University of Groningen Improving outcomes of patients with Alzheimer's disease Droogsma, Hinderika IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2015 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Droogsma, H. (2015). Improving outcomes of patients with Alzheimer's disease: long-term disease course and nutritional status in a 'real-life' setting [Groningen]: University of Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 11-02-2018
Improving outcomes of patients with Alzheimer s disease long-term disease course and nutritional status in a real-life setting Hinderika Droogsma
Copyright 2015: H. Droogsma No parts of this thesis may be reproduced or transmitted in any forms or by any means, electronic or mechanical, including photocopying, recording or any information storage and retrieval system, without permission of the author ISBN: 978-90-367-8162-6 Lay-out: Peter van der Sijde, Proefschriftgroningen.nl Printed by: Dekker drukwerken te Leeuwarden
Improving outcomes of patients with Alzheimer s disease long-term disease course and nutritional status in a real-life setting Proefschrift ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op maandag 23 november 2015 om 15.00 uur door Hinderika Droogsma geboren op 19 december 1986 te Sneek
Promotor Prof. dr. P.P. De Deyn Copromotor Dr. D. van Asselt Beoordelingscommissie Prof. dr. H.W.G.M. Boddeke Prof. dr. H.P.H. Kremer Prof. dr. M.G.M. Olde Rikkert
Paranimfen Susanne Lubbers Marloes Prins
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Table of content 1. General introduction, aims and outline of this thesis 9 2. Long-term course of Alzheimer s disease in patients treated in a real-life setting 19 2.1 Long-term course of Alzheimer s disease in patients treated according to the 19 Dutch dementia guideline at a memory clinic: a real-life study 2.2 Initial cognitive response to cholinesterase inhibitors and subsequent long-term 37 course in patients with mild Alzheimer s disease 3. Alzheimer s disease and nutritional status 53 3.1 Nutritional status of community-dwelling elderly with newly diagnosed 53 Alzheimer s disease: prevalence of malnutrition and the relation of various factors to nutritional status 3.2 The relation of weight change trajectory with medial temporal lobe atrophy in 65 patients with mild Alzheimer s disease: results from a cohort study 3.3 Effect of long-term treatment with galantamine on weight of patients with 85 Alzheimer s dementia 3.4 Nutritional interventions in community-dwelling Alzheimer patients with (risk of) 79 undernutrition: a systematic review 4. Main outcomes and general discussion 111 5. Summary/samenvatting/gearfetting 125 5.1 Summary in English 127 5.2 Samenvatting in het Nederlands 131 5.3 Gearfetting yn it Frysk 135 6. Appendices 141 6.1 List of publications 143 6.2 About the author 145 6.3 Dankwoord 147 7
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