List of changes in Out-Patients Formulary

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List of changes in Out-Patients Formulary Change in prescriber criteria Alpha Tocopheryl (Vitamin E) suspension 100mg/mL, tablets 50-150mg, tablets 670mg Atorvastatin tablets Bezafibrate tablets 400mg Bromocriptine capsules 10mg Chlorpromazine Hydrochloride (as embiolate) oral liquid 100mg/5mL Colestipol powder Colestyramine powder Compound Thymol Glycerin mouthwash Co-Proxamol (Paracetamol + Dextropropoxyphene HCl) tablets 325mg + 32.5mg Cycloserine tablets 250mg Cyproterone Acetate Injection 300mg/mL Dithranol (Anthralin) lipid stabilized cream 1% Etanercept injection 50mg Ethambutol tablets 100mg, 400mg Fenofibrate non-micronised 100mg capsules or micronized 67mg capsules Fenofibrate non-micronised 300mg capsules or micronized 200mg capsules or tablets 145mg All Medical Practitioners, i.e. doctors working within the National Health Services and private doctors, can change the dose of treatment for the following conditions when an item is marked on the formulary as Medical Practitioners or Consultant but not for medicines which are protocol regulated. 1. Hypertension 2. Diabetes Mellitus 3. Chronic Heart Failure 4. Asthma 5. Chronic Obstructive Pulmonary Disease 6. Treatment for hypercholesterolaemia under the respective Schedule V conditions 7. Chronic Mood Disorders 8. Chronic Neurotic Disorders Added Consultant Endocrinologists to the 1

Fluvastatin prolonged released tablets 80mg Fluvastatin tablets 20mg and 40mg Glibenclamide tablets 5mg Gliclazide tablets 80mg Glucagon injection 1mg Haloperidol oral solution 2mg/mL Added Consultant Geriatricians to the Ibuprofen oral suspension 100mg/5mL Added Consultant Rheumatologists to the Insulin Aspart injection 100IU/mL Insulin Biphasic Isophane (Isophane + Neutral) cartridges (70%. 30%) 100IU/mL Insulin Biphasic Isophane (Isophane + Neutral) injection 100IU/mL Insulin Glargine cartridge 100IU/mL Insulin Isophane cartridge 100units/mL in 3mL Insulin Isophane injection 100IU/mL in 10mL Insulin Neutral (Soluble Insulin) cartridge 100units/mL in 3mL Insulin Neutral (Soluble Insulin) injection SC 100IU/mL in 10mL Interferon Alfa 2b injection 18M IU SC, IV, IM Interferon Alfa 2b injection 30mcg (6MIU) Changed dose from 5mcg to 30mcg Added Consultant Haematologists to the Interferon Alfa 2b injection 3M IU Isoniazid + Rifampicin tablets 100mg + 150mg Isoniazid tablets 100mg Ivermectin tablets 3mg Added Senior Public Health Physicians to the Mesterolone tablets 25mg Metformin tablets 500mg Methylprednisolone Aceponate cream 1mg and ointment 1mg Only renewal of permits will be accepted Minoxidil topical solution 5% Only renewal of permits will be accepted Montelukast chewable tablets 5mg and tablets 10mg Moxifloxacin tablets 400mg Nicotinamide tablets 250mg Octreotide Long Acting injection IM 30mg Orciprenaline Sulphate mixture 10mg/5mL Polymyxin + Bacitracin cream Removed from Out-patients formulary. 2

