, please identify yourself as a member of this UCSF conference to receive the special rate. By staying at the host hotel, you help the University of California meet its contractual obligations and keep future registration fees reasonable. Please take this into consideration when making your accommodation decisions. **Hotel Policies Reservations must be cancelled at least 24 hours in advance or a onenight s stay {and applicable taxes} will be charged. A credit card number is required to confirm your reservation. Check-in is 3:00 pm; Check-out is 12:00 noon. Room rates are subject to all state and local taxes {currently 12%, subject to change without notice}. RENTAL CAR Hertz is offering special rates for participants of this conference; simply call 1 800/654 2240 and refer to identification number 03BW0078, or call your travel agent. You may also make reservations at www.hertz.com. Advance reservations are recommended. AIR TRANSPORTATION Special arrangements have been made with Montgomery Travel. Simply call 1 800/391 2287 or complete the form on the UCSF web page at www.montgomerytravel.com. In addition to offering lower rates than published airfares, ticketed passengers may take advantage of the 24 hour emergency service. There is a $35 service fee. UCSF OCME has negotiated special fares with American and United Airlines for our course attendees. You may use the following tour codes to book on your own: American 1 800/433 1790 Code 15273. United 1 800/521 4041 Code 510CF. Brent Miller Photographer, WineCountry.com