Comment les cellules osseuses communiquent entre elles. Gérard Friedlander Journées UPA 2011

Comment les cellules osseuses communiquent entre elles Gérard Friedlander Journées UPA 2011

Structure de l os

Osteocyte

Ostéoclaste

Remodelage osseux

RANKL RANK NF-kB pathway Stem cell progenitor precursor Osteoblast M-CSF Osteoprotegerin

RANKL RANK NF-kB pathway Stem cell progenitor precursor Osteoblast M-CSF Osteoprotegerin

RANKL RANK NF-kB pathway Stem cell progenitor precursor Osteoblast M-CSF Osteoprotegerin

RANKL RANK NF-kB pathway Stem cell progenitor precursor Osteoblast M-CSF Osteoprotegerin

Human osteopetrosis due to RANKL mutations: the osteoclast is not guilty

progenitor precursor

NF-kB pathway RANK progenitor precursor

RANKL Osteoblast NF-kB pathway RANK progenitor precursor

RANKL Osteoblast NF-kB pathway RANK progenitor precursor

RANKL Osteoblast NF-kB pathway RANK progenitor precursor

Nuclear factor-kb inhibits osteoblastic bone formation

RANK RANKL NF-kB OPG Osteoblast

RANK RANKL NF-kB NF-kB OPG Osteoblast

RANK RANKL NF-kB NF-kB Fra-1 OPG Osteoblast

Suppression of NF-kB increases bone formation and ameliorates osteopenia in ovariectomized mice

I B IKK- I B P NF- B

I B NF- B IKK- I B P NF- B

I B NF- B IKK- I B P proteasome NF- B NF- B

I B IKK- proteasome Marrow stromal cell NF- B NF- B I B P precursor - NF- B + Osteoblast

I B IKK- proteasome Marrow stromal cell NF- B NF- B I B P precursor - NF- B + NF- B inhibitors Osteoblast

Bidirectional ephrin signalling controls bone homeostasis

ephrinb2 Monocytes s Pre-osteoblasts Osteoblasts Osteocytes

ephrinb2 EphB4 Monocytes s Pre-osteoblasts Osteoblasts Osteocytes

ephrinb2 EphB4 Monocytes + s Pre-osteoblasts Osteoblasts Osteocytes

EphB4 Monocytes s Pre-osteoblasts Osteoblasts Osteocytes

ephrinb2 EphB4 Monocytes s Pre-osteoblasts Osteoblasts Osteocytes

ephrinb2 EphB4 - Monocytes s Pre-osteoblasts Osteoblasts Osteocytes

ephrinb2 EphB4 - + Monocytes s Pre-osteoblasts Osteoblasts Osteocytes

PTH and PTHrP stimulate bone formation through EphrinB2

Action de la PTH

ephrinb2 EphB4 - + Monocytes s Pre-osteoblastsOsteoblasts Osteocytes

ephrinb2 EphB4 PTH PTHrP - + Monocytes s Pre-osteoblastsOsteoblasts Osteocytes

ephrinb2 EphB4 PTH PTHrP - + Monocytes s Pre-osteoblastsOsteoblasts Osteocytes

ephrinb2 EphB4 PTH PTHrP - + Monocytes s Pre-osteoblastsOsteoblasts Osteocytes

Intermittent PTH requires osteoclasts and c-fos to enhance bone formation

Osteoblast PTH

Osteoblast PTH

PTH Osteoblast

PTH C-fos Osteoblast

Osteocalcin: a skeleton key to metabolism

Osteoblast

Osteoblast Ocn

Osteoblast Ocn OST-PTP Gla Ocn

Osteoblast Pancreas beta cell Ocn OST-PTP Gla Ocn Adipocyte

Osteoblast Pancreas beta cell Insulin Ocn OST-PTP Gla Ocn Adipocyte

Osteoblast Pancreas beta cell Insulin Ocn OST-PTP Adiponectin Gla Ocn Adipocyte

Osteoblast Pancreas beta cell Insulin Ocn Improve Glucose handling Lower fat mass OST-PTP Adiponectin Gla Ocn Adipocyte

Jagged1 Promotes Breast Cancer Bone Metastasis

Jagged1 Bone tumor cell

Bone tumor cell Bone tumor cell proliferation Jagged1 Il-6 secreted Notch Hey1 Il-6 Osteoblast

Bone tumor cell Bone tumor cell proliferation Jagged1 Il-6 secreted Notch Notch Hey1 Il-6 Osteoblast Pre-osteoclast Cell differentiation osteoclast Bones osteolysis

Bone tumor cell Bone tumor cell proliferation Jagged1 Il-6 secreted Notch Notch Hey1 Il-6 Osteoblast Pre-osteoclast Cell differentiation osteoclast Bones osteolysis TGF

Bone tumor cell Bone tumor cell proliferation Jagged1 Il-6 secreted -secretase Notch inhibitor Notch Hey1 Il-6 Osteoblast Pre-osteoclast Cell differentiation osteoclast Bones osteolysis TGF