Potassium Citrate + Citric Acid effervescent tablets Added Consultant Paediatricians to the 1.5g + 0.25mg Prednisolone retention enema 20mg/100mL Added Consultant Oncologists and Consultant Palliative Care to the Promazine Hydrochloride tablets 25mg Protionamide tablets 500mg Pyrazinamide tablets 500mg Rifabutin capsules 150mg Rifampicin capsules 300mg, syrup 100mg/5mL Risperidone depot injections 50mg Roxithromycin tablets 150mg Simvastatin tablets 10mg and 20mg Changed the from Consultants to Medical Practitioner Sucralfate oral liquid 1g/5mL Added Consultant Geriatricians to the Teriparatide pre-filled pen 20mcg/80mcL Testosterone Ester Depot (Sustanon ) injection 100mg Travoprost eye drops Vitamin B [Strong compound] (Nicotinamide + Riboflavin + Thiamine + Pyridoxine tablets 20mg + 2mg + 5mg + 2mg Zoledronic Acid vials 5mg Added to Out-patients formulary 3

List of changes in Hospital Formulary Change in prescriber criteria Alpha Tocopheryl (Vitamin E) suspension 100mg/mL, tablets 50-150mg, tablets 670mg Botulinum A Toxin Heamagglutinin Complex Bromocriptine capsules 10mg Chlorpromazine Hydrochloride (as embiolate) oral liquid 100mg/5mL Compound Thymol Glycerin mouthwash Co-Proxamol (Paracetamol + Dextropropoxyphene HCl) tablets 325mg + 32.5mg Cyproterone Acetate Injection 300mg/mL Daunorubicin liposomal infusion 2mg/mL vials (stand-by) Diphtheria (adsorbed) + antitoxin vaccine Diphtheria (adsorbed) + tetanus (whole cell) + pertussis + polio + Haemophilus Influenzae type B vaccine Diphtheria (adsorbed) + tetanus (whole cell) + pertussis + polio vaccine All Medical Practitioners, i.e. doctors working within the National Health Services and private doctors, can change the dose of treatment for the following conditions when an item is marked on the formulary as Medical Practitioners or Consultant but not for medicines which are protocol regulated. 1. Hypertension 2. Diabetes Mellitus 3. Chronic Heart Failure 4. Asthma 5. Chronic Obstructive Pulmonary Disease 6. Treatment for hypercholesterolaemia under the respective Schedule V conditions 9. Chronic Mood Disorders 7. Chronic Neurotic Disorders Added Consultant Endocrinologists to the Added Consultant Urologists and Consultant Paediatricians to the 4

Diphtheria (adsorbed) + tetanus (whole cell) + pertussis vaccine Diphtheria (adsorbed) + tetanus vaccine paediatric Diphtheria (low dose) + tetanus + polio vaccine (adsorbed) Diphtheria + tetanus + pertussis (acellular) + polio + Heamophilus Influenzae type B conjugate vaccine (adsorbed) Dithranol (Anthralin) lipid stabilized cream 1% Drotrecogin Alfa (activated) [Recombinant Activated Protein C] injection IV 20mg Etanercept injection 50mg Fluvastatin prolonged released tablets 80mg Haloperidol oral solution 2mg/mL Added Consultant Geriatricians to the Ibuprofen oral suspension 100mg/5mL Added Consultant Rheumatologists to the Interferon Alfa 2b injection 18M IU SC, IV, IM Interferon Alfa 2b injection 30mcg (6MIU) Changed dose from 5mcg to 30mcg Added Consultant Haematologists to the Interferon Alfa 2b injection 3M IU Ipecacuanha solution ready-to-use 1g/15mL Ivermectin tablets 3mg Added Senior Public Health Physicians to the Lepirudin vials 50mg Mesterolone tablets 25mg Methylprednisolone Aceponate cream 1mg and ointment 1mg Only renewal of permits will be accepted Minoxidil topical solution 5% Only renewal of permits will be accepted Montelukast chewable tablets 5mg and tablets 10mg Nicotine patches 5mg, 10mg and 15mg Octreotide Long Acting injection IM 30mg Oral polio vaccine Orciprenaline Sulphate mixture 10mg/5mL Potassium Citrate + Citric Acid effervescent tablets Added Consultant Paediatricians to the 1.5g + 0.25mg 5

Prednisolone retention enema 20mg/100mL Added Consultant Oncologists and Consultant Palliative Care to the Promazine Hydrochloride tablets 25mg Propranolol injections 1mg/mL Risperidone depot injections 50mg Rivaroxaban tablets 10mg Added Resident Specialist Orthopaedic Department and Senior Registrar Orthopaedic Department to the prescriber criteria Roxithromycin tablets 150mg Simvastatin tablets 10mg and 20mg Changed the from Consultants to Medical Practitioner Sucralfate oral liquid 1g/5mL Added Consultant Geriatricians to the Teriparatide pre-filled pen 20mcg/80mcL Testosterone Ester Depot (Sustanon ) injection 100mg Travoprost eye drops Vitamin B [Strong compound] (Nicotinamide + Riboflavin + Thiamine + Pyridoxine tablets 20mg + 2mg + 5mg + 2mg 6

List of changes in Protocols Changed format of all protocols Protocol 12: Atorvastatin tablets New protocol (replaces protocol 181) Protocol 64: Epoprostenol (Prostacyclin) 500mcg Injections Protocol 71: Fluvastatin Capsules and Prolonged Release Tablets Protocol 74: Fludarabine 10mg Capsules. Item no longer protocol regulated. New protocol (replaces protocol 181) Changed protocol. Removed information about injections (covered by protocol 75) Protocol 75: Fludarabine 50mg Injections New protocol (replaces part of protocol 74) Protocol 79: Fluvoxamine 100mg Tablets Protocol 92: Ibuprofen 100mg/5mL Syrup Added Consultant Rheumatologist to the Protocol 119: Levomepromazine Tablets and Injecions Protocol 126: Methylprednisolone aceponate cream and ointment Protocol 131: Minoxidil lotion Protocol 150: Olanzapine 5mg and 10mg Tablets Protocol 171: Quetiapine 25mg, 100mg and 200mg Tablets Protocol 180: Sunscreen SPF 50 + Milk or Lotion Protocol 181: HMG CoA Reductase Inhibitors (Statins) Protocol 184: Sucralfate 1g/5mL syrup Protocol 190: Teriparatide 20mcg/80mcl solution for injection in a pre-filled pen Protocol 192: Tramadol Capsules protocol. Protocol replaced by protocol 286 for Levomepromazine Injections and protocol 287 for Levomepromazine Tablets Item Item New protocol protocol. Protocol replaced by Protocol 12 for Atorvastatin and Protocol 71 for Fluvastatin. Simvastatin is no longer a protocol regulated item. Added Consultant Geriatrician to the Prescriber Criteria New protocol Changed protocol. Removed information about injections (covered by protocol 193) Protocol 193: Tramadol Injections New protocol (replaces part of protocol 192) Protocol 194: Travoprost eye drops Protocol 195: Venlafaxine 75mg and 150mg MR Capsules New protocol 7

Protocol 229: Zoledronic Acid 5mg vials Added new indications Protocol 230: Sirolimus syrup New protocol (replaces part of protocol 231) Protocol 231: Sirolimus tablets Changed protocol, removed sirolimus syrup information (which is covered by protocol 230) Protocol 267: Cyclizine 50mg/mL Ampoules Updated protocol Protocol 276: Clopidogrel 75mg Tablets Updated protocol Protocol 286: Levomepromazine Injections New protocol (replaces protocol 119) Protocol 287: Levomepromazine Tablets New protocol (replaces protocol 119) Protocol 290: Rivaroxaban 10mg tablets Added Resident Specialist Orthopaedic Department and Senior Registrar Orthopaedic Department to the prescriber criteria Protocol 291: Risperidone 25mg, 37.5mg and Added new doses 50mg Depot Injections Protocol 295: Montelukast 5mg Chewable New protocol Tablets and 10mg Tablets Protocol 296: Nicotine 5mg, 10mg and 15mg New protocol Patches 8